Romero, Ignacio A.

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

Helms, H. C., Abbott, N. J., Burek, M., Cecchelli, R., Couraud, P.-O., Deli, M. A., Förster, C., Galla, H. J., Romero, I. A., Shusta, E. V., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 843

The hCMEC/D3 cell line as a model of the human blood brain barrier

Weksler, B., Romero, I. A., & Couraud, P.-O. (2013) · Fluids and Barriers of the CNS

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 753

Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase and PKB signaling

Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P., Piontek, J., et al. (2007) · The FASEB Journal

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 347

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

Vukic, V., Callaghan, D., Walker, D., Lue, L.-F., Liu, Q. Y., Couraud, P.-O., Romero, I. A., Weksler, B., Stanimirovic, D. B., & Zhang, W. (2009) · Neurobiology of Disease

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 232

Differences in amyloid-β clearance across mouse and human blood–brain barrier models: Kinetic analysis and mechanistic modeling

Qosa, H., Abuasal, B. S., Romero, I. A., Weksler, B., Couraud, P.-O., Keller, J. N., & Kaddoumi, A. (2014) · Neuropharmacology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 146

MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Reijerkerk, A., Lopez-Ramirez, M. A., van het Hof, B., Drexhage, J. A. R., Kamphuis, W. W., Kooij, G., Vos, J. B., van der Pouw Kraan, T. C. T. M., van Zonneveld, A. J., Horrevoets, A. J., et al. (2013) · The Journal of Neuroscience

Barrier Structure and Function StudiesMicroRNA in disease regulation

Cited by 138

Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

Vu, K., Weksler, B., Romero, I., Couraud, P.-O., & Gelli, A. (2009) · Eukaryotic Cell

Barrier Structure and Function StudiesFungal Infections and Studies

Cited by 124

Solid lipid nanoparticles as a vehicle for brain-targeted drug delivery: two new strategies of functionalization with apolipoprotein E

Neves, A. R., Queiroz, J. F., Weksler, B., Romero, I. A., Couraud, P.-O., & Reis, S. (2015) · Nanotechnology

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 122

Uptake and permeability studies of BBB-targeting immunoliposomes using the hCMEC/D3 cell line.

Markoutsa, E., Pampalakis, G., Niarakis, A., Romero, I. A., Weksler, B., Couraud, P.-O., & Antimisiaris, S. G. (2011) · European Journal of Pharmaceutics and Biopharmaceutics

Nanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

Cited by 122

CCL2 disrupts the adherens junction: implications for neuroinflammation

Roberts, T. K., Eugenin, E. A., Lopez, L., Romero, I. A., Weksler, B. B., Couraud, P.-O., & Berman, J. W. (2012) · Laboratory Investigation

Barrier Structure and Function StudiesCell Adhesion Molecules Research

Cited by 115

Alteration of Blood–Brain Barrier Integrity by Retroviral Infection

Afonso, P. V., Ozden, S., Cumont, M.-C., Seilhean, D., Cartier, L., Rezaie, P., Mason, S., Lambert, S., Huerre, M., Gessain, A., et al. (2008) · PLoS Pathogens

Barrier Structure and Function StudiesT-cell and Retrovirus Studies

Cited by 112

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

Garwood, C. J., Ratcliffe, L. E., Morgan, S. V., Simpson, J. E., Owens, H., Vazquez-Villaseñor, I., Heath, P. R., Romero, I. A., Ince, P. G., & Wharton, S. B. (2015) · Molecular Brain

Growth Hormone and Insulin-like Growth FactorsAlzheimer's disease research and treatments

Cited by 101

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

Duan, H., Xing, S., Luo, Y., Feng, L., Gramaglia, I., Zhang, Y., Lu, D., Zeng, Q., Fan, K., Feng, J., et al. (2013) · Scientific Reports

Multiple Sclerosis Research StudiesBarrier Structure and Function Studies

Cited by 59

Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells

Coelho-Santos, V., Socodato, R., Portugal, C., Leitão, R. A., Rito, M., Barbosa, M., Couraud, P.-O., Romero, I. A., Weksler, B., Minshall, R. D., et al. (2016) · Cellular and Molecular Life Sciences

Caveolin-1 and cellular processesBarrier Structure and Function Studies

Cited by 36