Wolfe, Scot A.

DNA Recognition by Cys2His2 Zinc Finger Proteins

Wolfe, S. A., Nekludova, L., & Pabo, C. O. (2000) · Annual Review of Biophysics and Biomolecular Structure

Protein Structure and DynamicsDiffusion and Search Dynamics

Cited by 1,053

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Yin, H., Song, C.-Q., Dorkin, J. R., Zhu, L. J., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., et al. (2016) · Nature Biotechnology

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 876

Highly efficient therapeutic gene editing of human hematopoietic stem cells

Wu, Y., Zeng, J., Roscoe, B. P., Liu, P., Yao, Q., Lazzarotto, C. R., Clement, K., Cole, M. A., Luk, K., Baricordi, C., et al. (2019) · Nature Medicine

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 515

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Yin, H., Song, C.-Q., Suresh, S., Wu, Q., Walsh, S., Rhym, L. H., Mintzer, E., Bolukbasi, M. F., Zhu, L. J., Kauffman, K., et al. (2017) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 499

Analysis of Homeodomain Specificities Allows the Family-wide Prediction of Preferred Recognition Sites

Noyes, M. B., Christensen, R. G., Wakabayashi, A., Stormo, G. D., Brodsky, M. H., & Wolfe, S. A. (2008) · Cell

Genomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

Cited by 452

Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice

Liu, P., Liang, S.-Q., Zheng, C., Mintzer, E., Zhao, Y. G., Ponnienselvan, K., Mir, A., Sontheimer, E. J., Gao, G., Flotte, T. R., et al. (2021) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 273

Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Yin, H., Song, C.-Q., Suresh, S., Kwan, S.-Y., Wu, Q., Walsh, S., Ding, J., Bogorad, R. L., Zhu, L. J., Wolfe, S. A., et al. (2018) · Nature Chemical Biology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 240

Genome editing of HBG1 and HBG2 to induce fetal hemoglobin

Métais, J.-Y., Doerfler, P. A., Mayuranathan, T., Bauer, D. E., Fowler, S. C., Hsieh, M. M., Katta, V., Keriwala, S., Lazzarotto, C. R., Luk, K., et al. (2019) · Blood Advances

Hemoglobinopathies and Related DisordersCRISPR and Genetic Engineering

Cited by 177

Evaluating and enhancing target specificity of gene-editing nucleases and deaminases

Kim, D., Luk, K., Wolfe, S. A., & Kim, J.-S. (2019) · Annual Review of Biochemistry

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 171

Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells

Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., et al. (2020) · Cell Stem Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 105

Genome-wide detection of CRISPR editing in vivo using GUIDE-tag

Liang, S.-Q., Liu, P., Smith, J. L., Mintzer, E., Maitland, S., Dong, X., Yang, Q., Lee, J., Haynes, C. M., Zhu, L. J., et al. (2022) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 54

Recognition models to predict DNA-binding specificities of homeodomain proteins

Christensen, R. G., Enuameh, M. S., Noyes, M. B., Brodsky, M. H., Wolfe, S. A., & Stormo, G. D. (2012) · Bioinformatics

Machine Learning in BioinformaticsGenomics and Chromatin Dynamics

Cited by 42

Generation and application of endogenously floxed alleles for cell-specific knockout in zebrafish

Shin, M., Yin, H.-M., Shih, Y.-H., Nozaki, T., Portman, D., Toles, B., Kolb, A., Luk, K., Isogai, S., Ishida, K., et al. (2023) · Developmental Cell

Zebrafish Biomedical Research ApplicationsCRISPR and Genetic Engineering

Cited by 28