Cited by 99Birth, Development, and HealthAdipokines, Inflammation, and Metabolic DiseasesGestational Diabetes Research and Management

Inverse Association Between Birth Weight and C-Reactive Protein Concentrations in the MIDSPAN Family Study

Sattar, Naveed, McConnachie, Alex, O’Reilly, Denis, Upton, Mark N., Greer, Ian A., Smith, George Davey, Watt, Graham·2004·Arteriosclerosis, Thrombosis, and Vascular Biology

Abstract

Objective— Inflammation markers and low birth weight each predict elevated risk of cardiovascular events and type 2 diabetes. However, potential associations between the low-grade inflammatory response as represented by C-reactive protein (CRP) concentrations and low birth weight have been sparsely examined. Methods and results— In the MIDSPAN Family Study, 1663 individuals had birth weight data and CRP concentrations measured as adults (age 30 to 59). The relationship between these parameters was examined after adjusting for factors known to influence CRP concentrations inclusive of age, body mass index, smoking, socio-economic deprivation, and hormone use in women. After adjusting for potential confounders, there was a negative association between birth weight and CRP, whereby a 1-kg increase in birth weight is associated with a 10.7% decrease in CRP (95% CI: 3.0% to 17.8% decrease). There was no strong evidence that the effects differed in men and women ( P =0.32). Conclusion— Low birth weight contributes to elevated CRP concentration in adult life. Future studies are required to determine to what extent this association reflects catch-up centile crossing, in utero programming, or genetic factors.

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Crossref · 10.1161/01.atv.0000118277.41584.63

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  • Given the consistency of the study's findings regarding other correlates of adult inflammation with evidence from different population-based studies worldwide, there is reason to believe that the results may be replicated in other settings.

    “However, given the consistency of our findings regarding other correlates of adult inflammation [e.g., low birth weight (13), low childhood socioeconomic status (SES) (14), and depression (17)] with evidence reported from different population-based studies worldwide, there is reason to believe that our results may be replicated in other settings.”

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  1. Sattar N, Gaw A, Scherbakova O, Ford I, O'Reilly DS, Haffner SM, Isles C, Macfarlane PW, Packard CJ, Cobbe SM, Shepherd J. Metabolic syndrome with and without CRP as a predictor of CHD and diabetes in West of Scotland Coronary Prevention Study. Circulation. 2003;108: 414 -419.

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Authors
Sattar, N., McConnachie, A., O’Reilly, D., Upton, M. N., Greer, I. A., Smith, G. D., & Watt, G.
Affiliations
Glasgow Royal Infirmary (GB)
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Published
2004-03
Volume
24
Issue
3
Pages
583-587
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
OpenAlex
W2161163787
Cited by
99
References
30
Citations by year
2025: 1 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 9
FWCI
7.56
Type
journal article
Language
en
Open access
closed
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
birth weight, C-reactive protein, low birth weight, low-grade inflammation, catch-up growth, fetal programming, cardiovascular risk, type 2 diabetes risk
MeSH terms
Adult, Age Factors, Birth Weight, C-Reactive Protein, Coronary Disease, Diabetes Mellitus, Type 2, England, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Scotland, Gonadal Steroid Hormones, Smoking, Socioeconomic Factors, Cohort Studies, Body Mass Index

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