Wu, Hao

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Liu, X., Zhang, Z., Ruan, J., Pan, Y., Magupalli, V. G., Wu, H., & Lieberman, J. (2016) · Nature

Inflammasome and immune disordersCell death mechanisms and regulation

Cited by 3,202

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,353

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

Lustbader, J. W., Cirilli, M., Lin, C., Xu, H. W., Takuma, K., Wang, N., Caspersen, C., Chen, X., Pollak, S., Chaney, M., et al. (2004) · Science

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 1,303

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

Li, J., McQuade, T., Siemer, A. B., Napetschnig, J., Moriwaki, K., Hsiao, Y.-S., Damko, E., Moquin, D., Walz, T., McDermott, A., et al. (2012) · Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 1,222

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

Hu, J. J., Liu, X., Xia, S., Zhang, Z., Zhang, Y., Zhao, J., Ruan, J., Luo, X., Lou, X., Bai, Y., et al. (2020) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,145

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Evavold, C. L., Ruan, J., Tan, Y., Xia, S., Wu, H., & Kagan, J. C. (2018) · Immunity

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 1,115

Helical Assembly in the MyD88-IRAK4-IRAK2 Complex in TLR/IL-1R Signalling

Lin, S.-C., Lo, Y.-C., & Wu, H. (2010) · Nature

Immune Response and InflammationNF-κB Signaling Pathways

Cited by 1,111

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

Sharif, H., Wang, L., Wang, W. L., Magupalli, V. G., Andreeva, L., Qiao, Q., Hauenstein, A. V., Wu, Z., Núñez, G., Mao, Y., et al. (2019) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 824

An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells

Zanoni, I., Tan, Y., Di Gioia, M., Broggi, A., Ruan, J., Shi, J., Donado, C. A., Shao, F., Wu, H., Springstead, J. R., et al. (2016) · Science

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 583

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

He, M., Chiang, H.-H., Luo, H., Zheng, Z., Qiao, Q., Wang, L., Tan, M., Ohkubo, R., Mu, W.-C., Zhao, S., et al. (2020) · Cell Metabolism

Inflammasome and immune disordersSirtuins and Resveratrol in Medicine

Cited by 425

NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation

Andreeva, L., David, L., Rawson, S., Shen, C., Pasricha, T., Pelegrin, P., & Wu, H. (2021) · Cell

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 292

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

Onizawa, M., Oshima, S., Schulze-Topphoff, U., Oses-Prieto, J. A., Lu, T., Tavares, R., Prodhomme, T., Duong, B., Whang, M. I., Advincula, R., et al. (2015) · Nature Immunology

Cell death mechanisms and regulationUbiquitin and proteasome pathways

Cited by 284

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

Wei, S., Kozono, S., Kats, L., Nechama, M., Li, W., Guarnerio, J., Luo, M., You, M.-H., Yao, Y., Kondo, A., et al. (2015) · Nature Medicine

Signaling Pathways in DiseaseRetinoids in leukemia and cellular processes

Cited by 272

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Fu, T.-M., Li, Y., Lu, A., Li, Z., Vajjhala, P. R., Cruz, A. C., Srivastava, D. B., DiMaio, F., Penczek, P. A., Siegel, R. M., et al. (2016) · Molecular Cell

Cell death mechanisms and regulationInflammasome and immune disorders

Cited by 196

Structure of cytoplasmic ring of nuclear pore complex by integrative cryo-EM and AlphaFold

Fontana, P., Dong, Y., Pi, X., Tong, A. B., Hecksel, C. W., Wang, L., Fu, T.-M., Bustamante, C., & Wu, H. (2022) · Science

Nuclear Structure and FunctionAdvanced Electron Microscopy Techniques and Applications

Cited by 195

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

Fu, Q., Fu, T.-M., Cruz, A. C., Sengupta, P., Thomas, S. K., Wang, S., Siegel, R. M., Wu, H., & Chou, J. J. (2016) · Molecular Cell

Cell death mechanisms and regulationProtein Structure and Dynamics

Cited by 191

Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

Huang, Y., Rich, R. L., Myszka, D. G., & Wu, H. (2003) · Journal of Biological Chemistry

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 152

Structural studies of NF-κB signaling

Zheng, C., Yin, Q., & Wu, H. (2011) · Cell Research

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 134

The Canine Parvovirus Empty Capsid Structure

Wu, H., & Rossmann, M. G. (1993) · Journal of Molecular Biology

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 101

Structural principles of B cell antigen receptor assembly

Dong, Y., Pi, X., Bartels-Burgahn, F., Saltukoglu, D., Liang, Z., Yang, J., Alt, F. W., Reth, M., & Wu, H. (2022) · Nature

T-cell and B-cell ImmunologyReceptor Mechanisms and Signaling

Cited by 82

SARS-CoV-2 infects blood monocytes to activate NLRP3 and AIM2 inflammasomes, pyroptosis and cytokine release

Junqueira, C., Crespo, Â., Ranjbar, S., Ingber, J., Parry, B., Ravid, S., Lacerda, L. B. D., Lewandrowski, M., Clark, S., Ho, F., et al. (2021) · medRxiv

Inflammasome and immune disordersCOVID-19 Clinical Research Studies

Cited by 70

Eating the dead to keep atherosclerosis at bay

Brophy, M. L., Dong, Y., Wu, H., Rahman, H. N. A., Song, K., & Chen, H. (2017) · Frontiers in Cardiovascular Medicine

Atherosclerosis and Cardiovascular DiseasesPhagocytosis and Immune Regulation

Cited by 68

Phage defence system CBASS is regulated by a prokaryotic E2 enzyme that imitates the ubiquitin pathway

Yan, Y., Xiao, J., Huang, F., Xian, W., Yu, B., Cheng, R., Wu, H., Lu, X., Wang, X., Huang, W., et al. (2024) · Nature Microbiology

Bacteriophages and microbial interactionsinterferon and immune responses

Cited by 29

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

Yan, Y., Xiao, J., Huang, F., Yu, B., Cheng, R., Wu, H., Lu, X., Wang, X., Oyejobi, G. K., Robinson, C. V., et al. (2022) · Nature Microbiology

Bacteriophages and microbial interactionsinterferon and immune responses

Cited by 29