Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells
Open accessAbstract
Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis (PF). Modalities to restore telomerase in stem cells throughout the body remain unclear. Here, we describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC). We identified BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells. When human blood stem cells engineered to carry DC-causing PARN mutations were xenotransplanted into immunodeficient mice, oral treatment with a repurposed PAPD5 inhibitor, the dihydroquinolizinone RG7834, rescued TERC 3' end maturation and telomere length. These findings pave the way for developing systemic telomere therapeutics to counteract stem cell exhaustion in DC, PF, and possibly other aging-related diseases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Small-molecule PAPD5 inhibitors rescue TERC levels in induced pluripotent stem cells from dyskeratosis congenita patients.
“Small-molecule inhibitors of PAPD5, a non-canonical poly(A) polymerase that destabilizes TERC RNA, have been shown to rescue TERC levels in induced pluripotent stem cells from patients with dyskeratosis congenita190.”
From Telomere dysfunction in ageing and age-related diseases (2022) · cites this paper as [190]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Cutadapt removes adapter sequences from high-throughput sequencing reads
Martin, M. (2011) · EMBnet.journal · doi:10.14806/ej.17.1.200 · Cited by 33,889 · see citing works
HISAT: a fast spliced aligner with low memory requirements
Kim, D., Langmead, B., & Salzberg, S. L. (2015) · Nature Methods · doi:10.1038/nmeth.3317 · Cited by 24,112 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Salmon provides fast and bias-aware quantification of transcript expression
Patro, R., Duggal, G., Love, M. I., Irizarry, R. A., & Kingsford, C. (2017) · Nature Methods · doi:10.1038/nmeth.4197 · Cited by 12,700 · see citing works
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091 · cited 24× · see citing works
“When primary fibroblasts were transduced with a retrovirus encoding TERT, both BCH001-treated and untreated cells were immortalized, but only cells treated with BCH001 showed telomere lengthening (Figure 4H).”
BackgroundInfluentialThe limited in vitro lifetime of human diploid cell strains
Hayflick, L. (1965) · Experimental Cell Research · doi:10.1016/0014-4827(65)90211-9 · Cited by 5,876 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Improved vectors and genome-wide libraries for CRISPR screening
Sanjana, N. E., Shalem, O., & Zhang, F. (2014) · Nature Methods · doi:10.1038/nmeth.3047 · Cited by 5,239 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Orchestrating high-throughput genomic analysis with Bioconductor
Huber, W. K., Carey, V. J., Gentleman, R. C., Anders, S., Carlson, M. R. J., Carvalho, B. S., Bravo, H. C., Davis, S. R., Gatto, L., Girke, T., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3252 · Cited by 3,499 · see citing works
A DNA damage checkpoint response in telomere-initiated senescence
Fagagna, F. D. D., Reaper, P. M., Clay-Farrace, L., Fiegler, H., Carr, P., von Zglinicki, T., Saretzki, G., Carter, N. P., & Jackson, S. P. (2003) · Nature · doi:10.1038/nature02118 · Cited by 2,855 · see citing works
Zerbino, D. R., Achuthan, P., Akanni, W., Amode, M. R., Barrell, D., Bhai, J., Billis, K., Cummins, C., Gall, A., Girón, C. G., et al. (2018) · Nucleic Acids Research · doi:10.1093/nar/gkx1098 · Cited by 2,605 · see citing works
Telomerase Catalytic Subunit Homologs from Fission Yeast and Human
Nakamura, T. M., Morin, G. B., Chapman, K. B., Weinrich, S. L., Andrews, W. H., Lingner, J., Harley, C. B., & Cech, T. R. (1997) · Science · doi:10.1126/science.277.5328.955 · Cited by 2,256 · see citing works
The RNA Component of Human Telomerase
Feng, J., Funk, W. D., Wang, S.-S., Weinrich, S. L., Avilion, A. A., Chiu, C.-P., Adams, R. R., Chang, E., Allsopp, R. C., Yu, J., et al. (1995) · Science · doi:10.1126/science.7544491 · Cited by 2,227 · see citing works
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80538-3 · Cited by 1,784 · see citing works
WATSON, J. D. (1972) · Nature New Biology · doi:10.1038/newbio239197a0 · Cited by 1,632 · see citing works
DNA Damage Foci at Dysfunctional Telomeres
Takai, H., Smogorzewska, A., & de Lange, T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00542-6 · Cited by 1,409 · see citing works
A telomerase component is defective in the human disease dyskeratosis congenita
Mitchell, J. R., Wood, E., & Collins, K. (1999) · Nature · doi:10.1038/990141 · Cited by 1,168 · see citing works
Vaziri, H., & Benchimol, S. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70109-5 · Cited by 1,003 · see citing works
Armanios, M., & Blackburn, E. H. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3246 · Cited by 982 · see citing works
Heiss, N. S., Knight, S. W., Vulliamy, T. J., Klauck, S. M., Wiemann, S., Mason, P. J., Poustka, A., & Dokal, I. (1998) · Nature Genetics · doi:10.1038/ng0598-32 · Cited by 976 · see citing works
The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P. J., & Dokal, I. (2001) · Nature · doi:10.1038/35096585 · Cited by 960 · see citing works
Calado, R. T., & Young, N. S. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0903373 · Cited by 783 · see citing works
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works
Counter, C. M., Hahn, W. C., Wei, W., Caddle, S. D., Beijersbergen, R. L., Lansdorp, P. M., Sedivy, J. M., & Weinberg, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14723 · Cited by 649 · see citing works
Hypervariable ultra-long telomeres in mice
Kipling, D., & Cooke, H. J. (1990) · Nature · doi:10.1038/347400a0 · Cited by 614 · see citing works
Dyskeratosis congenita in all its forms
Dokal, I. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02109.x · Cited by 575 · see citing works
A New Yeast Poly(A) Polymerase Complex Involved in RNA Quality Control
Vaňáčová, Š., Wolf, J., Martin, G., Blank, D., Dettwiler, S., Friedlein, A., Langen, H., Keith, G., & Keller, W. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030189 · Cited by 567 · see citing works
Teixeira, M. T., Arneric, M., Sperisen, P., & Lingner, J. (2004) · Cell · doi:10.1016/s0092-8674(04)00334-4 · Cited by 526 · see citing works
A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis
Venteicher, A. S., Abreu, E. B., Meng, Z., McCann, K. E., Terns, R. M., Veenstra, T. D., Terns, M. P., & Artandi, S. E. (2009) · Science · doi:10.1126/science.1165357 · Cited by 522 · see citing works
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Wu, Y., Zeng, J., Roscoe, B. P., Liu, P., Yao, Q., Lazzarotto, C. R., Clement, K., Cole, M. A., Luk, K., Baricordi, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0401-y · Cited by 515 · see citing works
Self-citationA Box H/ACA Small Nucleolar RNA-Like Domain at the Human Telomerase RNA 3′ End
Mitchell, J. R., Cheng, J., & Collins, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.567 · Cited by 510 · see citing works
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases
Haycock, P., Burgess, S., Nounu, A., Zheng, J., Okoli, G. N., Bowden, J., Wade, K. H., Timpson, N. J., Evans, D. M., Willeit, P., et al. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2016.5945 · Cited by 510 · see citing works
Telomeres in the mouse have large inter-chromosomal variations in the number of T 2 AG 3 repeats
Zijlmans, J. M. J. M., Martens, U. M., Poon, S. S. S., Raap, A. K., Tanke, H. J., Ward, R. K., & Lansdorp, P. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7423 · Cited by 501 · see citing works
Stuart, B. D., Choi, J., Zaidi, S., Xing, C., Holohan, B., Chen, R., Choi, M., Dharwadkar, P., Torres, F., Girod, C. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3278 · Cited by 469 · see citing works
Flow cytometry and FISH to measure the average length of telomeres (flow FISH)
Baerlocher, G. M., Vulto, I., de Jong, G., & Lansdorp, P. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.263 · Cited by 449 · see citing works
Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex
Lubas, M., Christensen, M. S., Kristiansen, M. S., Domanski, M., Falkenby, L. G., Lykke‐Andersen, S., Andersen, J., Dziembowski, A., & Jensen, T. H. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.028 · Cited by 422 · see citing works
Common variants near TERC are associated with mean telomere length
Wellcome Trust Case Control Consortium, Codd, V., Mangino, M., van der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.532 · Cited by 344 · see citing works
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
Agarwal, S., Loh, Y., McLoughlin, E. M., Huang, J.-J., Park, I.-H., Miller, J. D., Huo, H.-G., Okuka, M., dos Reis, R., Loewer, S., et al. (2010) · Nature · doi:10.1038/nature08792 · Cited by 335 · see citing works
Self-citationVulliamy, T., Beswick, R., Kirwan, M., Marrone, A., Digweed, M., Walne, A., & Dokal, I. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800042105 · Cited by 334 · see citing works
Aravind, L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.7.1609 · Cited by 322 · see citing works
Walne, A. J., Vulliamy, T., Marrone, A., Beswick, R., Kirwan, M., Masunari, Y., Al-Qurashi, F.-H., Aljurf, M., & Dokal, I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm111 · Cited by 316 · see citing works
Stuart, B. D., Lee, J. S., Kozlitina, J., Noth, I., Devine, M. S., Glazer, C. S., Torres, F., Kaza, V., Girod, C. E., Jones, K. D., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70124-9 · Cited by 310 · see citing works
Human telomerase RNA and box H/ACA scaRNAs share a common Cajal body–specific localization signal
Jády, B. E., Bertrand, É., & Kiss, T. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200310138 · Cited by 272 · see citing works
Warlich, E., Kuehle, J., Cantz, T., Brugman, M., Maetzig, T., Galla, M., Filipczyk, A., Halle, S., Klump, H., Schöler, H., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2010.314 · Cited by 265 · see citing works
Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita
Zhong, F., Savage, S. A., Shkreli, M., Giri, N., Jessop, L., Myers, T., Chen, R., Alter, B. P., & Artandi, S. E. (2011) · Genes & Development · doi:10.1101/gad.2006411 · Cited by 262 · see citing works
McIntosh, B. E., Brown, M. E., Duffin, B. M., Maufort, J. P., Vereide, D. T., Slukvin, I. I., & Thomson, J. A. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2014.12.005 · Cited by 258 · see citing works
Aubert, G., Baerlocher, G. M., Vulto, I. M., Poon, S. S. S., & Lansdorp, P. M. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002696 · Cited by 257 · see citing works
Haycock, P. C., Hemani, G., & Aviv, A. (2017) · JAMA Oncology · doi:10.1001/jamaoncol.2017.2316 · Cited by 209 · see citing works
Stanley, S. E., Gable, D. L., Wagner, C. L., Carlile, T. M., Hanumanthu, V. S., Podlevsky, J. D., Khalil, S. E., Dezern, A. E., Rojas-Durán, M. F., Applegate, C. D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7837 · Cited by 207 · see citing works
Telomerase RNA level limits telomere maintenance in X-linked dyskeratosis congenitaPreprint
Wong, J. M. Y., & Collins, K. (2006) · Genes & Development · doi:10.1101/gad.1476206 · Cited by 201 · see citing works
Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita
Tummala, H., Walne, A. J., Collopy, L. C., Cardoso, S. R., de la Fuente, J., Lawson, S., Powell, J., Cooper, N. S., Foster, A. C., Mohammed, S. N., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78963 · Cited by 198 · see citing works
Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component
Moon, D. H., Segal, M., Boyraz, B., Guinan, E. C., Hofmann, I., Cahan, P., Tai, A., & Agarwal, S. (2015) · Nature Genetics · doi:10.1038/ng.3423 · Cited by 183 · see citing works
Self-citationExtensive telomere repeat arrays in mouse are hypervariable
Starling, J., Maule, J., Hastie, N. D., & Allshire, R. C. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.23.6881 · Cited by 173 · see citing works
The molecular genetics of the telomere biology disorders
Bertuch, A. A. (2015) · RNA Biology · doi:10.1080/15476286.2015.1094596 · Cited by 169 · see citing works
Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation
Lim, J., Kim, D., Lee, Y.-S., Ha, M., Lee, M., Yeo, J., Chang, H., Song, J., Ahn, K., & Kim, V. N. (2018) · Science · doi:10.1126/science.aam5794 · Cited by 165 · see citing works
Dietz, A. C., Orchard, P. J., Baker, K. S., Giller, R., Savage, S. A., Alter, B. P., & Tolar, J. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2010.65 · Cited by 151 · see citing works
Human Telomerase RNA Processing and Quality Control
Tseng, C.-K., Wang, H.-F., Burns, A. M., Schroeder, M. R., Gaspari, M., & Baumann, P. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.075 · Cited by 148 · see citing works
Povedano, J. M., Martinez, P., Serrano, R., Tejera, Á., Gómez-López, G., Bobadilla, M., Flores, J. M., Bosch, F., & Blasco, M. A. (2018) · eLife · doi:10.7554/elife.31299 · Cited by 139 · see citing works
A novel orally available small molecule that inhibits hepatitis B virus expression
Mueller, H., Wildum, S., Luangsay, S., Walther, J., Lopez, A., Tropberger, P., Ottaviani, G., Lu, W., Parrott, N. J., Zhang, J. D., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.10.014 · Cited by 133 · see citing works
Marrone, A., Stevens, D., Vulliamy, T., Dokal, I. S., & Mason, P. J. (2004) · Blood · doi:10.1182/blood-2004-05-1829 · Cited by 124 · see citing works
Soerensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., Andersen‐Ranberg, K., Stevnsner, T., Bohr, V. A., Kimura, M., et al. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00775.x · Cited by 124 · see citing works
Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells
Ramunas, J., Yakubov, E., Brady Jennifer, J., Corbel, S. Y., Holbrook, C., Brandt, M., Stein, J., Santiago, J. G., Cooke, J. P., & Blau, H. M. (2015) · The FASEB Journal · doi:10.1096/fj.14-259531 · Cited by 123 · see citing works
Revertant Somatic Mosaicism by Mitotic Recombination in Dyskeratosis Congenita
Jongmans, M. C. J., Verwiel, E. T. P., Heijdra, Y. F., Vulliamy, T., Kamping, E. J., Hehir‐Kwa, J. Y., Bongers, E. M. H. F., Pfundt, R., van Emst, L., van Leeuwen, F. N., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.01.004 · Cited by 121 · see citing works
Nguyen, D., St-Sauveur, V. G., Bergeron, D., Dupuis‐Sandoval, F., Scott, M. S., & Bachand, F. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.11.003 · Cited by 121 · see citing works
Gable, D. L., Gaysinskaya, V. A., Atik, C. C., Talbot, C. C., Kang, B., Stanley, S. E., Pugh, E., Amat-Codina, N., Schenk, K. M., Arcasoy, M. O., et al. (2019) · Genes & Development · doi:10.1101/gad.326785.119 · Cited by 121 · see citing works
Nagpal, N., Ahmad, H. M., Molparia, B., & Kulshreshtha, R. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt107 · Cited by 120 · see citing works
Self-citationInhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects
Shukla, S., Schmidt, J. C., Goldfarb, K. C., Cech, T. R., & Parker, R. (2016) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3184 · Cited by 114 · see citing works
Dhanraj, S., Gunja, S. M. R., Deveau, A. P., Nissbeck, M., Boonyawat, B., Coombs, A. J., Renieri, A., Mucciolo, M., Marozza, A., Buoni, S., et al. (2015) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2015-103292 · Cited by 96 · see citing works
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation
Shukla, S., Bjerke, G. A., Muhlrad, D., Yi, R., & Parker, R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.010 · Cited by 91 · see citing works
Regulating telomere length from the inside out: the replication fork modelPreprint
Greider, C. W. (2016) · Genes & Development · doi:10.1101/gad.280578.116 · Cited by 88 · see citing works
PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization
Mueller, H., Lopez, A., Tropberger, P., Wildum, S., Schmaler, J., Pedersen, L., Han, X., Wang, Y., Ottosen, S., Song, Y., et al. (2018) · Hepatology · doi:10.1002/hep.30329 · Cited by 87 · see citing works
Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants
Swaminathan, A. C., Neely, M. L., Frankel, C. W., Kelly, F. L., Petrovski, S., Durheim, M. T., Bush, E., Snyder, L. D., Goldstein, D. B., Todd, J. L., et al. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.03.030 · Cited by 82 · see citing works
PARN and TOE1 Constitute a 3′ End Maturation Module for Nuclear Non-coding RNAs
Son, A., Park, J.-E., & Kim, V. N. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.089 · Cited by 75 · see citing works
Hyrina, A., Jones, C. T., Chen, D., Clarkson, S., Cochran, N. R., Feucht, P. H., Hoffman, G. R., Lindeman, A., Russ, C., Sigoillot, F. D., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.113 · Cited by 69 · see citing works
Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts
Westin, E. R., Chavez, E. A., Lee, K. M., Gourronc, F. A., Riley, S., Lansdorp, P. M., Goldman, F. D., & Klingelhutz, A. J. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00288.x · Cited by 67 · see citing works
Shen, Q., Zhang, Z., Yu, L., Cao, L., Zhou, D., Kan, M., Li, B., Zhang, D., He, L., & Liu, Y. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.4 · Cited by 65 · see citing works
Posttranscriptional manipulation of TERC reverses molecular hallmarks of telomere disease
Boyraz, B., Moon, D. H., Segal, M., Muosieyiri, M. Z., Aykanat, A., Tai, A., Cahan, P., & Agarwal, S. (2016) · Journal of Clinical Investigation · doi:10.1172/jci87547 · Cited by 59 · see citing works
Self-citationTelomerase RNA Levels Limit the Telomere Length EquilibriumPreprint
Greider, C. W. (2006) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2006.71.063 · Cited by 56 · see citing works
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease
Roake, C. M., Chen, L., Chakravarthy, A. L., Ferrell, J. E., Raffa, G. D., & Artandi, S. E. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.02.033 · Cited by 52 · see citing works
Evaluation and Management of Hematopoietic Failure in Dyskeratosis Congenita
Agarwal, S. (2018) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2018.04.003 · Cited by 49 · see citing works
Self-citationThe H/ACA complex disrupts triplex in hTR precursor to permit processing by RRP6 and PARN
Tseng, C. K., Wang, H., Schroeder, M. R., & Baumann, P. (2018) · Nature Communications · doi:10.1038/s41467-018-07822-6 · Cited by 47 · see citing works
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia
Aalbers, A. M., Calado, R. T., Young, N. S., Zwaan, C. M., Wu, C. O., Kajigaya, S., Coenen, E. A., Baruchel, A., Geleijns, K. P. W., de Haas, V., et al. (2013) · Leukemia · doi:10.1038/leu.2013.57 · Cited by 44 · see citing works
Fok, W. C., Shukla, S., Vessoni, A. T., Brenner, K. A., Parker, R., Sturgeon, C. M., & Batista, L. F. Z. (2019) · Blood · doi:10.1182/blood-2018-11-885368 · Cited by 40 · see citing works
Kirwan, M., Beswick, R. W., Vulliamy, T., Nathwani, A. C., Walne, A. J., Casimir, C. M., & Dokal, I. S. (2008) · British Journal of Haematology · doi:10.1111/j.1365-2141.2008.07516.x · Cited by 37 · see citing works
3′ terminal diversity of MRP RNA and other human noncoding RNAs revealed by deep sequencing
Goldfarb, K. C., & Cech, T. R. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-23 · Cited by 36 · see citing works
PARN Modulates Y RNA Stability and Its 3′-End Formation
Shukla, S., & Parker, R. (2017) · Molecular and Cellular Biology · doi:10.1128/mcb.00264-17 · Cited by 35 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00842-x · Cited by 754 · see citing works
Telomeres: history, health, and hallmarks of aging
Chakravarti, D., LaBella, K. A., & DePinho, R. A. (2021) · Cell · doi:10.1016/j.cell.2020.12.028 · Cited by 637 · see citing works
Genetics of human telomere biology disorders
Revy, P., Kannengiesser, C., & Bertuch, A. A. (2022) · Nature Reviews Genetics · doi:10.1038/s41576-022-00527-z · Cited by 243 · see citing works
Molecular mechanisms of telomere biology disorders
Grill, S., & Nandakumar, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.014017 · Cited by 107 · see citing works
The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation
Shukla, S., Bjerke, G. A., Muhlrad, D., Yi, R., & Parker, R. (2019) · Molecular Cell · doi:10.1016/j.molcel.2019.01.010 · Cited by 91 · see citing works
Inherited bone marrow failure in the pediatric patient
Dokal, I. S., Tummala, H., & Vulliamy, T. (2022) · Blood · doi:10.1182/blood.2020006481 · Cited by 87 · see citing works
Immunological factors linked to geographical variation in vaccine responses
van Dorst, M. M. A. R., Pyuza, J. J., Nkurunungi, G., Kullaya, V. I., Smits, H. H., Hogendoorn, P. C. W., Wammes, L. J., Everts, B., Elliott, A. M., Jochems, S. P., et al. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00941-2 · Cited by 85 · see citing works
Kam, M. L. W., Nguyen, T. T. T., & Ngeow, J. Y. Y. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00198-5 · Cited by 82 · see citing works
Bountziouka, V. P., Musicha, C., Allara, E., Kaptoge, S. K., Wang, Q., Angelantonio, E. D., Butterworth, A. S., Thompson, J. R., Danesh, J., Wood, A., et al. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(22)00072-1 · Cited by 77 · see citing works
Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963054 · Cited by 78 · see citing works
Thymidine nucleotide metabolism controls human telomere length
Mannherz, W. P., & Agarwal, S. (2023) · Nature Genetics · doi:10.1038/s41588-023-01339-5 · Cited by 76 · see citing works
Self-citationThe biology and management of dyskeratosis congenita and related disorders of telomeres
Tummala, H., Walne, A. J., & Dokal, I. S. (2022) · Expert Review of Hematology · doi:10.1080/17474086.2022.2108784 · Cited by 71 · see citing works
Adegunsoye, A., Kropski, J. A., Behr, J., Blackwell, T. S., Corte, T. J., Cottin, V., Glanville, A. R., Glassberg, M. K., Griese, M., Hunninghake, G. M., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202401-0238so · Cited by 76 · see citing works
Perspectives on scaling production of adipose tissue for food applications
Yuen, J. S. K., Stout, A. J., Kawecki, N. S., Letcher, S. M., Theodossiou, S. K., Cohen, J. M., Barrick, B. M., Saad, M. K., Rubio, N. R., Pietropinto, J. A., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121273 · Cited by 53 · see citing works
Telomerase RNA processing: Implications for human health and disease
Nagpal, N., & Agarwal, S. (2020) · Stem Cells · doi:10.1002/stem.3270 · Cited by 46 · see citing works
Self-citationShukla, S., Jeong, H., Sturgeon, C. M., Parker, R., & Batista, L. F. Z. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001848 · Cited by 41 · see citing works
Telomeres in Interstitial Lung Disease
Stock, C. J. W., & Renzoni, E. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10071384 · Cited by 43 · see citing works
Telomere length and metabolic syndrome traits: A Mendelian randomisation study
Loh, N. Y., Noordam, R., & Christodoulides, C. (2021) · Aging Cell · doi:10.1111/acel.13445 · Cited by 39 · see citing works
Zhao, N., Yin, G., Liu, R. C.-F., Zhang, W.-Y., Shen, Y., Wang, D., Lin, Z., Yang, J., Mao, J., Guo, R., et al. (2023) · Cell Discovery · doi:10.1038/s41421-023-00538-y · Cited by 14 · see citing works
TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly
Klump, B. M., Perez, G. I., Patrick, E. M., Adams-Boone, K., Cohen, S. B., Li, H., Yu, K., & Schmidt, J. C. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112577 · Cited by 38 · see citing works
Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine
Alonso-González, A., Tosco-Herrera, E., Molina‐Molina, M., & Flores, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1152211 · Cited by 33 · see citing works
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita
Tummala, H., Walne, A. J., Badat, M., Patel, M., Walne, A. M., Alnajar, J., Chow, C. C., Albursan, I., Frost, J. M., Ballard, D., et al. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00118-x · Cited by 28 · see citing works
The ZCCHC14/TENT4 complex is required for hepatitis A virus RNA synthesis
Li, Y., Misumi, I., Shiota, T., Sun, L., Lenarcic, E. M., Kim, H., Shirasaki, T., Hertel-Wulff, A., Tibbs, T., Mitchell, J. E., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204511119 · Cited by 28 · see citing works
Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review
Xue, T., Zhu, Z., Wang, L., Li, C., Sun, L., Wang, W., & Gong, W. (2023) · Aging and Disease · doi:10.14336/ad.2023.00808-1 · Cited by 34 · see citing works
Telomeres, telomerase, and cancer: mechanisms, biomarkers, and therapeutics
Shou, S., Maolan, A., Zhang, D., Jiang, X., Liu, F., Li, Y., Zhang, X., Geer, E., Pu, Z., Hua, B., et al. (2025) · Experimental Hematology and Oncology · doi:10.1186/s40164-025-00597-9 · Cited by 29 · see citing works
Regulation of human telomerase RNA biogenesis and localization
Jian, Q., & Autexier, C. (2020) · RNA Biology · doi:10.1080/15476286.2020.1809196 · Cited by 26 · see citing works
Vieri, M., Brümmendorf, T. H., & Beier, F. (2021) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2021.101282 · Cited by 23 · see citing works
Telomere biology disorders: time for moving towards the clinic?
Batista, L. F. Z., Dokal, I. S., & Parker, R. (2022) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2022.08.001 · Cited by 24 · see citing works
Telomeres: Dysfunction, Maintenance, Aging and Cancer
Liao, P., Yan, B., Wang, C., & Lei, P. (2023) · Aging and Disease · doi:10.14336/ad.2023.1128 · Cited by 22 · see citing works
Premature aging and metabolic diseases: the impact of telomere attrition
Jinesh, S., Özüpek, B., & Aditi, P. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1541127 · Cited by 21 · see citing works
Choo, S.-A. S., Lorbeer, F. K., Regalado, S. G., Short, S. B., Wu, S., Rieser, G., Bertuch, A. A., & Hockemeyer, D. F. (2022) · Blood · doi:10.1182/blood.2021013750 · Cited by 20 · see citing works
Bhoopalan, S. V., Włodarski, M. W., Reiss, U. M., Triplett, B. M., & Sharma, A. (2021) · Pediatric Blood & Cancer · doi:10.1002/pbc.29177 · Cited by 20 · see citing works
Rolles, B., Tometten, M., Meyer, R., Kirschner, M., Beier, F., & Brümmendorf, T. H. (2024) · Transfusion Medicine and Hemotherapy · doi:10.1159/000540109 · Cited by 18 · see citing works
Nurturing longevity through natural compounds: Where do we stand, and where do we go?
Todorova, M. N., Savova, M. S., Mihaylova, L. V., & Georgiev, M. I. (2024) · Food Frontiers · doi:10.1002/fft2.350 · Cited by 17 · see citing works
Stem cells at odds with telomere maintenance and protection
Penev, A., Markiewicz-Potoczny, M., Sfeir, A., & Denchi, E. L. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2021.12.007 · Cited by 18 · see citing works
Recent advances in understanding telomere diseases
Carvalho, V. S., Gomes, W. R., & Calado, R. T. (2022) · Faculty Reviews · doi:10.12703/r/11-31 · Cited by 17 · see citing works
Li, X., Liu, Y., Yao, H., Wang, M., Gao, L., Lou, J., Mao, J., Wu, W., Zhou, Y., Tang, Y., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00094-22 · Cited by 15 · see citing works
RNA tailing machinery drives amyloidogenic phase transition
Bokros, M., Balukoff, N. C., Grunfeld, A. M., Sebastiao, M., Beurel, E., Bourgault, S., & Lee, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316734121 · Cited by 15 · see citing works
Sande, C. M., Chen, S., Mitchell, D. V., Lin, P., Abraham, D. M., Cheng, J. M., Gebhard, T., Deolikar, R. J., Freeman, C. M., Zhou, M., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci181659 · Cited by 15 · see citing works
Self-citationInduced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility
Adegunsoye, A., Gonzales, N. M., & Gilad, Y. (2023) · Annual Review of Genetics · doi:10.1146/annurev-genet-022123-090319 · Cited by 13 · see citing works
Host RNA quality control as a hepatitis B antiviral target
Block, T. M., Young, J. A. T., Javanbakht, H., Sofia, M. J., & Zhou, T. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104972 · Cited by 11 · see citing works
Choi, Y., Kim, M. S., Rhoades, J. H., Johnson, N. M., Berry, C. T., Root, S., Chen, Q., Tian, Y., Fernandez, R. J., Cramer, Z., et al. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.06.003 · Cited by 11 · see citing works
A roadmap to precision treatments for familial pulmonary fibrosis
Hurley, K., Ozaki, M., Philippot, Q., Galvin, L., Crosby, D., Kirwan, M., Gill, D. R., Alysandratos, K., Jenkins, G. R., Griese, M., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105135 · Cited by 10 · see citing works
Chen, Z. S., Peng, S. I., Leong, L. I., Gall-Duncan, T., Wong, N., Li, T. H., Lin, X., Wei, Y., Koon, A. C., Huang, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58618-4 · Cited by 9 · see citing works
Telomere biology and ribosome biogenesis: structural and functional interconnections
Valeeva, L. R., Abdulkina, L. R., Аgabekian, I. A., & Shakirov, E. V. (2023) · Biochemistry and Cell Biology · doi:10.1139/bcb-2022-0383 · Cited by 10 · see citing works
Li, S., Qian, X., Fang, G., Deng, Y., Yang, F., Qiu, C., Yang, Y., & Lan, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166859 · Cited by 8 · see citing works
Regulation of telomerase towards tumor therapy
Yan, S., Song, L., Qiu, H., Wang, X., He, Y., Wang, C., & Huang, Y. Y. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01181-6 · Cited by 9 · see citing works
A missense variant in the nuclear localization signal of DKC1 causes Hoyeraal-Hreidarsson syndrome
Chu, C.-M., Yu, H., Kao, T.-L., Chen, Y.-H., Lu, H., Wu, E., Yang, Y., Lin, C., Lin, S., Tsai, M.-J. M., et al. (2022) · npj Genomic Medicine · doi:10.1038/s41525-022-00335-8 · Cited by 8 · see citing works
Pediatric Bone Marrow Failure: A Broad Landscape in Need of Personalized Management
Vissers, L. T. W., van der Burg, M., Lankester, A. C., Smiers, F. J. W., Bartels, M., & Mohseny, A. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12227185 · Cited by 10 · see citing works
Small Molecules Restore Telomeres in Patient Stem Cells
Brenner, K. A., & Nandakumar, J. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.05.003 · Cited by 8 · see citing works
Nagpal, N., & Agarwal, S. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01429-1 · Cited by 7 · see citing works
Self-citationDomain specific mutations in dyskerin disrupt 3′ end processing of scaRNA13
Nagpal, N., Tai, A., Nandakumar, J., & Agarwal, S. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac706 · Cited by 7 · see citing works
Self-citationTavares-Marcos, C., Correia, M., & de Jesus, B. B. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102773 · Cited by 6 · see citing works
Galati, A., Scatolini, L., Micheli, E., Bavasso, F., Cicconi, A., Maccallini, P., Chen, L., Roake, C. M., Schoeftner, S., Artandi, S. E., et al. (2021) · FEBS Letters · doi:10.1002/1873-3468.14240 · Cited by 6 · see citing works
Inducible pluripotent stem cell models to study bone marrow failure and MDS predisposition syndromes
Sahoo, S. S., Khiami, M., & Włodarski, M. W. (2024) · Experimental Hematology · doi:10.1016/j.exphem.2024.104669 · Cited by 6 · see citing works
Maturation and shuttling of the yeast telomerase RNP: assembling something new using recycled parts
Bartle, L., Vasianovich, Y., & Wellinger, R. J. (2021) · Current Genetics · doi:10.1007/s00294-021-01210-2 · Cited by 6 · see citing works
Molecular insight of dyskeratosis congenita: Defects in telomere length homeostasis
Dorgaleleh, S., Naghipoor, K., Hajimohammadi, Z., Dastaviz, F., & Oladnabi, M. (2022) · Journal of Clinical and Translational Research · doi:10.18053/jctres.08.202201.002 · Cited by 5 · see citing works
Mechanistic insights into stem cell aging: Pathways and processes
Fauzi, A., Wong, C. Z. E., Tee, P. Y. E., Yau, A. W. N., Rashid, E. A., Tang, Y. Q., & Chia, A. Y. Y. (2026) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2026.112160 · Cited by 5 · see citing works
Advances in understanding telomerase assembly
Klump, B. M., & Schmidt, J. C. (2023) · Biochemical Society Transactions · doi:10.1042/bst20230269 · Cited by 5 · see citing works
TCAB1 prevents nucleolar accumulation of the telomerase RNA to promote telomerase assemblyPreprint
Klump, B. M., Perez, G. I., Patrick, E. M., Adams-Boone, K., Cohen, S. B., Li, H., Yu, K., & Schmidt, J. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.27.445986 · Cited by 5 · see citing works
Telomere biology disorders and hepatic disease
Pirzada, S. A., Aleyadeh, W., Fathma, S., Koh, C., Plessier, A., Kleiner, D. E., & Heller, T. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.05.004 · Cited by 4 · see citing works
Kuru, G., Üner, G., & Bedіr, E. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-022-09829-w · Cited by 4 · see citing works
Comparative transcriptomics analysis at the key stage of maize ear development dissect heterosis
Wang, L., Li, J., Lin, Y. Y., Dang, K., Wan, J., Meng, S., Qiu, X., Wang, Q., Mu, L., Ding, D., et al. (2022) · The Plant Genome · doi:10.1002/tpg2.20293 · Cited by 4 · see citing works
Telomeropathies in Interstitial Lung Disease and Lung Transplant Recipients
Southern, B. D., & Gadre, S. K. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14051496 · Cited by 6 · see citing works
Saad, F. A. (2024) · Current Gene Therapy · doi:10.2174/0115665232286489240320051925 · Cited by 5 · see citing works
Oppezzo, A., Sepe, S., Cicio, G., Cancila, V., Sasso, E., Conti, A., Marinelli, E., Cabrini, M., Pallavi, R., Iacomino, N., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01136-9 · Cited by 3 · see citing works
Klinaki, E., & Ogrodnik, M. B. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111929 · Cited by 3 · see citing works
Discovery, optimization and biological evaluation of novel HBsAg production inhibitors
Zhang, L., Ge, X., Jin, H., Lu, D., Chen, S., Zhang, Y., Wang, X., Xu, H., Ao, W., & Zhang, Y. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115387 · Cited by 3 · see citing works
Therapeutic strategies targeting somatic stem cells: Chemical approaches
Chen, Y., & Ding, S. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115824 · Cited by 3 · see citing works
Ignatieva, E. V., Yudin, N. S., & Larkin, D. M. (2023) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vjgb-23-34 · Cited by 3 · see citing works
Samajdar, A., Amato, R., Jo, S., Cordes, E., Tai, A., Raffa, G. D., & Batista, L. F. Z. (2026) · Genes & Development · doi:10.1101/gad.353100.125 · Cited by 3 · see citing works
Self-citationEstablished and emerging non-cellular therapies in inherited bone marrow failure syndromes
Janczar, S., Urbański, B., Ussowicz, M., & Mlynarski, W. M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1773574 · Cited by 2 · see citing works
Primer- and template-independent RNA polymerization by terminal nucleotidyltransferase TENT4B
Nagpal, N., Tai, A., Fong, Y. W., & Agarwal, S. (2026) · Nucleic Acids Research · doi:10.1093/nar/gkag864 · Cited by 2 · see citing works
Self-citationTelomerase-Mediated Anti-Ageing Interventions
Dunn, P. L., Logeswaran, D., & Chen, J. J. ‐. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-66768-8_1 · Cited by 2 · see citing works
Genetic aspects of telomere biology disorders
de Tocqueville, S., Morel, H., Ba, I., Revy, P., & Kannengiesser, C. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.03.011 · Cited by 2 · see citing works
Inherited Bone Marrow Failure Syndromes
Mangaonkar, A. A., Ferrer, A., Ali, A., Kohorst, M. A., & Patnaik, M. M. (2024) · doi:10.1002/9781683674023.ch72 · Cited by 2 · see citing works
Telomere Shortening in Interstitial Lung Disease: Challenges and Promises
Jin, H., Song, J., Gao, R., Sha, B., Wang, S., Luo, P., Yu, L., Xu, X., & Wang, X. (2025) · The Clinical Respiratory Journal · doi:10.1111/crj.70103 · Cited by 1 · see citing works
circHERC1—A telomerase activator
Cui, Y., He, Y., Wu, X., Dong, Y., Li, Y., Man, W., Li, X., Chen, S., Pang, F., Li, Y., et al. (2025) · Science Advances · doi:10.1126/sciadv.adz3680 · Cited by 2 · see citing works
Extracellular vesicles for delivery of functional telomerase
He, Y., Cui, Y., Wang, L., Yang, W., Wang, R., Li, Y., Ma, Y., Lin, Y., Wu, X., Cheng, L., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02524-1 · Cited by 1 · see citing works
Carbene-Catalyzed Asymmetric Synthesis of Thiophene-Fused Lactams
Shi, D., Zhang, H., Zhang, Y., & Fu, Z. (2026) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.5c02874 · Cited by 1 · see citing works
Telomeres and telomerase: revealing the end game
Rivosecchi, J., Wu, G., & Cech, T. R. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.07.010 · Cited by 1 · see citing works
Telomere dysfunction in some pediatric congenital and growth-related diseases
Zheng, B., & Fu, J. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1133102 · Cited by 1 · see citing works
Wen, J. M., Gloude, N. J., & Ebens, C. L. (2025) · Seminars in Hematology · doi:10.1053/j.seminhematol.2026.03.002 · Cited by 1 · see citing works
End Products of Telomere Research
Reddel, R. R., MacKenzie, K. L., & Bryan, T. M. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.05.006
Fyn interrupts telomere maintenance in stem cells by phosphorylating menin at tyrosine 603Preprint
Paul, S., McCourt, P. M., Le, L. T. M., Ryu, J., Czaja, W., Bode, A. M., Contreras-Galindo, R., & Dong, Z. (2022) · Research Square · doi:10.21203/rs.3.rs-1425640/v1
Liu, S., Chen, T., Tan, Y., Qin, J., Han, Y., Fan, W., & Qu, S.-L. (2022) · Research Square · doi:10.21203/rs.3.rs-2146456/v1
Ma, H., Wu, X., Li, Y., & Xia, Y. (2022) · Kompass Neumología · doi:10.1159/000526906
Pulmonary Fibrosis: One Manifestation, Various Diseases
Ruaro, B., Matucci‐Cerinic, M., Baratella, E., Confalonieri, M., Salton, F., & Hughes, M. (2022) · Frontiers research topics · doi:10.3389/978-2-83250-654-7
The molecular basis of bone marrow failure syndromes and red cell enzymopathies
Iskander, D., Luzzatto, L., & Karadimitris, A. (2024) · Wiley eBooks · doi:10.1002/9781394180486.ch11
The Immune System and Hematopoietic Stem Cells
Elshimali, Y., Chatty, E. M., & Vadgama, J. V. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15717-2.00094-9
Kannengiesser, C., & Revy, P. (2024) · Wiley eBooks · doi:10.1002/9781394300808.ch12
The Immunologic Complications and Genetic Origins of Telomere Biology Disorders
de Tocqueville, S., Touzot, F., & Revy, P. (2024) · Elsevier eBooks · doi:10.1016/b978-0-128-24465-4.00040-5
Stern, J. L., Rizzardi, L. F., & Gassman, N. R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614488
Dyskeratosis congenita future: Hematopoietic stem cell transplantation or gene therapy?
Manoochehrabadi, S., Behfar, M., Ahmadvand, M., & Hamidieh, A. A. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.102072
Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?
Block, T. M., Gotchev, D., & Du, Y. (2025) · Antiviral Research · doi:10.1016/j.antiviral.2025.106288
Qu, L., Ding, S., Qian, L., & Yi, W. (2025) · Discover Oncology · doi:10.1007/s12672-025-03594-w
Glass, J., Groarke, E. M., & Young, N. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-02386-5_17
Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanismPreprint
Mannherz, W. P., Homfeldt, L., Lampl, N. M., & Agarwal, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.01.728939
Self-citationSenescence modulated cardiac repair with pluripotent stem cell-derived cardiomyocytes
Zhao, J., Kadota, S., Ichimura, H., Yang, X., Kusabuka, H., Kobayashi, H., Kitaori, Y., Takahashi, H., Omar, Z. G., Caruso, A., et al. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05062-w
- Authors
- Nagpal, N., Wang, J., Zeng, J., Lo, E., Moon, D. H., Luk, K., Braun, R. O., Burroughs, L. M., Keel, S. B., Reilly, C., Lindsley, R. C., Wolfe, S. A., Tai, A. K., Cahan, P., Bauer, D. E., Fong, Y. W., & Agarwal, S.
- Affiliations
- Boston Children's Hospital (US)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Johns Hopkins University (US)
- University of Massachusetts Chan Medical School (US)
- Seattle Children's Hospital (US)
- Dana-Farber Cancer Institute (US)
- Tufts University (US)
- Corresponding author
- Agarwal, Suneet
- ORCID
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 26
- Issue
- 6
- Pages
- 896-909.e8
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC7275922
- OpenAlex
- W3017218125
- Cited by
- 105
- References
- 89
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 17 · 2023: 17 · 2022: 22 · 2021: 10 · 2020: 8 · 2019: 1
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Defense
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- telomerase activity, dyskeratosis congenita, pulmonary fibrosis, induced pluripotent stem cells, blood stem cells, xenotransplantation, stem cell exhaustion, age-related diseases
- MeSH terms
- Animals, Humans, Mutation, RNA, Telomere, Telomerase, Dyskeratosis Congenita, Mice, Induced Pluripotent Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review