Gu, Wei

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature

Ferroptosis and cancer prognosisCancer-related Molecular Pathways

Cited by 3,398

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Wang, W., Green, M., Choi, J. E., Gijón, M., Kennedy, P. D., Johnson, J. K., Liao, P., Lang, X., Kryczek, I., Sell, A., et al. (2019) · Nature

Ferroptosis and cancer prognosisCancer Immunotherapy and Biomarkers

Cited by 2,880

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell

Sirtuins and Resveratrol in MedicineCancer-related Molecular Pathways

Cited by 2,081

Modes of p53 regulation.

Kruse, J.-P., & Gu, W. (2009) · Cell

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 1,610

Cysteine depletion induces pancreatic tumor ferroptosis in mice

Badgley, M. A., Kremer, D. M., Maurer, H. C., DelGiorno, K. E., Lee, H.-J., Purohit, V., Sagalovskiy, I. R., Ma, A., Kapilian, J., Firl, C. E. M., et al. (2020) · Science

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 1,294

p53 ubiquitination: Mdm2 and beyond

Brooks, C. L., & Gu, W. (2006) · Molecular Cell

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 924

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 912

Acetylation Is Indispensable for p53 Activation

Tang, Y., Zhao, W., Chen, Y., Zhao, Y., & Gu, W. (2008) · Cell

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 838

Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2

Li, M., Brooks, C. L., Wu-Baer, F., Chen, D., Baer, R., & Gu, W. (2003) · Science

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 804

Lysine propionylation and butyrylation are novel post-translational modifications in histones

Chen, Y., Sprung, R., Tang, Y., Ball, H., Sangras, B., Kim, S. C., Falck, J. R., Peng, J., Gu, W., & Zhao, Y. (2007) · Molecular & Cellular Proteomics

Genomics and Chromatin DynamicsCancer-related gene regulation

Cited by 764

SIRT1 transgenic mice show phenotypes resembling calorie restriction

Bordone, L., Cohen, D., Robinson, A., Motta, M. C., Van Veen, E., Czopik, A., Steele, A. D., Crowe, H., Marmor, S., Luo, J., et al. (2007) · Aging Cell

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 722

A dynamic role of HAUSP in the p53-Mdm2 pathway

Li, M., Brooks, C. L., Kon, N., & Gu, W. (2004) · Molecular Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 679

p53 in ferroptosis regulation: The new weapon for the old guardian

Liu, Y., & Gu, W. (2022) · Cell Death & Differentiation

Ferroptosis and cancer prognosisCancer-related Molecular Pathways

Cited by 540

p53 modifications: exquisite decorations of the powerful guardian

Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 392

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

Yao, H., Chung, S., Hwang, J.-W., Rajendrasozhan, S., Sundar, I. K., Dean, D. A., McBurney, M. W., Guarente, L., Gu, W., Rönty, M., et al. (2012) · Journal of Clinical Investigation

Sirtuins and Resveratrol in MedicineChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 358

A local mechanism mediates NAD-dependent protection of axon degeneration

Wang, J., Zhai, Q., Chen, Y., Lin, E., Gu, W., McBurney, M. W., & He, Z. (2005) · The Journal of Cell Biology

Nerve injury and regenerationSirtuins and Resveratrol in Medicine

Cited by 352

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Chen, D., Chu, B., Yang, X., Liu, Z., Jin, Y., Kon, N., Rabadan, R., Jiang, X., Stockwell, B. R., & Gu, W. (2021) · Nature Communications

Ferroptosis and cancer prognosisCancer, Lipids, and Metabolism

Cited by 348

Direct Interactions between HIF-1α and Mdm2 Modulate p53 Function

Chen, D., Li, M., Luo, J., & Gu, W. (2003) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 334

The multiple levels of regulation by p53 ubiquitination

Lee, J. T., & Gu, W. (2010) · Cell Death & Differentiation

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 289

Inactivation of HAUSP in vivo modulates p53 function.

Kon, N., Kobayashi, Y., Li, M., Brooks, C. L., Ludwig, T., & Gu, W. (2010) · Oncogene

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 176

Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

Chen, D., Shan, J., Zhu, W.-G., Qin, J., & Gu, W. (2010) · Nature

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 160

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

Velimezi, G., Liontos, M., Vougas, K., Roumeliotis, T., Bartkova, J., Sideridou, M., Dereli-Oz, A., Kocylowski, M., Pateras, I. S., Evangelou, K., et al. (2013) · Nature Cell Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 131

Roles of HAUSP-mediated p53 regulation in central nervous system development

Kon, N., Zhong, J., Kobayashi, Y., Li, M., Szabolcs, M., Ludwig, T., Canoll, P. D., & Gu, W. (2011) · Cell Death & Differentiation

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 79

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 4 Targets MDM2 To Deregulate the p53 Tumor Suppressor Pathway

Lee, H.-R., Toth, Z., Shin, Y. C., Lee, J.-S., Chang, H., Gu, W., Oh, T.-K., Kim, M. H., & Jung, J. U. (2009) · Journal of Virology

Viral-associated cancers and disordersCancer-related Molecular Pathways

Cited by 78