Rajewsky, Klaus

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 1,783

A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells

Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research

Animal Genetics and ReproductionCRISPR and Genetic Engineering

Cited by 1,289

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

Chu, V. T., Weber, T., Wefers, B., Wurst, W., Sander, S., Rajewsky, K., & Kühn, R. (2015) · Nature Biotechnology

CRISPR and Genetic EngineeringDNA Repair Mechanisms

Cited by 1,210

Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting

Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell

T-cell and B-cell ImmunologyDNA Repair Mechanisms

Cited by 989

Clonal Expansions of Cd8+ T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction

Babbe, H., Roers, A., Waisman, A., Lassmann, H., Goebels, N., Hohlfeld, R., Friese, M., Schröder, R., Deckert, M., Schmidt, S., et al. (2000) · The Journal of Experimental Medicine

Multiple Sclerosis Research StudiesT-cell and B-cell Immunology

Cited by 951

Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1

Iwakoshi, N. N., Lee, A.-H., Vallabhajosyula, P., Otipoby, K. L., Rajewsky, K., & Glimcher, L. H. (2003) · Nature Immunology

Endoplasmic Reticulum Stress and DiseaseT-cell and B-cell Immunology

Cited by 880

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Ko, M., Bandukwala, H. S., An, J., Lamperti, E. D., Thompson, E. C., Hastie, R., Tsangaratou, A., Rajewsky, K., Koralov, S. B., & Rao, A. (2011) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 616

FOXO1 couples metabolic activity and growth state in the vascular endothelium

Wilhelm, K., Happel, K., Eelen, G., Schoors, S., Oellerich, M. F., Lim, R., Zimmermann, B., Aspalter, I. M., Franco, C. A., Boettger, T., et al. (2016) · Nature

FOXO transcription factor regulationAngiogenesis and VEGF in Cancer

Cited by 579

MicroRNA profiling of the murine hematopoietic system

Monticelli, S., Ansel, K. M., Xiao, C., Socci, N. D., Krichevsky, A. M., Thai, T.-H., Rajewsky, N., Marks, D. S., Sander, C., Rajewsky, K., et al. (2005) · Genome Biology

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 436

Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma

Finkin, S., Yuan, D., Stein, I., Taniguchi, K., Weber, A., Unger, K., Browning, J. L., Goossens, N., Nakagawa, S., Gunasekaran, G., et al. (2015) · Nature Immunology

Immune cells in cancerLiver physiology and pathology

Cited by 433

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

Kaji, T., Ishige, A., Hikida, M., Taka, J., Hijikata, A., Kubo, M., Nagashima, T., Takahashi, Y., Kurosaki, T., Okada, M., et al. (2012) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 263

Immunological memory: lessons from the past and a look to the future

Farber, D. L., Netea, M. G., Radbruch, A., Rajewsky, K., & Zinkernagel, R. M. (2016) · Nature Reviews Immunology

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 200

Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity

Mesaros, A., Koralov, S. B., Rother, E., Wunderlich, F. T., Ernst, M. B., Barsh, G. S., Rajewsky, K., & Brüning, J. C. (2008) · Cell Metabolism

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 128

Postnatal DNA demethylation and its role in tissue maturation

Reizel, Y., Sabag, O., Skversky, Y., Spiro, A., Steinberg, B., Bernstein, D., Wang, A., Kieckhaefer, J., Li, C., Pikarsky, E., et al. (2018) · Nature Communications

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 83

PLC-γ2 is essential for formation and maintenance of memory B cells

Hikida, M., Casola, S., Takahashi, N., Kaji, T., Takemori, T., Rajewsky, K., & Kurosaki, T. (2009) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyImmune responses and vaccinations

Cited by 73

Precise CRISPR-Cas-mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells

Tran, N. T., Danner, E., Li, X., Graf, R., Lebedin, M., de la Rosa, K., Kühn, R., Rajewsky, K., & Chu, V. T. (2022) · Science Advances

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 49

miR-23∼27∼24 clusters restrict Th2 immunity and associated immunopathology during airway allergic reaction (HYP2P.335)

Wu, C.-J., Cho, S., Yasuda, T., Cruz, L., Lin, L.-L., Miller, M., Lee, H.-M., Broide, D., Rajewsky, K., & Lu, L.-F. (2015) · The Journal of Immunology

MicroRNA in disease regulationAsthma and respiratory diseases

Cited by 1