AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance

Basic local alignment search tool

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

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AMPK in Health and Disease

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Characterization of the AMP-activated Protein Kinase Kinase from Rat Liver and Identification of Threonine 172 as the Major Site at Which It Phosphorylates AMP-activated Protein Kinase

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes

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AMP-activated Protein Kinase Plays a Role in the Control of Food Intake

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Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms

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Mammalian AMP-activated protein kinase subfamily

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How Obesity Causes Diabetes: Not a Tall Tale

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AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons

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The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

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Muscle-specific Pparg deletion causes insulin resistance

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Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice

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AMP-activated protein kinase, super metabolic regulator

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Tumor necrosis factor α-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

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Short-Term Overexpression of a Constitutively Active Form of AMP-Activated Protein Kinase in the Liver Leads to Mild Hypoglycemia and Fatty Liver

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Hypothalamic CaMKK2 Contributes to the Regulation of Energy Balance

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Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase.

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CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK

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Mammalian AMP-activated protein kinase is homologous to yeast and plant protein kinases involved in the regulation of carbon metabolism

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Thienopyridone Drugs Are Selective Activators of AMP-Activated Protein Kinase β1-Containing Complexes

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Identification of a Novel AMP-activated Protein Kinase β Subunit Isoform That Is Highly Expressed in Skeletal Muscle

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Liver Adenosine Monophosphate-Activated Kinase-α2 Catalytic Subunit Is a Key Target for the Control of Hepatic Glucose Production by Adiponectin and Leptin But Not Insulin

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Impaired Activation of AMP-Kinase and Fatty Acid Oxidation by Globular Adiponectin in Cultured Human Skeletal Muscle of Obese Type 2 Diabetics

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AMP-activated Protein Kinase Activation Increases Phosphorylation of Glycogen Synthase Kinase 3β and Thereby Reduces cAMP-responsive Element Transcriptional Activity and Phosphoenolpyruvate Carboxykinase C Gene Expression in the Liver

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Crystal Structures of the Adenylate Sensor from Fission Yeast AMP-Activated Protein Kinase

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Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders

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Posttranslational Modifications of the 5′-AMP-activated Protein Kinase β1 Subunit

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Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway

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The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease

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AMP-activated Protein Kinase β Subunit Tethers α and γ Subunits via Its C-terminal Sequence (186–270)

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Expression of the AMP‐activated protein kinase β1 and β2 subunits in skeletal muscle

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AMP-Activated Protein Kinase Phosphorylates Retinoblastoma Protein to Control Mammalian Brain Development

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Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity

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Ciliary Neurotrophic Factor Suppresses Hypothalamic AMP-Kinase Signaling in Leptin-Resistant Obese Mice

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Cytokine secretion by human adipocytes is differentially regulated by adiponectin, AICAR, and troglitazone

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Role of Adenosine 5′-Monophosphate-Activated Protein Kinase in Interleukin-6 Release from Isolated Mouse Skeletal Muscle

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AMP-activated Protein Kinase Subunit Interactions

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New insights into activation and function of the AMPK

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

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AMP-activated protein kinase: the current landscape for drug development

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

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AMPK as a Therapeutic Target for Treating Metabolic Diseases

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PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

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Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

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AMP-activated protein kinase (AMPK) β1β2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

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Hypothalamic AMPK: a canonical regulator of whole-body energy balance

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Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss

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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

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Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation

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Leptin's Role in Lipodystrophic and Nonlipodystrophic Insulin-Resistant and Diabetic Individuals

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NOD1 activators link innate immunity to insulin resistance

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The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration

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Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

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AMP-activated protein kinase (AMPK) beyond metabolism: A novel genomic stress sensor participating in the DNA damage response pathway

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Adipose tissue: between the extremes

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Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

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Quercetin activates AMP‐activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol‐induced neurotoxicity

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mTOR signaling in tumorigenesis

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Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

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Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity

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An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

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Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity

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Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models

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Evidence for the role of AMPK in regulating PGC‐1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue

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Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms

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AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress

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Mechanism of Action of Compound-13: An α1-Selective Small Molecule Activator of AMPK

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Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

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Structure of an AMPK complex in an inactive, ATP-bound state

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Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance

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Role of SIRT1 and AMPK in mesenchymal stem cells differentiation

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The role of AMP-activated protein kinase in regulating white adipose tissue metabolism

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Altered Metabolism and Persistent Starvation Behaviors Caused by Reduced AMPK Function in Drosophila

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Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice

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Liver-Specific Suppressor of Cytokine Signaling-3 Deletion in Mice Enhances Hepatic Insulin Sensitivity and Lipogenesis Resulting in Fatty Liver and Obesity

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AMPK and the Endocrine Control of Metabolism

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Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver

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Glucolipotoxicity Alters Lipid Partitioning and Causes Mitochondrial Dysfunction, Cholesterol, and Ceramide Deposition and Reactive Oxygen Species Production in INS832/13 ß-Cells

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The role of ampk in controlling metabolism and mitochondrial biogenesis during exercise

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Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance

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ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia

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Salicylate activates AMPK and synergizes with metformin to reduce the survival of prostate and lung cancer cells ex vivo through inhibition of de novo lipogenesis

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Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance

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Exercise reverses age‐related vulnerability of the retina to injury by preventing complement‐mediated synapse elimination via a BDNF ‐dependent pathway

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Hypothalamic AMP-Activated Protein Kinase Regulates Glucose Production

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CAMKK2 Promotes Prostate Cancer Independently of AMPK via Increased Lipogenesis

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Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance

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Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

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A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

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Platycodin D, a novel activator of AMP-activated protein kinase, attenuates obesity in db/db mice via regulation of adipogenesis and thermogenesis

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Adenosine Monophosphate–Activated Kinase and Its Key Role in Catabolism: Structure, Regulation, Biological Activity, and Pharmacological Activation

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Involvement of AMP‐activated protein kinase in neuroinflammation and neurodegeneration in the adult and developing brain

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Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice.

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Creatine maintains intestinal homeostasis and protects against colitis

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PPARδ activation attenuates hepatic steatosis in Ldlr mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity

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Function of the master energy regulator adenosine monophosphate‐activated protein kinase in stroke

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Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

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The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK

Morrow, N. M., Burke, A. C., Samsoondar, J. P., Seigel, K. E., Wang, A., Telford, D. E., Sutherland, B. G., O’Dwyer, C., Steinberg, G. R., Fullerton, M. D., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra119000542 · Cited by 69 · see citing works

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk

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A Narrative Review on the Role of AMPK on De Novo Lipogenesis in Non-Alcoholic Fatty Liver Disease: Evidence from Human Studies

von Loeffelholz, C., Coldewey, S. M., & Birkenfeld, A. L. (2021) · Cells · doi:10.3390/cells10071822 · Cited by 67 · see citing works

Kaempferol attenuates nonalcoholic fatty liver disease in type 2 diabetic mice via the Sirt1/AMPK signaling pathway

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Bempedoic acid: effects on lipoprotein metabolism and atherosclerosis

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The metabolic sensor AMPK: Twelve enzymes in one

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AMPK activation regulates neuronal structure in developing hippocampal neurons

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Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release

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AMPK-dependent modulation of hepatic lipid metabolism by nesfatin-1

Yin, Y., Li, Z., Gao, L., Li, Y., Zhao, J., & Zhang, W. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.006 · Cited by 62 · see citing works

AMP-Activated Protein Kinase (AMPK) and Energy-Sensing in the Brain

Ramamurthy, S., & Ronnett, G. V. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.2.52 · Cited by 60 · see citing works

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

Hughey, C. C., James, F. D., Bracy, D. P., Donahue, E. P., Young, J. D., Viollet, B., Foretz, M., & Wasserman, D. H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.811547 · Cited by 59 · see citing works

Radix Polygoni Multiflori and Its Main Component Emodin Attenuate Non-Alcoholic Fatty Liver Disease in Zebrafish by Regulation of AMPK Signaling Pathway

Yu, L., Gong, L., Wang, C., Hu, N., Tang, Y.-Q., Li, Z., Dai, X., & Li, Y. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s243893 · Cited by 57 · see citing works

Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related Lipolytic Activation in Adipocytes

Zhang, X., Wang, Z., Li, J., Gu, D., Li, S., Shen, C., & Song, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070663 · Cited by 56 · see citing works

Salicylates Ameliorate Intestinal Inflammation by Activating Macrophage AMPK.

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AMPK beta subunits: more than just a scaffold in the formation of AMPK complex

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Homocysteine suppresses lipolysis in adipocytes by activating the AMPK pathway

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Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance

Palanivel, R., Fullerton, M. D., Galić, S., Honeyman, J. E., Hewitt, K., Jørgensen, S. B., & Steinberg, G. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2665-3 · Cited by 51 · see citing works

Discovery of natural alkaloid bouchardatine as a novel inhibitor of adipogenesis/lipogenesis in 3T3-L1 adipocytes

Rao, Y., Liu, H., Gao, L., Yu, H., Tan, J., Ou, T., Huang, S., Gu, L., Ye, J., & Huang, Z. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.05.057 · Cited by 49 · see citing works

AMPK mediates energetic stress‐induced liver GDF15

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ESR1, FTO, and UCP2 Genes Interact with Bariatric Surgery Affecting Weight Loss and Glycemic Control in Severely Obese Patients

Liou, T., Chen, H., Wang, W., Wu, S., Lee, Y.-C., Yang, W., & Lee, W. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0457-3 · Cited by 45 · see citing works

The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

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AMPK regulates macrophage polarization in adipose tissue inflammation and NASH

Weng, S., & Schuppan, D. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.09.031 · Cited by 44 · see citing works

AMPK β1 reduces tumor progression and improves survival in p53 null mice

Houde, V. P., Donzelli, S., Sacconi, A., Galić, S., Hammill, J. A., Bramson, J. L., Foster, R. A., Tsakiridis, T. K., Kemp, B. E., Grasso, G., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12079 · Cited by 39 · see citing works

The Outcome of Renal Ischemia-Reperfusion Injury Is Unchanged in AMPK-β1 Deficient Mice

Mount, P. F., Gleich, K., Tam, S., Fraser, S. A., Choy, S., Dwyer, K. M., Lü, B., van Denderen, B., Fingerle‐Rowson, G., Bucala, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029887 · Cited by 41 · see citing works

Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis

Basseri, S., Lhoták, Š., Fullerton, M. D., Palanivel, R., Jiang, H. L., Lynn, E. G., Ford, R. J., Maclean, K. N., Steinberg, G. R., & Austin, R. C. (2012) · Diabetes · doi:10.2337/db12-0256 · Cited by 41 · see citing works

The SGLT2 inhibitor canagliflozin suppresses lipid synthesis and interleukin-1 beta in ApoE deficient mice

Day, E. A., Ford, R. J., Lu, J. H., Lu, R., Lundenberg, L., Desjardins, E. M., Green, A. E., Lally, J., Schertzer, J. D., & Steinberg, G. R. (2020) · Biochemical Journal · doi:10.1042/bcj20200278 · Cited by 41 · see citing works

Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK

Xu, H., Liu, M., Liu, H., Zhao, B., Zheng, M., & Liu, J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104582 · Cited by 39 · see citing works

Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis

Lee, M. K. S., Cooney, O. D., Lin, X., Nadarajah, S., Dragoljevic, D., Huynh, K., Onda, D.-A., Galić, S., Meikle, P. J., Edlund, H., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101514 · Cited by 37 · see citing works

AMPK inhibits liver gluconeogenesis: fact or fiction?

Johanns, M., Hue, L., & Rider, M. H. (2023) · Biochemical Journal · doi:10.1042/bcj20220582 · Cited by 42 · see citing works

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney

Christensen, M. S., Jensen, J., Jakobsen, S., Jessen, N., Frøkiær, J., Kemp, B. E., Marciszyn, A. L., Li, H., Pastor‐Soler, N. M., Hallows, K. R., et al. (2016) · Scientific Reports · doi:10.1038/srep35952 · Cited by 37 · see citing works

Meroterpenoid-rich fraction of an ethanolic extract from Sargassum serratifolium alleviates obesity and non-alcoholic fatty liver disease in high fat-fed C57BL/6J mice

Kwon, M., Lim, S.-J., Joung, E., Lee, B., Oh, C., & Kim, H. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.05.063 · Cited by 37 · see citing works

CB1 receptor mediates the effects of glucocorticoids on AMPK activity in the hypothalamus

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AMP ‐activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events

Jiang, S., Wang, Y., Luo, L., Shi, F., Zou, J., Lin, H., Ying, Y., Luo, Y., Zhan, Z., Liu, P., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14279 · Cited by 36 · see citing works

Effect of 24 h Fasting on Gene Expression of AMPK, Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks

Liu, L., & LiXian, Z. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2012.12153 · Cited by 33 · see citing works

Targeting AMPK Signaling in the Liver: Implications for Obesity and Type 2 Diabetes Mellitus

Liu, Y., Wang, D., & Yang, L. (2022) · Current Drug Targets · doi:10.2174/1389450123666220429082702 · Cited by 35 · see citing works

Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis

Kuwako, K.-I., & Okano, H. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00354 · Cited by 30 · see citing works

AMP-Activated Protein Kinase a1 Protects Against Diet-Induced Insulin Resistance and Obesity

(2016)

Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity

Steinberg, G. R., O'Neill, H. M., Dzamko, N. L., Galic, S., Naim, T., Koopman, R., Jørgensen, S. B., Honeyman, J., Hewitt, K., Chen, Z.-P., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.102434 · Cited by 164 · see citing works

Early prediction of outcome in acute pancreatitis: A retrospective study on single parameters and scores

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Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., Henriksen, T. I., Rebalka, I. A., Razi, A., Sakamoto, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.006 · Cited by 323 · see citing works

Ablation of AMP-activated protein kinase α1 and α2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo

Sun, G., Tarasov, A. I., McGinty, J., McDonald, A., Xavier, G. D. S., Gorman, T., Marley, A. E., French, P. M. W., Parker, H., Gribble, F. M., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1692-1 · Cited by 97 · see citing works