The proteasome in brain aging

Keller, J

doi:10.1016/s1568-1637(01)00006-x

Cited by 247Ubiquitin and proteasome pathwaysGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

The proteasome in brain aging

Keller, J·2002·Ageing Research Reviews

DOI 10.1016/s1568-1637(01)00006-x

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Abstract

The proteasome is a large intracellular protease, present in all cells of the central nervous system (CNS), that is responsible for the majority of intracellular protein degradation. In particular, the proteasome is responsible for the degradation of most oxidized, aggregated, and misfolded proteins. The importance of proteasome activity to neuronal homeostasis is highlighted by previous studies demonstrating that proteasome inhibition alone is sufficient to induce neuron death in vitro. Recent studies indicate that alterations in proteasome activity may occur during, and possibly contribute to, the aging process. These data raise the possibility that alterations in the proteasome proteolytic pathway may contribute to the elevations in protein oxidation, protein aggregation, and neurodegeneration evident in the aging CNS. The focus of this review is to describe what is currently known about the proteasome in the CNS, describe established age-related alterations in proteasome biology, and to discuss how such alterations in proteasome biology may ultimately contribute to the aging of the CNS.

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Evidence of impaired UPS in the aging brain includes age-dependent accumulation of polyubiquitinated proteins in neurons and brain-region-specific reduction of proteasome activity in hippocampus and cerebral cortex.
“Similar to age-dependent reduction of autophagy, evidence of impaired UPS in the aging brain arises from studies showing age-dependent accumulation of polyubiquitinated proteins in neurons and a brain region-specific reduction of age-dependent proteasome activity in the hippocampus and cerebral cortex (Keller et al., 2002; Mattson and Arumugam, 2018).”
From NAD+ in Brain Aging and Neurodegenerative Disorders (2019) · cites this paper as Keller et al., 2002

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995 · see citing works
Cyclin is degraded by the ubiquitin pathway
Glotzer, M., Murray, A. W., & Kirschner, M. W. (1991) · Nature · doi:10.1038/349132a0 · Cited by 2,381 · see citing works
Aggresomes: A Cellular Response to Misfolded Proteins
Johnston, J. A., Ward, C. L., & Kopito, R. R. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.7.1883 · Cited by 2,148 · see citing works
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
Voges, D., Zwickl, P., & Baumeister, W. P. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.1015 · Cited by 1,894 · see citing works
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.Preprint
Chen, Z., Hagler, J., Palombella, V. J., Melandri, F. D., Scherer, D. C., Ballard, D. W., & Maniatis, T. (1995) · Genes & Development · doi:10.1101/gad.9.13.1586 · Cited by 1,270 · see citing works
Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences
Stadtman, E. R. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90006-5 · Cited by 1,155 · see citing works
NF-κB in neuronal plasticity and neurodegenerative disorders
Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877 · see citing works
Degradation of oxidized proteins by the 20S proteasome
Davies, K. J. A. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01250-0 · Cited by 849 · see citing works
Degradation of oxidized proteins in mammalian cells
Grune, T., Reinheckel, T., & Davies, K. J. A. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.7.9212076 · Cited by 835 · see citing works
Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.
Carney, J. M., Starke-Reed, P. E., Oliver, C., Landum, R. W., Cheng, M. S., Wu, J., & Floyd, R. A. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3633 · Cited by 724 · see citing works
The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation
Lonard, D. M., Nawaz, Z., Smith, C. L., & O’Malley, B. W. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)80259-2 · Cited by 559 · see citing works
The Proteasome, a Novel Protease Regulated by Multiple Mechanisms
Demartino, G., & Slaughter, C. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22123 · Cited by 535 · see citing works
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
Tanaka, Y. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.9.919 · Cited by 497 · see citing works
The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome
Lüders, J., Demand, J., & Höhfeld, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.4613 · Cited by 491 · see citing works
p53-dependent Induction of Apoptosis by Proteasome Inhibitors
Lopes, U. G., Erhardt, P., Yao, R., & Cooper, G. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.20.12893 · Cited by 467 · see citing works
Comparative resistance of the 20S and 26S proteasome to oxidative stress
REINHECKEL, T., SITTE, N., ULLRICH, O., KUCKELKORN, U., DAVIES, K. J. A., & GRUNE, T. (1998) · Biochemical Journal · doi:10.1042/bj3350637 · Cited by 447 · see citing works
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
Alkalay, I., Yaron, A., Hatzubai, A., Orian, A., Ciechanover, A. J., & Ben‐Neriah, Y. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10599 · Cited by 441 · see citing works
Proteasomes: multicatalytic proteinase complexes
Rivett, A. J. (1993) · Biochemical Journal · doi:10.1042/bj2910001 · Cited by 395 · see citing works
Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation
Rodríguez, M. S., Desterro, J. M. P., Laı́n, S., Lane, D. P., & Hay, R. T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.22.8458-8467.2000 · Cited by 386 · see citing works
Hybrid Proteasomes
Tanahashi, N., Murakami, Y., Minami, Y., Shimbara, N., Hendil, K. B., & Tanaka, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.19.14336 · Cited by 347 · see citing works
4-Hydroxy-2-nonenal-mediated Impairment of Intracellular Proteolysis during Oxidative Stress
Okada, K., Wangpoengtrakul, C., Osawa, T., Uchida, K., Toyokuni, S., & Tanaka, K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.23787 · Cited by 325 · see citing works
Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts
Sitte, N., Huber, M., Grune, T., Ladhoff, A., Doecke, W., Zglinicki, T. V., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.14.11.1490 · Cited by 318 · see citing works
Cation‐Sensitive Neutral Endopeptidase: Isolation and Specificity of the Bovine Pituitary Enzyme
Wilk, S., & Orłowski, M. (1980) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1980.tb07873.x · Cited by 316 · see citing works
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
Keller, J. N., Huang, F. F., & Markesbery, W. R. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00067-1 · Cited by 297 · see citing works
Self-citation
Possible involvement of proteasome inhibition in aging: implications for oxidative stress
Keller, J. N., Hanni, K. B., & Markesbery, W. R. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00101-3 · Cited by 263 · see citing works
Self-citation
Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein
Friguet, B., & Szweda, L. I. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00148-8 · Cited by 261 · see citing works
Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome
Grune, T., Blasig, I. E., Sitte, N., Roloff, B., Haseloff, R., & Davies, K. J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10857 · Cited by 250 · see citing works
Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.
Rivett, A. J. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38913-5 · Cited by 241 · see citing works
α-Synuclein–enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons
McLean, P. J., Kawamata, H., & Hyman, B. T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00113-0 · Cited by 236 · see citing works
Proteasome Inhibitors Induce Cytochrome c–Caspase-3-Like Protease-Mediated Apoptosis in Cultured Cortical Neurons
Qiu, J. H., Asai, A., Chi, S., Saito, N., Hamada, H., & Kirino, T. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00259.2000 · Cited by 232 · see citing works
The neuroprotective potential of heat shock protein 70 (HSP70)
Yenari, M. A., Giffard, R. G., Sapolsky, R. M., & Steinberg, G. K. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(99)01599-3 · Cited by 229 · see citing works
Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones
Ullrich, O., Reinheckel, T., Sitte, N., Hass, R., Grune, T., & Davies, K. J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6223 · Cited by 229 · see citing works
Displacement of housekeeping proteasome subunits by MHC‐encoded LMPs: a newly discovered mechanism for modulating the multicatalytic proteinase complex.
Früh, K., Gossen, M., Wang, K., Bujard, H., Peterson, P. A., & Yang, Y. D. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06625.x · Cited by 218 · see citing works
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I— effects of proliferative senescence
Sitte, N., Merker, K., von Zglinicki, T., Grune, T., & Davies, K. J. A. (2000) · The FASEB Journal · doi:10.1096/fj.00-0209com · Cited by 213 · see citing works
Age-Related Decline of Rat Liver Multicatalytic Proteinase Activity and Protection from Oxidative Inactivation by Heat-Shock Protein 90
Conconi, M., Szweda, L. I., Levine, R. L., Stadtman, E. R., & Friguet, B. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0303 · Cited by 213 · see citing works
Increase of Oxidatively Modified Protein Is Associated With a Decrease of Proteasome Activity and Content in Aging Epidermal Cells
Petropoulos, I., Conconi, M., Wang, X., Hoenel, B., Brégégère, F. M., Milner, Y., & Friguet, B. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.5.b220 · Cited by 212 · see citing works
Ubiquitination of the G1 cyclin Cln2p by a Cdc34p‐dependent pathway.
Deshaies, R. J., Chau, V., & Kirschner, M. W. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07004.x · Cited by 211 · see citing works
Fibroblast cultures from healthy centenarians have an active proteasome
Chondrogianni, N., Petropoulos, I., Franceschi, C., Friguet, B., & Gonos, E. S. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00137-6 · Cited by 200 · see citing works
The 19S Regulatory Complex of the Proteasome Functions Independently of Proteolysis in Nucleotide Excision Repair
Russell, S. J., Reed, S. H., Huang, W., Friedberg, E. C., & Johnston, S. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(01)80001-0 · Cited by 197 · see citing works
Age-related alterations of proteasome structure and function in aging epidermis
Bulteau, A., Petropoulos, I., & Friguet, B. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00136-4 · Cited by 183 · see citing works
Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins
Ding, Q., & Keller, J. N. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00302.x · Cited by 181 · see citing works
Self-citation
Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells
Pacifici, R. E., Salo, D. C., & Davies, K. J. A. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90028-2 · Cited by 181 · see citing works
Proteasomes: Structure and Biology
Tanaka, K. (1998) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021922 · Cited by 161 · see citing works
Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II—aging of nondividing cells
Sitte, N., Merker, K., von Zglinicki, T., Davies, K. J. A., & Grune, T. (2000) · The FASEB Journal · doi:10.1096/fj.00-0210com · Cited by 157 · see citing works
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts
Sitte, N., Merker, K., von Zglinicki, T., & Grune, T. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00279-8 · Cited by 153 · see citing works
The stress gene response in brain.
Massa, S. M., Swanson, R. A., & Sharp, F. R. (1996) · PubMed · Cited by 145 · see citing works
Distinct Proteolytic Processes Generate the C and N Termini of MHC Class I-Binding Peptides
Mo, X. Y., Cascio, P., Lemerise, K., Goldberg, A. L., & Rock, K. L. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.5851 · Cited by 142 · see citing works
New insights into the mechanisms and importance of the proteasome in intracellular protein degradation.
Goldberg, A. L., Akopian, T. N., Kisselev, A. F., Lee, D. H., & Rohrwild, M. (1997) · PubMed · Cited by 141 · see citing works
4-Hydroxynonenal-modified amyloid-β peptide inhibits the proteasome: possible importance in Alzheimer’s disease*
Shringarpure, R., Grune, T., Sitte, N., & Davies*, K. J. A. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000660 · Cited by 140 · see citing works
Oxidative Stress-Associated Impairment of Proteasome Activity during Ischemia–Reperfusion Injury
Keller, J. N., Huang, F. F., Zhu, H., Yu, J., Ho, Y., & Kindy, M. S. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200010000-00008 · Cited by 139 · see citing works
Self-citation
Proteasome Involvement in Agonist-induced Down-regulation of μ and δ Opioid Receptors
Chaturvedi, K., Bandari, P. S., Chinen, N., & Howells, R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008054200 · Cited by 133 · see citing works
Tissue Distribution of Constitutive Proteasomes, Immunoproteasomes, and PA28 in Rats
Noda, C., Tanahashi, N., Shimbara, N., Hendil, K. B., & Tanaka, K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3676 · Cited by 126 · see citing works
Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome
Glockzin, S., von Knethen, A., Scheffner, M., & Brüne, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19581 · Cited by 123 · see citing works
Release of a macromolecular protein component from human erythrocyte ghosts
Harris, J. R. (1968) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(68)90157-0 · Cited by 120 · see citing works
Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage
Forster, M. J., Sohal, B. H., & Sohal, R. S. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.11.b522 · Cited by 118 · see citing works
Aging and Proteolysis of Oxidized Proteins
Agarwal, S., & Sohal, R. S. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1078 · Cited by 116 · see citing works
Proteasomes and proteasome inhibition in the central nervous system
Ding, Q., & Keller, J. N. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00635-9 · Cited by 114 · see citing works
Self-citation
Dopamine induces proteasome inhibition in neural PC12 cell line
Keller, J. N., Huang, F. F., Dimayuga, E. R., & Maragos, W. F. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00412-3 · Cited by 93 · see citing works
Self-citation
The unfolding of substrates and ubiquitin-independentprotein degradation by proteasomes
Benaroudj, N., Tarcsa, E., Cascio, P., & Goldberg, A. L. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01244-5 · Cited by 93 · see citing works
Immunohistochemical Distribution and Electron Microscopic Subcellular Localization of the Proteasome in the Rat CNS
Mengual, E., Arizti, P., Rodrigo, J., Giménez‐Amaya, J. M., & Castaño, J. G. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-20-06331.1996 · Cited by 91 · see citing works
The proteasome: a protein‐destroying machine
Tanaka, K., & Chiba, T. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00207.x · Cited by 91 · see citing works
Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia
Chain, D. G., Hegde, A., Yamamoto, N., Liu-Marsh, B., & Schwartz, J. H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07592.1995 · Cited by 86 · see citing works
Down-regulation of types I, II and III inositol 1,4,5-trisphosphate receptors is mediated by the ubiquitin/proteasome pathway
Oberdorf, J. A., Webster, J. M., Chang Cheng, Z. H. U., Luo, S. G., & Wojcikiewicz, R. J. H. (1999) · Biochemical Journal · doi:10.1042/bj3390453 · Cited by 79 · see citing works
A Distinct ER/IC γ-Secretase Competes with the Proteasome for Cleavage of APP
Skovronsky, D., Pijak, D. S., Doms, R. W., & Lee, V. M. ‐. (1999) · Biochemistry · doi:10.1021/bi991728z · Cited by 76 · see citing works
Proteolysis, caloric restriction and aging
Merker, K. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00219-6 · Cited by 73 · see citing works
Hydrogen Peroxide-Mediated Protein Oxidation in Young and Old Human MRC-5 Fibroblasts
Merker, K., Sitte, N., & Grune, T. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1657 · Cited by 71 · see citing works
Dietary Self-Selection Can Compensate an Age-Related Decrease of Rat Liver 20 S Proteasome Activity Observed With Standard Diet
Anselmi, B., Conconi, M., Veyrat‐Durebex, C., Turlin, É., Biville, F., Alliot, J., & Friguet, B. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.3.b173 · Cited by 66 · see citing works
Involvement of the Ubiquitin-Proteasome Pathway in the Degradation of Nontyrosine Kinase-Type Cytokine Receptors of IL-9, IL-2, and Erythropoietin
Yen, C.-H., Yang, Y., Ruscetti, S. K., Kirken, R. A., Dai, R. M., & Li, C.-C. H. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6372 · Cited by 57 · see citing works
Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
Keller, J. N., & Markesbery, W. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 54 · see citing works
Self-citation
Activation of the Multicatalytic Endopeptidase by Oxidants. Effects on Enzyme Structure
Strack, P. R., Waxman, L., & Fagan, J. M. (1996) · Biochemistry · doi:10.1021/bi9518048 · Cited by 54 · see citing works
Parkin is metabolized by the ubiquitin/proteosome system
Choi, P., Golts, N., Sparkman, D. R., Cochran, E. J., Lee, J. M., & Wolozin, B. L. (2000) · Neuroreport · doi:10.1097/00001756-200008210-00006 · Cited by 53 · see citing works
Aging of the Liver: Proteolysis of Oxidatively Modified Glutamine Synthetase
Sahakian, J. A., Szweda, L. I., Friguet, B., Kitani, K., & Levine, R. L. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.1248 · Cited by 52 · see citing works
Dual Roles of Proteasome in the Metabolism of Presenilin 1
Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M., Takahashi, H., Murayama, O., Murayama, M., Sato, K., Omori, A., Tsubuki, S., et al. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0720255.x · Cited by 48 · see citing works
Constitutive and Protein Kinase C‐Regulated Secretory Cleavage of Alzheimer's β‐Amyloid Precursor Protein: Different Control of Early and Late Events by the Proteasome
Marambaud, P., Lopez‐Perez, E., Wilk, S., & Checler, F. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69062500.x · Cited by 41 · see citing works
Short-term treatment with interferon-?/? promotes remyelination, whereas long-term treatment aggravates demyelination in a murine model of multiple sclerosis
Njenga, M. K., Coenen, M. J., DeCuir, N., Yeh, H., & Rodriguez, M. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000301)59:5 · Cited by 35 · see citing works
Role of proteasomal degradation in the cell cycle-dependent regulation of DNA topoisomerase IIα expression☆
Salmena, L., Lam, V., McPherson, J. P., & Goldenberg, G. J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00580-9 · Cited by 30 · see citing works
Purification and properties of the 26S proteasome from the rat brain: Evidence for its degradation of myelin basic protein in a ubiquitin-dependent manner
Akaishi, T., Shiomi, T., Sawada, H., & Yokosawa, H. (1996) · Brain Research · doi:10.1016/0006-8993(96)00212-0 · Cited by 22 · see citing works
Biochemical Purification of Distinct Proteasome Subsets
Brown, M. G., & Monaco, J. J. (2017) · Enzyme and Protein · doi:10.1159/000468692 · Cited by 19 · see citing works
Cytosolic Components Are Required for Proteasomal Degradation of Newly Synthesized Apolipoprotein B in Permeabilized HepG2 Cells
Sakata, N., Stoops, J. D., & Dixon, J. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17068 · Cited by 17 · see citing works
Cytokine Induced Changes in Proteasome Subunit Composition Are Concentration Dependent
Stohwasser, R., & Kloetzel, P. (1996) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1996.377.9.571 · Cited by 16 · see citing works
Cytoplasmic Presenilin Aggregates in Proteasome Inhibitor‐treated Cells
Ingano, L. A. M., Lentini, K. M., Kovács, I., Tanzi, R. E., & KOVACS, D. M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06933.x · Cited by 9 · see citing works
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Zujovic (2000) · doi:10.1002/(sici)1098-1136(20000215)29:4

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Grune, T., Jung, T., Merker, K., & Davies, K. J. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.020 · Cited by 653 · see citing works
Activation of Chaperone-mediated Autophagy during Oxidative Stress
Kiffin, R., Christian, C., Knecht, E., & Cuervo, A. M. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-06-0477 · Cited by 611 · see citing works
Oxidative Stress and Autophagy
Kiffin, R., Bandyopadhyay, U., & Cuervo, A. M. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.152 · Cited by 527 · see citing works
Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
Mattson, M. P., Chan, S. L., & Duan, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00004.2002 · Cited by 438 · see citing works
Protein composition of the intranuclear inclusions of FXTAS
Iwahashi, C., Yasui, D. H., An, H. J., Greco, C., Tassone, F., Nannen, K., Babineau, B. A., Lebrilla, C. B., Hagerman, R. J., & Hagerman, P. J. (2005) · Brain · doi:10.1093/brain/awh650 · Cited by 359 · see citing works
Causes of oxidative stress in Alzheimer disease
Zhu, X., Su, B., Wang, X., Smith, M. A., & Perry, G. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7218-4 · Cited by 336 · see citing works
Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein
Dorval, V., & Fraser, P. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510127200 · Cited by 319 · see citing works
Chemoprevention through the Keap1–Nrf2 signaling pathway by phase 2 enzyme inducers
Kwak, M.-K., Wakabayashi, N., & Kensler, T. W. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.06.041 · Cited by 311 · see citing works
Integration of Clearance Mechanisms: The Proteasome and AutophagyPreprint
Wong, E. S. P., & Cuervo, A. M. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a006734 · Cited by 302 · see citing works
Lipofuscin: formation, effects and role of macroautophagy
Höhn, A., & Grune, T. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.006 · Cited by 298 · see citing works
Free radicals and brain aging
Poon, H. F., Calabrese, V., Scapagnini, G., & Butterfield, D. A. (2004) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2004.02.005 · Cited by 292 · see citing works
Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process
Tonoki, A., Kuranaga, E., Tomioka, T., Hamazaki, J., Murata, S., Tanaka, K., & Miura, M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01227-08 · Cited by 288 · see citing works
Clearance of cerebral Aβ in Alzheimer’s disease: reassessing the role of microglia and monocytes
Zuroff, L. R., Daley, D. A., Black, K. L., & Koronyo‐Hamaoui, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2463-7 · Cited by 275 · see citing works
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
Keller, J. N., Dimayuga, E. R., Chen, Q., Thorpe, J. A., Gee, J. R., & Ding, Q. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.05.003 · Cited by 271 · see citing works
Self-citation
Protein damage, repair and proteolysis
Chondrogianni, N., Petropoulos, I., Grimm, S., Georgila, K., Catalgol, B., Friguet, B., Grune, T., & Gonos, E. S. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.09.001 · Cited by 254 · see citing works
Protein oxidation in aging and the removal of oxidized proteins
Höhn, A., König, J., & Grune, T. (2013) · Journal of Proteomics · doi:10.1016/j.jprot.2013.01.004 · Cited by 236 · see citing works
Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains
Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., et al. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.12.004 · Cited by 210 · see citing works
Proteasome Inhibition Alters Neural Mitochondrial Homeostasis and Mitochondria Turnover
Sullivan, P. G., Dragicevic, N., Deng, J., Bai, Y., Dimayuga, E. R., Ding, Q., Chen, Q., Bruce‐Keller, A. J., & Keller, J. N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313579200 · Cited by 202 · see citing works
Self-citation
Cellular environment facilitates protein accumulation in aged rat hippocampus
Gavilán, M. P., Vela, J. M., Castaño, A., Ramos, B., del Río, J. C., Vitórica, J., & Ruano, D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.05.010 · Cited by 201 · see citing works
The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease
Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006361 · Cited by 190 · see citing works
Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration
Berke, S. J. S., & Paulson, H. L. (2003) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(03)00053-4 · Cited by 178 · see citing works
Cytosolic Prion Protein Is Not Toxic and Protects against Bax-mediated Cell Death in Human Primary Neurons
Roucou, X., Guo, Q., Zhang, Y., Goodyer, C. G., & LeBlanc, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306177200 · Cited by 177 · see citing works
Innate immune receptor expression in normal brain aging
Letiembre, M., Hao, W., Liu, Y., Walter, S., Mihaljevic, I., Rivest, S., Hartmann, T., & Fassbender, K. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.01.004 · Cited by 175 · see citing works
Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications
Huang, Q., & Figueiredo‐Pereira, M. E. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0466-z · Cited by 171 · see citing works
Oxidative Modification of Proteins: Age-Related Changes
Chakravarti, B., & Chakravarti, D. N. (2006) · Gerontology · doi:10.1159/000097865 · Cited by 172 · see citing works
Heat shock proteins in neurodegenerative disorders and aging
Leak, R. K. (2014) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-014-0243-9 · Cited by 170 · see citing works
Aging perturbs 26S proteasome assembly in Drosophila melanogaster
Vernace, V. A., Arnaud, L. T., Schmidt‐Glenewinkel, T., & Figueiredo‐Pereira, M. E. (2007) · The FASEB Journal · doi:10.1096/fj.06-6751com · Cited by 165 · see citing works
Convergence of Heat Shock Protein 90 with Ubiquitin in Filamentous α-Synuclein Inclusions of α-Synucleinopathies
Uryu, K., Richter‐Landsberg, C., Welch, W., Sun, E., Goldbaum, O., Norris, E. H., Pham, C.-T., Yazawa, I., Hilburger, K., Micsenyi, M. C., et al. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050770 · Cited by 157 · see citing works
Protein quality control in Alzheimer's disease by the ubiquitin proteasome system
de Vrij, F. M. S., Fischer, D. F., VANLEEUWEN, F., & Hol, E. M. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.10.001 · Cited by 152 · see citing works
Disease-related Prion Protein Forms Aggresomes in Neuronal Cells Leading to Caspase Activation and Apoptosis
Kristiansen, M., Messenger, M. J., Klöhn, P., Brandner, S., Wadsworth, J. D. F., Collinge, J., & Tabrizi, S. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506600200 · Cited by 149 · see citing works
Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
Migliore, L., Fontana, I., Colognato, R., Coppedè, F., Siciliano, G., & Murri, L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.10.002 · Cited by 149 · see citing works
Ubiquitin-Proteasome System and Proteasome Inhibition: New Strategies in Stroke Therapy
Wójcik, C., & Napoli, M. D. (2004) · Stroke · doi:10.1161/01.str.0000126891.93919.4e · Cited by 137 · see citing works
Impact of ageing on proteasome structure and function in human lymphocytes
Carrard, G., Dieu, M., Raes, M., Toussaint, O., & Friguet, B. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00356-4 · Cited by 131 · see citing works
The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties
Näsström, T., Fagerqvist, T., Barbu, M., Karlsson, M., Nikolajeff, F. K., Kasrayan, A., Ekberg, M., Lannfelt, L., Ingelsson, M., & Bergström, J. J. E. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.027 · Cited by 131 · see citing works
Proteasome Regulation of Oxidative Stress in Aging and Age-Related Diseases of the CNS
Ding, Q., Dimayuga, E. R., & Keller, J. N. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.163 · Cited by 127 · see citing works
Self-citation
Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo
Wang, P., Joberty, G., Buist, A., Vanoosthuyse, A., Stancu, I., Vasconcelos, B., Pierrot, N., Faelth-Savitski, M., Kienlen‐Campard, P., Octave, J., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1663-9 · Cited by 118 · see citing works
The aging brain: impact of heavy metal neurotoxicity
Ijomone, O. M., Ifenatuoha, C. W., Aluko, O. M., Ijomone, O. K., & Aschner, M. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1838441 · Cited by 116 · see citing works
Explaining oscillations and variability in the p53-Mdm2 system
Proctor, C. J., & Gray, D. A. (2008) · BMC Systems Biology · doi:10.1186/1752-0509-2-75 · Cited by 111 · see citing works
The role of ubiquitin–proteasome system in ageing
Lőw, P. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.02.005 · Cited by 114 · see citing works
Therapeutic strategies for the treatment of tauopathies: Hopes and challenges
Khanna, M. R., Kovalevich, J., Lee, V. M. ‐., Trojanowski, J. Q., & Brunden, K. R. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.06.006 · Cited by 112 · see citing works
Aging and regulated protein degradation: who has the UPPer hand?
Vernace, V. A., Schmidt‐Glenewinkel, T., & Figueiredo‐Pereira, M. E. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00329.x · Cited by 110 · see citing works
Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity
Mead, S. (2006) · Brain · doi:10.1093/brain/awl226 · Cited by 110 · see citing works
Ubiquitin conjugation triggers misfolded protein sequestration into quality control foci when Hsp70 chaperone levels are limiting
Shiber, A., Breuer, W. V., Brandeis, M., & Ravid, T. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-01-0010 · Cited by 107 · see citing works
It Is All about (U)biquitin: Role of Altered Ubiquitin‐Proteasome System and UCHL1 in Alzheimer Disease
Tramutola, A., Domenico, F. D., Barone, E., Marzia Perluigi, A., & Butterfield, D. A. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2756068 · Cited by 108 · see citing works
Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease
Mitra, S. S., Tsvetkov, A. S., & Finkbeiner, S. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806269200 · Cited by 106 · see citing works
Ubiquitin, Proteasomes, and the Aging Brain
Gray, D. A., Tsirigotis, M., & Woulfe, J. (2003) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2003.34.re6 · Cited by 104 · see citing works
Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
Richter‐Landsberg, C., & Leyk, J. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1158-x · Cited by 104 · see citing works
Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis
England, K., O’Driscoll, C. M., & Cotter, T. G. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401338 · Cited by 102 · see citing works
Radical Oxygen Species, Exercise and Aging: An Update
Bouzid, M. A., Filaire, E., McCall, A., & Fabre, C. (2015) · Sports Medicine · doi:10.1007/s40279-015-0348-1 · Cited by 111 · see citing works
Morphine and HIV‐Tat increase microglial‐free radical production and oxidative stress: possible role in cytokine regulation
Turchan-Cholewo, J. T., Dimayuga, F. O., Gupta, S., Keller, J. N., Knapp, P. E., Hauser, K. F., & Bruce‐Keller, A. J. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05756.x · Cited by 98 · see citing works
Self-citation
Protein folding: Then and now
Chen, Y., Ding, F., Nie, H., Serohijos, A. W. R., Sharma, S. K., Wilcox, K. C., Yin, S., & Dokholyan, N. V. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.05.014 · Cited by 98 · see citing works
Direct cellular delivery of human proteasomes to delay tau aggregation
Han, D. H., Na, H., Choi, W. H., Lee, J. H., Kim, Y. K., Won, C., Lee, S., Kim, K. P., Kuret, J., Min, D., et al. (2014) · Nature Communications · doi:10.1038/ncomms6633 · Cited by 97 · see citing works
Assessment of proteasome activity in cell lysates and tissue homogenates using peptide substrates
Rodgers, K. J., & Dean, R. T. (2003) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(02)00391-6 · Cited by 94 · see citing works
Proteasome inhibition induces reversible impairments in protein synthesis
Ding, Q., Dimayuga, E. R., Markesbery, W. R., & Keller, J. N. (2006) · The FASEB Journal · doi:10.1096/fj.05-5495com · Cited by 94 · see citing works
Self-citation
The Cytoskeleton in Oligodendrocytes: Microtubule Dynamics in Health and Disease
Richter-Landsberg, C. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9017-7 · Cited by 89 · see citing works
Role of the proteasome in protein oxidation and neural viability following low‐level oxidative stress
Ding, Q., Reinacker, K., Dimayuga, E. R., Nukala, V. N., Drake, J., Butterfield, D. A., Dunn, J. C., Martin, S. K., Bruce‐Keller, A. J., & Keller, J. N. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00582-9 · Cited by 89 · see citing works
Self-citation
17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
Riedel, M., Goldbaum, O., Schwarz, L., Schmitt, S., & Richter-Landsberg, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008753 · Cited by 87 · see citing works
Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes
Jänen, S. B., Chaachouay, H., & Richter‐Landsberg, C. (2010) · Glia · doi:10.1002/glia.21047 · Cited by 87 · see citing works
Ump1 extends yeast lifespan and enhances viability during oxidative stress: Central role for the proteasome?
Chen, Q., Thorpe, J. A., Dohmen, R. J., Li, F., & Keller, J. N. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.048 · Cited by 87 · see citing works
Self-citation
Natural polyphenols as proteasome modulators and their role as anti‐cancer compounds
Bonfili, L., Cecarini, V., Amici, M., Cuccioloni, M., Angeletti, M., Keller, J. N., & Eleuteri, A. M. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06696.x · Cited by 86 · see citing works
Self-citation
In Pursuit of Healthy Aging: Effects of Nutrition on Brain Function
Melzer, T. M., Manosso, L. M., Yau, S., Gil‐Mohapel, J., & Brocardo, P. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22095026 · Cited by 90 · see citing works
Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes
Schwarz, L., Goldbaum, O., Bergmann, M., Probst‐Cousin, S., & Richter‐Landsberg, C. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9733-5 · Cited by 82 · see citing works
The Hippocampal Neuroproteome with Aging and Cognitive Decline: Past Progress and Future Directions
VanGuilder, H. D., & Freeman, W. M. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00008 · Cited by 76 · see citing works
Proteolytic Stress Causes Heat Shock Protein Induction, Tau Ubiquitination, and the Recruitment of Ubiquitin to Tau-Positive Aggregates in Oligodendrocytes in Culture
Goldbaum, O., & Richter‐Landsberg, C. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1307-04.2004 · Cited by 75 · see citing works
Proteasome Inhibition Stabilizes Tau Inclusions in Oligodendroglial Cells that Occur after Treatment with Okadaic Acid
Goldbaum, O., Oppermann, M., Handschuh, M., Dabir, D. V., Zhang, B., Forman, M. S., Trojanowski, J. Q., Lee, V. M. ‐., & Richter‐Landsberg, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08872.2003 · Cited by 73 · see citing works
Oxidative protein damage and the proteasome
Grimm, S., Höhn, A., & Grune, T. (2010) · Amino Acids · doi:10.1007/s00726-010-0646-8 · Cited by 71 · see citing works
The stationary phase model of aging in yeast for the study of oxidative stress and age-related neurodegeneration
Chen, Q., Ding, Q., & Keller, J. N. (2005) · Biogerontology · doi:10.1007/s10522-004-7379-6 · Cited by 71 · see citing works
Self-citation
Brain aging in acquired immunodeficiency syndrome: Increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation
Gelman, B. B., & Schuenke, K. W. (2004) · Journal of NeuroVirology · doi:10.1080/13550280490279816 · Cited by 70 · see citing works
Deconstructing the axon: Wallerian degeneration and the ubiquitin–proteasome system
Ehlers, M. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.015 · Cited by 66 · see citing works
Protein homeostasis and aging: Role of ubiquitin protein ligases
Jana, N. R. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.02.009 · Cited by 67 · see citing works
Changes of the Proteasomal System During the Aging Process
Baraibar, M. A., & Friguet, B. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-397863-9.00007-9 · Cited by 63 · see citing works
The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress
Kim, S., Kim, D. K., Jeong, S., & Lee, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115894 · Cited by 67 · see citing works
20S proteasome and accumulation of oxidized and ubiquitinated proteins in maize leaves subjected to cadmium stress
Pena, L. B., Pasquini, L. A., Tomaro, M. L., & Gallego, S. M. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.02.022 · Cited by 62 · see citing works
Age-dependent remodelling of retinal circuitry
Terzibasi, E., Calamusa, M., Novelli, E., Domenici, L., Strettoi, E., & Cellerino, A. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.017 · Cited by 62 · see citing works
Interplay between protein synthesis and degradation in the CNS: physiological and pathological implications
Ding, Q., Cecarini, V., & Keller, J. N. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.11.003 · Cited by 62 · see citing works
Self-citation
Inhibition of lysosomal functions reduces proteasomal activity
Qiao, L., & Zhang, J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.03.085 · Cited by 61 · see citing works
A single amino acid substitution in a proteasome subunit triggers aggregation of ubiquitinated proteins in stressed neuronal cells
Li, Z., Arnaud, L. T., Rockwell, P., & Figueiredo‐Pereira, M. E. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02456.x · Cited by 59 · see citing works
Integrating fetal neural transplants into a therapeutic strategy: the example of Huntington's disease
Peschanski, M. (2004) · Brain · doi:10.1093/brain/awh145 · Cited by 57 · see citing works
Reactive oxygen species induced by proteasome inhibition in neuronal cells mediate mitochondrial dysfunction and a caspase-independent cell death
Papa, L., Gomes, E., & Rockwell, P. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0069-5 · Cited by 58 · see citing works
A critical review of the development and importance of proteinaceous aggregates in animal models of Parkinson's disease: new insights into Lewy body formation
Meredith, G. E., Halliday, G. M., & Totterdell, S. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.01.001 · Cited by 57 · see citing works
Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes
Goldbaum, O., Vollmer, G., & Richter‐Landsberg, C. (2006) · Glia · doi:10.1002/glia.20348 · Cited by 57 · see citing works
LMP2 Knock-Out Mice Have Reduced Proteasome Activities and Increased Levels of Oxidatively Damaged Proteins
Ding, Q., Martin, S. K., Dimayuga, E. R., Bruce‐Keller, A. J., & Keller, J. N. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.130 · Cited by 56 · see citing works
Self-citation
Induction of 26S proteasome subunit PSMB5 by the bifunctional inducer 3-methylcholanthrene through the Nrf2-ARE, but not the AhR/Arnt-XRE, pathway
Kwak, M.-K., & Kensler, T. W. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.043 · Cited by 56 · see citing works
Contribution of Yeast Models to Neurodegeneration Research
Pereira, C., Bessa, C., Soares, J., Leão, M., & Saraiva, L. (2012) · BioMed Research International · doi:10.1155/2012/941232 · Cited by 54 · see citing works
The effects of proteasomal inhibition on synaptic proteostasis
Hakim, V., Cohen, L. D., Zuchman, R., Ziv, T., & Ziv, N. E. (2016) · The EMBO Journal · doi:10.15252/embj.201593594 · Cited by 52 · see citing works
Serine 421 regulates mutant huntingtin toxicity and clearance in mice
Kratter, I. H., Zahed, H., Lau, A., Tsvetkov, A. S., Daub, A. C., Weiberth, K. F., Gu, X., Saudou, F., Humbert, S., Yang, X. W., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci80339 · Cited by 54 · see citing works
Polyglutamine gene function and dysfunction in the ageing brain
Hands, S. L., Sinadinos, C., & Wyttenbach, A. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.05.008 · Cited by 54 · see citing works
The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition
Goldbaum, O., Riedel, M. J., Stahnke, T., & Richter‐Landsberg, C. (2009) · Glia · doi:10.1002/glia.20870 · Cited by 53 · see citing works
‘Tagging’ along memories in aging: Synaptic tagging and capture mechanisms in the aged hippocampus
Shetty, M. S., & Sajikumar, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.008 · Cited by 53 · see citing works
Multi-Omics Analysis Provides Novel Insight into Immuno-Physiological Pathways and Development of Thermal Resistance in Rainbow Trout Exposed to Acute Thermal Stress
Roh, H., Kim, A., Kim, N., Lee, Y., & Kim, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239198 · Cited by 54 · see citing works
Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems
Amici, M. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01369-2 · Cited by 53 · see citing works
Proteasome synthesis and assembly are required for survival during stationary phase
Chen, Q., Thorpe, J. A., Ding, Q., El-Amouri, I. S., & Keller, J. N. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.025 · Cited by 51 · see citing works
Self-citation
Persistent Hijacking of Brain Proteasomes in HIV-Associated Dementia
Nguyen, T. P., Soukup, V. M., & Gelman, B. B. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090390 · Cited by 50 · see citing works
The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseases
Seiberlich, V., Goldbaum, O., Zhukareva, V. A., & Richter‐Landsberg, C. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.04.011 · Cited by 49 · see citing works
Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures
Ding, Q., Dimayuga, E. R., Markesbery, W. R., & Keller, J. N. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02802.x · Cited by 49 · see citing works
Self-citation

Proteasome Regulation of Oxidative Stress in Aging and Age-Related Diseases of the CNS
Ding, Q., Dimayuga, E. R., & Keller, J. N. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.163 · Cited by 127 · see citing works
Self-citation
The proteasome: A key modulator of nervous system function, brain aging, and neurodegenerative disease
Davidson, K., & Pickering, A. M. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1124907 · Cited by 84 · see citing works
Oxidative protein damage and the proteasome
Grimm, S., Höhn, A., & Grune, T. (2010) · Amino Acids · doi:10.1007/s00726-010-0646-8 · Cited by 71 · see citing works
Proteasomes and proteasome inhibition in the central nervous system
Ding, Q., & Keller, J. N. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00635-9 · Cited by 114 · see citing works
Self-citation
O.054 Effect of CSF tap test on symptoms and extracellular fluid biomarkers in NPH
Rabie, K., Tisell, M., Bergqvist, J., Hjort, S., Barrows, G., & Wikkelsø, C. (2008) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(08)70059-3

Authors: Keller, J.
Affiliations: University of Kentucky (US)
Corresponding author: Keller, J
ORCID: Keller, J
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2002-04
Volume: 1
Issue: 2
Pages: 279-293
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/s1568-1637(01)00006-x
OpenAlex: W1983882750
Cited by: 247
References: 82
Citations by year: 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 13 · 2013: 8 · 2012: 15
FWCI: 8.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG018437, AG18437)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: proteasome, brain aging, protein degradation, protein oxidation, protein aggregation, protein misfolding, neurodegeneration, neuronal homeostasis, proteasome inhibition, central nervous system
MeSH terms: Aging, Brain, Cysteine Endopeptidases, Humans, Multienzyme Complexes, Oxidative Stress, Proteasome Endopeptidase Complex

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