An orally-active adiponectin receptor agonist mitigates cutaneous fibrosis, inflammation and microvascular pathology in a murine model of systemic sclerosis
Open accessAbstract
The hallmarks of systemic sclerosis (SSc) are autoimmunity, microangiopathy and fibrosis. Skin fibrosis is accompanied by attrition of the dermal white adipose tissue layer, and alterations in the levels and function of adiponectin. Since these findings potentially implicate adiponectin in the pathogenesis of SSc, we employed a novel pharmacological approach to augment adiponectin signaling using AdipoRon, an orally active adiponectin receptor agonist. Chronic treatment with AdipoRon significantly ameliorated bleomycin-induced dermal fibrosis in mice. AdipoRon attenuated fibroblast activation, adipocyte-to-myofibroblast transdifferentiation, Th2/Th17-skewed polarization of the immune response, vascular injury and endothelial-to-mesenchymal transition within the lesional skin. In vitro, AdipoRon abrogated profibrotic responses elicited by TGF-β in normal fibroblasts, and reversed the inherently-activated profibrotic phenotype of SSc fibroblasts. In view of these broadly beneficial effects on all three cardinal pathomechanisms underlying the clinical manifestations of SSc, pharmacological augmentation of adiponectin signaling might represent a novel strategy for the treatment of SSc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AdipoRon's beneficial effects have been demonstrated in other non-metabolic conditions such as cancer, systemic sclerosis, depression, anxiety, PTSD, and cerebral ischemia.
“Since then, its beneficial effects have also been demonstrated in other non-metabolic conditions such as cancer [139,140], systemic sclerosis [141], depression [107], anxiety [142], post-traumatic stress disorder [143], and cerebral ischemia [144,145].”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [141]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A gene atlas of the mouse and human protein-encoding transcriptomes
Su, A. I., Wiltshire, T., Batalov, S., Lapp, H., Ching, K. A., Block, D., Zhang, J., Soden, R., Hayakawa, M., Kreiman, G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400782101 · Cited by 3,475 · see citing works
Gabrielli, A., Avvedimento, E. V., & Krieg, T. M. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0806188 · Cited by 1,388 · see citing works
Origin and function of myofibroblasts in kidney fibrosis
LeBleu, V. S., Taduri, G., O’Connell, J. T., Teng, Y., Cooke, V. G., Woda, C. B., Sugimoto, H., & Kalluri, R. (2013) · Nature Medicine · doi:10.1038/nm.3218 · Cited by 1,267 · see citing works
Allanore, Y., Simms, R. W., Distler, O., Trojanowska, M. E., Pope, J. E., Denton, C. P., & Varga, J. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.2 · Cited by 934 · see citing works
Self-citationA small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
Okada-Iwabu, M., Yamauchi, T., Iwabu, M., Honma, T., Hamagami, K.-I., Matsuda, K., Yamaguchi, M., Tanabe, H., Kimura-Someya, T., Shirouzu, M., et al. (2013) · Nature · doi:10.1038/nature12656 · Cited by 757 · see citing works
New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases
Nigro, E., Scudiero, O., Monaco, M. L., Palmieri, A., Mazzarella, G., Costagliola, C., Bianco, A., & Daniele, A. (2014) · BioMed Research International · doi:10.1155/2014/658913 · Cited by 607 · see citing works
Role of endothelial-mesenchymal transition (EndoMT) in the pathogenesis of fibrotic disorders
Piera-Velazquez, S., Li, Z., & Jimenez, S. A. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.06.001 · Cited by 580 · see citing works
An Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls
Okamoto, Y., Arita, Y., Nishida, M., Muraguchi, M., Ouchi, N., Takahashi, M., Igura, T., Inui, Y., Kihara, S., Nakamura, T., et al. (2000) · Hormone and Metabolic Research · doi:10.1055/s-2007-978586 · Cited by 567 · see citing works
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
Kamada, Y., Tamura, S., Kiso, S., Matsumoto, H., Saji, Y., Yoshida, Y., Fukui, K., Maeda, N., Nishizawa, H., Nagaretani, H., et al. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.029 · Cited by 480 · see citing works
Adiponectin and inflammation: Consensus and controversy
Fantuzzi, G. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.10.018 · Cited by 402 · see citing works
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
Bhattacharyya, S., Wei, J., & Varga, J. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.149 · Cited by 381 · see citing works
Self-citationBioGPS and MyGene.info: organizing online, gene-centric information
Wu, C., MacLeod, I., & Su, A. I. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1114 · Cited by 355 · see citing works
Arciniegas, E., Frid, M. G., Douglas, I. S., & Stenmark, K. R. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00378.2006 · Cited by 338 · see citing works
Marangoni, R. G., Korman, B. D., Wei, J., Wood, T. A., Graham, L. V., Whitfield, M. L., Scherer, P. E., Tourtellotte, W. G., & Varga, J. (2015) · Arthritis & Rheumatology · doi:10.1002/art.38990 · Cited by 337 · see citing works
Self-citationManetti, M., Romano, E., Rosa, I., Guiducci, S., Bellando-Randone, S., De Paulis, A., Ibba-Manneschi, L., & Matucci-Cerinic, M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210229 · Cited by 278 · see citing works
Higashi‐Kuwata, N., Jinnin, M., Makino, T., Fukushima, S., Inoue, Y., Muchemwa, F. C., Yonemura, Y., Komohara, Y., Takeya, M., Mitsuya, H., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3066 · Cited by 252 · see citing works
Crystal structures of the human adiponectin receptors
Tanabe, H., Fujii, Y., Okada‐Iwabu, M., Iwabu, M., Nakamura, Y., Hosaka, T., Motoyama, K., Ikeda, M., Wakiyama, M., Terada, T., et al. (2015) · Nature · doi:10.1038/nature14301 · Cited by 217 · see citing works
Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis
Rho, Y. H., Solus, J. F., Sokka, T., Oeser, A. M., Chung, C. P., Gebretsadik, T. S., Shintani, A., Pincus, T., & Stein, C. M. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24626 · Cited by 200 · see citing works
Asano, Y., & Sato, S. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0505-5 · Cited by 187 · see citing works
Self-citationAdiponectin Protects Against Angiotensin II–Induced Cardiac Fibrosis Through Activation of PPAR-α
Fujita, K., Maeda, N., Sonoda, M., Ohashi, K., Hibuse, T., Nishizawa, H., Nishida, M., Hiuge, A., Kurata, A., Kihara, S., et al. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.156687 · Cited by 185 · see citing works
Chung, C. P., Long, A. A., Solus, J. F., Rho, Y., Oeser, A. M., Raggi, P., & Stein, C. M. (2009) · Lupus · doi:10.1177/0961203309103582 · Cited by 178 · see citing works
Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
MacDonald, K. G., Dawson, N. A. J., Huang, Q., Dunne, J. V., Levings, M. K., & Broady, R. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.12.1932 · Cited by 170 · see citing works
Matsushita, T., Hasegawa, M., Hamaguchi, Y., Takehara, K., & Sato, S. (2006) · PubMed · Cited by 140 · see citing works
Self-citationYoshizaki, A., Yanaba, K., Iwata, Y., Komura, K., Ogawa, A., Akiyama, Y., Muroi, E., Hara, T., Ogawa, F., Takenaka, M., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901778 · Cited by 139 · see citing works
Self-citationPotential roles of interleukin‐17A in the development of skin fibrosis in mice
Okamoto, Y., Hasegawa, M., Matsushita, T., Hamaguchi, Y., Huu, D. L., Iwakura, Y., Fujimoto, M., & Takehara, K. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34643 · Cited by 138 · see citing works
Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin
Kumar, S. A., Kumari, P. H., Kumar, G. S., Mohanalatha, C., & Kishor, P. B. K. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00163 · Cited by 127 · see citing works
Mendoza, F. A., Piera‐Velazquez, S., Farber, J. L., Feghali‐Bostwick, C., & Jiménez, S. A. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39421 · Cited by 121 · see citing works
Murata, M., Fujimoto, M., Matsushita, T., Hamaguchi, Y., Hasegawa, M., Takehara, K., Komura, K., & Sato, S. (2008) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2008.01.001 · Cited by 117 · see citing works
Self-citationChujo, S., Shirasaki, F., Kawara, S., Inagaki, Y., Kinbara, T., Inaoki, M., Takigawa, M., & Takehara, K. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20251 · Cited by 117 · see citing works
Chaudhuri, V., Zhou, L. Y., & Karasek, M. A. (2006) · Journal of Cutaneous Pathology · doi:10.1111/j.1600-0560.2006.00584.x · Cited by 116 · see citing works
Importance of Adipocytokines in Obesity-Related Diseases
Matsuzawa, Y., Shimomura, I., Kihara, S., & Funahashi, T. (2003) · Hormone Research in Paediatrics · doi:10.1159/000074502 · Cited by 116 · see citing works
Gray, B. R., Steyn, F. J., Davies, P. S. W., & Vitetta, L. (2013) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2013.197 · Cited by 115 · see citing works
Fang, F., Liu, L., Yang, Y., Tamaki, Z., Wei, J., Marangoni, R. G., Bhattacharyya, S., Summer, R. S., Ye, B., & Varga, J. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4070 · Cited by 110 · see citing works
Self-citationJiménez, S. A., & Piera-Velázquez, S. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.01.012 · Cited by 104 · see citing works
Lakota, K., Wei, J., Carns, M. A., Hinchcliff, M., Lee, J. J., Whitfield, M. L., Sodin‐Šemrl, S., & Varga, J. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3827 · Cited by 103 · see citing works
Self-citationZhang, Y., Zhao, J., Li, R., Lau, W. B., Yuan, Y.-X., Liang, B., Li, R., Gao, E.-H., Koch, W. J., Ma, X.-L., et al. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00577.2014 · Cited by 97 · see citing works
Transforming growth factor-beta in systemic sclerosis scleroderma
Varga, J. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s22 · Cited by 96 · see citing works
Self-citationTaniguchi, T., Asano, Y., Akamata, K., Noda, S., Takahashi, T., Ichimura, Y., Toyama, T., Trojanowska, M. E., & Sato, S. (2014) · Arthritis & Rheumatology · doi:10.1002/art.38948 · Cited by 88 · see citing works
Self-citationAdiponectin Agonist ADP355 Attenuates CCl4-Induced Liver Fibrosis in Mice
Kumar, P., Smith, T., Rahman, K., Thorn, N. E., & Anania, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110405 · Cited by 84 · see citing works
Ronning After the Adiponectin Receptors
Holland, W. L., & Scherer, P. E. (2013) · Science · doi:10.1126/science.1249077 · Cited by 79 · see citing works
Almabouada, F., Díaz‐Ruiz, A., Rabanal‐Ruiz, Y., Peinado, J. R., Vázquez‐Martínez, R., & Malagón, M. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.404624 · Cited by 70 · see citing works
Mast cells are a source of transforming growth factor β in systemic sclerosis
Hügle, T., Hogan, V. E., White, K., et al. (2010) · Arthritis & Rheumatism · doi:10.1002/art.30190 · Cited by 67 · see citing works
Adiponectin Attenuates Lung Fibroblasts Activation and Pulmonary Fibrosis Induced by Paraquat
Yao, R., Cao, Y., He, Y., Lau, W. B., Zeng, Z., & Liang, Z.-A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125169 · Cited by 64 · see citing works
Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis
Saigusa, R., Asano, Y., Taniguchi, T., Yamashita, T., Ichimura, Y., Takahashi, T., Toyama, T., Yoshizaki, A., Sugawara, K., Tsuruta, D., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520997112 · Cited by 62 · see citing works
Self-citationSun, Y., Zang, Z., Zhong, L., Wu, M., Su, Q., Gao, X., Zan, W., Lin, D., Zhao, Y., & Zhang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063354 · Cited by 60 · see citing works
Kupchak, B. R., Garitaonandia, I., Villa, N., Smith, J. L., & Lyons, T. J. (2009) · Biochemistry · doi:10.1021/bi9006258 · Cited by 58 · see citing works
Masui, Y., Asano, Y., Shibata, S., Noda, S., Aozasa, N., Akamata, K., Yamada, D., Tamaki, Z., Tada, Y., Sugaya, M., et al. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04077.x · Cited by 57 · see citing works
Self-citationHasegawa, M., Asano, Y., Endo, H., Fujimoto, M., Goto, D., Ihn, H., Inoue, K., Ishikawa, O., Kawaguchi, Y., Kuwana, M., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088150 · Cited by 55 · see citing works
Self-citationSun, X., Feng, X., Tan, W., Lin, N., Hua, M., Wei, Y., Wang, F., Li, N., & Zhang, M. (2015) · Scientific Reports · doi:10.1038/srep11296 · Cited by 54 · see citing works
Arakawa, H., Jinnin, M., Muchemwa, F. C., Makino, T., Kajihara, I., Makino, K., Honda, N., Sakai, K., Fukushima, S., & Ihn, H. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01310.x · Cited by 54 · see citing works
Xu, H., Zaidi, M., Struve, J. A., Jones, D. W., Krolikowski, J. G., Nandedkar, S. D., Lohr, N. L., Gadicherla, A. K., Pagel, P. S., Csuka, M. E., et al. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00123.2010 · Cited by 46 · see citing works
Takahashi, T., Asano, Y., Noda, S., Aozasa, N., Akamata, K., Taniguchi, T., Ichimura, Y., Toyama, T., Sumida, H., Kuwano, Y., et al. (2015) · British Journal of Dermatology · doi:10.1111/bjd.13779 · Cited by 40 · see citing works
Self-citationAkamata, K., Asano, Y., Aozasa, N., Noda, S., Taniguchi, T., Takahashi, T., Ichimura, Y., Toyama, T., & Sato, S. (2014) · Arthritis Research & Therapy · doi:10.1186/ar4529 · Cited by 37 · see citing works
Self-citationAdiponectin in Asthma and Obesity: Protective Agent or Risk Factor for More Severe Disease?
Azambuja, R. D. L., Azambuja, L. S. E. D. C. S., da Costa, C. H., & Rufino, R. (2015) · Lung · doi:10.1007/s00408-015-9793-8 · Cited by 35 · see citing works
Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis
Tomčík, M., Arima, K., Hulejová, H., Kuklová, M., Filková, M., BRAUN, M. A., Běláček, J., Novák, M., Bečvář, R., Vencovský, J., et al. (2012) · Cytokine · doi:10.1016/j.cyto.2012.02.003 · Cited by 33 · see citing works
Masui, Y., Asano, Y., Shibata, S., Noda, S., Akamata, K., Aozasa, N., Taniguchi, T., Takahashi, T., Ichimura, Y., Toyama, T., et al. (2013) · Lara D. Veeken · doi:10.1093/rheumatology/ket010 · Cited by 32 · see citing works
Self-citationHong, K., Lee, S., Li, R., Yang, Y., Tanner, M. A., Wu, J., & Hill, M. A. (2016) · Microcirculation · doi:10.1111/micc.12266 · Cited by 30 · see citing works
Yamane, T., Kobayashi, K., & Oishi, Y. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.09.151 · Cited by 29 · see citing works
Aozasa, N., Asano, Y., Akamata, K., et al. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04354.x · Cited by 28 · see citing works
Self-citationClinical significance of serum retinol binding protein‐4 levels in patients with systemic sclerosis
Toyama, T., Asano, Y., Takahashi, T., et al. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04413.x · Cited by 26 · see citing works
Self-citationManetti, M., Guiducci, S., & Matucci‐Cerinic, M. (2011) · Arthritis & Rheumatism · doi:10.1002/art.30316 · Cited by 26 · see citing works
Toyama, T., Asano, Y., Akamata, K., et al. (2015) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2015.10.058 · Cited by 26 · see citing works
Self-citationMasui, Y., Asano, Y., Akamata, K., et al. (2013) · Rheumatology International · doi:10.1007/s00296-013-2880-3 · Cited by 25 · see citing works
Self-citationMasui, Y., Asano, Y., Takahashi, T., Shibata, S., Akamata, K., Aozasa, N., Noda, S., Taniguchi, T., Ichimura, Y., Toyama, T., et al. (2012) · Modern Rheumatology · doi:10.1007/s10165-012-0660-7 · Cited by 25 · see citing works
Self-citationInterfacial Adipose Tissue in Systemic Sclerosis
Kruglikov, I. L. (2017) · Current Rheumatology Reports · doi:10.1007/s11926-017-0627-y · Cited by 23 · see citing works
Masui, Y., Asano, Y., Takahashi, T., Shibata, S., Akamata, K., Aozasa, N., Noda, S., Taniguchi, T., Ichimura, Y., Toyama, T., et al. (2013) · Modern Rheumatology · doi:10.3109/s10165-012-0660-7 · Cited by 21 · see citing works
Self-citationMiura, S., Asano, Y., Saigusa, R., et al. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12824 · Cited by 18 · see citing works
Self-citationDermal mast cell density in fingers reflects severity of skin sclerosis in systemic sclerosis
Yukawa, S., Yamaoka, K., Sawamukai, N., et al. (2013) · Modern Rheumatology · doi:10.3109/s10165-012-0813-8 · Cited by 18 · see citing works
Dermal mast cell density in fingers reflects severity of skin sclerosis in systemic sclerosis
Yukawa, S., Yamaoka, K., Sawamukai, N., et al. (2012) · Modern Rheumatology · doi:10.1007/s10165-012-0813-8 · Cited by 15 · see citing works
Serum vaspin levels: A possible correlation with digital ulcers in patients with systemic sclerosis
Miura, S., Asano, Y., Saigusa, R., et al. (2015) · The Journal of Dermatology · doi:10.1111/1346-8138.12810 · Cited by 13 · see citing works
Self-citationNakasone, H., Terasako‐Saito, K., Yamazaki, R., et al. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2013.12.009 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The endocrine function of adipose tissues in health and cardiometabolic disease
Scheja, L., & Heeren, J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0230-6 · Cited by 663 · see citing works
Abou-Samra, M., Selvais, C. M., Dubuisson, N., & Brichard, S. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072620 · Cited by 72 · see citing works
Liu, Y., Vu, V., & Sweeney, G. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00842 · Cited by 69 · see citing works
- Authors
- Yamashita, T., Lakota, K., Taniguchi, T., Yoshizaki, A., Sato, S., Hong, W., Zhou, X., Sodin-Semrl, S., Fang, F., Asano, Y., & Varga, J.
- Affiliations
- The University of Tokyo (JP)
- Northwestern University (US)
- Corresponding author
- Asano, Yoshihide
- Varga, John
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-08-07
- Volume
- 8
- Issue
- 1
- Pages
- 11843-11843
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6081386
- OpenAlex
- W2886938658
- Cited by
- 56
- References
- 71
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 3 · 2023: 5 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 6
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministrstvo za visoko šolstvo, znanost in tehnologijo
- National Institutes of Health (AR- 42309, 42309)
- Japan Society for the Promotion of Science (16H05366)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Health Sciences › Medicine › Rheumatology › Dupuytren's Contracture and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Keywords
- systemic sclerosis, adiponectin receptor agonist, AdipoRon, skin fibrosis, bleomycin-induced fibrosis, microangiopathy, skin inflammation, endothelial-to-mesenchymal transition, TGF-beta signaling, Th17 polarization, fibroblast activation, oral therapy
- MeSH terms
- Administration, Oral, Animals, Bleomycin, Disease Models, Animal, Female, Fibrosis, Humans, Inflammation, Mice, Inbred C57BL, Piperidines, Scleroderma, Systemic, Skin, Signal Transduction, Receptors, Adiponectin, Vascular System Injuries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
