KRAS4A directly regulates hexokinase 1

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043 · see citing works

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Hay, N. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.77 · Cited by 1,123 · see citing works

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

Gottlob, K., Majewski, N., Kennedy, S., Kandel, E., Robey, R. B., & Hay, N. (2001) · Genes & Development · doi:10.1101/gad.889901 · Cited by 961 · see citing works

Glucose Deprivation Contributes to the Development of <i>KRAS</i> Pathway Mutations in Tumor Cells

Yun, J., Rago, C., Cheong, I., Pagliarini, R., Angenendt, P., Rajagopalan, H., Schmidt, K., Willson, J. K. V., Markowitz, S., Zhou, S., et al. (2009) · Science · doi:10.1126/science.1174229 · Cited by 914 · see citing works

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

Patra, K. C., Wang, Q., Bhaskar, P. T., Miller, L. L., Wang, Z., Wheaton, W. W., Chandel, N. S., Laakso, M., Muller, W. J., Allen, E. L., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.06.014 · Cited by 856 · see citing works

Ras signalling on the endoplasmic reticulum and the Golgi

Chiu, V. K., Bivona, T., Hach, A., Sajous, J. B., Silletti, J., Wiener, H., Johnson, R. L., Cox, A. D., & Philips, M. R. (2002) · Nature Cell Biology · doi:10.1038/ncb783 · Cited by 594 · see citing works

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562 · see citing works

Video-rate nanoscopy using sCMOS camera–specific single-molecule localization algorithms

Huang, F., Hartwich, T. M. P., Rivera-Molina, F. E., Lin, Y., Duim, W. C., Long, J. J., Uchil, P. D., Myers, J. R., Baird, M. A., Mothes, W., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2488 · Cited by 531 · see citing works

Ras oncogenes and their downstream targets

Rajalingam, K., Schreck, R., Rapp, U. R., & Albert, Š. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2007.01.012 · Cited by 458 · see citing works

The Palmitoylation Machinery Is a Spatially Organizing System for Peripheral Membrane Proteins

Rocks, O., Gerauer, M., Vartak, N., Koch, S., Huang, Z., Pechlivanis, M., Kuhlmann, J., Brunsveld, L., Chandra, A., Ellinger, B., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.007 · Cited by 454 · see citing works

COMPARTMENTALIZED RAS/MAPK SIGNALING

Mor, A., & Philips, M. R. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090723 · Cited by 400 · see citing works

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., & Rabinowitz, J. D. (2018) · Cell Systems · doi:10.1016/j.cels.2018.06.003 · Cited by 368 · see citing works

Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities

Kerr, E. M., Gaude, E., Turrell, F. K., Frezza, C., & Martins, C. P. (2016) · Nature · doi:10.1038/nature16967 · Cited by 308 · see citing works

High Precision Isotope Ratio Monitoring Techniques in Mass Spectrometry

Brand, W. A. (1996) · Journal of Mass Spectrometry · doi:10.1002/(sici)1096-9888(199603)31:3 · Cited by 299 · see citing works

Four Human Ras Homologs Differ in Their Abilities to Activate Raf-1, Induce Transformation, and Stimulate Cell Motility

Voice, J. K., Klemke, R. L., Le, A., & Jackson, J. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.24.17164 · Cited by 288 · see citing works

IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism

Grassian, A. R., Parker, S. J., Davidson, S. M., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0772-t · Cited by 280 · see citing works

Subcellular localization of hexokinases I and II directs the metabolic fate of glucose

John, S., Weiss, J. N., & Ribalet, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017674 · Cited by 239 · see citing works

K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif

Tsai, F. D., Lopes, M. S., Zhou, M., Court, H., Ponce, O., Fiordalisi, J. J., Gierut, J. J., Cox, A. D., Haigis, K. M., & Philips, M. R. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412811112 · Cited by 226 · see citing works

Metabolic Dependencies in RAS -Driven Cancers

Kimmelman, A. C. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2425 · Cited by 220 · see citing works

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

Jennings, B. C., Nadolski, M. J., Ling, Y., Beckham, M. L., Harrison, M. L., Deschenes, R. J., & Linder, M. E. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800270-jlr200 · Cited by 214 · see citing works

The function of complexes between the outer mitochondrial membrane pore (VDAC) and the adenine nucleotide translocase in regulation of energy metabolism and apoptosis.

Vyssokikh, M. Y., & Brdiczka, D. G. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3693 · Cited by 185 · see citing works

Recognizing and Defining True Ras Binding Domains I: Biochemical Analysis

Wohlgemuth, S., Kiel, C., Kraemer, A., Serrano, L. G., Wittinghofer, F., & Herrmann, C. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.02.048 · Cited by 177 · see citing works

Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor

Peled, M., Tocheva, A. S., Sandigursky, S., Nayak, S., Philips, E. A., Nichols, K. E., Strazza, M., Azoulay-Alfaguter, I., Askenazi, M., Neel, B. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710437115 · Cited by 87 · see citing works

Posttranslational Modifications of RAS ProteinsPreprint

Ahearn, I. M., Zhou, M., & Philips, M. R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031484 · Cited by 86 · see citing works

Functional Organization of Mammalian Hexokinases: Both N- and C-Terminal Halves of the Rat Type II Isozyme Possess Catalytic Sites

Tsai, H. J., & Wilson, J. E. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0186 · Cited by 81 · see citing works

Quantification of spatiotemporal patterns of Ras isoform expression during development

Newlaczyl, A. U., Coulson, J. M., & Prior, I. A. (2017) · Scientific Reports · doi:10.1038/srep41297 · Cited by 58 · see citing works

An enzymatic colorimetric assay for glucose-6-phosphate

Zhu, A., Romero, R. J., & Petty, H. R. (2011) · Analytical Biochemistry · doi:10.1016/j.ab.2011.08.037 · Cited by 54 · see citing works

Ultrafast data mining of molecular assemblies in multiplexed high-density super-resolution images

Yin, Y., Lee, W. T. C., & Rothenberg, E. (2019) · Nature Communications · doi:10.1038/s41467-018-08048-2 · Cited by 32 · see citing works

Compartmentalized Ras signaling differentially contributes to phenotypic outputs

Aran, V., & Prior, I. A. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.05.004 · Cited by 28 · see citing works

Allosteric Regulation of Type I Hexokinase: A Site-Directed Mutational Study Indicating Location of the Functional Glucose 6-Phosphate Binding Site in the N-Terminal Half of the Enzyme

Sebastian, S., Wilson, J. E., Mulichak, A. M., & Garavito, R. M. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.1043 · Cited by 24 · see citing works

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells

Zhou, M., & Philips, M. R. (2017) · Journal of Visualized Experiments · doi:10.3791/56037 · Cited by 16 · see citing works

KRAS Mutation: From Undruggable to Druggable in Cancer

Huang, L., Guo, Z., Wang, F., & Fu, L. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00780-4 · Cited by 1,127 · see citing works

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 770 · see citing works

Metabolic Codependencies in the Tumor Microenvironment

Dey, P., Kimmelman, A. C., & DePinho, R. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1211 · Cited by 342 · see citing works

The metabolic landscape of RAS-driven cancers from biology to therapy

Mukhopadhyay, S., Vander Heiden, M. G., & McCormick, F. (2021) · Nature Cancer · doi:10.1038/s43018-021-00184-x · Cited by 315 · see citing works

First-in-human study of the safety, pharmacokinetics, and pharmacodynamics of first-in-class fatty acid synthase inhibitor TVB-2640 alone and with a taxane in advanced tumors

Falchook, G. S., Infante, J. R., Arkenau, H., Patel, M. R., Dean, E. J., Borazanci, E. H., Brenner, A. J., Cook, N., Lopez, J., Pant, S., et al. (2021) · EClinicalMedicine · doi:10.1016/j.eclinm.2021.100797 · Cited by 302 · see citing works

Pathological implication of protein post-translational modifications in cancer

Pan, S., & Chen, R. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101097 · Cited by 272 · see citing works

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works

Targeting KRAS(G12C): From Inhibitory Mechanism to Modulation of Antitumor Effects in Patients

Kim, D., Xue, J. Y., & Lito, P. (2020) · Cell · doi:10.1016/j.cell.2020.09.044 · Cited by 239 · see citing works

Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment

Kerk, S. A., Papagiannakopoulos, T. Y., Shah, Y. M., & Lyssiotis, C. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00375-9 · Cited by 238 · see citing works

Metabolic reprogramming by traditional Chinese medicine and its role in effective cancer therapy

Wang, S., Fu, J., Hao, H., Jiao, Y., Li, P., & Han, S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105728 · Cited by 204 · see citing works

Insights into the post-translational modification and its emerging role in shaping the tumor microenvironment

Li, W., Li, F., Zhang, X., Lin, H., & Xu, C. S. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00825-8 · Cited by 203 · see citing works

Protein palmitoylation in cancer: molecular functions and therapeutic potential

Zhou, B., Hao, Q., Liang, Y., & Kong, E. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13308 · Cited by 185 · see citing works

YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect

Hou, Y., Zhang, Q., Pang, W., Hou, L., Liang, Y., Han, X., Luo, X., Wang, P., Zhang, X., Li, L., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00804-0 · Cited by 183 · see citing works

Harnessing metabolic dependencies in pancreatic cancers

Encarnación-Rosado, J., & Kimmelman, A. C. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-021-00431-7 · Cited by 180 · see citing works

The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC)

Salgia, R., Pharaon, R. R., Mambetsariev, I., Nam, A., & Sattler, M. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100186 · Cited by 163 · see citing works

HK1 from hepatic stellate cell–derived extracellular vesicles promotes progression of hepatocellular carcinoma

Chen, Q.-T., Zhang, Z., Huang, Q., Chen, H., Hong, W., Lin, T., Zhao, W., Wang, X., Ju, C.-Y., Wu, L.-Z., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00642-5 · Cited by 141 · see citing works

RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms

Yang, X., & Wu, H. K. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01631-9 · Cited by 122 · see citing works

Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect

Mirzaei, H., & Hamblin, M. R. (2020) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2020.10.003 · Cited by 115 · see citing works

Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies

Santarpía, M., Aguilar, A., CHAIB-OUKADOUR, I., Cardona, A. F., Fancelli, S., Laguía, F., Bracht, J. W. P., Cao, P., Molina‐Vila, M. Á., Karachaliou, N., et al. (2020) · Cancers · doi:10.3390/cancers12061475 · Cited by 100 · see citing works

Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1

Liu, Y., Zhang, H., Liu, Y., Zhang, S., Su, P., Wang, L., Li, Y., Liang, Y., Wang, X., Zhao, W., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2182482 · Cited by 100 · see citing works

Hexokinases in cancer and other pathologies

Guo, D. S., Meng, Y., Jiang, X., & Lu, Z. (2023) · Cell Insight · doi:10.1016/j.cellin.2023.100077 · Cited by 91 · see citing works

The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy

Ma, Q., Zhang, W., Wu, K., & Shi, L. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02218-1 · Cited by 88 · see citing works

Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications

Cao, L., Wu, J., Qu, X., Sheng, J., Cui, M., Liu, S., Huang, X., Xiang, Y., Li, B., Zhang, X., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01765-x · Cited by 86 · see citing works

Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

Yin, G., Huang, J., Petela, J., Jiang, H., Zhang, Y., Gong, S., Wu, J., Liu, B., Shi, J., & Gao, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01441-4 · Cited by 87 · see citing works

Oncogenic KRAS blockade therapy: renewed enthusiasm and persistent challenges

Tang, D., Kroemer, G., & Kang, R. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01422-7 · Cited by 80 · see citing works

Targeting KRAS: from metabolic regulation to cancer treatment

Shi, Y., Zheng, H., Wang, T., Zhou, S., Zhao, S., Li, M., & Cao, B. (2025) · Molecular Cancer · doi:10.1186/s12943-024-02216-3 · Cited by 75 · see citing works

Palmitoylation as a Key Regulator of Ras Localization and Function

Busquets-Hernández, C., & Triola, G. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.659861 · Cited by 69 · see citing works

Protein Lipidation by Palmitoylation and Myristoylation in Cancer

Fhu, C. W., & Ali, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673647 · Cited by 70 · see citing works

Post-translational modification of RAS proteins

Campbell, S. L., & Philips, M. R. (2021) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2021.06.015 · Cited by 66 · see citing works

Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids

Liu, J., van der Hoeven, R., Kattan, W. E., Chang, J. T., Montufar‐Solis, D., Chen, W., Wong, M., Zhou, Y., Lebrilla, C. B., & Hancock, J. F. (2023) · Nature Communications · doi:10.1038/s41467-023-36128-5 · Cited by 65 · see citing works

Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61 · see citing works

GLUT3 promotes macrophage signaling and function via RAS-mediated endocytosis in atopic dermatitis and wound healing

Yu, D.-M., Zhao, J., Lee, E. E., Kim, D., Mahapatra, R., Rose, E. K., Zhou, Z., Hosler, C., Kurdi, A., Choe, J., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci170706 · Cited by 60 · see citing works

Protein lipidation in cancer: mechanisms, dysregulation and emerging drug targets

Tate, E. W., Soday, L., de la Lastra, A. L., Wang, M., & Lin, H. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00666-x · Cited by 61 · see citing works

KRAS: Biology, Inhibition, and Mechanisms of Inhibitor Resistance

Ash, L. J., Busia-Bourdain, O., Okpattah, D., Kamel, A., Liberchuk, A., & Wolfe, A. L. (2024) · Current Oncology · doi:10.3390/curroncol31040150 · Cited by 59 · see citing works

The Ins and Outs of RAS Effector Complexes

Kiel, C., Matallanas, D., & Kölch, W. (2021) · Biomolecules · doi:10.3390/biom11020236 · Cited by 57 · see citing works

Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection

Dey, S., Murmu, N., Mondal, T., Saha, I., Chatterjee, S., Manna, R., Haldar, S., Dash, S. K., Sarkar, T. R., & Giri, B. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113801 · Cited by 58 · see citing works

Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers

Kobayashi, Y., Chhoeu, C., Li, J., Price, K. S., Kiedrowski, L. A., Hutchins, J. L., Hardin, A. I., Wei, Z., Hong, F., Bahcall, M., et al. (2022) · Nature · doi:10.1038/s41586-022-04451-4 · Cited by 56 · see citing works

Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy

Chen, L., Xing, X., Zhu, Y., Chen, Y., Pei, H., Song, Q., Li, J., & Zhang, P. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216696 · Cited by 55 · see citing works

Post-translational modification of KRAS: potential targets for cancer therapy

Wang, W., Yuan, T., Qian, M., Yan, F., Yang, L., He, Q., Yang, B., Lu, J., & Zhu, H. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-00542-y · Cited by 54 · see citing works

A pan-cancer analysis of the role of hexokinase II (HK2) in human tumors

Li, R., Mei, S., Ding, Q., Wang, Q., Yu, L., & Zi, F. (2022) · Scientific Reports · doi:10.1038/s41598-022-23598-8 · Cited by 48 · see citing works

Targeted inhibition of glutamine metabolism enhances the antitumor effect of selumetinib in KRAS-mutant NSCLC

Xia, M., Li, X., Diao, Y., Du, B., & Li, Y. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100920 · Cited by 48 · see citing works

Lactate-related metabolic reprogramming and immune regulation in colorectal cancer

Sun, Q., Wu, J., Zhu, G., Li, T., Zhu, X., Ni, B., Xu, B., Ma, X., & Li, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1089918 · Cited by 45 · see citing works

RHOF promotes Snail1 lactylation by enhancing PKM2-mediated glycolysis to induce pancreatic cancer cell endothelial–mesenchymal transition

Zhao, R., Yi, Y., Liu, H., Xu, J., Chen, S., Wu, D., Wang, L., & Li, F. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00362-2 · Cited by 48 · see citing works

The role of KRAS splice variants in cancer biology

Nuevo‐Tapioles, C., & Philips, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1033348 · Cited by 46 · see citing works

ONC212 is a Novel Mitocan Acting Synergistically with Glycolysis Inhibition in Pancreatic Cancer

Ferrarini, I., Louie, A. D., Zhou, L., & El‐Deiry, W. S. (2021) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-20-0962 · Cited by 44 · see citing works

Not all RAS mutations are equal: A detailed review of the functional diversity of RAS hot spot mutations

Burge, R. A., & Hobbs, G. A. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2021.07.004 · Cited by 44 · see citing works

From bench to bedside: current development and emerging trend of KRAS-targeted therapy

Chen, Y., Liu, Q.-P., Xie, H., & Ding, J. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01194-4 · Cited by 44 · see citing works

Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

Zhang, C., Ma, H., Wu, S., Shen, J., Zhang, N., Xu, Y., Li, C.-X., He, P., Ge, M.-K., Chu, X., et al. (2024) · Developmental Cell · doi:10.1016/j.devcel.2024.08.003 · Cited by 40 · see citing works

Mapping the KRAS proteoform landscape in colorectal cancer identifies truncated KRAS4B that decreases MAPK signaling

Adams, L. M., DeHart, C. J., Drown, B., Anderson, L. C., Bocik, W., Boja, E. S., Hiltke, T., Hendrickson, C. L., Rodriguez, H., Caldwell, M. A., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102768 · Cited by 38 · see citing works

Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties

Whitley, M. J., Tran, T. H., Rigby, M., Yi, M., Dharmaiah, S., Waybright, T. J., Ramakrishnan, N., Perkins, S. C., Taylor, T. E., Messing, S. A. J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adj4137 · Cited by 39 · see citing works

The biological role of metabolic reprogramming in pancreatic cancer

Suzuki, T., Otsuka, M., Seimiya, T., Iwata, T., Kishikawa, T., & Koike, K. (2020) · MedComm · doi:10.1002/mco2.37 · Cited by 37 · see citing works

The Warburg effect: The hacked mitochondrial-nuclear communication in cancer

Jiang, H., & Ye, J. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.03.006 · Cited by 38 · see citing works

Targeting RAS mutants in malignancies: successes, failures, and reasons for hope

Yang, H. S., Zhou, X., Fu, D., Le, C., Wang, J., Zhou, Q., Liu, X., Yuan, Y., Ding, K., & Xiao, Q. (2022) · 癌症：英文版 · doi:10.1002/cac2.12377 · Cited by 35 · see citing works

Signaling Pathways That Drive18F-FDG Accumulation in Cancer

Salas, J. R., & Clark, P. M. (2022) · Journal of Nuclear Medicine · doi:10.2967/jnumed.121.262609 · Cited by 35 · see citing works

Aiding Cancer’s “Sweet Tooth”: Role of Hexokinases in Metabolic Reprogramming

Farooq, Z., Ismail, H., Bhat, S. A., Layden, B. T., & Khan, M. W. (2023) · Life · doi:10.3390/life13040946 · Cited by 33 · see citing works

Metabolomic biomarkers in liquid biopsy: accurate cancer diagnosis and prognosis monitoring

Wang, W., Zhen, S., Yu, P., Wang, L., & Zhang, Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1331215 · Cited by 34 · see citing works

Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis

García‐Navas, R., Liceras-Boillos, P., Gómez, C., Baltanás, F. C., Calzada, N., Nuevo‐Tapioles, C., Cuezva, J. M., & Santos, E. (2021) · Oncogene · doi:10.1038/s41388-021-01886-3 · Cited by 32 · see citing works

Functional and structural insights into RAS effector proteins

Mozzarelli, A. M., Simanshu, D. K., & Castel, P. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.06.027 · Cited by 31 · see citing works

RAS Function in cancer cells: translating membrane biology and biochemistry into new therapeutics

Kattan, W. E., & Hancock, J. F. (2020) · Biochemical Journal · doi:10.1042/bcj20190839 · Cited by 31 · see citing works

The Intricate Crosstalk Between Insulin and Pancreatic Ductal Adenocarcinoma: A Review From Clinical to Molecular

Deng, J., Guo, Y., Du, J., Gu, J., Kong, L., Tao, B., Li, J., & Fu, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.844028 · Cited by 31 · see citing works

Oridonin inhibits bladder cancer survival and immune escape by covalently targeting HK1

Liu, S., Wang, X., Sun, X., Wei, B., Jiang, Z., Ouyang, Y., Ozaki, T., Yu, M., Liu, Y., Zhang, R., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155426 · Cited by 28 · see citing works

Crosstalk between Epigenetics and Metabolic Reprogramming in Metabolic Dysfunction-Associated Steatotic Liver Disease-Induced Hepatocellular Carcinoma: A New Sight

Li, A., Wang, R., Zhao, Y. Q., Zhao, P., & Yang, J. (2024) · Metabolites · doi:10.3390/metabo14060325 · Cited by 28 · see citing works

A pan-cancer analysis of molecular characteristics and oncogenic role of hexokinase family genes in human tumors

Jiang, M., Liu, S., Lin, J., Hao, W., Wei, B., Gao, Y., Kong, C., Meng, Y., & Zhu, Y. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118669 · Cited by 28 · see citing works

Metabolic landscapes in sarcomas

MIALLOT, R., Galland, F., Millet, V., Blay, J., & Naquet, P. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01125-y · Cited by 27 · see citing works

Ras isoform-specific expression, chromatin accessibility, and signaling

Nussinov, R., Zhang, M., Maloney, R., & Jang, H. (2021) · Biophysical Reviews · doi:10.1007/s12551-021-00817-6 · Cited by 28 · see citing works

Novel insight into the Warburg effect: Sweet temptation

Zhang, H., Liu, S., Fu, S., Zhao, Q., Wang, Y., Yuan, Y., & Zhang, C. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104844 · Cited by 28 · see citing works

Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer

Li, Y., Tian, H., Luo, H., Fu, J., Jiao, Y., & Li, Y. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s270688 · Cited by 27 · see citing works

Role of TNF-α-Inducing Protein Secreted by Helicobacter pylori as a Tumor Promoter in Gastric Cancer and Emerging Preventive Strategies

Suganuma, M., Watanabe, T., Sueoka, E., Lim, I. K., & Fujiki, H. (2021) · Toxins · doi:10.3390/toxins13030181 · Cited by 27 · see citing works

RAS nanoclusters are cell surface transducers that convert extracellular stimuli to intracellular signalling

Zhou, Y., & Hancock, J. F. (2023) · FEBS Letters · doi:10.1002/1873-3468.14569 · Cited by 27 · see citing works

Phlorotannins: Novel Orally Administrated Bioactive Compounds That Induce Mitochondrial Dysfunction and Oxidative Stress in Cancer

Simón, L., Arazo-Rusindo, M. C., Quest, A. F. G., & Mariotti‐Celis, M. S. (2023) · Antioxidants · doi:10.3390/antiox12091734 · Cited by 30 · see citing works

Role of EGFR and FASN in breast cancer progression

Chaturvedi, S., Biswas, M., Sadhukhan, S., & Sonawane, A. (2023) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-023-00771-w · Cited by 26 · see citing works

Mutant KRAS drives metabolic reprogramming and autophagic flux in premalignant pancreatic cells

Suzuki, T., Kishikawa, T., Sato, T., Takeda, N., Sugiura, Y., Seimiya, T., Sekiba, K., Ohno, M., Iwata, T., Ishibashi, R., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-021-00326-4 · Cited by 27 · see citing works

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

Wallon, L., Khan, I., Teng, K. W., Koide, A., Zuberi, M., Li, J., Ketavarapu, G., Traaseth, N. J., O’Bryan, J. P., & Koide, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204481119 · Cited by 26 · see citing works

MIF/NR3C2 axis regulates glucose metabolism reprogramming in pancreatic cancer through MAPK–ERK and AP-1 pathways

Yang, S. S., Tang, W., Azizian, A., Gaedcke, J., Ohara, Y., Cawley, H., Hanna, N. N., Ghadimi, M. B., Lal, T., Sen, S., et al. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae025 · Cited by 25 · see citing works

KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC

Jiang, X., Wang, T., Zhao, B. X., Sun, H., Dong, Y., Ma, Y., Li, Z., Wu, Y., Wang, K., Guan, X., et al. (2025) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.101966 · Cited by 23 · see citing works

A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners

Adariani, S. R., Jasemi, N. S. K., Bazgir, F., Wittich, C., Amin, E., Seidel, C. A. M., Dvorský, R., & Ahmadian, M. R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100626 · Cited by 23 · see citing works

How Do Hexokinases Inhibit Receptor-Mediated Apoptosis?

Schoeniger, A., Wolf, P., & Edlich, F. (2022) · Biology · doi:10.3390/biology11030412 · Cited by 25 · see citing works

Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

Padinharayil, H., Rai, V., & George, A. (2023) · Cancers · doi:10.3390/cancers15041070 · Cited by 24 · see citing works

Origin and Evolution of RAS Membrane Targeting

García‐España, A., & Philips, M. R. (2023) · Oncogene · doi:10.1038/s41388-023-02672-z · Cited by 23 · see citing works

On the Role of Glycolysis in Early Tumorigenesis—Permissive and Executioner Effects

Marcucci, F., & Rumio, C. (2023) · Cells · doi:10.3390/cells12081124 · Cited by 22 · see citing works

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma

Liu, W., Wang, H., Zhao, Q., Tao, C., Qu, W., Hou, Y., Huang, R., Sun, Z., Zhu, G., Jiang, X., et al. (2023) · 癌症：英文版 · doi:10.1002/cac2.12513 · Cited by 20 · see citing works

ErbB2-upregulated HK1 and HK2 promote breast cancer cell proliferation, migration and invasion

Ma, X., Chen, J., Huang, B., Fu, S., Qu, S., Yu, R., & Zhao, Y. (2023) · Medical Oncology · doi:10.1007/s12032-023-02008-7 · Cited by 21 · see citing works

RAS Nanoclusters Selectively Sort Distinct Lipid Headgroups and Acyl Chains

Zhou, Y., Gorfe, A. A., & Hancock, J. F. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.686338 · Cited by 21 · see citing works

A brief history of RAS and the RAS Initiative

McCormick, F. P. (2022) · Advances in cancer research · doi:10.1016/bs.acr.2021.07.003 · Cited by 19 · see citing works

KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform

Salmón, M., Paniagua, G., Lechuga, C. G., Fernández-García, F., Zarzuela, E., Álvarez, R., Musteanu, M., Guerra, C. E., Caleiras, E. J., Muñoz, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2023112118 · Cited by 19 · see citing works

Splice variants of RAS—translational significance

Rásó, E. (2020) · Cancer and Metastasis Reviews · doi:10.1007/s10555-020-09920-8 · Cited by 19 · see citing works

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics

Xu, M., & Xu, B. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02309-7 · Cited by 18 · see citing works

Glycometabolic rearrangements–aerobic glycolysis in pancreatic ductal adenocarcinoma (PDAC): roles, regulatory networks, and therapeutic potential

Zhang, Z., & Zhang, H. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.2015321 · Cited by 18 · see citing works

Effect of Potato Glycoside Alkaloids on Energy Metabolism of Fusarium solani

Zhang, C., Ding, D., Wang, B., Wang, Y., Li, N., Li, R., Yan, Y., & He, J. (2023) · Journal of Fungi · doi:10.3390/jof9070777 · Cited by 18 · see citing works

Proteins moonlighting in tumor metabolism and epigenetics

Lv, L., & Lei, Q. (2021) · Frontiers of Medicine · doi:10.1007/s11684-020-0818-1 · Cited by 17 · see citing works

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Ma, J., Fu, S., Tan, J., Han, Y., Chen, Y., Deng, X., Shen, H., Zeng, S., Peng, Y., & Cai, C. (2025) · Advanced Science · doi:10.1002/advs.202502714 · Cited by 17 · see citing works

Parkin exerts the tumor‐suppressive effect through targeting mitochondria

Sun, X., Ye, G., Mai, Y., Shu, Y., Wang, L., & Zhang, J. (2023) · Medicinal Research Reviews · doi:10.1002/med.21938 · Cited by 16 · see citing works

RNA splicing alterations in lung cancer pathogenesis and therapy

Yan, Y., Ren, Y., Bao, Y., & Wang, Y. (2023) · Cancer Pathogenesis and Therapy · doi:10.1016/j.cpt.2023.04.004 · Cited by 15 · see citing works

5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis

Cao, W., Zeng, Z., & Lei, S. (2023) · Biomolecules · doi:10.3390/biom13101513 · Cited by 15 · see citing works

PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Benzarti, M., Neises, L., Oudin, A., Krötz, C., Viry, E., Gargiulo, E., Pulido, C., Schmoetten, M., Pozdeev, V. I., Lorenz, N. I., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113868 · Cited by 14 · see citing works

Integrated Analysis of Cancer Tissue and Vitreous Humor from Retinoblastoma Eyes Reveals Unique Tumor-Specific Metabolic and Cellular Pathways in Advanced and Non-Advanced Tumors

Babu, V. S., Mallipatna, A. C., Deepak, S. A., Dudeja, G., Kannan, R., Shetty, R., Nair, A. P., Gundimeda, S., Chaurasia, S. S., Verma, N. K., et al. (2022) · Cells · doi:10.3390/cells11101668 · Cited by 15 · see citing works

Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis

Roux, Ö. L., Pershing, N. L., Kaltenbrun, E., Newman, N. J., Everitt, J. I., Baldelli, E., Pierobon, M., Petricoin, E. F., & Counter, C. M. (2022) · eLife · doi:10.7554/elife.75715 · Cited by 15 · see citing works

Metabolic reprogramming in KRAS-mutant cancers: Proven targetable vulnerabilities and potential therapeutic strategies

Wu, R., Zhu, H., He, Q., Yuan, T., & Yang, B. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104220 · Cited by 14 · see citing works

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

Tsutsumi, R., Ueberheide, B. M., Liang, F., Neel, B. G., Sakai, R., & Saito, Y. (2024) · Nature Communications · doi:10.1038/s41467-024-46971-9 · Cited by 14 · see citing works

Resistance to immune checkpoint inhibitors in KRAS-mutant non-small cell lung cancer

Li, Y., Hu, L., Peng, X., Xu, H., Tang, B., & Xu, C. S. (2022) · Cancer Drug Resistance · doi:10.20517/cdr.2021.102 · Cited by 13 · see citing works

Abstract A13: KRAS4A directly regulates hexokinase 1

Mahaffety, J. P., Amendola, C. R., Chen, W.-C., Kimmelman, A. C., Balmain, A., & Philips, M. R. (2020) · Molecular Cancer Research · doi:10.1158/1557-3125.ras18-a13

Isoform-Specific KRAS–Hexokinase 1 Interaction Affects Metabolism

(2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2019-189

Oncogenic KRAS Drives Metabolic Vulnerabilities by Directly Regulating Metabolic Enzymes in Cancer

Zhang, L. (2020) · Global Medical Genetics · doi:10.1055/s-0040-1712456 · Cited by 3 · see citing works

KRAS4A promotes oligomerization of hexokinase 1 on mitochondria

Nuevo‐Tapioles, C., Qin, Z., Bazley, A., Branco, C., Hamilton, G., Kong, X., Rothenberg, E., & Philips, M. R. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117392 · Cited by 1 · see citing works

Abstract IA009: Differential Biology of KRAS Splice Variants

Fissore-O'Leary, M., Su, W., Nuevo‐Tapioles, C., Rossi, J. A. K., & Mr, P. (2026) · Cancer Research · doi:10.1158/1538-7445.rasoncother26-ia009