An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance
Open accessAbstract
It is well documented that the rate of aging can be slowed, but it remains unclear to which extent aging-associated conditions can be reversed. How the interface of immunity and metabolism impinges upon the diabetes pandemic is largely unknown. Here, we show that NLRP3, a pattern recognition receptor, is modified by acetylation in macrophages and is deacetylated by SIRT2, an NAD+-dependent deacetylase and a metabolic sensor. We have developed a cell-based system that models aging-associated inflammation, a defined co-culture system that simulates the effects of inflammatory milieu on insulin resistance in metabolic tissues during aging, and aging mouse models; and demonstrate that SIRT2 and NLRP3 deacetylation prevent, and can be targeted to reverse, aging-associated inflammation and insulin resistance. These results establish the dysregulation of the acetylation switch of the NLRP3 inflammasome as an origin of aging-associated chronic inflammation and highlight the reversibility of aging-associated chronic inflammation and insulin resistance.
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Reduced NAD+ levels impair SIRT2 activity, which normally deacetylates and inactivates the NLRP3 inflammasome, thereby counteracting inflammation.
“Reduced NAD+ levels also impair SIRT2 activity, which normally deacetylates and inactivates the NLR family pyrin domain containing 3 (NLRP3) inflammasome, thereby counteracting inflammation (71).”
From Connecting aging biology and inflammation in the omics era (2022) · cites this paper as [71]
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<i>Coot</i> : model-building tools for molecular graphics
Emsley, P., & Cowtan, K. (2004) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444904019158 · Cited by 30,571 · see citing works
The PyMOL Molecular Graphics System
DeLano, W. L. (2002) · Medical Entomology and Zoology · Cited by 18,147 · see citing works
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Inference of macromolecular assemblies from crystalline state.
Krissinel, E., & Henrick, K. (2007) · Journal of Molecular Biology · doi:10.1016/j.jmb.2007.05.022 · Cited by 10,189 · see citing works
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841 · see citing works
Large-scale analysis of the yeast proteome by multidimensional protein identification technology
Washburn, M. P., Wolters, D. A., & Yates, J. R. (2001) · Nature Biotechnology · doi:10.1038/85686 · Cited by 4,759 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence
Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531 · see citing works
Inflammasomes: mechanism of action, role in disease, and therapeutics
Guo, H., Callaway, J. B., & Ting, J. P.-Y. (2015) · Nature Medicine · doi:10.1038/nm.3893 · Cited by 3,340 · see citing works
Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works
NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
The Inflammasomes: Guardians of the Body
Martinon, F., Mayor, A., & Tschopp, J. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132715 · Cited by 2,436 · see citing works
Inflammasomes in health and disease
Strowig, T., Henao-Mejia, J., Elinav, E., & Flavell, R. (2012) · Nature · doi:10.1038/nature10759 · Cited by 2,230 · see citing works
Regulation of cellular metabolism by protein lysine acetylation
Zhao, S., Xu, W., Jiang, W., Yu, W., Lin, Y., Zhang, T., Yao, J., Zhou, L., Zeng, Y., Li, H., et al. (2010) · Science · doi:10.1126/science.1179689 · Cited by 1,910 · see citing works
Self-citationAge-related mutations associated with clonal hematopoietic expansion and malignancies
Xie, M., Lu, C., Wang, J., McLellan, M. D., Johnson, K. J., Wendl, M. C., McMichael, J. F., Schmidt, H. K., Yellapantula, V., Miller, C. A., et al. (2014) · Nature Medicine · doi:10.1038/nm.3733 · Cited by 1,874 · see citing works
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
Wen, H., Gris, D., Lei, Y. L., Jha, S., Zhang, L., Huang, M. T.-H., Brickey, W. J., & Ting, J. P. ‐. (2011) · Nature Immunology · doi:10.1038/ni.2022 · Cited by 1,811 · see citing works
Peng, J., Elias, J. E., Thoreen, C. C., Licklider, L., & Gygi, S. P. (2002) · Journal of Proteome Research · doi:10.1021/pr025556v · Cited by 1,652 · see citing works
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
Kuida, K., Lippke, J. A., Ku, G., Harding, M. W., Livingston, D. J., Su, M. S. S., & Flavell, R. A. (1995) · Science · doi:10.1126/science.7535475 · Cited by 1,606 · see citing works
Recent progress in the biology and physiology of sirtuins
Finkel, T., Deng, C., & Mostoslavsky, R. (2009) · Nature · doi:10.1038/nature08197 · Cited by 1,484 · see citing works
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Du, J., Zhou, Y., Su, X., Yu, J. J., Khan, S., Jiang, H., Kim, J., Woo, J., Kim, J. H., Choi, B. H., et al. (2011) · Science · doi:10.1126/science.1207861 · Cited by 1,429 · see citing works
Krieger, E., Joo, K., Lee, J., Lee, J., Raman, S., Thompson, J., Tyka, M., Baker, D. A., & Karplus, K. J. (2009) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.22570 · Cited by 1,396 · see citing works
Tabb, D. L., McDonald, W. H., & Yates, J. R. (2002) · Journal of Proteome Research · doi:10.1021/pr015504q · Cited by 1,369 · see citing works
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schröder, G. F., Fitzgerald, K. A., Wu, H., & Egelman, E. H. (2014) · Cell · doi:10.1016/j.cell.2014.02.008 · Cited by 1,353 · see citing works
Self-citationInflammation and cancer: how hot is the link?
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312 · see citing works
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
Qiu, X., Brown, K., Hirschey, M. D., Verdin, E., & Chen, D. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.11.015 · Cited by 1,310 · see citing works
Self-citationSomeya, S., Yu, W., Hallows, W. C., Xu, J., Vann, J. M., Leeuwenburgh, C., Tanokura, M., Denu, J. M., & Prolla, T. A. (2010) · Cell · doi:10.1016/j.cell.2010.10.002 · Cited by 1,150 · see citing works
Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
Yan, Y., Jiang, W., Liu, L., Wang, X., Ding, C., Tian, Z., & Zhou, R. (2015) · Cell · doi:10.1016/j.cell.2014.11.047 · Cited by 1,014 · see citing works
Acetylation of Metabolic Enzymes Coordinates Carbon Source Utilization and Metabolic Flux
Wang, Q., Zhang, Y., Yang, C., Xiong, H., Lin, Y., Yao, J., Li, H., Xie, L., Zhao, W., Yao, Y., et al. (2010) · Science · doi:10.1126/science.1179687 · Cited by 1,008 · see citing works
Self-citationInflammatory Markers and Onset of Cardiovascular Events: Results From the Health ABC Study
Cesari, M., Penninx, B. W. J. H., Newman, A. B., Kritchevsky, S. B., Nicklas, B. J., Sutton-Tyrrell, K., Rubin, S. M., Ding, J., Simonsick, E. M., Harris, T. B., et al. (2003) · Circulation · doi:10.1161/01.cir.0000097109.90783.fc · Cited by 978 · see citing works
Changes in Proinflammatory Cytokine Activity after Menopause
Pfeilschifter, J., Köditz, R., Pfohl, M., & Schatz, H. (2002) · Endocrine Reviews · doi:10.1210/edrv.23.1.0456 · Cited by 911 · see citing works
The origins of age-related proinflammatory state
Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D. D., Guralnik, J. M., & Longo, D. L. (2005) · Blood · doi:10.1182/blood-2004-07-2599 · Cited by 908 · see citing works
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901 · see citing works
Tao, R., Coleman, M. C., Pennington, J. D., Ozden, O., Park, S.-H., Jiang, H., Kim, H.-S., Flynn, C. R., Hill, S., Hayes McDonald, W., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.013 · Cited by 899 · see citing works
Pou, K. M., Massaro, J. M., Hoffmann, U., Vasan, R. S., Maurovich‐Horvat, P., Larson, M. G., Keaney, J. F., Meigs, J. B., Lipinska, I., Kathiresan, S., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.710509 · Cited by 898 · see citing works
Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
Zhao, C., Chen, A., Jamieson, C. H. M., Fereshteh, M., Abrahamsson, A. E., Blum, J. M., Kwon, H. Y., Kim, J., Chute, J. P., Rizzieri, D. A., et al. (2009) · Nature · doi:10.1038/nature07737 · Cited by 868 · see citing works
Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
Misawa, T., Takahama, M., Kozaki, T., Lee, H., Zou, J., Saitoh, T., & Akira, S. (2013) · Nature Immunology · doi:10.1038/ni.2550 · Cited by 863 · see citing works
Tracy, R. P., Lemaitre, R. N., Psaty, B. M., Ives, D. G., Evans, R. W., Cushman, M., Meilahn, E. N., & Kuller, L. H. (1997) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.17.6.1121 · Cited by 836 · see citing works
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis
Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830 · see citing works
Deubiquitination of NLRP3 by BRCC3 Critically Regulates Inflammasome Activity
Py, B. F., Kim, M.-S., Vakifahmetoglu-Norberg, H., & Yuan, J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.11.009 · Cited by 718 · see citing works
Inflammatory markers and cognition in well-functioning African-American and white elders
Yaffe, K., Lindquist, K., Penninx, B. W., Simonsick, E. M., Pahor, M., Kritchevsky, S., Launer, L., Kuller, L., Rubin, S., & Harris, T. (2003) · Neurology · doi:10.1212/01.wnl.0000073620.42047.d7 · Cited by 706 · see citing works
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., Harris, T. B., Kritchevsky, S. B., Newman, A. B., Colbert, L. H., Pahor, M., Rubin, S. M., Tylavsky, F. A., et al. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp097 · Cited by 683 · see citing works
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Plasma interleukin-6, tumour necrosis factor α and blood cytokine production in type 2 diabetes
Pickup, J. C., Chusney, G. D., Thomas, S. M., & Burt, D. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00622-6 · Cited by 566 · cited 1× · see citing works
“, 2009) and diseases (Aggarwal et al., 2006; Cesari et al., 2003; Cushman et al., 2005; Kalogeropoulos et al., 2010; Pickup et al., 2000; Pradhan et al., 2001; Ravaglia et al., 2007; Rodondi et al., 2010; Tracy et al., 1997; Weaver et al., 2002; Yaffe et al., 2003), but the origins of agingand overnutrition-associated…”
BackgroundA fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S. A., Ravnskjær, K., Schenk, S., Milne, J. C., Meyers, D. J., Cole, P., Yates, J. R., et al. (2008) · Nature · doi:10.1038/nature07349 · Cited by 556 · see citing works
Self-citationInterleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
Weaver, J. D., Huang, M.-H., Albert, M., Harris, T., Rowe, J. W., & Seeman, T. E. (2002) · Neurology · doi:10.1212/wnl.59.3.371 · Cited by 536 · see citing works
Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis
McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534 · see citing works
Leeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science · doi:10.1126/science.aag3048 · Cited by 528 · see citing works
ProLuCID: An improved SEQUEST-like algorithm with enhanced sensitivity and specificity
Xu, T., Park, S. K., Venable, J. D., Wohlschlegel, J. A., Diedrich, J. K., Cociorva, D., Lu, B., Liao, L., Hewel, J., Han, X., et al. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.07.001 · Cited by 511 · see citing works
NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation
Song, N., Liu, Z.-S., Xue, W., Bai, Z., Wang, Q., Dai, J., Liu, X., Huang, Y.-J., Cai, H., Zhan, X., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.08.017 · Cited by 494 · see citing works
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging
Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490 · see citing works
Self-citationInflammatory Markers and Incident Heart Failure Risk in Older Adults
Kalogeropoulos, A., Georgiopoulou, V., Psaty, B. M., Rodondi, N., Smith, A. L., Harrison, D. G., Liu, Y., Hoffmann, U., Bauer, D. C., Newman, A. B., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.045 · Cited by 478 · see citing works
The molecular inflammatory process in aging
Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., & Yu, B. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.572 · Cited by 437 · see citing works
SIRT3 Reverses Aging-Associated Degeneration
Brown, K., Xie, S., Qiu, X., Mohrin, M., Shin, J., Liu, Y., Zhang, D., Scadden, D. T., & Chen, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.005 · Cited by 436 · see citing works
Self-citationJiang, W., Wang, S., Xiao, M., Lin, Y., Zhou, L., Lei, Q., Xiong, Y., Guan, K., & Zhao, S. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.04.028 · Cited by 415 · see citing works
Self-citationQuantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8
Wang, G. G., Calvo, K. R., Pasillas, M. P., Sykes, D. B., Häcker, H., & Kamps, M. P. (2006) · Nature Methods · doi:10.1038/nmeth865 · Cited by 408 · see citing works
A quantitative analysis software tool for mass spectrometry–based proteomics
Park, S. K., Venable, J. D., Xu, T., & Yates, J. R. (2008) · Nature Methods · doi:10.1038/nmeth.1195 · Cited by 401 · see citing works
Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1
Lu, M., Wan, M., Leavens, K. F., Chu, Q., Monks, B. R., Fernandez, S., Ahima, R. S., Ueki, K., Kahn, C. R., & Birnbaum, M. J. (2012) · Nature Medicine · doi:10.1038/nm.2686 · Cited by 396 · see citing works
Jourdan, T., Godlewski, G., Cinar, R., Bertola, A., Szanda, G., Liu, J., Tam, J., Han, T., Mukhopadhyay, B., Skarulis, M. C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3265 · Cited by 388 · see citing works
Cushman, M., Arnold, A. M., Psaty, B. M., Manolio, T. A., Kuller, L. H., Burke, G. L., Polak, J. F., & Tracy, R. P. (2005) · Circulation · doi:10.1161/circulationaha.104.504159 · Cited by 368 · see citing works
Walker, A. K., Yang, F., Jiang, K., Ji, J., Watts, J. L., Purushotham, A., Boss, O., Hirsch, M. L., Ribich, S. A., Smith, J. J., et al. (2010) · Genes & Development · doi:10.1101/gad.1901210 · Cited by 352 · see citing works
Goodell, M. A., & Rando, T. A. (2015) · Science · doi:10.1126/science.aab3388 · Cited by 347 · see citing works
McDonald, W. H., Tabb, D. L., Sadygov, R. G., MacCoss, M. J., Venable, J. D., Graumann, J., Johnson, J. R., Cociorva, D., & Yates, J. R. (2004) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.1603 · Cited by 345 · see citing works
Recent advances in inflammasome biology
Place, D. E., & Kanneganti, T. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.10.011 · Cited by 331 · see citing works
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2002 · Cited by 303 · see citing works
Inoue, M., Williams, K. L., Gunn, M. D., & Shinohara, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201836109 · Cited by 288 · see citing works
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease
Shin, J., He, M., Liu, Y., Paredes, S., Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.10.007 · Cited by 287 · see citing works
Plasma cytokine profiles in elderly humans
Forsey, R. J., Thompson, J. M., Ernerudh, J., HURST, T. L., Strindhall, J., Johansson, B. E. A., Nilsson, B.-O., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00025-3 · Cited by 249 · see citing works
Inflammation and Race and Gender Differences in Computerized Tomography‐measured Adipose Depots
Beasley, L. E., Koster, A., Newman, A. B., Javaid, M. K., Ferrucci, L., Kritchevsky, S. B., Kuller, L. H., Pahor, M., Schaap, L. A., Visser, M., et al. (2009) · Obesity · doi:10.1038/oby.2008.627 · Cited by 234 · see citing works
Jing, H., Hu, J., He, B., Abril, Y. L. N., Stupinski, J., Weiser, K., Carbonaro, M., Chiang, Y., Southard, T. L., Giannakakou, P., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.02.007 · Cited by 234 · see citing works
Validation of Tandem Mass Spectrometry Database Search Results Using DTASelect
Cociorva, D., Tabb, D. L., & Yates, J. R. (2006) · Current Protocols in Bioinformatics · doi:10.1002/0471250953.bi1304s16 · Cited by 228 · see citing works
Maggio, M., Basaria, S., Ble, A., Lauretani, F., Bandinelli, S., Ceda, G. P., Valenti, G., Ling, S. M., & Ferrucci, L. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1097 · Cited by 200 · see citing works
Blood inflammatory markers and risk of dementia: The Conselice Study of Brain Aging
Ravaglia, G., Forti, P., Maioli, F., Chiappelli, M., Montesi, F., Tumini, E., Mariani, E., Licastro, F., & Patterson, C. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.08.012 · Cited by 198 · see citing works
Jing, H., Hu, J., He, B., Abril, Y. L. N., Stupinski, J., Weiser, K., Carbonaro, M., Chiang, Y., Southard, T. L., Giannakakou, P., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.04.005 · Cited by 190 · see citing works
Interleukin-6 and selected plasma proteins in healthy persons of different ages
Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works
The Nlrp3 inflammasome promotes age-related thymic demise and immunosenescence
Youm, Y.-H., Kanneganti, T.-D., Vandanmagsar, B., Zhu, X., Ravussin, A., Adijiang, A., Owen, J. S., Thomas, M. J., Francis, J., Parks, J. S., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.005 · Cited by 172 · see citing works
The relationship between testosterone and molecular markers of inflammation in older men.
Maggio, M. C., Basaria, S. S., Ceda, G. P., Blè, A., Ling, S. M., Bandinelli, S., Valenti, G., & Ferrucci, L. (2005) · PubMed · Cited by 169 · see citing works
Luo, H., Mu, W.-C., Karki, R., Chiang, H.-H., Mohrin, M., Shin, J. J., Ohkubo, R., Ito, K., Kanneganti, T.-D., & Chen, D. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.101 · Cited by 161 · see citing works
Self-citationBobrowska, A., Donmez, G., Weiss, A., Guarente, L., & Bates, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034805 · Cited by 140 · see citing works
Bonnefond, A., Skrobek, B., Lobbens, S., Eury, E., Thuillier, D., Cauchi, S., Lantieri, O., Balkau, B., Riboli, E., Marre, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2700 · Cited by 139 · see citing works
Hsu, F., Kritchevsky, S. B., Liu, Y., Kanaya, A. M., Newman, A. B., Perry, S. E., Visser, M., Pahor, M., Harris, T. B., Nicklas, B. J., et al. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/glp005 · Cited by 127 · see citing works
Myśliwska, J. M., Bryl, E., Foerster, J., & Myśliwski, A. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00154-1 · Cited by 108 · see citing works
Markers of Atherosclerosis and Inflammation for Prediction of Coronary Heart Disease in Older Adults
Rodondi, N., Marques-Vidal, P. M., Butler, J., Sutton-Tyrrell, K., Cornuz, J., Satterfield, S., Harris, T. B., Bauer, D. C., Ferrucci, L., Vittinghoff, E., et al. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp428 · Cited by 104 · see citing works
Nutrient Sensing and the Oxidative Stress Response
Luo, H., Chiang, H.-H., Louw, M., Susanto, A., & Chen, D. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.02.008 · Cited by 102 · see citing works
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Kania, D. M., Binkley, N., Checovich, M. M., Havighurst, T. C., Schilling, M. L., & Ershler, W. B. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07328.x · Cited by 97 · see citing works
Miao, H., Ou, J., Ma, Y., Guo, F., Yang, Z., Wiggins, M., Liu, C., Song, W., Han, X., Wang, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.02.047 · Cited by 94 · see citing works
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Oroz, J., Barrera-Vilarmau, S., Alfonso, C., Rivas, G., & de Alba, E. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.741082 · Cited by 86 · see citing works
Age-related differences in inflammatory markers in men: contribution of visceral adiposity
Cartier, A., Côté, M., Lemieux, I., Përusse, L., Tremblay, A., Bouchard, C., & Després, J. (2009) · Metabolism · doi:10.1016/j.metabol.2009.04.025 · Cited by 84 · see citing works
The Epigenetics of Stem Cell Aging Comes of Age
Chen, D., & Kerr, C. L. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.03.006 · Cited by 61 · see citing works
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Mohrin, M., & Chen, D. (2016) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000244 · Cited by 43 · see citing works
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Shin, J. J., Zhang, D., & Chen, D. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.06.010 · Cited by 13 · see citing works
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Mueller, A. L., McNamara, M. S., & Sinclair, D. A. (2020) · Aging · doi:10.18632/aging.103344 · Cited by 1,128 · see citing works
Meta-hallmarks of aging and cancer
López-Otín, C., Pietrocola, F., Roiz-Valle, D., Galluzzi, L., & Kroemer, G. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2022.11.001 · Cited by 529 · see citing works
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442 · see citing works
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Walker, K. A., Basisty, N., Wilson, D. M., & Ferrucci, L. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158448 · Cited by 189 · see citing works
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Lin, L., Guo, Z., He, E., Long, X., Wang, D., Zhang, Y., Guo, W., Wei, Q., He, W., Wu, W., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00803-0 · Cited by 88 · see citing works
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Zheng, M., Schultz, M. B., & Sinclair, D. A. (2022) · Trends in Immunology · doi:10.1016/j.it.2022.02.001 · Cited by 62 · see citing works
Emerging role of liver-bone axis in osteoporosis
Gao, H., Peng, X., Li, N., Gou, L., Xu, T., Wang, Y., Qin, J., Liang, H., Ma, P., Li, S., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.07.008 · Cited by 36 · see citing works
- Authors
- He, M., Chiang, H.-H., Luo, H., Zheng, Z., Qiao, Q., Wang, L., Tan, M., Ohkubo, R., Mu, W.-C., Zhao, S., Wu, H., & Chen, D.
- Affiliations
- University of California, Berkeley (US)
- Boston Children's Hospital (US)
- Fudan University (CN)
- Corresponding author
- Chen, Danica
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2020-03
- Volume
- 31
- Issue
- 3
- Pages
- 580-591.e5
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC7104778
- OpenAlex
- W3004952813
- Cited by
- 425
- References
- 95
- Citations by year
- 2026: 54 · 2025: 82 · 2024: 82 · 2023: 69 · 2022: 57 · 2021: 47 · 2020: 33 · 2019: 1
- FWCI
- 16.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Food and Agriculture
- National Institutes of Health
- American Federation for Aging Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- NLRP3 inflammasome, protein acetylation, SIRT2, deacetylation, insulin resistance, macrophages, NAD+-dependent deacetylase, diabetes mellitus, co-culture model, aging reversal
- MeSH terms
- NLR Family, Pyrin Domain-Containing 3 Protein, Acetylation, Aging, Amino Acid Sequence, Animals, Chronic Disease, Disease Models, Animal, Glucose, Homeostasis, Inflammation, Insulin Resistance, Mice, Inbred C57BL, Models, Biological, Peptides, Mice, Knockout, Overnutrition, Sirtuin 2, Inflammasomes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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