Cited by 177Advanced MRI Techniques and ApplicationsTraumatic Brain Injury and Neurovascular DisturbancesNeuroscience and Neuropharmacology Research

The role of neuronal signaling in controlling cerebral blood flow

DRAKE, C, IADECOLA, C·2007·Brain and Language

Abstract

Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI).

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Crossref · 10.1016/j.bandl.2006.08.002

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Authors
DRAKE, C., & IADECOLA, C.
Affiliations
Cornell University (US)
Corresponding author
DRAKE, C
Venue
Brain and Language
Publisher
Elsevier BV
Published
2007-08
Volume
102
Issue
2
Pages
141-152
ISSN
0093-934X (ISSN-L)
OpenAlex
W2144914358
Cited by
177
References
132
Citations by year
2025: 3 · 2024: 2 · 2023: 5 · 2022: 8 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 12 · 2017: 10 · 2016: 19 · 2015: 11 · 2014: 13 · 2013: 14 · 2012: 6
FWCI
5.65
Type
journal article
Language
en
Open access
closed
Locations
  • Brain and Language (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cerebral blood flow, functional hyperemia, neuronal signaling, neuronal activity, synaptic activity, BOLD signal, functional MRI, neurovascular coupling, blood flow regulation
MeSH terms
Brain, Cerebrovascular Circulation, Humans, Hyperemia, Magnetic Resonance Imaging, Neurons

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