Shirouzu, Mikako

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity

Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 757

Atomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinase

Verba, K. A., Wang, R. Y.-R., Arakawa, A., Liu, Y., Shirouzu, M., Yokoyama, S., & Agard, D. A. (2016) · Science

Heat shock proteins researchProtein Structure and Dynamics

Cited by 424

DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., et al. (2012) · Blood

Immunodeficiency and Autoimmune DisordersImmunotherapy and Immune Responses

Cited by 236

A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling

HATAKEYAMA, M., KIMURA, S., NAKA, T., KAWASAKI, T., YUMOTO, N., ICHIKAWA, M., KIM, J.-H., SAITO, K., SAEKI, M., SHIROUZU, M., et al. (2003) · Biochemical Journal

HER2/EGFR in Cancer ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 233

TNIK inhibition abrogates colorectal cancer stemness

Masuda, M., Uno, Y., Ohbayashi, N., Ohata, H., Mimata, A., Kukimoto-Niino, M., Moriyama, H., Kashimoto, S., Inoue, T., Goto, N., et al. (2016) · Nature Communications

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 168

Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor

Yoshikawa, S., Kukimoto-Niino, M., Parker, L., Handa, N., Terada, T., Fujimoto, T., Terazawa, Y., Wakiyama, M., Sato, M., Sano, S., et al. (2013) · Oncogene

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 138

Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport

Shima, T., Morikawa, M., Kaneshiro, J., Kambara, T., Kamimura, S., Yagi, T., Iwamoto, H., Uemura, S., Shigematsu, H., Shirouzu, M., et al. (2018) · Journal of Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 125

Multiple Post-translational Modifications Affect Heterologous Protein Synthesis

Tokmakov, A. A., Kurotani, A., Takagi, T., Toyama, M., Shirouzu, M., Fukami, Y., & Yokoyama, S. (2012) · Journal of Biological Chemistry

Protein purification and stabilityRNA and protein synthesis mechanisms

Cited by 88

Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms

Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S.-I., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., et al. (2012) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 70

Differential Structural Requirements for Interaction of Ras Protein with Its Distinct Downstream Effectors

Akasaka, K., Tamada, M., Wang, F., Kariya, K.-I., Shima, F., Kikuchi, A., Yamamoto, M., Shirouzu, M., Yokoyama, S., & Kataoka, T. (1996) · Journal of Biological Chemistry

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 69

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs

Shigematsu, H., Imasaki, T., Doki, C., Sumi, T., Aoki, M., Uchikubo-Kamo, T., Sakamoto, A., Tokuraku, K., Shirouzu, M., & Nitta, R. (2018) · Journal of Cell Biology

Microtubule and mitosis dynamicsAlzheimer's disease research and treatments

Cited by 54

Structural Basis for the Dual Substrate Specificity of DOCK7 Guanine Nucleotide Exchange Factor

Kukimoto-Niino, M., Tsuda, K., Ihara, K., Mishima-Tsumagari, C., Honda, K., Ohsawa, N., & Shirouzu, M. (2019) · Structure

Protein Kinase Regulation and GTPase SignalingProtein Structure and Dynamics

Cited by 25