Constable, Ian J.

A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., Burdon, K. P., Hebbring, S. J., Wen, C., Gorski, M., et al. (2016) · Nature Genetics

Retinal Diseases and TreatmentsGenetic Associations and Epidemiology

Cited by 1,544

Gene therapy with recombinant adeno-associated vectors for neovascular age-related macular degeneration: 1 year follow-up of a phase 1 randomised clinical trial

Rakoczy, E. P., Lai, C.-M., Magno, A. L., Wikstrom, M. E., French, M. A., Pierce, C. M., Schwartz, S. D., Blumenkranz, M. S., Chalberg, T. W., Degli-Esposti, M. A., et al. (2015) · The Lancet

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 189

Phase 2a randomized clinical trial: safety and post hoc analysis of subretinal rAAV.sFLT-1 for wet age-related macular degeneration

Constable, I. J., Pierce, C. M., Lai, C.-M., Magno, A. L., Degli-Esposti, M. A., French, M. A., McAllister, I. L., Butler, S., Barone, S. B., Schwartz, S. D., et al. (2016) · EBioMedicine

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 152

Expression of cell adhesion molecules and vascular endothelial growth factor in experimental choroidal neovascularisation in the rat

Shen, W. Y., Yu, M. J. T., Barry, C. J., Constable, I. J., & Rakoczy, P. E. (1998) · British Journal of Ophthalmology

Retinal Diseases and TreatmentsRetinal and Macular Surgery

Cited by 140

Gene Therapy in Neovascular Age-related Macular Degeneration: Three-Year Follow-up of a Phase 1 Randomized Dose Escalation Trial

Constable, I. J., Lai, C.-M., Magno, A. L., French, M. A., Barone, S. B., Schwartz, S. D., Blumenkranz, M. S., Degli-Esposti, M. A., & Rakoczy, E. P. (2017) · American Journal of Ophthalmology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 76

Three-year follow-up of phase 1 and 2a rAAV.sFLT-1 subretinal gene therapy trials for exudative age-related macular degeneration

Rakoczy, E. P., Magno, A. L., Lai, C.-M., Pierce, C. M., Degli-Esposti, M. A., Blumenkranz, M. S., & Constable, I. J. (2019) · American Journal of Ophthalmology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 70

Modulation of cathepsin D activity in retinal pigment epithelial cells

RAKOCZY, P. E., LAI, C. M., BAINES, M., GRANDI, S. D., FITTON, J. H., & CONSTABLE, I. J. (1997) · Biochemical Journal

Protease and Inhibitor MechanismsRetinal Diseases and Treatments

Cited by 64

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration

Strunz, T., Lauwen, S., Kiel, C., International AMD Genomics Consortium (IAMDGC), Fritsche, L. G., Igl, W., Bailey, J. N. C., Grassmann, F., Sengupta, S., Bragg-Gresham, J. L., et al. (2020) · Scientific Reports

Genetic Associations and EpidemiologyRetinal Diseases and Treatments

Cited by 60

Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration

Feng, X., Xiao, J., Longville, B., Tan, A. X. J., Wu, X. N., Cooper, M. N., McAllister, I. L., Isaacs, T., Palmer, L. J., & Constable, I. J. (2009) · Ophthalmology

Retinal Diseases and TreatmentsComplement system in diseases

Cited by 54

Correlation between autofluorescent debris accumulation and the presence of partially processed forms of cathepsin D in cultured retinal pigment epithelial cells challenged with rod outer segments

RAKOCZY, P. E., BAINES, M., KENNEDY, C. J., & CONSTABLE, I. J. (1996) · Experimental Eye Research

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 43

Surgical removal of internal limiting membrane and layering of AAV vector on the retina under air enhances gene transfection in a nonhuman primate

Teo, K. Y. C., Lee, S. Y., Barathi, A. V., Tun, S. B. B., Tan, L., & Constable, I. J. (2018) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 33

Controlled production of active Cathepsin D in Retinal Pigment Epithelial cells following adenovirus-mediated gene delivery

Lai, C.-M., Robertson, T., Papadimitriou, J., Shen, W.-Y., Daw, N., Constable, I. J., & Rakoczy, P. E. (2000) · Molecular Therapy

Protease and Inhibitor MechanismsRetinal Development and Disorders

Cited by 5