The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Evidence of increased oxidative damage in subjects with mild cognitive impairment
Abstract
OBJECTIVE: To determine if increased levels of oxidative damage are present in the brains of persons with mild cognitive impairment (MCI), a condition that often precedes Alzheimer disease (AD). METHODS: The authors assessed the amount of protein carbonyls, thiobarbituric acid-reactive substances (TBARS), and malondialdehyde in the superior and middle temporal gyri (SMTG) and cerebellum of short postmortem interval and longitudinally evaluated normal subjects and those with MCI and early AD. RESULTS: Elevated levels of protein carbonyls (approximately 25%), malondialdehyde (approximately 60%), and TBARS (approximately 210%) were observed in the SMTG of individuals with MCI and early AD vs normal control subjects. The elevation in TBARS was associated with the numbers of neuritic but not diffuse plaques. Levels of protein carbonyls increased as delayed verbal memory performance declined. CONCLUSION: Oxidative damage occurs in the brain of subjects with mild cognitive impairment, suggesting that oxidative damage may be one of the earliest events in the onset and progression of Alzheimer disease.
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“Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive impairment (MCI).”
From Mitochondrial Oxidative and Nitrosative Stress and Alzheimer Disease (2020) · cites this paper as [11]
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Cites
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Mild Cognitive Impairment: Clinical Characterization and Outcome
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Oxidative stress hypothesis in Alzheimer’s disease
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Self-citationPetersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., & DeKosky, S. T. (2001) · Neurology · doi:10.1212/wnl.56.9.1133 · Cited by 2,065
Oxidative Damage Is the Earliest Event in Alzheimer Disease
Nunomura, A., Perry, G., Aliev, G., Hirai, K., Takeda, A., Balraj, E. K., Jones, P. K., Ghanbari, H., Wataya, T., Shimohama, S., et al. (2001) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/60.8.759 · Cited by 1,885
Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
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Aging, Memory, and Mild Cognitive Impairment
Petersen, R. C., Kokmen, E., Waring, S. C., Smith, G. E., Ivnik, R. J., & Tangelos, E. G. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004717 · Cited by 895
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Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
Oxidative stress and mitochondrial dysfunction in Alzheimer’s disease
Wang, X., Wang, W., Li, L., Perry, G., Lee, H.-G., & Zhu, X. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.015 · Cited by 1,357
Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration
Liu, L., Zhang, K., Sandoval, H., Yamamoto, S., Jaiswal, M., Sanz, E., Li, Z., Hui, J., Graham, B. H., Quintana, A., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.019 · Cited by 876
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
Scheff, S. W., Price, D. A., Schmitt, F. A., DeKosky, S. T., & Mufson, E. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260698.46517.8f · Cited by 824
Self-citationOxidative stress in Alzheimer’s disease
Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797
Metadata
- Authors
- Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R.
- Affiliations
- University of Kentucky (US)
- Venue
- Neurology
- Published
- 2005-04-12
- Volume
- 64
- Issue
- 7
- Pages
- 1152-1156
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2161844942
- Cited by
- 539
- References
- 44
- Citations by year
- 2026: 3 · 2025: 14 · 2024: 10 · 2023: 17 · 2022: 23 · 2021: 25 · 2020: 16 · 2019: 15 · 2018: 21 · 2017: 26 · 2016: 19 · 2015: 22 · 2014: 30 · 2013: 28 · 2012: 43
- FWCI
- 21.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (5P50AG05114, R01AG018437, P01AG005119, AG0 18437)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- mild cognitive impairment, Alzheimer's disease, oxidative stress, protein carbonyls, malondialdehyde, TBARS, lipid peroxidation, temporal lobe, cerebellum, neuritic plaques, verbal memory, postmortem brain
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Brain, Cognition Disorders, Female, Free Radicals, Humans, Male, Malondialdehyde, Memory Disorders, Nerve Degeneration, Neuropsychological Tests, Predictive Value of Tests, Up-Regulation, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Disease Progression, Protein Carbonylation, Plaque, Amyloid
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