Kimmelman, Alec C.

KRAS4A directly regulates hexokinase 1

Amendola, C. R., Mahaffey, J. P., Parker, S. J., Ahearn, I. M., Chen, W.-C., Zhou, M., Court, H., Shi, J., Mendoza, S. L., Morten, M. J., et al. (2019) · Nature

Cancer, Hypoxia, and MetabolismProtein Kinase Regulation and GTPase Signaling

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Mechanisms of Selective Autophagy in Normal Physiology and Cancer

Mancias, J. D., & Kimmelman, A. C. (2016) · Journal of Molecular Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 196

Selective alanine transporter utilization creates a targetable metabolic niche in pancreatic cancer

Parker, S. J., Amendola, C. R., Hollinshead, K. E. R., Yu, Q., Yamamoto, K., Encarnación-Rosado, J., Rose, R. E., LaRue, M. M., Sohn, A. S. W., Biancur, D. E., et al. (2020) · Cancer Discovery

Amino Acid Enzymes and MetabolismPancreatic and Hepatic Oncology Research

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Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 147

R-Ras3, a brain-specific Ras-related protein, activates Akt and promotes cell survival in PC12 cells

Kimmelman, A. C., Osada, M., & Chan, A. M.-L. (2000) · Oncogene

Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR signaling in cancer

Cited by 50

Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma

Anglin, J., Zavareh, R. B., Sander, P. N., Haldar, D., Mullarky, E., Cantley, L. C., Kimmelman, A. C., Lyssiotis, C. A., & Lairson, L. L. (2018) · Bioorganic & Medicinal Chemistry Letters

Pancreatic and Hepatic Oncology ResearchCancer, Hypoxia, and Metabolism

Cited by 39

USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer

Hou, P., Ma, X., Yang, Z., Zhang, Q., Wu, C.-J., Li, J., Tan, L., Yao, W., Yan, L., Zhou, X., et al. (2021) · Genes & Development

Pancreatic and Hepatic Oncology ResearchUbiquitin and proteasome pathways

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Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway

Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature

Cancer, Hypoxia, and MetabolismPancreatic and Hepatic Oncology Research

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