Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy

Selenica, M.-L. B., Brownlow, M., Jimenez, J. P., Lee, D. C., Pena, G., Dickey, C. A., Gordon, M. N., & Morgan, D. (2013) · Neurodegenerative Diseases · doi:10.1159/000337230 · Cited by 10,359 · see citing works

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023 · see citing works

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 1× · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis

Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426 · see citing works

Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury

McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295 · see citing works

The spectrum of disease in chronic traumatic encephalopathy

McKee, A. C., Stein, T. D., Nowinski, C. J., Stern, R. A., Daneshvar, D. H., Alvarez, V. E., Lee, H.-S., Hall, G., Wojtowicz, S. M., Baugh, C. M., et al. (2013) · Brain · doi:10.1093/brain/aws307 · Cited by 2,098 · see citing works

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

Elmore, M. R. P., Najafi, A. R., Koike, M. A., Dagher, N. N., Spangenberg, E. E., Rice, R. A., Kitazawa, M., Matusow, B., Nguyen, H., West, B. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.040 · Cited by 1,968 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice

Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674 · see citing works

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works

Inflammation is detrimental for neurogenesis in adult brain

Ekdahl, C. T., Claasen, J.-H., Bonde, S., Kokaia, Z., & Lindvall, O. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2234031100 · Cited by 1,559 · see citing works

The microglial sensome revealed by direct RNA sequencing

Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works

Acute Effects and Recovery Time Following Concussion in Collegiate Football Players

McCrea, M., Guskiewicz, K. M., Marshall, S. W., Barr, W., RANDOLPH, C. C., Cantu, R. C., Oñate, J. A., Yang, J. G., & Kelly, J. P. (2003) · JAMA · doi:10.1001/jama.290.19.2556 · Cited by 1,492 · see citing works

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473 · see citing works

Animal models of traumatic brain injury

Xiong, Y., Mahmood, A., & Chopp, M. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3407 · Cited by 1,413 · see citing works

Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 1× · see citing works

In-vivo measurement of activated microglia in dementia

Cagnin, A., Brooks, D. J., Kennedy, A. M., Gunn, R. N., Myers, R., Turkheimer, F. E., Jones, T., & Banati, R. B. (2001) · The Lancet · doi:10.1016/s0140-6736(01)05625-2 · Cited by 1,054 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Inflammation and white matter degeneration persist for years after a single traumatic brain injury

Johnson, V. E., Stewart, J. E., Begbie, F. D., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2013) · Brain · doi:10.1093/brain/aws322 · Cited by 1,045 · see citing works

Systemic infections and inflammation affect chronic neurodegeneration

Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027 · see citing works

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Griciuc, A., Serrano-Pozo, A., Parrado, A. R., Lesinski, A. N., Asselin, C. N., Mullin, K., Hooli, B., Choi, S. H., Hyman, B. T., & Tanzi, R. E. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.014 · Cited by 1,004 · see citing works

Inflammation after trauma: Microglial activation and traumatic brain injury

Ramlackhansingh, A. F., Brooks, D. J., Greenwood, R. J., Bose, S. K., Turkheimer, F. E., Kinnunen, K. M., Gentleman, S., Heckemann, R. A., Gunanayagam, K., Gelosa, G., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22455 · Cited by 999 · see citing works

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

McGeer, P. L., Itagaki, S., Tago, H., & McGeer, E. G. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90696-3 · Cited by 836 · see citing works

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813 · see citing works

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works

Microglia and neurodegeneration: The role of systemic inflammation

Cunningham, C. (2013) · Glia · doi:10.1002/glia.22350 · Cited by 769 · see citing works

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768 · see citing works

Major Depression Following Traumatic Brain Injury

Jorge, R. E., Robinson, R. G., Moser, D., Tateno, A., Crespo-Facorro, B., & Arndt, S. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.1.42 · Cited by 737 · see citing works

The Role of Markers of Inflammation in Traumatic Brain Injury

Woodcock, T. M., & Morganti-Kossmann, M. C. (2013) · Frontiers in Neurology · doi:10.3389/fneur.2013.00018 · Cited by 719 · see citing works

Dystrophic microglia in the aging human brain

Streit, W. J., Sammons, N. W., Kuhns, A. J., & Sparks, D. L. (2004) · Glia · doi:10.1002/glia.10319 · Cited by 705 · see citing works

Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

Smith, D. H., Johnson, V. E., & Stewart, W. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.29 · Cited by 699 · see citing works

Microglia derived from aging mice exhibit an altered inflammatory profile

Sierra, A., Gottfried‐Blackmore, A. C., McEwen, B. S., & Bulloch, K. (2007) · Glia · doi:10.1002/glia.20468 · Cited by 688 · see citing works

Immune activation in brain aging and neurodegeneration: too much or too little?

Lucin, K. M., & Wyss-Coray, T. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.039 · Cited by 679 · see citing works

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

Henry, C. J., Huang, Y., Wynne, A., Hanke, M., Himler, J., Bailey, M. T., Sheridan, J. F., & Godbout, J. P. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-15 · Cited by 678 · see citing works

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

Youm, Y.-H., Grant, R. W., McCabe, L. R., Albarado, D. C., Nguyen, K. Y., Ravussin, A., Pistell, P., Newman, S., Carter, R., Laque, A., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.09.010 · Cited by 674 · see citing works

β-Adrenergic Receptor Antagonism Prevents Anxiety-Like Behavior and Microglial Reactivity Induced by Repeated Social Defeat

Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638 · see citing works

Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans

Johnson, V. E., Stewart, W., & Smith, D. H. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00513.x · Cited by 620 · see citing works

Systemic inflammation induces acute behavioral and cognitive changes and accelerates neurodegenerative disease.

Cunningham, C., Campion, S., Lunnon, K., Murray, C. L., Woods, J. F. C., Deacon, R. M. J., Rawlins, J. N. P., & Perry, V. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.07.024 · Cited by 584 · see citing works

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.002 · Cited by 565 · see citing works

Long‐term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy

Stern, R. A., Riley, D., Daneshvar, D. H., Nowinski, C. J., Cantu, R. C., & McKee, A. C. (2011) · PM&R · doi:10.1016/j.pmrj.2011.08.008 · Cited by 564 · see citing works

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

Lee, S., Varvel, N. H., Konerth, M. E., Xu, G., Cardona, A. E., Ransohoff, R. M., & Lamb, B. T. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100265 · Cited by 539 · cited 1× · see citing works

Sublime Microglia: Expanding Roles for the Guardians of the CNS

Salter, M. W., & Beggs, S. (2014) · Cell · doi:10.1016/j.cell.2014.06.008 · Cited by 531 · see citing works

Age-related alterations in the dynamic behavior of microglia

Damani, M. R., Zhao, L., Fontainhas, A. M., Amaral, J., Fariss, R. N., & Wong, W. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00660.x · Cited by 504 · see citing works

Progressive Neurodegeneration After Experimental Brain Trauma: Association With Chronic Microglial Activation

Loane, D. J., Kumar, A., Stoica, B. A., Cabatbat, R., & Faden, A. I. (2014) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0000000000000021 · Cited by 498 · see citing works

Axis I Psychopathology in Individuals with Traumatic Brain Injury

Hibbard, M. R., Uysal, S., Kepler, K., Bogdany, J., & Silver, J. (1998) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199808000-00003 · Cited by 491 · see citing works

Inflammation, microglia, and alzheimer's disease

Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 440 · see citing works

The prevalence and symptom rates of depression after traumatic brain injury: a comprehensive examination

Kreutzer, J. S., Seel, R. T., & Gourley, E. (2001) · Brain Injury · doi:10.1080/02699050010009108 · Cited by 417 · see citing works

GFAP mRNA increases with age in rat and human brain

Nichols, N. R., Day, J. R., Laping, N. J., Johnson, S. A., & Finch, C. E. (1993) · Neurobiology of Aging · doi:10.1016/0197-4580(93)90100-p · Cited by 413 · see citing works

Functions of Astrocytes and their Potential As Therapeutic Targets

Kimelberg, H. K., & Nedergaard, M. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.07.006 · Cited by 409 · see citing works

Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice

Krstic, D., Madhusudan, A., Doehner, J., Vogel, P., Notter, T., Imhof, C., Manalastas, A., Hilfiker, M., Pfister, S., Schwerdel, C., et al. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-151 · Cited by 400 · see citing works

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 396 · see citing works

GFAP Versus S100B in Serum after Traumatic Brain Injury: Relationship to Brain Damage and Outcome

Pelinka, L. E., Kroepfl, A., Leixnering, M., Buchinger, W., Raabe, A., & Redl, H. R. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1553 · Cited by 388 · see citing works

Early age-related changes in adult hippocampal neurogenesis in C57 mice

Abdallah, N. M. ‐. B., Slomianka, L., Vyssotski, A. L., & Lipp, H. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.002 · Cited by 368 · see citing works

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats

Bachstetter, A. D., Morganti, J. M., Jernberg, J., Schlunk, A., Mitchell, S. H., Brewster, K. W., Hudson, C. E., Cole, M. J., Harrison, J. K., Bickford, P. C., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.11.022 · Cited by 364 · see citing works

Experimental models of traumatic brain injury: do we really need to build a better mousetrap?

Morales, D. M., Marklund, N., Lebold, D., Thompson, H. J., Pitkanen, A., Maxwell, W. L., Longhi, L., Laurer, H., Maegele, M., Neugebauer, E., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.030 · Cited by 339 · cited 2× · see citing works

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

Njie, E. G., Boelen, E., Stassen, F. R., Steinbusch, H. W. M., Borchelt, D. R., & Streit, W. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.008 · Cited by 335 · see citing works

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson’s disease

Pott Godoy, M. C., Tarelli, R., Ferrari, C. C., Sarchi, M. I., & Pitossi, F. J. (2008) · Brain · doi:10.1093/brain/awn101 · Cited by 335 · see citing works

TGFβ produced by IL‐10 redirected astrocytes attenuates microglial activation

Norden, D. M., Fenn, A. M., Dugan, A., & Godbout, J. P. (2014) · Glia · doi:10.1002/glia.22647 · Cited by 332 · see citing works

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model

Mouzon, B., Bachmeier, C. J., Ferro, A., Ojo, J., Crynen, G. C., Acker, C. M., Davies, P., MULLAN, M. J., Stewart, W. B., Jr., & Crawford, F. (2013) · Annals of Neurology · doi:10.1002/ana.24064 · Cited by 331 · see citing works

Peripheral infection and aging interact to impair hippocampal memory consolidation

Barrientos, R. M., Higgins, E. A., Biedenkapp, J. C., Sprunger, D. B., Wright-Hardesty, K. J., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.010 · Cited by 330 · see citing works

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.013 · Cited by 327 · see citing works

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

Kraft, A. W., Hu, X., Yoon, H., Yan, P., Xiao, Q., Wang, Y., Gil, S. C., Brown, J., Wilhelmsson, U., Restivo, J. L., et al. (2013) · The FASEB Journal · doi:10.1096/fj.12-208660 · Cited by 324 · cited 1× · see citing works

Homeostatic and injury‐induced microglia behavior in the aging brain

Hefendehl, J. K., Neher, J. J., Sühs, R. B., Kohsaka, S., Skodras, A., & Jucker, M. (2014) · Aging Cell · doi:10.1111/acel.12149 · Cited by 319 · see citing works

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319 · see citing works

The immune system and memory consolidation: a role for the cytokine IL-1β

Pugh, C., Fleshner, M., Watkins, L. R., Maier, S. F., & Rudy, J. W. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00048-8 · Cited by 311 · see citing works

Aging Exacerbates Depressive-like Behavior in Mice in Response to Activation of the Peripheral Innate Immune System

Godbout, J. P., Moreau, M., Lestage, J., Chen, J., Sparkman, N. L., Connor, J. O., Castanon, N., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301649 · Cited by 299 · see citing works

Traumatic brain injury and time to onset of Alzheimer’s disease: a population-based study

Nemetz, P. N., Leibson, C., Naessens, J. M., Beard, M., Kokmen, E., Annegers, J. F., & Kurland, L. T. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009724 · Cited by 295 · see citing works

Axis II psychopathology in individuals with traumatic brain injury

Hibbard, M. R., Bogdany, J., Uysal, S., Kepler, K., Silver, J., Gordon, W. A., & Haddad, L. B. (2000) · Brain Injury · doi:10.1080/026990500120925 · Cited by 291 · see citing works

Immune activation promotes depression 1 month after diffuse brain injury: a role for primed microglia

Fenn, A. M., Gensel, J. C., Huang, Y., Popovich, P. G., Lifshitz, J., & Godbout, J. P. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.10.014 · Cited by 283 · see citing works

The age‐related attenuation in long‐term potentiation is associated with microglial activation

Griffin, R. J., Nally, R. E., Nolan, Y. M., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04165.x · Cited by 277 · see citing works

Intracerebral inflammatory response to experimental brain contusion

Holmin, S., Mathiesen, T. I., Shetye, J., & Biberfeld, P. (1995) · Acta Neurochirurgica · doi:10.1007/bf01404857 · Cited by 275 · see citing works

Head Injury in Early Adulthood and the Lifetime Risk of Depression

Holsinger, T., Steffens, D. C., Phillips, C., Helms, M. J., Havlik, R. J., Breitner, J. C. S., Guralnik, J. M., & Plassman, B. L. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.1.17 · Cited by 267 · see citing works

Repeated Mild Traumatic Brain Injury Causes Chronic Neuroinflammation, Changes in Hippocampal Synaptic Plasticity, and Associated Cognitive Deficits

Aungst, S. L., Kabadi, S. V., Thompson, S. M., Stoica, B. A., & Faden, A. I. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.75 · Cited by 254 · see citing works

Age-Related Activation of Microglia and Astrocytes: In Vitro Studies Show Persistent Phenotypes of Aging, Increased Proliferation, and Resistance to Down-Regulation

Rozovsky, I., Finch, C. E., & Morgan, T. E. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00169-3 · Cited by 254 · see citing works

Traumatic brain injury in aged animals increases lesion size and chronically alters microglial/macrophage classical and alternative activation states

Kumar, A., Stoica, B. A., Sabirzhanov, B., Burns, M. P., Faden, A. I., & Loane, D. J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.013 · Cited by 244 · see citing works

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

Bodea, L.-G., Wang, Y., Linnartz-Gerlach, B., Kopatz, J., Sinkkonen, L., Musgrove, R., Kaoma, T., Muller, A., Vallar, L., Di Monte, D. A., et al. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5002-13.2014 · Cited by 234 · see citing works

Enlarged and phagocytic, but not primed, interleukin-1α-immunoreactive microglia increase with age in normal human brain

Sheng, J. G., Mrak, R. E., & Griffin, W. S. T. (1998) · Acta Neuropathologica · doi:10.1007/s004010050792 · Cited by 229 · see citing works

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.002 · Cited by 226 · see citing works

Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

Murray, C., Sanderson, D. J., Barkus, C., Deacon, R. M. J., Rawlins, J. N. P., Bannerman, D. M., & Cunningham, C. M. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.04.002 · Cited by 225 · see citing works

Protracted downregulation of CX3CR1 on microglia of aged mice after lipopolysaccharide challenge

Wynne, A. M., Henry, C. J., Huang, Y., Cleland, A., & Godbout, J. P. (2010) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.05.011 · Cited by 224 · see citing works

Depression following traumatic brain injury: a 1 year longitudinal study

Jorge, R. E., Robinson, R. G., Arndt, S. V., STARKSTEIN, S. E., Forrester, A. W., & Geisler, F. H. (1993) · Journal of Affective Disorders · doi:10.1016/0165-0327(93)90047-n · Cited by 221 · see citing works

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

Huang, Y., Henry, C. J., Dantzer, R., Johnson, R. W., & Godbout, J. P. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.012 · Cited by 220 · see citing works

The Spectrum of Neurobehavioral Sequelae after Repetitive Mild Traumatic Brain Injury: A Novel Mouse Model of Chronic Traumatic Encephalopathy

Petraglia, A. L., Plog, B. A., Dayawansa, S., Chen, M. J., Dashnaw, M. L., Czerniecka, K. H., Walker, C. T., Viterise, T., Hyrien, O., Iliff, J. J., et al. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3255 · Cited by 219 · see citing works

Knockdown of Interleukin-1 Receptor Type-1 on Endothelial Cells Attenuated Stress-Induced Neuroinflammation and Prevented Anxiety-Like Behavior

Wohleb, E. S., Patterson, J. M., Sharma, V., Quan, N., Godbout, J. P., & Sheridan, J. F. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3723-13.2014 · Cited by 209 · see citing works

IL-4 Signaling Drives a Unique Arginase+/IL-1 + Microglia Phenotype and Recruits Macrophages to the Inflammatory CNS: Consequences of Age-Related Deficits in IL-4R  after Traumatic Spinal Cord Injury

Fenn, A. M., Hall, J. C. E., Gensel, J. C., Popovich, P. G., & Godbout, J. P. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1146-14.2014 · Cited by 207 · see citing works

Life and Death of Microglia

Streit, W. J., & Xue, Q.-S. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9163-5 · Cited by 205 · see citing works

An Age-Related Decline in Interleukin-10 May Contribute to the Increased Expression of Interleukin-6 in Brain of Aged Mice

Ye, S.-M., & Johnson, R. W. (2001) · Neuroimmunomodulation · doi:10.1159/000049025 · Cited by 203 · see citing works

Fractalkine receptor (CX3CR1) deficiency sensitizes mice to the behavioral changes induced by lipopolysaccharide

Corona, A. W., Huang, Y., O’Connor, J. C., Dantzer, R., Kelley, K. W., Popovich, P. G., & Godbout, J. P. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-93 · Cited by 200 · see citing works

Functions of Mature Mammalian Astrocytes: A Current View

Kimelberg, H. K. (2010) · The Neuroscientist · doi:10.1177/1073858409342593 · Cited by 199 · see citing works

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198 · see citing works

EVIDENCE FOR AN EARLY INFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM OF MICE WITH SCRAPIE

Betmouni, S., Perry, V. H., & Gordon, J. L. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00212-6 · Cited by 196 · see citing works

Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury

Ziebell, J. M., Taylor, S. E., Cao, T., Harrison, J., & Lifshitz, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-247 · Cited by 185 · see citing works

Exacerbated glial response in the aged mouse hippocampus following controlled cortical impact injury

Sandhir, R., Onyszchuk, G., & Berman, N. E. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.06.013 · Cited by 184 · see citing works

Long-term psychiatric disorders after traumatic brain injury

Fleminger, S. (2008) · European Journal of Anaesthesiology · doi:10.1017/s0265021507003250 · Cited by 183 · see citing works

Dysregulated neuronal–microglial cross-talk during aging, stress and inflammation

Jurgens, H. A., & Johnson, R. W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2010.11.014 · Cited by 179 · see citing works

Lipopolysaccharide Inhibits Long Term Potentiation in the Rat Dentate Gyrus by Activating Caspase-1

Vereker, E., Campbell, V. A., Roche, E., McEntee, E., & Lynch, M. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002226200 · Cited by 178 · see citing works

Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer’s disease

Sly, L. M., KRZESICKI, R. F., Brashler, J. R., Buhl, A.-L., McKinley, D. D., Carter, D. B., & Chin, J. E. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00730-4 · Cited by 174 · see citing works

Phagocytic glial cells: sculpting synaptic circuits in the developing nervous system

Schafer, D. P., & Stevens, B. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.012 · Cited by 174 · see citing works

Neurons, glia, and plasticity in normal brain aging

Finch, C. E. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00051-4 · Cited by 170 · see citing works

Activation of microglia in the brains of humans with heart disease and hypercholesterolemic rabbits

Streit, W. J., & Sparks, D. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050097 · Cited by 168 · see citing works

Intermediate filaments regulate astrocyte motility

Lepekhin, E. A., Eliasson, C., Berthold, C., Berezin, V., Bock, E., & Pekny, M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00595.x · Cited by 164 · see citing works

Astrocytes in the aging brain

Cotrina, M. L., & Nedergaard, M. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10121 · Cited by 162 · see citing works

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 160 · see citing works

Luteolin Inhibits Microglia and Alters Hippocampal-Dependent Spatial Working Memory in Aged Mice

Jang, S., Dilger, R. N., & Johnson, R. W. (2010) · Journal of Nutrition · doi:10.3945/jn.110.123273 · Cited by 154 · see citing works

Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat

Maher, F. O., Nolan, Y. M., & Lynch, M. A. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.07.002 · Cited by 153 · see citing works

Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus

Murray, C. A., & Lynch, M. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12161 · Cited by 153 · see citing works

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice

Koenigsknecht-Talboo, J., Meyer-Luehmann, M., Parsadanian, M., Garcia-Alloza, M., Finn, M. B., Hyman, B. T., Bacskai, B. J., & Holtzman, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4147-08.2008 · Cited by 149 · see citing works

Microglial activation in healthy aging

Schuitemaker, A., van der Doef, T. F., Boellaard, R., van der Flier, W. M., Yaqub, M., Windhorst, A. D., Barkhof, F., Jonker, C., Kloet, R. W., Lammertsma, A. A., et al. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.09.016 · Cited by 142 · see citing works

Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination

Zhao, C., Li, W.-W., & Franklin, R. J. M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.008 · Cited by 142 · cited 2× · see citing works

The Anti-inflammatory Cytokine, Interleukin (IL)-10, Blocks the Inhibitory Effect of IL-1β on Long Term Potentiation

Kelly, A. M., Lynch, A. M., Vereker, E., Nolan, Y. M., Queenan, P., Whittaker, E., O'Neill, L. A. J., & Lynch, M. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108757200 · Cited by 140 · see citing works

Aging and glial responses to lipopolysaccharide in vitro: greater induction of IL-1 and IL-6, but smaller induction of neurotoxicity

Xie, Z. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00057-8 · Cited by 133 · see citing works

Concurrent hippocampal induction of MHC II pathway components and glial activation with advanced aging is not correlated with cognitive impairment

VanGuilder, H. D., Bixler, G. V., Brucklacher, R. M., Farley, J. A., Yan, H., Warrington, J. P., Sonntag, W. E., & Freeman, W. M. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-138 · Cited by 132 · see citing works

Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice

Abraham, J., & Johnson, R. W. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0888 · Cited by 131 · see citing works

Analysis of gial acidic fibrillary protein in the human entorhinal cortex during aging and in Alzheimer's disease

Porchet, R., Probst, A., Bouras, C., Dráberová, E., Dráber, P., & Riederer, B. M. (2003) · PROTEOMICS · doi:10.1002/pmic.200300456 · Cited by 121 · see citing works

Don't fence me in: Harnessing the beneficial roles of astrocytes for spinal cord repair

White, R., & Jakeman, L. B. (2008) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2008-00442 · Cited by 120 · see citing works

TREM2 in Alzheimer’s disease

Jiang, T., Yu, J., Zhu, X., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8424-8 · Cited by 117 · see citing works

Perisomatic Thalamic Axotomy After Diffuse Traumatic Brain Injury Is Associated With Atrophy Rather Than Cell Death

Lifshitz, J., Kelley, B., & Povlishock, J. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000248558.75950.4d · Cited by 114 · see citing works

Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus

Czerniawski, J. L., & Guzowski, J. F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0542-14.2014 · Cited by 113 · see citing works

Early-life infection is a vulnerability factor for aging-related glial alterations and cognitive decline

Bilbo, S. D. (2010) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2010.04.001 · Cited by 108 · see citing works

The delayed neurobehavioural sequelae of traumatic brain injury

Gualtieri, T., & Cox, D. R. (1991) · Brain Injury · doi:10.3109/02699059109008093 · Cited by 108 · see citing works

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

Palin, K., Cunningham, C. M., Forse, P. A., Perry, V. H., & Platt, N. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.11.012 · Cited by 103 · see citing works

Astrocyte changes in aging cerebral cortex and hippocampus: A quantitative immunohistochemical study

Amenta, F., Bronzetti, E., Sabbatini, M., & Vega, J. A. (1998) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19981001)43:1 · Cited by 102 · see citing works

Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury

Weil, Z. M., Gaier, K. R., & Karelina, K. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.06.016 · Cited by 99 · see citing works

Age-dependent changes on TGFβ1 Smad3 pathway modify the pattern of microglial cell activation

Tichauer, J. E., Flores, B., Soler, B., Bernhardi, L. E.-V., Ramírez, G., & Rommy von Bernhardi, M. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.018 · Cited by 97 · see citing works

Increased micro-RNA 29b in the aged brain correlates with the reduction of insulin-like growth factor-1 and fractalkine ligand

Fenn, A. M., Smith, K. M., Lovett‐Racke, A. E., Guerau‐de‐Arellano, M., Whitacre, C. C., & Godbout, J. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.007 · Cited by 95 · see citing works

Cognitive and Behavioral Consequences of Impaired Immunoregulation in Aging

Corona, A. W., Fenn, A. M., & Godbout, J. P. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9313-4 · Cited by 84 · see citing works

Chronic ibuprofen administration worsens cognitive outcome following traumatic brain injury in rats.

Browne, K., Iwata, A., Putt, M., & Smith, D. H. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.04.008 · Cited by 80 · see citing works

Central inhibition of interleukin-1β ameliorates sickness behavior in aged mice

Abraham, J., & Johnson, R. W. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2008.12.008 · Cited by 80 · see citing works

IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 × BN F1 rats

Frank, M. G., Barrientos, R. M., Hein, A. M., Biedenkapp, J. C., Watkins, L. R., & Maier, S. F. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.005 · Cited by 78 · see citing works

A Concussive-Like Brain Injury Model in Mice (I): Impairment in Learning and Memory

Tang, Y., Noda, Y., Hasegawa, T., & Nabeshima, T. (1997) · Journal of Neurotrauma · doi:10.1089/neu.1997.14.851 · Cited by 77 · see citing works

Aging sensitizes mice to behavioral deficits induced by central HIV-1 gp120

Abraham, J., Jang, S., Godbout, J. P., Chen, J., Kelley, K. W., Dantzer, R., & Johnson, R. W. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.11.002 · Cited by 73 · see citing works

CR8, a Novel Inhibitor of CDK, Limits Microglial Activation, Astrocytosis, Neuronal Loss, and Neurologic Dysfunction after Experimental Traumatic Brain Injury

Kabadi, S. V., Stoica, B. A., Loane, D. J., Luo, T., & Faden, A. I. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.228 · Cited by 73 · see citing works

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

Chapman, T. R., Barrientos, R. M., Ahrendsen, J. T., Maier, S. F., & Patterson, S. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5172-09.2010 · Cited by 72 · see citing works

Treatment with an anti-CD11d integrin antibody reduces neuroinflammation and improves outcome in a rat model of repeated concussion

Shultz, S. R., Bao, F., Weaver, L. C., Cain, D. P., & Brown, A. M. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-26 · Cited by 71 · see citing works

α-Tocopherol attenuates NFκB activation and pro-inflammatory cytokine production in brain and improves recovery from lipopolysaccharide-induced sickness behavior

Godbout, J. P., Berg, B. M., Krzyszton, C. P., & Johnson, R. W. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.08.003 · Cited by 71 · see citing works

Modulation by Astrocytes of Microglial Cell-Mediated Neuroinflammation: Effect on the Activation of Microglial Signaling Pathways

Tichauer, J. E., Saud, K., & Rommy von Bernhardi, M. (2007) · NeuroImmunoModulation · doi:10.1159/000110642 · Cited by 68 · see citing works

Animal Models of Acute Neurological Injuries

Chen, J., Xu, Z. C., Xu, X., & Zhang, J. H. (2008) · Springer protocols handbooks/Springer protocols · doi:10.1007/978-1-60327-185-1 · Cited by 66 · see citing works

Characterization of the sickness response in young and aging rats following E. coli infection

Barrientos, R. M., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.01.016 · Cited by 65 · see citing works

Protection of rat primary hippocampal cultures from Aβ cytotoxicity by pro-inflammatory molecules is mediated by astrocytes

Ramírez, G., Toro, R., Döbeli, H., & von Bernhardi, R. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.01.007 · Cited by 60 · see citing works

Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response.

Lifshitz, J., Witgen, B., & Grady, M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.11.014 · Cited by 54 · see citing works

Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin

Kelley, K. W., O’Connor, J. C., Lawson, M. A., Dantzer, R., Rodriguez-Zas, S. L., & McCusker, R. H. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.02.003 · Cited by 49 · see citing works

Human Traumatic Brain Injury Alters Circulating L-Arginine and Its Metabolite Levels: Possible Link to Cerebral Blood Flow, Extracellular Matrix Remodeling, and Energy Status

Jeter, C. B., Hergenroeder, G. W., Ward, N. H., Moore, A. N., & Dash, P. K. (2011) · Journal of Neurotrauma · doi:10.1089/neu.2011.2029 · Cited by 46 · see citing works

Comparison of Ionized Calcium-binding Adapter Molecule 1 Immunoreactivity of the Hippocampal Dentate Gyrus and CA1 Region in Adult and Aged Dogs

Hwang, I. K., Lee, C. H., Li, H., Yoo, K.-Y., Choi, J. H., Kim, D. W., Kim, D.-W., Suh, H.-W., & Won, M.-H. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9584-6 · Cited by 40 · see citing works

Age-Related Changes in Ionized Calcium-Binding Adapter Molecule 1 Immunoreactivity and Protein Level in the Gerbil Hippocampal CA1 Region

Choi, J. H., Lee, C. H., Hwang, I. K., Won, M. H., Seong, J. K., Yoon, Y. S., Lee, H. S., & Lee, I. S. (2007) · Journal of Veterinary Medical Science · doi:10.1292/jvms.69.1131 · Cited by 38 · see citing works

Remote effects on the striatal dopamine system after fluid percussion injury

Huang, E. Y., Tsai, T.-H., Kuo, T., Tsai, J.-J., Tsui, P.-F., Chou, Y., Ma, H.-I., Chiang, Y. H., & Chen, Y.-H. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.03.033 · Cited by 23 · see citing works

Animal Models of Acute Neurological Injuries

(2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1433 · Cited by 22 · see citing works

Fluid Percussion Injury Model

Rowe, R. K., Griffiths, D. R., & Lifshitz, J. (2009) · Springer Series in Translational Stroke Research · doi:10.1007/978-1-60327-185-1_32 · Cited by 17 · see citing works

Exaggerated sickness behavior and brain proinflammatory cytokine expression in aged mice in response to intracerebroventricular lipopolysaccharide

Henry, C. J., Huang, Y., Dantzer, R., Johnson, R. W., & Godbout, J. P. (2007) · The Journal of Immunology · Cited by 7 · see citing works

Overview of General and Discriminating Markers of Differential Microglia Phenotypes

Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works

The Biology of Regeneration Failure and Success After Spinal Cord Injury

Tran, A. P., Warren, P. M., & Silver, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00017.2017 · Cited by 883 · see citing works

Microglia in the TBI brain: The good, the bad, and the dysregulated

Loane, D. J., & Kumar, A. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.018 · Cited by 816 · see citing works

Glial responses to implanted electrodes in the brain

Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642 · see citing works

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge

Norden, D. M., Trojanowski, P. J., Villanueva, E., Navarro, E., & Godbout, J. P. (2015) · Glia · doi:10.1002/glia.22930 · Cited by 596 · see citing works

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works

Neuroinflammation in the central nervous system: Symphony of glial cells

Yang, Q., & Zhou, J. (2018) · Glia · doi:10.1002/glia.23571 · Cited by 520 · see citing works

Microbiome–microglia connections via the gut–brain axis

Abdel-Haq, R., Schlachetzki, J. C. M., Glass, C. K., & Mazmanian, S. K. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20180794 · Cited by 471 · see citing works

Immunoneuropsychiatry — novel perspectives on brain disorders

Pape, K., Tamouza, R., Leboyer, M., & Zipp, F. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0174-4 · Cited by 455 · see citing works

Replacement of microglia in the aged brain reverses cognitive, synaptic, and neuronal deficits in mice

Elmore, M. R. P., Hohsfield, L. A., Kramár, E. A., Soreq, L., Lee, R. J., Pham, S. T., Najafi, A. R., Spangenberg, E. E., Wood, M. A., West, B. L., et al. (2018) · Aging Cell · doi:10.1111/acel.12832 · Cited by 380 · see citing works

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Dodiya, H. B., Forsyth, C. B., Voigt, R. M., Engen, P. A., Patel, J., Shaikh, M., Green, S. J., Naqib, A., Roy, A., Kordower, J. H., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.12.012 · Cited by 305 · see citing works

Cellular senescence in brain aging

Sikora, E., Bielak-Zmijewska, A., Dudkowska, M., Krzystyniak, A., Mosieniak, G., Wesierska, M., & Wlodarczyk, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646924 · Cited by 304 · see citing works

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration

Tsarouchas, T. M., Wehner, D., Cavone, L., Munir, T., Keatinge, M., Lambertus, M., Underhill, A., Barrett, T., Kassapis, E., Ogryzko, N. V., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07036-w · Cited by 294 · see citing works

The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

Chu, F., Shi, M., Zheng, C., Shen, D., Zhu, J., Zheng, X., & Cui, L. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.02.015 · Cited by 304 · see citing works

The Immune System and Its Dysregulation with Aging

Müller, L., Benedetto, S. D., & Pawelec, G. (2019) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-981-13-3681-2_2 · Cited by 292 · see citing works

Contribution of neuroinflammation and immunity to brain aging and the mitigating effects of physical and cognitive interventions

Benedetto, S. D., Müller, L., Wenger, E., Düzel, S., & Pawelec, G. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.01.044 · Cited by 280 · see citing works

Switching of the Microglial Activation Phenotype Is a Possible Treatment for Depression Disorder

Zhang, L., Zhang, J., & You, Z. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00306 · Cited by 279 · see citing works

MicroRNAs: Roles in Regulating Neuroinflammation

Gaudet, A. D., Fonken, L. K., Watkins, L. R., Nelson, R. J., & Popovich, P. G. (2017) · The Neuroscientist · doi:10.1177/1073858417721150 · Cited by 270 · see citing works

Pathophysiological Role of Neuroinflammation in Neurodegenerative Diseases and Psychiatric Disorders

Hong, H., Kim, B. S., & Im, H. (2016) · International Neurourology Journal · doi:10.5213/inj.1632604.302 · Cited by 260 · see citing works

Inhibitors of NF-κB and P2X7/NLRP3/Caspase 1 pathway in microglia: Novel therapeutic opportunities in neuroinflammation induced early-stage Alzheimer’s disease

Thawkar, B. S., & Kaur, G. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.11.010 · Cited by 247 · see citing works

Rodent models of neuroinflammation for Alzheimer’s disease

Nazem, A., Sankowski, R., Bacher, M., & Al‐Abed, Y. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0291-y · Cited by 249 · see citing works

Microglia: Housekeeper of the Central Nervous System

Kabba, J. A., Xu, Y., Christian, H., Ruan, W., Kitchen, C., Xiang, Y., Zhang, L., Saavedra, J. M., & Pang, T. (2017) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0504-2 · Cited by 251 · see citing works

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043515 · Cited by 212 · see citing works

Molecular Mechanisms of Glutamate Toxicity in Parkinson’s Disease

Wang, J., Wang, F., Mai, D., & Qu, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.585584 · Cited by 228 · see citing works

Microglia Gone Rogue: Impacts on Psychiatric Disorders across the Lifespan

Tay, T. L., Béchade, C., D’Andrea, I., St‐Pierre, M., Henry, M. S., Roumier, A., & Tremblay, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00421 · Cited by 211 · see citing works

Transcriptional and epigenetic decoding of the microglial aging process

Li, X., Li, Y., Jin, Y., Zhang, Y., Wu, J., Xu, Z., Huang, Y., Cai, L., Gao, S., Liu, T., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00479-x · Cited by 225 · see citing works

CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

Subbarayan, M. S., Joly‐Amado, A., Bickford, P. C., & Nash, K. R. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107989 · Cited by 204 · see citing works

The bidirectional gut-brain-microbiota axis as a potential nexus between traumatic brain injury, inflammation, and disease

Sundman, M., Chen, N., Subbian, V., & Chou, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.009 · Cited by 200 · see citing works

Microglia in the Neurovascular Unit: Blood–Brain Barrier–microglia Interactions After Central Nervous System Disorders

Thurgur, H., & Pinteaux, E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.06.046 · Cited by 181 · see citing works

Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ

Ta, T., Dikmen, H. O., Schilling, S., Chausse, B., Lewen, A., Hollnagel, J., & Kann, O. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1813562116 · Cited by 151 · see citing works

Microglial dysfunction connects depression and Alzheimer’s disease

Santos, L. E., Beckman, D., & Ferreira, S. T. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.11.011 · Cited by 119 · see citing works

Stress-induced neuroinflammatory priming: A liability factor in the etiology of psychiatric disorders

Frank, M. G., Weber, M. D., Watkins, L. R., & Maier, S. F. (2015) · Neurobiology of Stress · doi:10.1016/j.ynstr.2015.12.004 · Cited by 148 · see citing works

Inflammation in Traumatic Brain Injury

Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., Hoisington, A. J., Scott, A. J., Potocki, E., Benros, M. E., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191150 · Cited by 150 · see citing works

Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets

van Tilborg, E., Heijnen, C. J., Benders, M. J. N. L., van Bel, F., Fleiss, B., Gressèns, P., & Nijboer, C. H. A. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.11.002 · Cited by 148 · see citing works

Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge

O’Neil, S. M., Witcher, K. G., McKim, D. B., & Godbout, J. P. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0636-8 · Cited by 138 · see citing works

Systemic Inflammation Mediates Age-Related Cognitive Deficits

Lin, T., Liu, G. A., Perez, E., Rainer, R. D., Febo, M., Cruz-Almeida, Y., & Ebner, N. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00236 · Cited by 138 · see citing works

Neuroinflammation as Fuel for Axonal Regeneration in the Injured Vertebrate Central Nervous System

Bollaerts, I., houcke, J. V., Andries, L., Groef, L. D., & Moons, L. (2017) · Mediators of Inflammation · doi:10.1155/2017/9478542 · Cited by 137 · see citing works

Neurogranin and YKL-40: independent markers of synaptic degeneration and neuroinflammation in Alzheimer’s disease

Hellwig, K., Kvartsberg, H., Portelius, E., Andréasson, U., Oberstein, T. J., Lewczuk, P., Blennow, K., Kornhuber, J., Maler, J. M., Zetterberg, H., et al. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0161-y · Cited by 136 · see citing works

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

Cirmi, S., Ferlazzo, N., Lombardo, G. E., Ventura-Spagnolo, E., Gangemi, S., Calapai, G., & Navarra, M. (2016) · Molecules · doi:10.3390/molecules21101312 · Cited by 129 · see citing works

The Inflammatory Continuum of Traumatic Brain Injury and Alzheimer’s Disease

Kokiko-Cochran, O. N., & Godbout, J. P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00672 · Cited by 128 · see citing works

Cognitive deficits develop 1 month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge

Muccigrosso, M. M., Ford, J., Benner, B., Moussa, D., Burnsides, C., Fenn, A. M., Popovich, P. G., Lifshitz, J., Walker, F. R., Eiferman, D. S., et al. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.01.009 · Cited by 146 · see citing works

Targeting innate immunity for neurodegenerative disorders of the central nervous system

Andreasson, K. I., Bachstetter, A. D., Colonna, M., Ginhoux, F., Holmes, C., Lamb, B., Landreth, G., Lee, D. C., Low, D., Lynch, M. A., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13667 · Cited by 126 · see citing works

An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition

Members, E. W. E., Terron, A., Bal-Price, A., Paini, A., Monnet-Tschudi, F., Bennekou, S. H., Leist, M., & Schildknecht, S. (2018) · Archives of Toxicology · doi:10.1007/s00204-017-2133-4 · Cited by 124 · see citing works

Microglial priming in Alzheimer’s disease

Li, J.-W., Zong, Y., Cao, X.-P., Tan, L., & Tan, L. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.22 · Cited by 122 · see citing works

Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges

Davinelli, S., Maes, M., Corbi, G., Zarrelli, A., Willcox, D. C., & Scapagnini, G. (2016) · Immunity &amp; Ageing · doi:10.1186/s12979-016-0070-3 · Cited by 122 · see citing works

Neuroinflammation in Mood Disorders: Role of Regulatory Immune Cells

Bauer, M. E., & Teixeira, A. L. (2021) · NeuroImmunoModulation · doi:10.1159/000515594 · Cited by 125 · see citing works

Interplay Between Age and Neuroinflammation in Multiple Sclerosis: Effects on Motor and Cognitive Functions

Musella, A., Gentile, A., Rizzo, F., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00238 · Cited by 109 · see citing works

Epigenetic regulation of innate immune memory in microglia

Zhang, X., Kracht, L., Lerário, A. M., Dubbelaar, M. L., Brouwer, N., Wesseling, E. M., Boddeke, E., Eggen, B. J. L., & Kooistra, S. M. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02463-5 · Cited by 113 · see citing works

From Healthy Aging to Frailty: In Search of the Underlying Mechanisms

Brivio, P., Paladini, M. S., Racagni, G., Riva, M. A., Calabrese, F., & Molteni, R. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190717152739 · Cited by 113 · see citing works

Microglial Priming as Trained Immunity in the Brain

Haley, M. J., Brough, D., Quintin, J., & Allan, S. M. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2017.12.039 · Cited by 104 · see citing works

Curcumin Prevents Acute Neuroinflammation and Long-Term Memory Impairment Induced by Systemic Lipopolysaccharide in Mice

Sorrenti, V., Contarini, G., Sut, S., Dall’Acqua, S., Confortin, F., Pagetta, A., Giusti, P., & Zusso, M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00183 · Cited by 113 · see citing works

Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury

Xiong, W., Li, C., Kong, G., Zeng, Q., Wang, S., Yin, G., Gu, J., & Fan, J. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01724-y · Cited by 105 · see citing works

Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response

Flowers, A., Bell‐Temin, H., Jalloh, A., Stevens, S. M., & Bickford, P. C. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0840-7 · Cited by 104 · see citing works

Dysregulation of Systemic Immunity in Aging and Dementia

Lutshumba, J., Nikolajczyk, B. S., & Bachstetter, A. D. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.652111 · Cited by 103 · see citing works

PGC-1α sparks the fire of neuroprotection against neurodegenerative disorders

Lv, J., Jiang, S., Yang, Z. P., Hu, W., Wang, Z., Li, T. X., & Yang, Y. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.03.004 · Cited by 101 · see citing works

Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets

Tenner, A. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901068 · Cited by 99 · see citing works

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia?

Joseph, J., Depp, C. A., Shih, P.-A. B., Cadenhead, K. S., & Schmid‐Schönbein, G. W. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00155 · Cited by 95 · see citing works

Aged lipid‐laden microglia display impaired responses to stroke

Arbaizar‐Rovirosa, M., Pedragosa, J., Lozano, J. J., Casal, C., Pol, A., Gallizioli, M., & Planas, A. M. (2023) · EMBO Molecular Medicine · doi:10.15252/emmm.202217175 · Cited by 94 · see citing works

Thymoquinone increases the expression of neuroprotective proteins while decreasing the expression of pro-inflammatory cytokines and the gene expression NFκB pathway signaling targets in LPS/IFNγ -activated BV-2 microglia cells

Cobourne-Duval, M. K., Taka, E., Mendonca, P., & Soliman, K. F. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.04.018 · Cited by 92 · see citing works

Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

(2019) · doi:10.1073/pnas.1903566116 · Cited by 92 · see citing works

Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease

Santos, L. E., & Ferreira, S. T. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.016 · Cited by 92 · see citing works

β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

Lee, E.-J., Ko, H.-M., Jeong, Y.-H., Park, E.-M., & Kim, H.-S. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0355-z · Cited by 91 · see citing works

Microglial depletion and repopulation in brain slice culture normalizes sensitized proinflammatory signaling

Coleman, L. G., Zou, J., & Crews, F. T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1678-y · Cited by 87 · see citing works

Revisiting the neuroinflammation hypothesis in Alzheimer’s disease: a focus on the druggability of current targets

Wong-Guerra, M., Calfío, C., Maccioni, R. B., & Rojo, L. E. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1161850 · Cited by 92 · see citing works

Microglial response to LPS increases in wild-type mice during aging but diminishes in an Alzheimer's mouse model: Implication of TLR4 signaling in disease progression

Go, M., Kou, J., Lim, J.-E., Yang, J., & Fukuchi, K.-I. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.073 · Cited by 87 · see citing works

The Cross-Talk Between the Dopaminergic and the Immune System Involved in Schizophrenia

Vidal, P. M., & Pacheco, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00394 · Cited by 89 · see citing works

Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet

Bordeleau, M., Lacabanne, C., Fernández de Cossío, L., Vernoux, N., Savage, J. C., González-Ibáñez, F., & Tremblay, M.-È. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01914-1 · Cited by 85 · see citing works

Does neuroinflammation drive the relationship between tau hyperphosphorylation and dementia development following traumatic brain injury?

Collins-Praino, L. E., & Corrigan, F. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.09.027 · Cited by 95 · see citing works

Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury

Morganti, J. M., Riparip, L., Chou, A., Liu, S., Gupta, N. M., & Rosi, S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0547-1 · Cited by 84 · see citing works

Could Alzheimer’s Disease Originate in the Periphery and If So How So?

Morris, G., Berk, M., Maes, M. H. J., & Puri, B. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1092-y · Cited by 83 · see citing works

Improvements to Healthspan Through Environmental Enrichment and Lifestyle Interventions: Where Are We Now?

Queen, N. J., Hassan, Q. N., & Cao, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00605 · Cited by 84 · see citing works

Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation

Müller, L., & Benedetto, S. D. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1575022 · Cited by 90 · see citing works

Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition

Denver, P., & McClean, P. L. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.238608 · Cited by 85 · see citing works

Luteolin Could Improve Cognitive Dysfunction by Inhibiting Neuroinflammation

Yao, Z., Yao, X.-L., Zhang, Y., Zhang, S., & Hu, J. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2482-2 · Cited by 81 · see citing works

Microglial Phagocytosis of Neurons: Diminishing Neuronal Loss in Traumatic, Infectious, Inflammatory, and Autoimmune CNS Disorders

Yanuck, S. F. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00712 · Cited by 80 · see citing works

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment

Webster, S. J., Van Eldik, L. J., Watterson, D. M., & Bachstetter, A. D. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.0291-15.2015 · Cited by 80 · see citing works

The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke

Sun, H., He, X., Tao, X., Hou, T., Chen, M., He, M., & Liao, H. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01845-x · Cited by 77 · see citing works

Macrophages in the cochlea; an immunological link between risk factors and progressive hearing loss

Hough, K., Verschuur, C. A., Cunningham, C. M., & Newman, T. A. (2021) · Glia · doi:10.1002/glia.24095 · Cited by 76 · see citing works

Chronic Cortical Inflammation, Cognitive Impairment, and Immune Reactivity Associated with Diffuse Brain Injury Are Ameliorated by Forced Turnover of Microglia

Bray, C. E., Witcher, K. G., Adekunle-Adegbite, D., Ouviña, M., Witzel, M., Hans, E., Tapp, Z. M., Packer, J. M., Goodman, E. J., Zhao, F., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1910-21.2022 · Cited by 76 · see citing works

Purine nucleosides in neuroregeneration and neuroprotection

Ribeiro, F. F., Xapelli, S., Miranda‐Lourenço, C., Tanqueiro, S. R., Fonseca‐Gomes, J., Diógenes, M. J., Ribeiro, J. A., & Sebastião, A. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.006 · Cited by 74 · see citing works

Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

von Leden, R. E., Khayrullina, G., Moritz, K. E., & Byrnes, K. R. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0933-3 · Cited by 75 · see citing works

Involvement of AMP‐activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain

Saito, M., Saito, M., & Das, B. C. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.01.007 · Cited by 73 · see citing works

Microglia dynamics in sleep/wake states and in response to sleep loss

Deurveilher, S., Golovin, T., Hall, S., & Semba, K. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104944 · Cited by 72 · see citing works

Spatiotemporal analysis of impaired microglia process movement at sites of secondary neurodegeneration post-stroke

Kluge, M. G., Abdolhoseini, M., Zalewska, K., Ong, L. K., Johnson, S. J., Nilsson, M., & Walker, F. R. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18797346 · Cited by 73 · see citing works

A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long‐Term Signal Recording

Lee, Y., Shin, H., Lee, D., Choi, S., Cho, I., & Seo, J. (2021) · Advanced Science · doi:10.1002/advs.202100231 · Cited by 70 · see citing works

Mechanisms Underlying Interferon-γ-Induced Priming of Microglial Reactive Oxygen Species Production

Spencer, N. G., Schilling, T., Miralles, F., & Eder, C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162497 · Cited by 72 · see citing works

From Traumatic Childhood to Cocaine Abuse: The Critical Function of the Immune System

Iacono, L. L., Catale, C., Martini, A., Valzania, A., Viscomi, M. T., Chiurchiù, V., Guatteo, E., Bussone, S., Perrone, F., Sabato, P. D., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.05.022 · Cited by 71 · see citing works

n-3 Polyunsaturated Fatty Acids and Their Derivates Reduce Neuroinflammation during Aging

Joffre, C., Dinel, A., Chataigner, M., Pallet, V., & Layé, S. (2020) · Nutrients · doi:10.3390/nu12030647 · Cited by 74 · see citing works

Stem cell therapy for neurological disorders: A focus on aging

Nguyen, H., Zarriello, S., Coats, A. B., Nelson, C., Kingsbury, C., Gorsky, A., Rajani, M., Neal, E. G., & Borlongan, C. V. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.09.011 · Cited by 72 · see citing works

Microglia Activation and Gene Expression Alteration of Neurotrophins in the Hippocampus Following Early-Life Exposure to E-Cigarette Aerosols in a Murine Model

Zelikoff, J. T., Parmalee, N. L., Corbett, K., Gordon, T., Klein, C. B., & Aschner, M. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfx257 · Cited by 76 · see citing works

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

Kuter, K., Olech, Ł., & Głowacka, U. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0529-z · Cited by 65 · see citing works

Cerebral Hypoperfusion and Other Shared Brain Pathologies in Ischemic Stroke and Alzheimer’s Disease

Dong, S., Maniar, S., Manole, M. D., & Sun, D. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0570-2 · Cited by 69 · see citing works

GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

Dikmen, H. O., Hemmerich, M., Lewen, A., Hollnagel, J., Chausse, B., & Kann, O. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01903-4 · Cited by 67 · see citing works

Microglia and HPA axis in depression: An overview of participation and relationship

Pereira, G. C., Piton, E., dos Santos, B. M., Ramanzini, L. G., Camargo, L. F. M., da Silva, R. M., & Bochi, G. V. (2021) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2021.1939154 · Cited by 69 · see citing works

Neuroimmune responses in the developing brain following traumatic brain injury

Nasr, I. W., Chun, Y., & Kannan, S. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112957 · Cited by 68 · see citing works

The Therapeutic Prospects of Targeting IL-1R1 for the Modulation of Neuroinflammation in Central Nervous System Disorders

Luís, J. P., Simões, C. J. V., & Brito, R. M. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031731 · Cited by 69 · see citing works

Parkinson's disease: Microglial/macrophage-induced immunoexcitotoxicity as a central mechanism of neurodegeneration

Blaylock, R. L. (2017) · Surgical Neurology International · doi:10.4103/sni.sni_441_16 · Cited by 66 · see citing works

NLRP3-dependent microglial training impaired the clearance of amyloid-beta and aggravated the cognitive decline in Alzheimer’s disease

He, X., Xu, J., Li, G., Li, M., Li, L., Pei, Z., Zhang, L., & Hu, X. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03072-x · Cited by 63 · see citing works

Tackling the glial scar in spinal cord regeneration: new discoveries and future directions

Shafqat, A., Albalkhi, I., Magableh, H. M., Saleh, T., AlKattan, K. M., & Yaqinuddin, A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1180825 · Cited by 67 · see citing works

Maladaptive trained immunity and clonal hematopoiesis as potential mechanistic links between periodontitis and inflammatory comorbidities

Hajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 67 · see citing works

Review: microglia of the aged brain: primed to be activated and resistant to regulation

Norden, D. M., & Godbout, J. P. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01306.x · Cited by 792 · see citing works

Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration

Perry, V. H., & Teeling, J. L. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0382-8 · Cited by 599 · see citing works

Cognitive Deficits after TBI are Exaggerated by Microglia-Associated Reactivity to Immune Challenge

Muccigrosso, M. M. (2015) · OhioLink ETD Center (Ohio Library and Information Network)

Microglial Cells and Inflammatory Cytokines in the Aged Brain

Richwine, A. F., & Johnson, R. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_19

Microglial priming in neurodegenerative disease

Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works