Brenner, David A.

Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice

Taura, K., Miura, K., Iwaisako, K., Österreicher, C. H., Kodama, Y., Penz-Österreicher, M., & Brenner, D. A. (2010) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 336

Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: Summary of a symposium

Purohit, V., Bode, J. C., Bode, C., Brenner, D. A., Choudhry, M. A., Hamilton, F., Kang, Y. J., Keshavarzian, A., Rao, R., Sartor, R. B., et al. (2008) · Alcohol

Alcohol Consumption and Health EffectsGut microbiota and health

Cited by 325

Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease

Fouts, D. E., Torralba, M., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2012) · Journal of Hepatology

Gut microbiota and healthLiver Disease and Transplantation

Cited by 311

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D. E., Stärkel, P., et al. (2018) · Hepatology

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 290

Hepatitis C virus–induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

Miura, K., Taura, K., Kodama, Y., Schnabl, B., & Brenner, D. A. (2008) · Hepatology

Iron Metabolism and DisordersHepatitis C virus research

Cited by 270

Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Llorente, C., Jepsen, P., Inamine, T., Wang, L., Bluemel, S., Wang, H. J., Loomba, R., Bajaj, J. S., Schubert, M. L., Sikaroodi, M., et al. (2017) · Nature Communications

Gut microbiota and healthAlcohol Consumption and Health Effects

Cited by 257

Human Hepatic Stellate Cells Express CCR5 and RANTES to Induce Proliferation and Migration

Schwabe, R. F., Bataller, R., & Brenner, D. A. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 252

Replicative Senescence of Activated Human Hepatic Stellate Cells Is Accompanied by A Pronounced Inflammatory But Less Fibrogenic Phenotype

Schnabl, B., Purbeck, C. A., Choi, Y. H., Hagedorn, C. H., & Brenner, D. (2003) · Hepatology

Liver physiology and pathologyTelomeres, Telomerase, and Senescence

Cited by 224

Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

Gao, H., Jin, Z., Bandyopadhyay, G., Wang, G., Zhang, D., Rocha, K. C. E., Liu, X., Zhao, H., Kisseleva, T., Brenner, D. A., et al. (2022) · Cell Metabolism

Liver Disease Diagnosis and TreatmentIron Metabolism and Disorders

Cited by 224

Collagenolysis-dependent DDR1 signalling dictates pancreatic cancer outcome

Su, H., Yang, F., Fu, R., Trinh, B., Sun, N., Liu, J., Kumar, A., Baglieri, J., Siruno, J., Le, M., et al. (2022) · Nature

Pancreatic and Hepatic Oncology ResearchProtease and Inhibitor Mechanisms

Cited by 221

Synergism between obesity and alcohol in increasing the risk of hepatocellular carcinoma: a prospective cohort study

Loomba, R., Yang, H.-I., Su, J., Brenner, D., Barrett-Connor, E., Iloeje, U., & Chen, C.-J. (2013) · American Journal of Epidemiology

Alcohol Consumption and Health EffectsHepatocellular Carcinoma Treatment and Prognosis

Cited by 221

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease

Ma, H.-Y., Yamamoto, G., Xu, J., Liu, X., Karin, D., Kim, J. Y., Alexandrov, L. B., Koyama, Y., Nishio, T., Benner, C., et al. (2020) · Journal of Hepatology

Liver physiology and pathologyHepatocellular Carcinoma Treatment and Prognosis

Cited by 216

CX3CL1-CX3CR1 Interaction Prevents Carbon Tetrachloride-Induced Liver Inflammation and Fibrosis in Mice

Aoyama, T., Inokuchi, S., Brenner, D. A., & Seki, E. (2010) · Hepatology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 211

Link between gut‐microbiome derived metabolite and shared gene‐effects with hepatic steatosis and fibrosis in NAFLD

Caussy, C., Hsu, C., Lo, M., Liu, A., Bettencourt, R., Ajmera, V. H., Bassirian, S., Hooker, J., Sy, E., Richards, L., et al. (2018) · Hepatology

Liver Disease Diagnosis and TreatmentGut microbiota and health

Cited by 205

Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice

Mazagova, M., Wang, L., Anfora, A. T., Wissmueller, M., Lesley, S. A., Miyamoto, Y., Eckmann, L., Dhungana, S., Pathmasiri, W., Sumner, S., et al. (2015) · The FASEB Journal

Liver physiology and pathologyGut microbiota and health

Cited by 199

Mechanisms of alcohol‐induced hepatic fibrosis: A summary of the Ron Thurman Symposium†

Purohit, V., & Brenner, D. A. (2006) · Hepatology

Liver physiology and pathologyAlcohol Consumption and Health Effects

Cited by 161

Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

Iwaisako, K., Haimerl, M., Paik, Y.-H., Taura, K., Kodama, Y., Sirlin, C., Yu, E., Yu, R. T., Downes, M., Evans, R. M., et al. (2012) · Proceedings of the National Academy of Sciences

Peroxisome Proliferator-Activated ReceptorsLiver physiology and pathology

Cited by 157

CD40 Activates NF-κB and c-Jun N-Terminal Kinase and Enhances Chemokine Secretion on Activated Human Hepatic Stellate Cells

Schwabe, R. F., Schnabl, B., Kweon, Y. O., & Brenner, D. A. (2001) · The Journal of Immunology

Liver physiology and pathologyNF-κB Signaling Pathways

Cited by 155

Sphingosine kinase 1 promotes liver fibrosis by preventing miR‐19b‐3p‐mediated inhibition of CCR2

Lan, T., Li, C., Yang, G., Sun, Y., Zhuang, L., Ou, Y., Li, H., Wang, G., Kisseleva, T., Brenner, D., et al. (2018) · Hepatology

Liver physiology and pathologySphingolipid Metabolism and Signaling

Cited by 153

Concanavalin A—induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice☆☆☆

Trautwein, C., Rakemann, T., Brenner, D. A., Streetz, K., Licato, L., Manns, M. P., & Tiegs, G. (1998) · Gastroenterology

Cell death mechanisms and regulationLiver physiology and pathology

Cited by 147

Heterogeneity of HSCs in a Mouse Model of NASH

Rosenthal, S. B., Liu, X., Ganguly, S., Dhar, D., Pasillas, M. P., Ricciardelli, E., Li, R. Z., Troutman, T. D., Kisseleva, T., Glass, C. K., et al. (2021) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 145

Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

Ganguly, S., Rosenthal, S. B., Ishizuka, K., Troutman, T. D., Rohm, T. V., Khader, N., Aleman-Muench, G., Sano, Y., Archilei, S., Soroosh, P., et al. (2024) · Proceedings of the National Academy of Sciences

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 145

Recommendations for Probiotic Use—2015 Update: Proceedings and Consensus Opinion

Floch, M. H., Walker, W. A., Sanders, M. E., Nieuwdorp, M., Kim, A. S., Brenner, D. A., Qamar, A. A., Miloh, T. A., Guarino, A., Guslandi, M., et al. (2015) · Journal of Clinical Gastroenterology

Probiotics and Fermented FoodsGastrointestinal motility and disorders

Cited by 119

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 112