Watt, Matthew J.

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 927

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 898

Hepatokines: Linking nonalcoholic fatty liver disease and insulin resistance

Meex, R. C. R., & Watt, M. J. (2017) · Nature Reviews Endocrinology

Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic Diseases

Cited by 631

The Liver as an Endocrine Organ—Linking NAFLD and Insulin Resistance

Watt, M. J., Miotto, P. M., De Nardo, W., & Montgomery, M. K. (2019) · Endocrine Reviews

Liver Disease Diagnosis and TreatmentAdipokines, Inflammation, and Metabolic Diseases

Cited by 615

Reactive oxygen species enhance insulin sensitivity

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism

Redox biology and oxidative stressMetabolism, Diabetes, and Cancer

Cited by 581

HSP72 protects against obesity-induced insulin resistance

Chung, J., Nguyen, A.-K., Henstridge, D. C., Holmes, A. G., Chan, M. H. S., Mesa, J. L., Lancaster, G. I., Southgate, R. J., Bruce, C. R., Duffy, S. J., et al. (2008) · Proceedings of the National Academy of Sciences

Heat shock proteins researchAdipokines, Inflammation, and Metabolic Diseases

Cited by 553

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

Monetti, M., Levin, M. C., Watt, M. J., Sajan, M. P., Marmor, S., Hubbard, B. K., Stevens, R. D., Bain, J. R., Newgard, C. B., Farese, R. V., et al. (2007) · Cell Metabolism

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 511

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 459

Particulate air pollution and the blood

Seaton, A., Soutar, A., Crawford, V., Elton, R., McNerlan, S., Cherrie, J., Watt, M., Agius, R., & Stout, R. (1999) · Thorax

Air Quality and Health ImpactsIndoor Air Quality and Microbial Exposure

Cited by 409

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

Grohmann, M., Wiede, F., Dodd, G. T., Gurzov, E. N., Ooi, G. J., Butt, T., Rasmiena, A. A., Kaur, S., Gulati, T., Goh, P. K., et al. (2018) · Cell

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 373

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance

Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 363

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 334

Impaired oxidative metabolism and inflammation are associated with insulin resistance in ERα-deficient mice

Ribas, V., Nguyen, M. T. A., Henstridge, D. C., Nguyen, A.-K., Beaven, S. W., Watt, M. J., & Hevener, A. L. (2010) · American Journal of Physiology-Endocrinology and Metabolism

Estrogen and related hormone effectsAdipokines, Inflammation, and Metabolic Diseases

Cited by 309

Skeletal muscle action of estrogen receptor α is critical for the maintenance of mitochondrial function and metabolic homeostasis in females

Ribas, V., Drew, B. G., Zhou, Z., Phun, J., Kalajian, N. Y., Soleymani, T., Daraei, P., Widjaja, K., Wanagat, J., de Aguiar Vallim, T. Q., et al. (2016) · Science Translational Medicine

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

Cited by 259

Fetuin B is a secreted hepatocyte factor linking steatosis to impaired glucose metabolism

Meex, R. C., Hoy, A. J., Morris, A., Brown, R. D., Lo, J. C. Y., Burke, M., Goode, R. J. A., Kingwell, B. A., Kraakman, M. J., Febbraio, M. A., et al. (2015) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 255

Integrative metabolism in MASLD and MASH: Pathophysiology and emerging mechanisms

Steinberg, G. R., Valvano, C. M., De Nardo, W., & Watt, M. J. (2025) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 240

Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression

Peng, K.-Y., Watt, M. J., Rensen, S., Greve, J. W., Huynh, K., Jayawardana, K. S., Meikle, P. J., & Meex, R. C. R. (2018) · Journal of Lipid Research

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 220

Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man

Watt, M. J., Heigenhauser, G. J. F., Dyck, D. J., & Spriet, L. L. (2002) · The Journal of Physiology

Muscle metabolism and nutritionCardiovascular and exercise physiology

Cited by 201

Activating HSP72 in Rodent Skeletal Muscle Increases Mitochondrial Number and Oxidative Capacity and Decreases Insulin Resistance

Henstridge, D. C., Bruce, C. R., Drew, B. G., Tory, K., Kolonics, A., Estevez, E., Chung, J., Watson, N., Gardner, T., Lee-Young, R. S., et al. (2014) · Diabetes

Heat shock proteins researchAdipose Tissue and Metabolism

Cited by 201

Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration

Stellingwerff, T., Spriet, L. L., Watt, M. J., Kimber, N. E., Hargreaves, M., Hawley, J. A., & Burke, L. M. (2006) · American Journal of Physiology-Endocrinology and Metabolism

Muscle metabolism and nutritionCardiovascular and exercise physiology

Cited by 195

AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Dzamko, N., van Denderen, B. J. W., Hevener, A. L., Jørgensen, S. B., Honeyman, J., Galic, S., Chen, Z.-P., Watt, M. J., Campbell, D. J., Steinberg, G. R., et al. (2010) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerRegulation of Appetite and Obesity

Cited by 175

Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans

Watt, M. J., Howlett, K. F., Febbraio, M. A., Spriet, L. L., & Hargreaves, M. (2001) · The Journal of Physiology

Cardiovascular and exercise physiologyMuscle metabolism and nutrition

Cited by 173

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

Steinberg, G. R., O'Neill, H. M., Dzamko, N. L., Galic, S., Naim, T., Koopman, R., Jørgensen, S. B., Honeyman, J., Hewitt, K., Chen, Z.-P., et al. (2010) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 164

Apoptosis in skeletal muscle myotubes is induced by ceramides and is positively related to insulin resistance

Turpin, S. M., Lancaster, G. I., Darby, I., Febbraio, M. A., & Watt, M. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 164