Smith, George Davey

Genomics and phenomics of body mass index reveals a complex disease network

Huang, J., Huffman, J. E., Huang, Y., Do Valle, Í., Assimes, T. L., Raghavan, S., Voight, B. F., Liu, C., Barabási, A.-L., Huang, R. D. L., et al. (2022) · Nature Communications

Genetic Associations and EpidemiologyGenetics and Physical Performance

Cited by 170

Effects of Promoting Longer-term and Exclusive Breastfeeding on Adiposity and Insulin-like Growth Factor-I at Age 11.5 Years: A Randomized Trial

Martin, R. M., Patel, R., Kramer, M. S., Guthrie, L., Vilchuck, K., Bogdanovich, N., Sergeichick, N., Gusina, N., Foo, Y., Palmer, T., et al. (2013) · JAMA

Breastfeeding Practices and InfluencesInfant Nutrition and Health

Cited by 168

Mendelian randomization in health research: Using appropriate genetic variants and avoiding biased estimates

Taylor, A. E., Davies, N. M., Ware, J. J., VanderWeele, T., Smith, G. D., & Munafò, M. R. (2014) · Economics & Human Biology

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 166

Plasma lipids and risk of aortic valve stenosis: a Mendelian randomization study

Nazarzadeh, M., Pinho-Gomes, A.-C., Bidel, Z., Dehghan, A., Canoy, D., Hassaine, A., Ayala Solares, J. R., Salimi-Khorshidi, G., Smith, G. D., Otto, C. M., et al. (2020) · European Heart Journal

Cardiac Valve Diseases and TreatmentsLipoproteins and Cardiovascular Health

Cited by 163

Association of genetic risk variants with attention-deficit/hyperactivity disorder trajectories in the general population

Riglin, L., Collishaw, S., Thapar, A. K., Dalsgaard, S., Langley, K., Smith, G. D., Stergiakouli, E., Maughan, B., O’Donovan, M. C., & Thapar, A. (2016) · JAMA Psychiatry

Attention Deficit Hyperactivity DisorderAutism Spectrum Disorder Research

Cited by 161

Where now for meta-analysis?

Egger, M., Ebrahim, S., & Smith, G. D. (2002) · International Journal of Epidemiology

Meta-analysis and systematic reviewsStatistical Methods in Epidemiology

Cited by 160

The many weak instruments problem and Mendelian randomization

Davies, N. M., von Hinke Kessler Scholder, S., Farbmacher, H., Burgess, S., Windmeijer, F., & Smith, G. D. (2015) · Statistics in Medicine

Advanced Causal Inference TechniquesGenetic Associations and Epidemiology

Cited by 140

Unraveling the directional link between adiposity and inflammation: A bidirectional Mendelian randomization approach

Welsh, P., Polisecki, E., Robertson, M., Jahn, S., Buckley, B. M., de Craen, A. J. M., Ford, I., Jukema, J. W., Macfarlane, P. W., Packard, C. J., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesGenetic Associations and Epidemiology

Cited by 140

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

White, J., Sofat, R., Hemani, G., Shah, T., Engmann, J., Dale, C., Shah, S., Kruger, F. A., Giambartolomei, C., Swerdlow, D. I., et al. (2016) · The Lancet Diabetes & Endocrinology

Gout, Hyperuricemia, Uric AcidGenetic Associations and Epidemiology

Cited by 132

Who benefits from medical interventions?

Smith, G. D., & Egger, M. (1994) · BMJ

Platelet Disorders and TreatmentsHeparin-Induced Thrombocytopenia and Thrombosis

Cited by 128

Triangulating Evidence through the Inclusion of Genetically Informed Designs

Munafò, M. R., Higgins, J. P. T., & Smith, G. D. (2021) · Cold Spring Harbor Perspectives in Medicine

Advanced Causal Inference TechniquesGenetic Associations and Epidemiology

Cited by 125

Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer

Yarmolinsky, J., Bull, C. J., Vincent, E. E., Robinson, J., Walther, A., Smith, G. D., Lewis, S. J., Relton, C. L., & Martin, R. M. (2020) · JAMA

Cancer, Lipids, and MetabolismBRCA gene mutations in cancer

Cited by 124

Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics

Bovijn, J., Krebs, K., Chen, C.-Y., Boxall, R., Censin, J. C., Ferreira, T., Pulit, S. L., Glastonbury, C. A., Laber, S., Millwood, I. Y., et al. (2020) · Science Translational Medicine

Bone health and osteoporosis researchGenetic Associations and Epidemiology

Cited by 119

Association of Genetic Loci With Glucose Levels in Childhood and Adolescence

Barker, A., Sharp, S. J., Timpson, N. J., Bouatia-Naji, N., Warrington, N. M., Kanoni, S., Beilin, L. J., Brage, S., Deloukas, P., Evans, D. M., et al. (2011) · Diabetes

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 117

Bias in relative odds estimation owing to imprecise measurement of correlated exposures

Phillips, A. N., & Smith, G. D. (1992) · Statistics in Medicine

Statistical Methods in EpidemiologyAdvanced Causal Inference Techniques

Cited by 108

Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms

Sofat, R., Hingorani, A. D., Smeeth, L., Humphries, S. E., Talmud, P. J., Cooper, J., Shah, T., Sandhu, M. S., Ricketts, S. L., Boekholdt, S. M., et al. (2010) · Circulation

Lipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Cited by 104

Investigating causality between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization

Treur, J. L., Demontis, D., Smith, G. D., Sallis, H., Richardson, T. G., Wiers, R. W., Børglum, A. D., Verweij, K. J. H., & Munafò, M. R. (2021) · Addiction Biology

Attention Deficit Hyperactivity DisorderGenetic Associations and Epidemiology

Cited by 102

Inverse Association Between Birth Weight and C-Reactive Protein Concentrations in the MIDSPAN Family Study

Sattar, N., McConnachie, A., O’Reilly, D., Upton, M. N., Greer, I. A., Smith, G. D., & Watt, G. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology

Birth, Development, and HealthAdipokines, Inflammation, and Metabolic Diseases

Cited by 99

Common risk variants identified in autism spectrum disorder

Grove, J., Ripke, S., Als, T. D., Mattheisen, M., Walters, R., Won, H., Pallesen, J., Agerbo, E., Andreassen, O. A., Anney, R., et al. (2017) · bioRxiv (Cold Spring Harbor Laboratory)

Autism Spectrum Disorder ResearchGenetic Associations and Epidemiology

Cited by 89

Negative Control Exposures in Epidemiologic Studies

Smith, G. D. (2012) · Epidemiology

Advanced Causal Inference TechniquesStatistical Methods in Epidemiology

Cited by 88

Automating Mendelian randomization through machine learning to construct a putative causal map of the human phenome

Hemani, G., Bowden, J., Haycock, P., Zheng, J., Davis, O., Flach, P., Gaunt, T., & Smith, G. D. (2017) · bioRxiv (Cold Spring Harbor Laboratory)

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 85

Variation in the SERPINA6/SERPINA1 locus alters morning plasma cortisol, hepatic corticosteroid binding globulin expression, gene expression in peripheral tissues, and risk of cardiovascular disease

Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., Friedrich, N., van der Harst, P., Joshi, P. K., Karhunen, V., et al. (2021) · Journal of Human Genetics

Genetic Associations and EpidemiologyStress Responses and Cortisol

Cited by 74

The causes and consequences of Alzheimer's disease: phenome-wide evidence from mendelian randomization

Korologou-Linden, R., Bhatta, L., Brumpton, B. M., Howe, L. D., Millard, L. A. C., Kolaric, K., Ben-Shlomo, Y., Williams, D. M., Smith, G. D., Anderson, E. L., et al. (2022) · Nature Communications

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 71

The causal role of smoking in anxiety and depression: a Mendelian randomization analysis of the HUNT study

Bjørngaard, J. H., Gunnell, D., Elvestad, M. B., Smith, G. D., Skorpen, F., Krokan, H., Vatten, L., & Romundstad, P. (2013) · Psychological Medicine

Smoking Behavior and CessationGenetic Associations and Epidemiology

Cited by 71