Threats to the Mind: Aging, Amyloid, and Hypertension
Open accessAbstract
Aging, Alzheimer disease, and hypertension, major determinants of cognitive dysfunction, are associated with profound alterations in the structure and function of cerebral blood vessels. These vascular alterations may impair the delivery of energy substrates and nutrients to the active brain, and impede the clearance of potentially toxic metabolic byproducts. Reactive oxygen species derived form the enzyme NADPH oxidase are key pathogenic effectors of the cerebrovascular dysregulation. The resulting alterations in the homeostasis of the cerebral microenvironment may lead to cellular dysfunction and death and to cognitive impairment. The prominent role that cerebrovascular oxidative stress plays in conditions associated with cognitive impairment suggests new therapeutic opportunities to counteract and, possibly, reverse the devastating effects of cerebrovascular dysfunction on the brain.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The neurovascular unit is profoundly disrupted in vascular cognitive impairment and Alzheimer disease.
“The neurovascular unit is profoundly disrupted in VCI and Alzheimer disease.95,100–103”
From Vascular Contributions to Cognitive Impairment and Dementia: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (2011) · cites this paper as [102]
The Alzheimer Disease section describes substantial structural and functional cerebrovascular abnormalities in AD. The Conclusions and “How Does Cerebrovascular Dysfunction Lead to Cognitive Deficits?” sections also link vascular and blood–brain barrier changes to cognitive deficits. The paper does not specifically discuss vascular cognitive impairment (VCI) as a condition or state that the neurovascular unit is profoundly disrupted in VCI. (LLM, conf=0.82)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
Zlokovic, B. V. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.003 · Cited by 3,280 · see citing works
Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works
Self-citationAngiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
Mehta, P. K., & Griendling, K. K. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00287.2006 · Cited by 1,924 · see citing works
Glial regulation of the cerebral microvasculature
Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works
Self-citationCerebral microvascular pathology in aging and Alzheimer's disease
Farkas, E., & Luiten, P. G. M. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00068-x · Cited by 1,102 · see citing works
Paulson, O. B., Strandgaard, S., & Edvinsson, L. (1990) · PubMed · Cited by 1,093 · see citing works
Oxidative Stress and Cardiovascular Injury
Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093661.90582.c4 · Cited by 720 · see citing works
Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy
Lambeth, J. D. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.027 · Cited by 677 · see citing works
Endocytosis Is Required for Synaptic Activity-Dependent Release of Amyloid-β In Vivo
Cirrito, J. R., Kang, J.-E., Lee, J., Stewart, F. R., Verges, D. K., Silverio, L. M., Bu, G., Mennerick, S., & Holtzman, D. M. (2008) · Neuron · doi:10.1016/j.neuron.2008.02.003 · Cited by 635 · see citing works
Fernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587 · see citing works
Hypertension and Cerebrovascular Dysfunction
Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557 · see citing works
Self-citationThe role of cerebral ischemia in Alzheimer’s disease
Kalaria, R. N. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00125-1 · Cited by 522 · see citing works
Biochemical mechanisms for translational regulation in synaptic plasticity
Klann, E., & Dever, T. E. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1557 · Cited by 422 · see citing works
Patterns of cerebral blood flow reduction in patients with ischemic leukoaraiosis
O’Sullivan, M., Lythgoe, D. J., Pereira, A. C., Summers, P. E., Jarosz, J. M., Williams, S. C. R., & Markus, H. S. (2002) · Neurology · doi:10.1212/wnl.59.3.321 · Cited by 360 · see citing works
Park, L., Zhou, P., Pitstick, R., Capone, C., Anrather, J., Norris, E. H., Younkin, L., Younkin, S., Carlson, G., McEwen, B. S., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711568105 · Cited by 332 · see citing works
Self-citationUpdate on hypertension and Alzheimer's disease
Skoog, I. G., & Gustafson, D. (2006) · Neurological Research · doi:10.1179/016164106x130506 · Cited by 287 · see citing works
Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse Brain
Park, L., Anrather, J., Girouard, H., Zhou, P., & Iadecola, C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600491 · Cited by 275 · see citing works
Self-citationThe Hemo-Neural Hypothesis: On The Role of Blood Flow in Information Processing
Moore, C. I., & Cao, R. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01366.2006 · Cited by 242 · see citing works
Endothelial influences on cerebrovascular tone
Andresen, J., Shafi, N. I., & Bryan, R. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00937.2005 · Cited by 235 · see citing works
NADPH oxidase activity and function are profoundly greater in cerebral versus systemic arteries
Miller, A. A., Drummond, G. R., Schmidt, H. H. H. W., & Sobey, C. G. (2005) · Circulation Research · doi:10.1161/01.res.0000189301.10217.87 · Cited by 211 · see citing works
Reactive oxygen species: influence on cerebral vascular tone
Faraci, F. M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01044.2005 · Cited by 189 · see citing works
Dede, D. S., Yavuz, B., Yavuz, B. B., Cankurtaran, M., Halil, M., Ulger, Z., Cankurtaran, E. S., Aytemir, K., Kabakci, G., & Ariogul, S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01378.x · Cited by 142 · see citing works
Wilkinson, B. L., Koenigsknecht-Talboo, J., Grommes, C., Lee, C. Y. D., & Landreth, G. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600627200 · Cited by 131 · see citing works
Perfusion abnormalities in prodromal AD
Johnson, K. A., & Albert, M. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00137-8 · Cited by 101 · see citing works
Rosenblum, W. I. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0416-9 · Cited by 64 · see citing works
Linking cerebrovascular defense mechanisms in brain ageing and Alzheimer's disease
Kalaria, R. N. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.10.020 · Cited by 48 · see citing works
Arterial hypertension and ischaemic stroke
Droste, D. W., Ritter, M., Dittrich, R., Heidenreich, S., Wichter, T., Freund, M., & Ringelstein, E. B. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00098.x · Cited by 44 · see citing works
Smooth muscle cells and the pathogenesis of cerebral microvascular disease (“angiomyopathies”)
Auerbach, I. D., Sung, S. H., Wang, Z., & Vinters, H. V. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00013-3 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works
Self-citationThe Science of Stroke: Mechanisms in Search of Treatments
Moskowitz, M. A., Lo, E. H., & Iadecola, C. (2010) · Neuron · doi:10.1016/j.neuron.2010.07.002 · Cited by 1,930 · see citing works
Self-citationCombating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899 · see citing works
Hypertension-induced cognitive impairment: From pathophysiology to public health
Ungvari, Z., Toth, P., Tarantini, S., Prodan, C. I., Sorond, F., Merkely, B., & Csiszar, A. (2021) · Nature Reviews Nephrology · doi:10.1038/s41581-021-00430-6 · Cited by 544 · see citing works
Toth, P., Tarantini, S., Csiszar, A., & Ungvari, Z. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00581.2016 · Cited by 522 · see citing works
Pathophysiologic Cascades in Ischemic Stroke
Xing, C., Arai, K., Lo, E. H., & Hommel, M. (2012) · International Journal of Stroke · doi:10.1111/j.1747-4949.2012.00839.x · Cited by 421 · see citing works
Tarantini, S., Tran, C. H. T., Gordon, G. R., Ungvari, Z., & Csiszar, A. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.11.004 · Cited by 411 · see citing works
Alterations in Cerebral Metabolic Rate and Blood Supply across the Adult Lifespan
Lu, H., Xu, F., Rodrigue, K. M., Kennedy, K. M., Cheng, Y., Flicker, B., Hebrank, A. C., Uh, J., & Park, D. C. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq224 · Cited by 400 · see citing works
Pathology and pathogenesis of vascular cognitive impairment—a critical update
Jellinger, K. A. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00017 · Cited by 353 · see citing works
White matter injury in ischemic stroke
Wang, Y., Liu, G., Hong, D., Chen, F., Ji, X., & Cao, G. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.005 · Cited by 309 · see citing works
Executive Function, Memory, and Gait Speed Decline in Well-Functioning Older Adults
Watson, N. L., Rosano, C., Boudreau, R. M., Simonsick, E. M., Ferrucci, L., Sutton-Tyrrell, K., Hardy, S. E., Atkinson, H. H., Yaffe, K. S., Satterfield, S., et al. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq111 · Cited by 289 · see citing works
Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07002.x · Cited by 261 · see citing works
Carnevale, D., Mascio, G., D'Andrea, I., Fardella, V., Bell, R. D., Branchi, I., Pallante, F., Zlokovic, B., Yan, S. S., & Lembo, G. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.195511 · Cited by 241 · see citing works
Rouch, L., Cestac, P., Hanon, O., Cool, C., Helmer, C., Bouhanick, B., Chamontin, B., Dartigues, J.-F., Vellas, B. J., & Andrieu, S. (2015) · CNS Drugs · doi:10.1007/s40263-015-0230-6 · Cited by 237 · see citing works
Tóth, P., Tucsek, Z., Sosnowska, D., Gautam, T., Mitschelen, M. C., Tarantini, S., Deák, F., Koller, Á., Sonntag, W. E., Csiszár, A., et al. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.143 · Cited by 233 · see citing works
Endothelial nitric oxide: protector of a healthy mind
Katušić, Z. S., & Austin, S. A. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht544 · Cited by 222 · see citing works
Cellular Senescence, Vascular Disease, and Aging
Kovacic, J. C., Moreno, P., Nabel, E. G., Hachinski, V., & Fuster, V. (2011) · Circulation · doi:10.1161/circulationaha.110.009118 · Cited by 222 · see citing works
Midlife Blood Pressure, Plasma β-Amyloid, and the Risk for Alzheimer Disease
Shah, N. S., Vidal, J., Masaki, K., Petrovitch, H., Ross, G. W., Tilley, C., Demattos, R. B., Tracy, R. P., White, L. R., & Launer, L. J. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.178962 · Cited by 212 · see citing works
Cellular Senescence, Vascular Disease, and Aging
Kovacic, J. C., Moreno, P., Hachinski, V., Nabel, E. G., & Fuster, V. (2011) · Circulation · doi:10.1161/circulationaha.110.007021 · Cited by 204 · see citing works
Vascular cognitive impairment and dementia
Gorelick, P. B., Counts, S., & Nyenhuis, D. L. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.12.015 · Cited by 187 · see citing works
Systemic Diseases and Oral Health
Tavares, M. A., Calabi, K. A. L., & Martin, L. S. (2014) · Dental Clinics of North America · doi:10.1016/j.cden.2014.07.005 · Cited by 169 · see citing works
Cerebral Hypoperfusion and Cognitive Impairment: The Pathogenic Role of Vascular Oxidative Stress
Liu, H., & Zhang, J. (2012) · International Journal of Neuroscience · doi:10.3109/00207454.2012.686543 · Cited by 161 · see citing works
Tóth, P., Tarantini, S., Ashpole, N. M., Tucsek, Z., Milne, G. L., Valcarcel‐Ares, M. N., Menyhárt, Á., Farkas, E., Sonntag, W. E., Csiszár, A., et al. (2015) · Aging Cell · doi:10.1111/acel.12372 · Cited by 153 · see citing works
Cerebral microbleeds and vascular cognitive impairment.
Werring, D. J., Gregoire, S. M., & Cipolotti, L. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.034 · Cited by 143 · see citing works
Vascular Aspects of Cognitive Impairment and Dementia
Wiesmann, M., Kiliaan, A. J., & Claassen, J. A. H. R. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.159 · Cited by 147 · see citing works
Aliev, G., Priyadarshini, M., Reddy, V., Grieg, N. H., Kaminsky, Y., Cacabelos, R., Ashraf, G., Jabir, N. R., Kamal, M. A., Nikolenko, V. N., et al. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666131227161303 · Cited by 138 · see citing works
Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer's disease
Yezhuvath, U. S., Uh, J., Cheng, Y., Martin‐Cook, K., Weiner, M., Diaz-Arrastia, R. R., van Osch, M. J. P., & Lu, H. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.02.005 · Cited by 131 · see citing works
Vascular Cognitive Impairment: Disease Mechanisms and Therapeutic Implications
Levine, D. A., & Langa, K. M. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0047-z · Cited by 130 · see citing works
KRIT1 Regulates the Homeostasis of Intracellular Reactive Oxygen Species
Goitre, L., Balzac, F., Degani, S., Degan, P., Marchi, S., Pinton, P., & Retta, S. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011786 · Cited by 129 · see citing works
Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125 · see citing works
Czakó, C. N., Kovács, T., Ungvari, Z. I., Csiszár, A., Yabluchanskiy, A., Conley, S. M., Csípő, T., Lipécz, Á., Horváth, H., Sándor, G. L., et al. (2020) · GeroScience · doi:10.1007/s11357-020-00252-7 · Cited by 126 · see citing works
Jia, J., Wei, C., Liang, J., Zhou, A., Zuo, X., Song, H., Wu, L., Chen, X., Chen, S., Zhang, J., et al. (2015) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2015.04.010 · Cited by 125 · see citing works
Heterogeneity of Astrocytes in Grey and White Matter
Köhler, S., Winkler, U., & Hirrlinger, J. (2021) · Neurochemical Research · doi:10.1007/s11064-019-02926-x · Cited by 123 · see citing works
Neurovascular coupling is impaired in slow walkers: the MOBILIZE Boston Study
Sorond, F. A., Kiely, D. K., Galica, A., Moscufo, N., Serrador, J. M., Iloputaife, I., Egorova, S., Dell'Oglio, E., Meier, D. S., Newton, E., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22433 · Cited by 111 · see citing works
Role of the Extracellular Matrix in Alzheimer’s Disease
Sun, Y., Xu, S., Jiang, M., Liu, X., Yang, L., Bai, Z., & Yang, Q. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.707466 · Cited by 113 · see citing works
Dong, Y.-F., Kataoka, K., Toyama, K., Sueta, D., Koibuchi, N., Yamamoto, E., Yata, K., Tomimoto, H., Ogawa, H., & Kim-Mitsuyama, S. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173534 · Cited by 109 · see citing works
Pulse Wave Velocity and Cognitive Decline in Elders
Hazzouri, A. Z. A., Newman, A. B., Simonsick, E. M., Sink, K. M., Tyrrell, K. S., Watson, N. L., Satterfield, S., Harris, T. B., Yaffe, K. S., & Study, F. T. H. A. (2013) · Stroke · doi:10.1161/strokeaha.112.673533 · Cited by 109 · see citing works
Prevention of Vascular Cognitive Impairment
Dichgans, M., & Zietemann, V. (2012) · Stroke · doi:10.1161/strokeaha.112.651778 · Cited by 107 · see citing works
Tóth, P., Csiszár, A., Tucsek, Z., Sosnowska, D., Gautam, T., Koller, Á., Schwartzman, M. L., Sonntag, W. E., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2013 · Cited by 102 · see citing works
Arterial Stiffness and Cognitive Decline in Well-Functioning Older Adults
Watson, N. L., Sutton-Tyrrell, K., Rosano, C., Boudreau, R. M., Hardy, S. E., Simonsick, E. M., Najjar, S. S., Launer, L. J., Yaffe, K. S., Atkinson, H. H., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr119 · Cited by 103 · see citing works
Vascular and metabolic dysfunction in Alzheimer’s disease: a review
Murray, I. V. J., Proza, J. F., Sohrabji, F., & Lawler, J. M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010355 · Cited by 104 · see citing works
Kovács, R., Heinemann, U., & Steinhäuser, C. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03703.x · Cited by 100 · see citing works
Bolduc, V., Thorin‐Trescases, N., & Thorin, É. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00624.2012 · Cited by 100 · see citing works
Angelova, P. R., & Abramov, A. Y. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.103 · Cited by 98 · see citing works
Caffeine and the Control of Cerebral Hemodynamics
Pelligrino, D. A., Xu, H.-L., & Vetri, F. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091261 · Cited by 93 · see citing works
Csiszar, A., Tarantini, S., Fülöp, G. A., Kiss, T., Valcarcel-Ares, M. N., Galvan, V., Ungvari, Z., & Yabluchanskiy, A. (2017) · GeroScience · doi:10.1007/s11357-017-9991-9 · Cited by 93 · see citing works
Levit, A., Hachinski, V., & Whitehead, S. N. (2020) · GeroScience · doi:10.1007/s11357-020-00164-6 · Cited by 89 · see citing works
The cerebrovascular role of the cholinergic neural system in Alzheimer's disease
van Beek, A. H. E. A., & Claassen, J. A. H. R. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.12.047 · Cited by 88 · see citing works
Tucsek, Z., Valcarcel‐Ares, M. N., Tarantini, S., Yabluchanskiy, A., Fülöp, G., Gautam, T., Orock, A. M., Csiszár, A., Deák, F., & Ungvari, Z. I. (2017) · GeroScience · doi:10.1007/s11357-017-9981-y · Cited by 89 · see citing works
Microvascular NADPH oxidase in health and disease
Li, Y., & Pagano, P. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.02.049 · Cited by 79 · see citing works
Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer's disease
van Beek, A. H. E. A., Lagró, J., Olde-Rikkert, M. G. M., Zhang, R., & Claassen, J. A. H. R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.016 · Cited by 77 · see citing works
Sato, N., & Morishita, R. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00143 · Cited by 78 · see citing works
Caruso, P., Signori, R., & Moretti, R. (2019) · Vascular Health and Risk Management · doi:10.2147/vhrm.s190470 · Cited by 76 · see citing works
Oxidative Stress, Reductive Stress and Antioxidants in Vascular Pathogenesis and Aging
Mladenov, M. I., Lubomirov, L. T., Grisk, O., Avtanski, D. B., Mitrokhin, V. M., Sazdova, I., Keremidarska‐Markova, M., Danailova, Y., Nikolaev, G., Konakchieva, R., et al. (2023) · Antioxidants · doi:10.3390/antiox12051126 · Cited by 77 · see citing works
Vasilevko, V., Passos, G. F., Quiring, D., Head, E., Kim, R. C., Fisher, M., & Cribbs, D. H. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05786.x · Cited by 72 · see citing works
Oudegeest‐Sander, M. H., van Beek, A. H. E. A., Abbink, K., Rikkert, M. G. M. O., Hopman, M. T. E., & Claassen, J. A. H. R. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.076455 · Cited by 74 · see citing works
Guardia, G. S., Custers, E., de Lange, A., Clijncke, E., Geenen, B., Gutierrez, J., Küsters, B., Claassen, J. A. H. R., de Leeuw, F., Wiesmann, M., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01497-3 · Cited by 73 · see citing works
Incidence of stroke in people with Alzheimer disease
Tolppanen, A., Lavikainen, P., Solomon, A., Kivipelto, M., Soininen, H. S., & Hartikainen, S. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f08c5 · Cited by 73 · see citing works
Perrotta, M., Lembo, G., & Carnevale, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17030347 · Cited by 74 · see citing works
Csiszár, A., Tucsek, Z., Tóth, P., Sosnowska, D., Gautam, T., Koller, Á., Deák, F., Sonntag, W. E., & Ungvari, Z. I. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00288.2013 · Cited by 72 · see citing works
Cerebral Microbleeds: Detection, Mechanisms and Clinical Challenges
Charidimou, A., & Werring, D. J. (2011) · Future Neurology · doi:10.2217/fnl.11.42 · Cited by 72 · see citing works
Csiszár, A., Ungvari, A., Patai, R., Gulej, R., Yabluchanskiy, A., Benyó, Z., Kovács, I., Sótonyi, P., Kirkpartrick, A. C., Prodan, C. I., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01139-7 · Cited by 72 · see citing works
Interaction of neurons and astrocytes underlies the mechanism of Aβ-induced neurotoxicity
Angelova, P. R., & Abramov, A. Y. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140153 · Cited by 71 · see citing works
Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention
Miller, A. A., Budzyn, K., & Sobey, C. G. (2010) · Clinical Science · doi:10.1042/cs20090649 · Cited by 70 · see citing works
Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysis
Craig, L., Hoo, Z. L., Yan, T. Z., Wardlaw, J. M., & Quinn, T. J. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-325796 · Cited by 68 · see citing works
Viboolvorakul, S., & Patumraj, S. (2014) · BioMed Research International · doi:10.1155/2014/230791 · Cited by 69 · see citing works
Faraco, G., Wijasa, T. S., Park, L., Moore, J. M. R., Anrather, J., & Iadecola, C. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.24 · Cited by 68 · see citing works
Self-citationMolecular Crosstalk between Integrins and Cadherins: Do Reactive Oxygen Species Set the Talk?
Goitre, L., Pergolizzi, B., Ferro, E., Trabalzini, L., & Retta, S. F. (2011) · Journal of Signal Transduction · doi:10.1155/2012/807682 · Cited by 67 · see citing works
Sato, N., & Morishita, R. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00064 · Cited by 63 · see citing works
Capone, C., Faraco, G., Anrather, J., Zhou, P., & Iadecola, C. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145813 · Cited by 61 · see citing works
Self-citationGregoire, S. M., Scheffler, G., Jäger, H. R., Yousry, T. A., Brown, M. M., Kallis, C., Lisa Cipolotti, A., & Werring, D. J. (2013) · Stroke · doi:10.1161/strokeaha.111.000245 · Cited by 57 · see citing works
Tarantini, S., Yabluchanksiy, A., Fülöp, G. Á., Hertelendy, P., Valcarcel‐Ares, M. N., Kiss, T., Bagwell, J. M., O’Connor, D., Farkas, E., Sorond, F. A., et al. (2017) · GeroScience · doi:10.1007/s11357-017-0003-x · Cited by 55 · see citing works
The axon–glia unit in white matter stroke: Mechanisms of damage and recovery
Rosenzweig, S., & Carmichael, S. T. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.019 · Cited by 56 · see citing works
Clinical trials for preventing post stroke cognitive impairment
Ankolekar, S., Geeganage, C. M., Anderton, P., Hogg, C., & Bath, P. M. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.08.052 · Cited by 56 · see citing works
Park, L., Zhou, P., Koizumi, K., Jamal, S. E., Previti, M. L., Nostrand, W. E. V., Carlson, G. A., & Iadecola, C. (2012) · Stroke · doi:10.1161/strokeaha.112.670976 · Cited by 55 · see citing works
Self-citationGuimond, M., & Gallo‐Payet, N. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00164 · Cited by 53 · see citing works
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 52 · see citing works
Poststroke cognitive impairment and dementia: prevalence, diagnosis, and treatment
Melkas, S., Jokinen, H., Hietanen, M., & Erkinjuntti, T. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s37353 · Cited by 53 · see citing works
Nyúl‐Tóth, Á., Tarantini, S., Kiss, T., Tóth, P., Galván, V., Tarantini, A., Yabluchanskiy, A., Csiszár, A., & Ungvari, Z. I. (2020) · GeroScience · doi:10.1007/s11357-020-00256-3 · Cited by 52 · see citing works
Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice
Yu, Y., Luo, X., Li, C., Ding, F., Wang, M., Xie, M., Yu, Z., Ransom, B. R., & Wang, W. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14925 · Cited by 47 · see citing works
Taniguchi, Y., Fujiwara, Y., Nofuji, Y., Nishi, M., Murayama, H., Seino, S., Tajima, R., Matsuyama, Y., & Shinkai, S. (2015) · Journal of Epidemiology · doi:10.2188/jea.je20140250 · Cited by 48 · see citing works
Cognitive Patterns in Relation to Biomarkers of Cerebrovascular Disease and Vascular Risk Factors
Miralbell, J., Elena López-Cancio, M., López-Olóriz, J., Arenillas, J. F., Barrios, M., Soriano-Raya, J. J., Galán, A., Cáceres, C. M., Alzamora, M. T., Pera, G., et al. (2013) · Cerebrovascular Diseases · doi:10.1159/000352059 · Cited by 47 · see citing works
Arterial stiffness and progression of structural brain changes
Jochemsen, H. M., Muller, M., Bots, M. L., Scheltens, P., Vincken, K. L., Mali, W. P. T. M., van der Graaf, Y., Geerlings, M. I., Algra, A., Doevendans, P. A., et al. (2015) · Neurology · doi:10.1212/wnl.0000000000001201 · Cited by 47 · see citing works
Arterial Stiffness and Cognitive Function in the Elderly
Hazzouri, A. Z. A., & Yaffe, K. S. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141563 · Cited by 46 · see citing works
Current pathophysiological concepts in cerebral small vessel disease
Rincón, F., & Wright, C. B. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00024 · Cited by 44 · see citing works
White Matter Hyperintensity Burden and Susceptibility to Cerebral Ischemia
Rost, N. S., Fitzpatrick, K. M., Biffi, A., Kanakis, A. S., Devan, W. J., Anderson, C. D., Cortellini, L., Furie, K. L., & Rosand, J. M. (2010) · Stroke · doi:10.1161/strokeaha.110.595355 · Cited by 45 · see citing works
Matrone, C., Djelloul, M., Taglialatela, G., & Perrone, L. (2015) · PubMed · doi:10.14670/hh-30.125 · Cited by 46 · see citing works
Catchlove, S. J., Pipingas, A., Hughes, M. E., & Macpherson, H. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0421-4 · Cited by 44 · see citing works
The links between complex coronary disease, cerebrovascular disease, and degenerative brain disease
Kovacic, J. C., Castellano, J. M., & Fuster, V. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06482.x · Cited by 43 · see citing works
Leoni, R. F., Mazzetto‐Betti, K. C., Silva, A. C., dos Santos, A. C., de Araújo, D. B., Leite, J. P., & Pontes‐Neto, O. M. (2012) · Radiology Research and Practice · doi:10.1155/2012/268483 · Cited by 40 · see citing works
Treating Hypertension to Prevent Cognitive Decline and Dementia: Re-Opening the Debate
Iulita, M. F., & Girouard, H. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_98 · Cited by 36 · see citing works
Neurobiology of Vascular Dementia
Enciu, A., Constantinescu, S. N., Popescu, L. M., Muresanu, D. F., & Popescu, B. O. (2011) · Journal of Aging Research · doi:10.4061/2011/401604 · Cited by 36 · see citing works
Amyloid-β Peptides Activate α 1 -Adrenergic Cardiovascular Receptors
Haase, N., Herse, F., Spallek, B., Haase, H., Morano, I. L., Qadri, F., Szijártó, I. A., Rohm, I., Yılmaz, A., Warrington, J. P., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01348 · Cited by 36 · see citing works
Alkan, E., Taporoski, T. P., Sterr, A., von Schantz, M., Vallada, H., Krieger, J. E., Pereira, A. C., Alvim, R. D. O., Horimoto, A. R. V. R., Pompéia, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-40630-6 · Cited by 35 · see citing works
Briyal, S., Shepard, C., & Gulati, A. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.02.008 · Cited by 35 · see citing works
van Beek, A. H. E. A., Sijbesma, J. C., Jansen, R. W. M. M., Rikkert, M. G. M. O., & Claassen, J. A. H. R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100288 · Cited by 35 · see citing works
What are the mechanisms for post-stroke dementia?
Hennerici, M. G. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70261-3 · Cited by 35 · see citing works
Ungvari, A., Gulej, R., Csík, B., Mukli, P., Negri, S., Tarantini, S., Yabluchanskiy, A., Benyó, Z., Csiszár, A., & Ungvari, Z. I. (2023) · Nutrients · doi:10.3390/nu15214662 · Cited by 34 · see citing works
Sharma, B., & Singh, N. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.11.011 · Cited by 34 · see citing works
Slice Cultures as a Model to Study Neurovascular Coupling and Blood Brain Barrier In Vitro
Kovács, R., Papageorgiou, I. E., & Heinemann, U. (2011) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2011/646958 · Cited by 34 · see citing works
- Authors
- Iadecola, C., Park, L., & Capone, C.
- Affiliations
- Cornell University (US)
- Venue
- Stroke
- Published
- 2009-03
- Volume
- 40
- Issue
- 3_suppl_1
- Pages
- S40-4
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC2704500
- OpenAlex
- W2068846977
- Cited by
- 207
- References
- 29
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 4 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 10 · 2017: 9 · 2016: 15 · 2015: 10 · 2014: 19 · 2013: 21 · 2012: 22
- FWCI
- 10.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ns038252-06)
- National Heart, Lung, and Blood Institute (HL-18974, P01HL018974)
- National Institute of Neurological Disorders and Stroke (NS-38252)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- cerebrovascular dysfunction, cognitive impairment, Alzheimer's disease, aging, hypertension, cerebral vasculature, reactive oxygen species, NADPH oxidase, oxidative stress, neurodegeneration
- MeSH terms
- Aging, Alzheimer Disease, Amyloid, Cognition Disorders, Humans, Hypertension, Dementia, Vascular, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review