Keller, Jeffrey N.

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction

Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 863

Impaired Proteasome Function in Alzheimer's Disease

Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 848

Evidence of increased oxidative damage in subjects with mild cognitive impairment

Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 539

The glial glutamate transporter, GLT‐1, is oxidatively modified by 4‐hydroxy‐2‐nonenal in the Alzheimer's disease brain: the role of Aβ1–42

Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 464

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

Keller, J. N., Pang, Z., Geddes, J. W., Begley, J. G., Germeyer, A., Waeg, G., & Mattson, M. P. (1997) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 439

Ribosome Dysfunction Is an Early Event in Alzheimer's Disease

Ding, Q., Markesbery, W. R., Chen, Q., Li, F., & Keller, J. N. (2005) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsRNA and protein synthesis mechanisms

Cited by 433

Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis

Dasuri, K., Zhang, L., & Keller, J. N. (2013) · Free Radical Biology and Medicine

Redox biology and oxidative stressUbiquitin and proteasome pathways

Cited by 371

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

Keller, J. N., Huang, F. F., & Markesbery, W. R. (2000) · Neuroscience

Ubiquitin and proteasome pathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 297

Protein oxidation and cellular homeostasis: Emphasis on metabolism

Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., & Keller, J. N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress

Cited by 274

The Lipid Peroxidation Product, 4‐Hydroxy‐2‐trans‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins

Subramaniam, R., Roediger, F., Jordan, B., Mattson, M. P., Keller, J. N., Waeg, G., & Butterfield, D. A. (1997) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsLipid Membrane Structure and Behavior

Cited by 270

The proteasome in brain aging

Keller, J. (2002) · Ageing Research Reviews

Ubiquitin and proteasome pathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 247

Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: Contributions of maternal diet

White, C. L., Pistell, P. J., Purpera, M. N., Gupta, S., Fernandez-Kim, S.-O., Hise, T. L., Keller, J. N., Ingram, D. K., Morrison, C. D., & Bruce-Keller, A. J. (2009) · Neurobiology of Disease

Birth, Development, and HealthFatty Acid Research and Health

Cited by 245

Obesity and vulnerability of the CNS

Bruce-Keller, A. J., Keller, J. N., & Morrison, C. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Adipokines, Inflammation, and Metabolic DiseasesRegulation of Appetite and Obesity

Cited by 200

Basic FGF attenuates amyloid β-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

Mark, R. J., Keller, J. N., Kruman, I., & Mattson, M. P. (1997) · Brain Research

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 167

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity

Tolar, M., Keller, J. N., Chan, S., Mattson, M. P., Marques, M. A., & Crutcher, K. A. (1999) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 148

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

Qosa, H., Abuasal, B. S., Romero, I. A., Weksler, B., Couraud, P.-O., Keller, J. N., & Kaddoumi, A. (2014) · Neuropharmacology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 146

Decreased RNA, and Increased RNA Oxidation, in Ribosomes from Early Alzheimer’s Disease

Ding, Q., Markesbery, W. R., Cecarini, V., & Keller, J. N. (2006) · Neurochemical Research

Alzheimer's disease research and treatmentsRNA and protein synthesis mechanisms

Cited by 140

Feasibility, reliability, and validity of a smartphone based application for the assessment of cognitive function in the elderly

Brouillette, R. M., Foil, H., Fontenot, S., Correro, A., Allen, R., Martin, C. K., Bruce-Keller, A. J., & Keller, J. N. (2013) · PLoS ONE

Dementia and Cognitive Impairment ResearchHistorical and Modern Theater Studies

Cited by 113

Cognitive impairment in humanized APP×PS1 mice is linked to Aβ1–42 and NOX activation

Bruce-Keller, A. J., Gupta, S., Knight, A. G., Beckett, T. L., McMullen, J. M., Davis, P. R., Murphy, M. P., Van Eldik, L. J., St Clair, D., & Keller, J. N. (2011) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 96

Effect of a long-term intensive lifestyle intervention on cognitive function: Action for Health in Diabetes study

Rapp, S. R., Luchsinger, J. A., Baker, L. D., Blackburn, G. L., Hazuda, H. P., Demos‐McDermott, K. E., Jeffery, R. W., Keller, J. N., McCaffery, J. M., Pajewski, N. M., et al. (2017) · Journal of the American Geriatrics Society

Dementia and Cognitive Impairment ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 62

Neuron Specific Toxicity of Oligomeric Amyloid-β: Role for JUN-Kinase and Oxidative Stress

Ebenezer, P. J., Weidner, A. M., LeVine, H., Markesbery, W. R., Murphy, M. P., Zhang, L., Dasuri, K., Fernandez-Kim, S. O., Bruce-Keller, A. J., Gavilán, E., et al. (2010) · Journal of Alzheimer's Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 58

Weight Change During the Postintervention Follow-up of Look AHEAD

Wing, R. R., Neiberg, R. H., Bahnson, J. L., Clark, J. M., Espeland, M. A., Hill, J. O., Johnson, K. C., Knowler, W. C., Olson, K., Steinburg, H., et al. (2022) · Diabetes Care

Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Cited by 14