Singh, Harinder

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 13,382

Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages

Scott, E. W., Simon, M. C., Anastasi, J., & Singh, H. (1994) · Science

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 1,532

Regulation of B lymphocyte and macrophage development by graded expression of PU.1

DeKoter, R. P., & Singh, H. (2000) · Science

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 749

Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates

Laslo, P., Spooner, C. J., Warmflash, A., Lancki, D. W., Lee, H.-J., Sciammas, R., Gantner, B. N., Dinner, A. R., & Singh, H. (2006) · Cell

Gene Regulatory Network AnalysisHematopoietic Stem Cell Transplantation

Cited by 632

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Ramirez-Carrozzi, V., Sambandam, A., Luis, E., Lin, Z., Jeet, S., Lesch, J., Hackney, J., Kim, J., Zhou, M., Lai, J., et al. (2011) · Nature Immunology

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 477

Single-cell analysis of mixed-lineage states leading to a binary cell fate choice

Olsson, A., Venkatasubramanian, M., Chaudhri, V. K., Aronow, B. J., Salomonis, N., Singh, H., & Grimes, H. L. (2016) · Nature

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 476

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

Eisenbeis, C. F., Singh, H., & Storb, U. (1995) · Genes & Development

Genomics and Chromatin Dynamicsinterferon and immune responses

Cited by 447

Regulation of macrophage and neutrophil cell fates by the PU.1:C/EBPα ratio and granulocyte colony-stimulating factor

Dahl, R., Walsh, J. C., Lancki, D., Laslo, P., Iyer, S. R., Singh, H., & Simon, M. C. (2003) · Nature Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 380

A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1–IRF Complexes

Glasmacher, E., Agrawal, S., Chang, A. B., Murphy, T. L., Zeng, W., Vander Lugt, B., Khan, A. A., Ciofani, M., Spooner, C. J., Rutz, S., et al. (2012) · Science

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 361

PU.1 Regulates Expression of the Interleukin-7 Receptor in Lymphoid Progenitors

DeKoter, R. P., Lee, H.-J., & Singh, H. (2002) · Immunity

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 319

PU.1 regulates both cytokine‐dependent proliferation and differentiation of granulocyte/macrophage progenitors

DeKoter, R. P., Walsh, J. C., & Singh, H. (1998) · The EMBO Journal

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 296

PU.1 Functions in a Cell‐autonomous Manner to Control the Differentiation of Multipotential Lymphoid‐myeloid Progenitors

Scott, E. W., Fisher, R. C., Olson, M. C., Kehrli, E. W., Simon, M. C., & Singh, H. (1997) · Immunity

Hematopoietic Stem Cell TransplantationDevelopmental Biology and Gene Regulation

Cited by 270

Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates

Walsh, J. C., DeKoter, R. P., Lee, H.-J., Smith, E. D., Lancki, D. W., Gurish, M. F., Friend, D. S., Stevens, R. L., Anastasi, J., & Singh, H. (2002) · Immunity

Mast cells and histamineHematopoietic Stem Cell Transplantation

Cited by 262

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

Brass, A. L., Kehrli, E., Eisenbeis, C. F., Storb, U., & Singh, H. (1996) · Genes & Development

Genomics and Chromatin Dynamicsinterferon and immune responses

Cited by 242

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

DePasquale, E. A. K., Schnell, D. J., Van Camp, P.-J., Valiente-Alandí, Í., Blaxall, B. C., Grimes, H. L., Singh, H., & Salomonis, N. (2019) · Cell Reports

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 207

Assembly requirements of PU.1–Pip (IRF‐4) activator complexes: inhibiting function in vivo using fused dimers

Brass, A. L., Zhu, A. Q., & Singh, H. (1999) · The EMBO Journal

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 204

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 191

A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates

Spooner, C. J., Cheng, J. X., Pujadas, E., Laslo, P., & Singh, H. (2009) · Immunity

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 188

PU.1 is a component of a multiprotein complex which binds an essential site in the murine immunoglobulin lambda 2-4 enhancer.

Eisenbeis, C. F., Singh, H., & Storb, U. (1993) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 182

Crystal structure of PU. 1/IRF-4/DNA ternary complex

Escalante, C. R., Brass, A. L., Pongubala, J. M. R., Shatova, E., Shen, L., Singh, H., & Aggarwal, A. K. (2002) · Molecular Cell

Genomics and Chromatin DynamicsProtein Structure and Dynamics

Cited by 154

Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells

Colucci, F., Samson, S. I., DeKoter, R. P., Lantz, O., Singh, H., & Di Santo, J. P. (2001) · Blood

Immune Cell Function and InteractionHematopoietic Stem Cell Transplantation

Cited by 136

A Two-Step, PU.1-Dependent Mechanism for Developmentally Regulated Chromatin Remodeling and Transcription of the c-fms Gene

Krysinska, H., Hoogenkamp, M., Ingram, R., Wilson, N., Tagoh, H., Laslo, P., Singh, H., & Bonifer, C. (2007) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 102

PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2

Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., et al. (2010) · Nature Medicine

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 96

PU.1, a Shared Transcriptional Regulator of Lymphoid and Myeloid Cell Fates

SINGH, H., DEKOTER, R. P., & WALSH, J. C. (1999) · Cold Spring Harbor Symposia on Quantitative Biology

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 66