Godbout, Jonathan P.

Neuroinflammation: The Devil Is in the Details

DiSabato, D. J., Quan, N., & Godbout, J. P. (2016) · Journal of Neurochemistry

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,640

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 813

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 792

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 678

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

Frakes, A. E., Ferraiuolo, L., Haidet-Phillips, A. M., Schmelzer, L., Braun, L., Miranda, C. J., Ladner, K. J., Bevan, A. K., Foust, K. D., Godbout, J. P., et al. (2014) · Neuron

Amyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 638

β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cited by 638

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 565

Stress-Induced Recruitment of Bone Marrow-Derived Monocytes to the Brain Promotes Anxiety-Like Behavior

Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cited by 563

Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior

Wohleb, E. S., McKim, D. B., Sheridan, J. F., & Godbout, J. P. (2015) · Frontiers in Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 420

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Norden, D. M., Muccigrosso, M. M., & Godbout, J. P. (2015) · Neuropharmacology

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 413

Microglia Priming with Aging and Stress

Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 398

Traumatic Brain Injury Causes Chronic Cortical Inflammation and Neuronal Dysfunction Mediated by Microglia

Witcher, K. G., Bray, C. E., Chunchai, T., Zhao, F., O'Neil, S. M., Gordillo, A. J., Campbell, W. A., McKim, D. B., Liu, X., Dziabis, J. E., et al. (2021) · The Journal of Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 387

Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety

McKim, D. B., Weber, M. D., Niraula, A., Sawicki, C. M., Liu, X., Jarrett, B. L., Ramirez-Chan, K., Wang, Y., Roeth, R. M., Sucaldito, A. D., et al. (2018) · Molecular Psychiatry

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 365

TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation

Norden, D. M., Fenn, A. M., Dugan, A., & Godbout, J. P. (2014) · Glia

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 332

Re-establishment of Anxiety in Stress-Sensitized Mice Is Caused by Monocyte Trafficking from the Spleen to the Brain

Wohleb, E. S., McKim, D. B., Shea, D. T., Powell, N. D., Tarr, A. J., Sheridan, J. F., & Godbout, J. P. (2014) · Biological Psychiatry

Stress Responses and CortisolTryptophan and brain disorders

Cited by 300

Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal

Weber, M. D., Godbout, J. P., & Sheridan, J. F. (2017) · Neuropsychopharmacology

Tryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 283

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia

Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry

Traumatic Brain Injury and Neurovascular DisturbancesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 283

Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice

Wohleb, E. S., Fenn, A. M., Pacenta, A. M., Powell, N. D., Sheridan, J. F., & Godbout, J. P. (2012) · Psychoneuroendocrinology

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 275

Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10

Voorhees, J. L., Tarr, A. J., Wohleb, E. S., Godbout, J. P., Mo, X., Sheridan, J. F., Eubank, T. D., & Marsh, C. B. (2013) · PLoS ONE

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 236

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 224

Age and neuroinflammation: a lifetime of psychoneuroimmune consequences

Godbout, J. P., & Johnson, R. W. (2009) · Immunology and Allergy Clinics of North America

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 224

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 209

IL-4 Signaling Drives a Unique Arginase+/IL-1 + Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4R after Traumatic Spinal Cord Injury

Fenn, A. M., Hall, J. C. E., Gensel, J. C., Popovich, P. G., & Godbout, J. P. (2014) · Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsSpinal Cord Injury Research

Cited by 207

Neuroinflammatory Dynamics Underlie Memory Impairments after Repeated Social Defeat

McKim, D. B., Niraula, A., Tarr, A. J., Wohleb, E. S., Sheridan, J. F., & Godbout, J. P. (2016) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsStress Responses and Cortisol

Cited by 204