Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity
Open accessAbstract
AMP-activated protein kinase (AMPK) β subunits (β1 and β2) provide scaffolds for binding α and γ subunits and contain a carbohydrate-binding module important for regulating enzyme activity. We generated C57Bl/6 mice with germline deletion of AMPK β2 (β2 KO) and examined AMPK expression and activity, exercise capacity, metabolic control during muscle contractions, aminoimidazole carboxamide ribonucleotide (AICAR) sensitivity, and susceptibility to obesity-induced insulin resistance. We find that β2 KO mice are viable and breed normally. β2 KO mice had a reduction in skeletal muscle AMPK α1 and α2 expression despite up-regulation of the β1 isoform. Heart AMPK α2 expression was also reduced but this did not affect resting AMPK α1 or α2 activities. AMPK α1 and α2 activities were not changed in liver, fat, or hypothalamus. AICAR-stimulated glucose uptake but not fatty acid oxidation was impaired in β2 KO mice. During treadmill running β2 KO mice had reduced maximal and endurance exercise capacity, which was associated with lower muscle and heart AMPK activity and reduced levels of muscle and liver glycogen. Reductions in exercise capacity of β2 KO mice were not due to lower muscle mitochondrial content or defects in contraction-stimulated glucose uptake or fatty acid oxidation. When challenged with a high-fat diet β2 KO mice gained more weight and were more susceptible to the development of hyperinsulinemia and glucose intolerance. In summary these data show that deletion of AMPK β2 reduces AMPK activity in skeletal muscle resulting in impaired exercise capacity and the worsening of diet-induced obesity and glucose intolerance.
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AMPK β2 KO mice have reduced exercise capacity and increased susceptibility to develop insulin resistance on a high-fat diet.
“AMPK β2 KO mice are characterized by reduced exercise capacity and increased susceptibility to develop insulin resistance on a high-fat diet possibly due to greater ceramide accumulation in skeletal muscle [28].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [28]
AMPK β2 KO mice have greater ceramide accumulation in skeletal muscle.
“AMPK β2 KO mice are characterized by reduced exercise capacity and increased susceptibility to develop insulin resistance on a high-fat diet possibly due to greater ceramide accumulation in skeletal muscle [28].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [28]
AMPK β2 KO mice have reduced AMPK activity in skeletal muscle but not liver or adipose.
“In contrast, AMPK β2 KO mice have reduced AMPK activity in skeletal muscle but not liver or adipose, and have a compensatory increase in AMPK β1 protein expression and maintained α1 expression in skeletal muscle [28].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [28]
AMPK α2, β2 and γ3 null and α2KD and β1β2 M-KO mice have normal insulin-stimulated glucose uptake in muscle.
“In support of this, insulin also does not increase AMPK T172 or ACC S79/212 phosphorylation [74] and AMPK α2, β2 and γ3 null and α2KD and β1β2 M-KO mice have normal insulin-stimulated glucose uptake in muscle [26,28,30,36,100] despite blunted TBC1D1 PAS and T590 phosphorylation in response to insulin [30,74].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [28]
Contraction-mediated glucose uptake was normal in β2 or γ3 KO mice.
“Although TBC1D1 expression or PAS phosphorylation was not assessed in skeletal muscle from β2 or γ3 KO mice, contraction-mediated glucose uptake was also normal [4,28], suggesting that the remaining subunit isoforms (likely contributing to maintained or elevated α1 AMPK activity) was sufficient to allow for normal glucose uptake.”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [28]
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- Authors
- Steinberg, G. R., O'Neill, H. M., Dzamko, N. L., Galic, S., Naim, T., Koopman, R., Jørgensen, S. B., Honeyman, J., Hewitt, K., Chen, Z.-P., Schertzer, J. D., Scott, J. W., Koentgen, F., Lynch, G. S., Watt, M. J., van Denderen, B. J. W., Campbell, D. J., & Kemp, B. E.
- Affiliations
- The University of Melbourne (AU)
- Monash University (AU)
- Corresponding author
- Steinberg, Gregory R.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 285
- Issue
- 48
- Pages
- 37198-37209
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC2988326
- OpenAlex
- W2042698420
- Cited by
- 164
- References
- 63
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 14 · 2016: 19 · 2015: 15 · 2014: 23 · 2013: 13 · 2012: 5
- FWCI
- 3.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Diabetes Australia Research Trust
- Diabetes Australia
- National Heart Foundation of Australia
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- AMPK, germline deletion, skeletal muscle, exercise capacity, endurance exercise, glucose uptake, fatty acid oxidation, glycogen, heart, obesity, insulin resistance, impaired glucose tolerance, hyperinsulinemia, high-fat diet, mitochondrial content
- MeSH terms
- Animals, Fatty Acids, Female, Glucose, Male, Mice, Inbred C57BL, Physical Conditioning, Animal, Gene Deletion, Mice, Knockout, Muscle, Skeletal, Mice, AMP-Activated Protein Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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