Varga, John

Cyclophosphamide versus placebo in scleroderma lung disease

Tashkin, D. P., Elashoff, R., Clements, P. J., Goldin, J., Roth, M. D., Furst, D. E., Arriola, E., Silver, R., Strange, C., Bolster, M., et al. (2006) · New England Journal of Medicine

Systemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 1,677

Recent Developments in Myofibroblast Biology

Hinz, B., Phan, S. H., Thannickal, V. J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., & Gabbiani, G. (2012) · The American Journal of Pathology

Wound Healing and TreatmentsLiver physiology and pathology

Cited by 1,193

Transforming growth factor β (TGF β) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts

Varga, J., Rosenbloom, J., & Jimenez, S. A. (1987) · Biochemical Journal

TGF-β signaling in diseasesLiver physiology and pathology

Cited by 591

Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities

Bhattacharyya, S., Wei, J., & Varga, J. (2012) · Nature Reviews Rheumatology

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 381

Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction

Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., et al. (2014) · Nature Communications

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 364

Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors

Marangoni, R. G., Korman, B. D., Wei, J., Wood, T. A., Graham, L. V., Whitfield, M. L., Scherer, P. E., Tourtellotte, W. G., & Varga, J. (2015) · Arthritis & Rheumatology

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 337

Identification of Novel Genetic Markers Associated with Clinical Phenotypes of Systemic Sclerosis through a Genome-Wide Association Strategy

Gorlova, O., Martin, J.-E., Rueda, B., Koeleman, B. P. C., Ying, J., Teruel, M., Diaz-Gallo, L.-M., Broen, J. C., Vonk, M. C., Simeon, C. P., et al. (2011) · PLoS Genetics

Systemic Sclerosis and Related DiseasesGenetic Associations and Epidemiology

Cited by 231

Wnt/β‐catenin signaling is hyperactivated in systemic sclerosis and induces Smad‐dependent fibrotic responses in mesenchymal cells

Wei, J., Fang, F., Lam, A. P., Sargent, J. L., Hamburg, E., Hinchcliff, M. E., Gottardi, C. J., Atit, R., Whitfield, M. L., & Varga, J. (2012) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesTGF-β signaling in diseases

Cited by 226

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: a novel mouse model for scleroderma?

Wei, J., Melichian, D., Komura, K., Hinchcliff, M., Lam, A. P., Lafyatis, R., Gottardi, C. J., MacDougald, O. A., & Varga, J. (2011) · Arthritis & Rheumatism

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 214

Disruption of transforming growth factor β signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator–activated receptor γ

Ghosh, A. K., Bhattacharyya, S., Lakos, G., Chen, S., Mori, Y., & Varga, J. (2004) · Arthritis & Rheumatism

Peroxisome Proliferator-Activated ReceptorsTGF-β signaling in diseases

Cited by 201

A deep catalogue of protein-coding variation in 983,578 individuals

Sun, K. Y., Bai, X., Chen, S., Bao, S., Zhang, C., Kapoor, M., Backman, J., Joseph, T., Maxwell, E., Mitra, G., et al. (2024) · Nature

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 127

Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing

Wu, M., Melichian, D. S., de la Garza, M., Gruner, K., Bhattacharyya, S., Barr, L., Nair, A., Shahrara, S., Sporn, P. H. S., Mustoe, T. A., et al. (2009) · The American Journal of Pathology

Wound Healing and TreatmentsSystemic Sclerosis and Related Diseases

Cited by 125

Trichostatin A blocks TGF-β-induced collagen gene expression in skin fibroblasts: Involvement of Sp1

Ghosh, A. K., Mori, Y., Dowling, E., & Varga, J. (2007) · Biochemical and Biophysical Research Communications

TGF-β signaling in diseasesHistone Deacetylase Inhibitors Research

Cited by 91

Novel lung imaging biomarkers and skin gene expression subsetting in dasatinib treatment of systemic sclerosis-associated interstitial lung disease

Martyanov, V., Kim, G.-H. J., Hayes, W., Du, S., Ganguly, B. J., Sy, O., Lee, S. K., Bogatkevich, G. S., Schieven, G. L., Schiopu, E., et al. (2017) · PLOS ONE

Systemic Sclerosis and Related DiseasesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 71

An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis

Yamashita, T., Lakota, K., Taniguchi, T., Yoshizaki, A., Sato, S., Hong, W., Zhou, X., Sodin-Semrl, S., Fang, F., Asano, Y., et al. (2018) · Scientific Reports

Systemic Sclerosis and Related DiseasesDupuytren's Contracture and Treatments

Cited by 56

Senescence signature in skin biopsies from systemic sclerosis patients treated with senolytic therapy: potential predictor of clinical response?

Martyanov, V., Whitfield, M. L., & Varga, J. (2019) · Arthritis & Rheumatology

Systemic Sclerosis and Related DiseasesTelomeres, Telomerase, and Senescence

Cited by 52

The relationship between skin symptoms and the scleroderma modification of the health assessment questionnaire, the modified Rodnan skin score, and skin pathology in patients with systemic sclerosis

Ziemek, J., Man, A., Hinchcliff, M., Varga, J., Simms, R. W., & Lafyatis, R. (2016) · Rheumatology

Systemic Sclerosis and Related DiseasesConnective tissue disorders research

Cited by 33