Endotrophin triggers adipose tissue fibrosis and metabolic dysfunction
Open accessAbstract
We recently identified endotrophin as an adipokine with potent tumour-promoting effects. However, the direct effects of local accumulation of endotrophin in adipose tissue have not yet been studied. Here we use a doxycycline-inducible adipocyte-specific endotrophin overexpression model to demonstrate that endotrophin plays a pivotal role in shaping a metabolically unfavourable microenvironment in adipose tissue during consumption of a high-fat diet (HFD). Endotrophin serves as a powerful co-stimulator of pathologically relevant pathways within the 'unhealthy' adipose tissue milieu, triggering fibrosis and inflammation and ultimately leading to enhanced insulin resistance. We further demonstrate that blocking endotrophin with a neutralizing antibody ameliorates metabolically adverse effects and effectively reverses metabolic dysfunction induced during HFD exposure. Collectively, our findings demonstrate that endotrophin exerts a major influence in adipose tissue, eventually resulting in systemic elevation of pro-inflammatory cytokines and insulin resistance, and the results establish endotrophin as a potential target in the context of metabolism and cancer.
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Collagen VI is cleaved at the C5 domain of the α3 subunit, and the resulting peptide increases collagen deposition, endothelial cell migration, and macrophage infiltration.
“For example collagen VI is cleaved at the C5 domain of the α3 subunit and the resulting peptide induces multiple processes including increasing collagen deposition, endothelial cell migration and macrophage infiltration (46,47).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [47]
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A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Scherer, P. E., Williams, S. P., Fogliano, M., Baldini, G., & Lodish, H. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.45.26746 · Cited by 3,238 · see citing works
Self-citationAdipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,195 · see citing works
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
Inflammatory links between obesity and metabolic disease
Lumeng, C. N., & Saltiel, A. R. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57132 · Cited by 2,319 · see citing works
Ricard-Blum, S. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004978 · Cited by 2,305 · see citing works
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · see citing works
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941 · see citing works
Self-citationPhysiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ
Trayhurn, P., & Beattie, J. H. (2001) · Proceedings of The Nutrition Society · doi:10.1079/pns200194 · Cited by 1,259 · see citing works
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
Hosogai, N., Fukuhara, A., Oshima, K., Miyata, Y., Tanaka, S., Segawa, K., Furukawa, S., Tochino, Y., Komuro, R., Matsuda, M., et al. (2007) · Diabetes · doi:10.2337/db06-0911 · Cited by 1,257 · see citing works
Insulin sensitivity: Modulation by nutrients and inflammation
Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191 · see citing works
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
Rajala, M. W., & Scherer, P. E. (2003) · Endocrinology · doi:10.1210/en.2003-0580 · Cited by 1,190 · see citing works
Self-citationPercutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research
Bergström, J. P. (1975) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365517509095787 · Cited by 1,159 · see citing works
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107 · see citing works
Scherer, P. E. (2006) · Diabetes · doi:10.2337/db06-0263 · Cited by 1,062 · see citing works
Self-citationMetabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI
Khan, T., Muise, E. S., Iyengar, P., Wang, Z. V., Chandalia, M., Abate, N., Zhang, B. B., Bonaldo, P., Chua, S., & Scherer, P. E. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01300-08 · Cited by 1,053 · see citing works
Self-citationAdipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Strissel, K. J., Stancheva, Z., Miyoshi, H., Perfield, J. W., DeFuria, J., Jick, Z., Greenberg, A. S., & Obin, M. S. (2007) · Diabetes · doi:10.2337/db07-0767 · Cited by 1,007 · see citing works
Adipose tissue as an endocrine and paracrine organ
Mohamed‐Ali, V., Pinkney, J. H., & Coppack, S. W. (1998) · International Journal of Obesity · doi:10.1038/sj.ijo.0800770 · Cited by 999 · see citing works
Fibrosis and adipose tissue dysfunction.
Sun, K., Tordjman, J., Clément, K., & Scherer, P. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.016 · Cited by 960 · see citing works
Self-citationHypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
Self-citationHypoxia and Adipose Tissue Function and Dysfunction in Obesity
Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works
Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works
Reduced Adipose Tissue Oxygenation in Human Obesity
Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works
Inflammatory pathways and insulin action
Hotamisligil, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802502 · Cited by 717 · see citing works
The “metabolically-obese,” normal-weight individual
Ruderman, N. B., Schneider, S. H., & Berchtold, P. (1981) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/34.8.1617 · Cited by 545 · see citing works
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Spencer, M., Yao-Borengasser, A., Unal, R., Rasouli, N., Gurley, C. M., Zhu, B., Peterson, C. A., & Kern, P. A. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00329.2010 · Cited by 439 · see citing works
Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity
Unger, R. H., & Scherer, P. E. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.01.009 · Cited by 436 · see citing works
Self-citationIyengar, P., Espina, V. A., Williams, T. W., Lin, Y., Berry, D. C., Jelicks, L. A., Lee, H., Temple, K. A., Graves, R., Pollard, J. W., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23424 · Cited by 429 · see citing works
Self-citationDichotomous effects of VEGF-A on adipose tissue dysfunction
Sun, K., Asterholm, I. W., Kusminski, C. M., Bueno, A. C., Wang, Z. V., Pollard, J. W., Brekken, R. A., & Scherer, P. E. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200447109 · Cited by 417 · see citing works
Self-citationA Pericellular Collagenase Directs the 3-Dimensional Development of White Adipose Tissue
Chun, T.-H., Hotary, K. B., Sabeh, F., Saltiel, A. R., Allen, E. D., & Weiss, S. J. (2006) · Cell · doi:10.1016/j.cell.2006.02.050 · Cited by 378 · see citing works
Adipocyte-derived endotrophin promotes malignant tumor progression
Park, J., & Scherer, P. E. (2012) · Journal of Clinical Investigation · doi:10.1172/jci63930 · Cited by 350 · see citing works
Self-citationAdipose Tissue Collagen VI in Obesity
Pasarica, M., Gawrońska‐Kozak, B., Burk, D. H., Remedios, I., Hymel, D., Gimble, J., Ravussin, É., Bray, G. A., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0947 · Cited by 338 · see citing works
Adipose tissue, insulin action and vascular disease: inflammatory signals
Yudkin, J. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802496 · Cited by 311 · see citing works
Ploug, T., van Deurs, B., Ai, H., Cushman, S. W., & Ralston, E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1429 · Cited by 302 · see citing works
Self-citationElectron-microscopical approach to a structural model of intima collagen
Furthmayr, H., Wiedemann, H. P., Timpl, R., Odermatt, E. K., & Engel, J. (1983) · Biochemical Journal · doi:10.1042/bj2110303 · Cited by 290 · see citing works
Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Sun, K., Halberg, N., Khan, M., Magalang, U. J., & Scherer, P. E. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00951-12 · Cited by 231 · see citing works
Self-citationSystemic Fate of the Adipocyte-Derived Factor Adiponectin
Halberg, N., Schraw, T., Wang, Z. V., Kim, J., Yi, J., Hamilton, M. P., Luby‐Phelps, K., & Scherer, P. E. (2009) · Diabetes · doi:10.2337/db08-1750 · Cited by 198 · see citing works
Self-citationIncreased collagen content in insulin-resistant skeletal muscle
Berria, R., Wang, L., Richardson, D. K., Finlayson, J., Belfort, R., Pratipanawatr, T., De Filippis, E. A., Kashyap, S., & Mandarino, L. J. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00202.2005 · Cited by 171 · see citing works
Amino acid sequence of the triple-helical domain of human collagen type VI.
Chu, M., Conway, D., Pan, T., Baldwin, C. T., Mann, K., Deutzmann, R., & Timpl, R. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37327-7 · Cited by 162 · see citing works
Wang, Z. V., Deng, Y., Wang, Q. A., Sun, K., & Scherer, P. E. (2010) · Endocrinology · doi:10.1210/en.2010-0136 · Cited by 156 · see citing works
Self-citationCloning of cell-specific secreted and surface proteins by subtractive antibody screening
Scherer, P. E., Bickel, P. E., Kotler, M., & Lodish, H. F. (1998) · Nature Biotechnology · doi:10.1038/nbt0698-581 · Cited by 144 · see citing works
Self-citationGene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice
Aouadi, M., Tencerová, M., Vangala, P., Yawe, J. C., Nicoloro, S. M. C., Amano, S. U., Cohen, J. L., & Czech, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300492110 · Cited by 144 · see citing works
Self-citationPark, J., Morley, T. S., & Scherer, P. E. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201202006 · Cited by 111 · see citing works
Self-citationThe C5 Domain of Col6A3 Is Cleaved Off from the Col6 Fibrils Immediately after Secretion
Aigner, T. G., Hambach, L., Söder, S., Schlötzer-Schrehardt, U. M., & Pöschl, E. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6227 · Cited by 89 · see citing works
Obesity-associated disorders in normal-weight individuals: some speculations.
Ruderman, N. B., Berchtold, P., & Schneider, S. H. (1982) · PubMed · Cited by 79 · see citing works
LeRoy, E. C., Trojanowska, M. I., & Smith, E. A. (1991) · PubMed · Cited by 68 · see citing works
Muona, P., Jaakkola, S., Zhang, R. Z., Pan, T., Pelliniemi, L. J., Risteli, L., Chu, M. L., Uitto, J., & Peltonen, J. T. K. (1993) · PubMed Central · Cited by 45 · see citing works
From Lipid Storage Compartment to Endocrine Organ
Scherer, P. E. (2006) · Cited by 16 · see citing works
Self-citation
Flagged first, then by citations
1 of the 55 references couldn’t be matched to a known paper.
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Chait, A., & den Hartigh, L. J. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.00022 · Cited by 1,529 · see citing works
Insulin action and resistance in obesity and type 2 diabetes
Czech, M. P. (2017) · Nature Medicine · doi:10.1038/nm.4350 · Cited by 1,258 · see citing works
Self-citationThe ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Self-citationTargeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Self-citationFuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 669 · see citing works
The good and the bad collagens of fibrosis – Their role in signaling and organ function
Karsdal, M. A., Nielsen, S. H., Leeming, D. J., Langholm, L. L., Nielsen, M. J., Manon-Jensen, T., Siebuhr, A., Gudmann, N. S., Rønnow, S., Sand, J. M., et al. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.014 · Cited by 509 · see citing works
Pan, Y., Hui, X. H., Hoo, R. L. C., Ye, D., Chan, C. Y. C., Feng, T., Wang, Y., Lam, K. S. L., & Xu, A. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123069 · Cited by 497 · see citing works
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432 · see citing works
Metabolic adaptation and maladaptation in adipose tissue
Chouchani, E. T., & Kajimura, S. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0021-8 · Cited by 383 · see citing works
Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Muir, L. A., Neeley, C. K., Meyer, K. A., Baker, N. A., Brosius, A. M., Washabaugh, A. R., Varban, O. A., Finks, J. F., Zamarron, B. F., Flesher, C. G., et al. (2016) · Obesity · doi:10.1002/oby.21377 · Cited by 367 · see citing works
Obese visceral fat tissue inflammation: from protective to detrimental?
Kolb, H. (2022) · BMC Medicine · doi:10.1186/s12916-022-02672-y · Cited by 359 · see citing works
Beyond adiponectin and leptin: adipose tissue-derived mediators of inter-organ communication
Funcke, J., & Scherer, P. E. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r094060 · Cited by 337 · see citing works
Self-citationMacrophage functions in lean and obese adipose tissue
Thomas, D. D., & Apovian, C. M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.04.005 · Cited by 318 · see citing works
Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases
Ruiz‐Ojeda, F. J., Méndez-Gutiérrez, A., Aguilera, C. M., & Plaza‐Díaz, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194888 · Cited by 312 · see citing works
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274 · see citing works
Obesity in Type 1 Diabetes: Pathophysiology, Clinical Impact, and Mechanisms
Corbin, K. D., Driscoll, K. A., Pratley, R. E., Smith, S. R., Maahs, D. M., Mayer-Davis, E. J., & Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON) (2018) · Endocrine Reviews · doi:10.1210/er.2017-00191 · Cited by 262 · see citing works
Obesity, Type 2 Diabetes, and Cancer Risk
Scully, T., Ettela, A., LeRoith, D., & Gallagher, E. J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.615375 · Cited by 269 · see citing works
Adipose extracellular matrix remodelling in obesity and insulin resistance
Lin, D., Chun, T., & Kang, L. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.05.005 · Cited by 239 · see citing works
The extracellular matrix and insulin resistance
Williams, A. S., Kang, L., & Wasserman, D. H. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.05.006 · Cited by 228 · see citing works
Heterogeneity of adipose tissue in development and metabolic function
Schöttl, T., Kapser-Fischer, I., & Ussar, S. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.162958 · Cited by 215 · see citing works
Collagen biology and non‐invasive biomarkers of liver fibrosis
Karsdal, M. A., Daniels, S. J., Holm Nielsen, S., Bager, C., Rasmussen, D. G. K., Loomba, R., Surabattula, R., Villesen, I. F., Luo, Y., Shevell, D., et al. (2020) · Liver International · doi:10.1111/liv.14390 · Cited by 197 · see citing works
Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome
Carobbio, S., Pellegrinelli, V., & Vidal‐Puig, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_7 · Cited by 191 · see citing works
The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance
Duong, M. N., Geneste, A., Fallone, F., Li, X., Dumontet, C., & Muller, C. (2017) · OncoTarget · doi:10.18632/oncotarget.18038 · Cited by 178 · see citing works
Contribution of adipose tissue to development of cancer
Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188 · see citing works
Collagen VI disorders: Insights on form and function in the extracellular matrix and beyond
Lamandé, S. R., & Bateman, J. F. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.12.008 · Cited by 185 · see citing works
Hasegawa, Y., Ikeda, K., Chen, Y., Alba, D., Stifler, D. R., Shinoda, K., Hosono, T., Maretich, P., Yang, Y., Ishigaki, Y., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.12.005 · Cited by 179 · see citing works
Molecular and tissue alterations of collagens in fibrosis
Ricard‐Blum, S., Baffet, G., & Théret, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.02.004 · Cited by 170 · see citing works
Luo, T., Nocon, A., Fry, J., Sherban, A., Rui, X., Jiang, B., Xu, X. J., Han, J., Yan, Y., Yang, Q., et al. (2016) · Diabetes · doi:10.2337/db15-1122 · Cited by 172 · see citing works
ECM formation and degradation during fibrosis, repair, and regeneration
Mayorca‐Guiliani, A. E., Leeming, D. J., Henriksen, K., Mortensen, J. H., Nielsen, S. H., Anstee, Q. M., Sanyal, A. J., Karsdal, M. A., & Schuppan, D. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00063-4 · Cited by 172 · see citing works
Reversible Optical Writing and Data Storage in an Anthracene‐Loaded Metal–Organic Framework
Tu, M., Reinsch, H., Rodríguez‐Hermida, S., Verbeke, R., Stassin, T., Egger, W., Dickmann, M., Dieu, B., Hofkens, J., Vankelecom, I. F. J., et al. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201813996 · Cited by 155 · see citing works
Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity
Petersen, M. C., Smith, G. I., Palacios, H. H., Farabi, S. S., Yoshino, M., Yoshino, J., Cho, K., Davila-Roman, V. G., Shankaran, M., Barve, R. A., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.002 · Cited by 149 · see citing works
Adipose Tissue Fibrosis: Mechanisms, Models, and Importance
DeBari, M. K., & Abbott, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176030 · Cited by 141 · see citing works
Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs
Ricard‐Blum, S., & Vallet, S. D. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.005 · Cited by 143 · see citing works
Buechler, C., Krautbauer, S., & Eisinger, K. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i4.548 · Cited by 141 · see citing works
Dermal Adipocytes: From Irrelevance to Metabolic Targets?
Kruglikov, I. L., & Scherer, P. E. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.11.002 · Cited by 135 · see citing works
Self-citationCurrent Mechanistic Understandings of Lymphedema and Lipedema: Tales of Fluid, Fat, and Fibrosis
Duhon, B. H., Phan, T., Taylor, S. L., Crescenzi, R. L., & Rutkowski, J. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126621 · Cited by 133 · see citing works
Decreased Adipose Tissue Oxygenation Associates with Insulin Resistance in Individuals with Obesity
Cifarelli, V., Beeman, S. C., Smith, G. I., Yoshino, J., Morozov, D., Beals, J. W., Kayser, B. D., Watrous, J. D., Jain, M., Patterson, B. W., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci141828 · Cited by 132 · see citing works
Ravassa, S., López, B., Treibel, T. A., José, G. S., Losada-Fuentenebro, B., Tapia, L., Bayés‐Genís, A., Dı́ez, J., & González, A. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101194 · Cited by 134 · see citing works
Engin, A. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-48382-5_13 · Cited by 124 · see citing works
He, J., Wei, X., Li, S., Liu, Y., Hu, H., Li, Z., Kuang, X.-H., Wang, L., Shi, X., Yuan, S., et al. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0309-z · Cited by 123 · see citing works
Peng, M., Wen, Z., & Sun, X. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202211548 · Cited by 123 · see citing works
MASH: the nexus of metabolism, inflammation, and fibrosis
Steinberg, G. R., Carpentier, A., & Wang, D.-D. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186420 · Cited by 110 · see citing works
Naomi, R., Teoh, S. H., Embong, H., Balan, S. S., Othman, F., Bahari, H., & Yazid, M. D. (2023) · Antioxidants · doi:10.3390/antiox12051071 · Cited by 121 · see citing works
Microenvironmental Control of Adipocyte Fate and Function
Pope, B. D., Warren, C. R., Parker, K. K., & Cowan, C. A. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.005 · Cited by 117 · see citing works
Datta, R., Podolsky, M. J., & Atabai, K. (2018) · JCI Insight · doi:10.1172/jci.insight.122289 · Cited by 121 · see citing works
Adipose Tissue: Physiology to Metabolic Dysfunction
Richard, A. J., White, U. A., Elks, C. M., & Stephens, J. M. (2020) · Europe PMC (PubMed Central) · Cited by 118 · see citing works
Matrikines as mediators of tissue remodelling
Jariwala, N., Ozols, M., Bell, M., Bradley, E., Gilmore, A. P., Debelle, L., & Sherratt, M. J. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114240 · Cited by 123 · see citing works
Park, J., Kim, M. G., Sun, K., An, Y., Gu, X., & Scherer, P. E. (2017) · Diabetes · doi:10.2337/db16-1081 · Cited by 114 · see citing works
Self-citationAdipose tissue in health and disease
Harvey, I. C., Boudreau, A., & Stephens, J. M. (2020) · Open Biology · doi:10.1098/rsob.200291 · Cited by 117 · see citing works
Kim, B., Farruggia, C., Ku, C. S., Pham, T. X., Yang, Y. J., Bae, M., Wegner, C., Farrell, N., Harness, E., Park, Y., et al. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.01.006 · Cited by 111 · see citing works
Collagen VI as a driver and disease biomarker in human fibrosis
Williams, L. M., Layton, T., Yang, N., Feldmann, M., & Nanchahal, J. (2021) · FEBS Journal · doi:10.1111/febs.16039 · Cited by 108 · see citing works
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis
Shen, H., Huang, X., Zhao, Y., Wu, D., Xue, K., Yao, J., Wang, Y., Tang, N., & Qiu, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33800-0 · Cited by 109 · see citing works
Extracellular matrix remodeling in human disease
Sonbol, H. S. (2018) · Journal of Microscopy and Ultrastructure · doi:10.4103/jmau.jmau_4_18 · Cited by 103 · see citing works
The Facial Adipose Tissue: A Revision
Kruglikov, I. L., Trujillo, O., Quick, K., Isac, K., Zorko, J., Fam, M., Okonkwo, K., Mian, A., Thanh, H., Koban, K. C., et al. (2016) · Facial Plastic Surgery · doi:10.1055/s-0036-1596046 · Cited by 102 · see citing works
Critical Role of Matrix Metalloproteinase 14 in Adipose Tissue Remodeling during Obesity
Li, X., Zhao, Y., Chen, C., Yang, L., Lee, H.-H., Wang, Z., Zhang, N., Kolonin, M. G., An, Z., Ge, X., et al. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00564-19 · Cited by 100 · see citing works
Self-citationAdipocyte mesenchymal transition contributes to mammary tumor progression
Zhu, Q., Zhu, Y., Hepler, C., Zhang, Q., Park, J., Gliniak, C. M., Henry, G. H., Crewe, C., Bu, D., Zhang, Z., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111362 · Cited by 99 · see citing works
Self-citationActomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues
Tharp, K. M., Kang, M. S., Timblin, G. A., Dempersmier, J. M., Dempsey, G., Zushin, P. H., Benavides, J., Choi, C., Li, C. X., Jha, A. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.005 · Cited by 98 · see citing works
Godfrey, C. C., Bremer, A. A., Alba, D., Apovian, C. M., Koethe, J. R., Koliwad, S. K., Lewis, D. E., Lo, J., McComsey, G. A., Eckard, A. R., et al. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz118 · Cited by 100 · see citing works
Identifying collagen VI as a target of fibrotic diseases regulated by CREBBP/EP300
Williams, L. M., McCann, F. E., Cabrita, M., Layton, T., Cribbs, A. P., Knezevic, B., Fang, H., Knight, J. C., Zhang, M., Fischer, R., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004281117 · Cited by 86 · see citing works
Pathologic HIF1α signaling drives adipose progenitor dysfunction in obesity
Shao, M., Hepler, C., Zhang, Q., Shan, B., Vishvanath, L., Henry, G. H., Zhao, S., An, Y., Wu, Y., Strand, D. W., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2020.12.008 · Cited by 86 · see citing works
Margina, D. M., Ungurianu, A., Purdel, C. N., Nițulescu, G. M., Tsoukalas, D., Sarandi, E., Thanasoula, M., Burykina, T. I., Tekos, F., Djordjević, A. B., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111558 · Cited by 86 · see citing works
Fu, M., Shu, S., Peng, Z., Liu, X., Chen, X., Zeng, Z., Yang, Y., Cui, H., Zhao, R., Wang, X., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319828 · Cited by 89 · see citing works
Bihlet, A. R., Karsdal, M. A., Sand, J. M. B., Leeming, D. J., Roberts, M. E. P., White, W., & Bowler, R. P. (2017) · Respiratory Research · doi:10.1186/s12931-017-0509-x · Cited by 84 · see citing works
Fenton, A., Jesky, M., Ferro, C. J., Sørensen, J., Karsdal, M. A., Cockwell, P., & Genovese, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175200 · Cited by 82 · see citing works
Cartilage extracellular matrix-derived matrikines in osteoarthritis
Rapp, A. E., & Zaucke, F. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00464.2022 · Cited by 83 · see citing works
Luo, Y., Oseini, A., Gagnon, R., Charles, E. D., Sidik, K., Vincent, R., Collen, R., Idowu, M., Contos, M. J., Mirshahi, F., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-30457-y · Cited by 74 · see citing works
Peuß, R., Box, A., Chen, S., Wang, Y., Tsuchiya, D., Persons, J. L., Kenzior, A., Maldonado, E., Krishnan, J., Scharsack, J. P., et al. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1234-2 · Cited by 79 · see citing works
Sand, J. M. B., Leeming, D. J., Byrjalsen, I., Bihlet, A. R., Lange, P., Tal‐Singer, R., Miller, B. E., Karsdal, M. A., & Vestbo, J. (2016) · Respiratory Research · doi:10.1186/s12931-016-0440-6 · Cited by 78 · see citing works
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun, K., Li, X., & Scherer, P. E. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220020 · Cited by 144 · see citing works
Self-citationThe Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet
Jones, J. E. C., Rabhi, N., Orofino, J., Gamini, R., Perissi, V., Vernochet, C., & Farmer, S. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-59284-w · Cited by 75 · see citing works
Proteases decode the extracellular matrix cryptome
Ricard‐Blum, S., & Vallet, S. D. (2015) · Biochimie · doi:10.1016/j.biochi.2015.09.016 · Cited by 76 · see citing works
Identification of an Altered Matrix Signature in Kidney Aging and Disease
Randles, M. J., Lausecker, F., Kong, Q., Suleiman, H. Y., Reid, G., Kolatsi‐Joannou, M., Davenport, B., Tian, P., Falcone, S., Potter, P. K., et al. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2020101442 · Cited by 75 · see citing works
Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes
Karsdal, M. A., Henriksen, K., Genovese, F., Leeming, D. J., Nielsen, M. J., Riis, B. J., Christiansen, C., Byrjalsen, I., & Schuppan, D. (2016) · Diabetologia · doi:10.1007/s00125-016-4094-1 · Cited by 74 · see citing works
Gallardo-Montejano, V. I., Yang, C., Hahner, L., McAfee, J. L., Johnson, J. A., Holland, W. L., Fernandez‐Valdivia, R., & Bickel, P. E. (2021) · Nature Communications · doi:10.1038/s41467-021-23601-2 · Cited by 73 · see citing works
Self-citationUrinary endotrophin predicts disease progression in patients with chronic kidney disease
Rasmussen, D. G. K., Fenton, A., Jesky, M., Ferro, C. J., Boor, P., Tepel, M., Karsdal, M. A., Genovese, F., & Cockwell, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-17470-3 · Cited by 71 · see citing works
Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and Perspectives
Sun, K., Li, X., & Scherer, P. E. (2023) · Comprehensive physiology · doi:10.1002/j.2040-4603.2023.tb00254.x · Cited by 71 · see citing works
Self-citationExtracellular matrix remodelling in obesity and metabolic disorders
Musale, V., Wasserman, D. H., & Kang, L. (2023) · Life Metabolism · doi:10.1093/lifemeta/load021 · Cited by 76 · see citing works
Human endotrophin as a driver of malignant tumor growth
Bu, D., Crewe, C., Kusminski, C. M., Gordillo, R., Ghaben, A. L., Kim, M., Park, J., Deng, H., Xiong, W., Liu, X., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.125094 · Cited by 69 · see citing works
Self-citationFetal development of subcutaneous white adipose tissue is dependent on Zfp423
Shao, M., Hepler, C., Vishvanath, L., MacPherson, K. A., Busbuso, N. C., & Gupta, R. K. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.009 · Cited by 67 · see citing works
Adipose tissue fibrosis: the unwanted houseguest invited by obesity
Gliniak, C. M., Pedersen, L., & Scherer, P. E. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0180 · Cited by 69 · see citing works
Self-citationHarney, D., Cielesh, M., Chu, R., Cooke, K. C., James, D. E., Stöckli, J., & Larance, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108804 · Cited by 67 · see citing works
Rasmussen, D. G. K., Hansen, T. W., von Scholten, B. J., Nielsen, S., Reinhard, H., Parving, H., Tepel, M., Karsdal, M. A., Jacobsen, P. K., Genovese, F., et al. (2018) · Diabetes Care · doi:10.2337/dc17-2392 · Cited by 65 · see citing works
Boucherat, O., Yokokawa, T., Krishna, V., Kalyana-Sundaram, S., Martineau, S., Breuils-Bonnet, S., Azhar, N., Bonilla, F., Gutstein, D., Potus, F., et al. (2022) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00113-w · Cited by 64 · see citing works
Endotrophin, a Collagen VI Formation–Derived Peptide, in Heart Failure
Chirinos, J. A., Zhao, L., Reese‐Petersen, A. L., Cohen, J. B., Genovese, F., Richards, M., Doughty, R. N., Dı́ez, J., González, A., Querejeta, R., et al. (2022) · NEJM Evidence · doi:10.1056/evidoa2200091 · Cited by 62 · see citing works
Villesen, I. F., Daniels, S. J., Leeming, D. J., Karsdal, M. A., & Nielsen, M. J. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15773 · Cited by 63 · see citing works
Senol-Cosar, O., Flach, R. J. R., DiStefano, M. T., Chawla, A., Nicoloro, S. M. C., Straubhaar, J., Hardy, O. T., Noh, H. L., Kim, J. K., Wabitsch, M., et al. (2016) · Nature Communications · doi:10.1038/ncomms10686 · Cited by 63 · see citing works
Self-citationHan, C. Y., Kang, I., Harten, I. A., Gebe, J. A., Chan, C. K., Omer, M., Alonge, K. M., den Hartigh, L. J., Kjerulf, D. G., Goodspeed, L., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107818 · Cited by 60 · see citing works
Beals, J. W., Smith, G. I., Shankaran, M., Fuchs, A. G., Schweitzer, G. G., Yoshino, J., Field, T., Matthews, M. D., Nyangau, E., Morozov, D., et al. (2021) · Hepatology · doi:10.1002/hep.31822 · Cited by 61 · see citing works
Animal models of scleroderma: recent progress
Marangoni, R. G., Varga, J., & Tourtellotte, W. G. (2016) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000331 · Cited by 61 · see citing works
Self-citationCho, H., Um, J., Lee, J., Kim, W., Kang, W. S., Kim, S. H., Ha, H., Kim, Y., Ahn, Y., Jung, D., et al. (2017) · Scientific Reports · doi:10.1038/srep44186 · Cited by 61 · see citing works
Wang, J., & Pan, W. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s256654 · Cited by 60 · see citing works
Divergent functions of endotrophin on different cell populations in adipose tissue
Zhao, Y., Gu, X., Zhang, N., Kolonin, M. G., An, Z., & Sun, K. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00314.2016 · Cited by 60 · see citing works
Self-citationHeumüller, S. E., Talantikite, M., Napoli, M., Armengaud, J., Mörgelin, M., Hartmann, U., Sengle, G., Paulsson, M., Moali, C., & Wagener, R. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.008641 · Cited by 60 · see citing works
Strieder‐Barboza, C., Baker, N. A., Flesher, C. G., Karmakar, M., Neeley, C. K., Polsinelli, D., Dimick, J. B., Finks, J. F., Ghaferi, A. A., Varban, O. A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-56242-z · Cited by 57 · see citing works
Collagens Regulating Adipose Tissue Formation and Functions
Jääskeläinen, I., Petäistö, T., Dahagi, E. M., Mahmoodi, M., Pihlajaniemi, T. A., Kaartinen, M. T., & Heljäsvaara, R. (2023) · Biomedicines · doi:10.3390/biomedicines11051412 · Cited by 58 · see citing works
Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix
Baker, N. A., Muir, L. A., Washabaugh, A. R., Neeley, C. K., Chen, S. Y.-P., Flesher, C. G., Vorwald, J., Finks, J. F., Ghaferi, A. A., Mulholland, M. W., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2915 · Cited by 56 · see citing works
Assessment of liver fibrosis progression and regression by a serological collagen turnover profile
Karsdal, M. A., Hjuler, S. T., Luo, Y., Rasmussen, D. G. K., Nielsen, M. J., Nielsen, S. H., Leeming, D. J., Goodman, Z. D., Arch, R. H., Patel, K., et al. (2018) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00158.2018 · Cited by 56 · see citing works
Sparding, N., Genovese, F., Rasmussen, D. G. K., Karsdal, M. A., Neprašová, M., Maixnerová, D., Satrapová, V., Frausová, D., Hornum, M., Bartoňová, L., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab163 · Cited by 54 · see citing works
Oh, J., Kim, C.-S., Kim, M., Jo, W., Sung, Y. H., & Park, J. (2020) · Metabolism · doi:10.1016/j.metabol.2020.154430 · Cited by 54 · see citing works
Self-citationGlucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance
Caratti, G., Stifel, U., Caratti, B., Jamil, A. J. M., Chung, K., Kiehntopf, M., Gräler, M. H., Blüher, M., Rauch, A., & Tuckermann, J. P. (2023) · Nature Communications · doi:10.1038/s41467-023-37831-z · Cited by 50 · see citing works
- Authors
- Sun, K., Park, J., Gupta, O. T., Holland, W. L., Auerbach, P., Zhang, N., Goncalves Marangoni, R., Nicoloro, S. M., Czech, M. P., Varga, J., Ploug, T., An, Z., & Scherer, P. E.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Ulsan National Institute of Science and Technology (KR)
- University of Copenhagen (DK)
- Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases (US)
- University of Massachusetts Chan Medical School (US)
- Northwestern University (US)
- Corresponding author
- Scherer, Philipp E.
- ORCID
- Venue
- Nature Communications
- Published
- 2014-03-19
- Volume
- 5
- Issue
- 1
- Pages
- 3485-3485
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC4076823
- OpenAlex
- W2003652844
- Cited by
- 364
- References
- 55
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 35 · 2023: 40 · 2022: 39 · 2021: 43 · 2020: 46 · 2019: 22 · 2018: 24 · 2017: 22 · 2016: 24 · 2015: 14 · 2014: 1
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Communications (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Scholarworks@UNIST (Ulsan National Institute of Science and Technology) (submittedVersion)
- Funders
- U.S. Department of Defense
- American Heart Association (12BGI-A8910006)
- University of Texas Southwestern Medical Center (P01DK088761)
- Ulsan National Institute of Science and Technology (1.130088.01)
- Ministério da Ciência, Tecnologia e Inovação
- Novo Nordisk
- Copenhagen Graduate School for Nanoscience and Nanotechnology
- Novo Nordisk Fonden
- National Institutes of Health (DK030898)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55758, R01DK030898, K99DK094973, R37DK030898, R01DK055758, P01DK088761, R01DK099110)
- Medical Research and Materiel Command
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- endotrophin, adipose tissue fibrosis, adipose tissue inflammation, insulin resistance, metabolic dysfunction, high-fat diet, adipokines, inflammatory cytokines
- MeSH terms
- Adipose Tissue, Adult, Animals, Diabetes Mellitus, Energy Metabolism, Female, Fibrosis, Humans, Inflammation, Insulin Resistance, Male, Mice, Inbred C57BL, Mice, Transgenic, Middle Aged, Obesity, Peptide Fragments, Gene Expression, Transforming Growth Factor beta, Adipocytes, Microscopy, Confocal, Reverse Transcriptase Polymerase Chain Reaction, Collagen Type VI, Mice, Matrix Metalloproteinase 12, Diet, High-Fat
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