p53 in ferroptosis regulation: The new weapon for the old guardian

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691 · see citing works

Ferroptosis: mechanisms, biology and role in disease

Jiang, X., Stockwell, B. R., & Conrad, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00324-8 · Cited by 7,720 · see citing works

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138 · see citing works

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293 · see citing works

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703 · see citing works

Ferroptosis as a p53-mediated activity during tumour suppression

Jiang, L., Kon, N., Li, T., Wang, S.-J., Su, T., Hibshoosh, H., Baer, R., & Gu, W. (2015) · Nature · doi:10.1038/nature14344 · Cited by 3,398 · see citing works

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341 · see citing works

A microRNA component of the p53 tumour suppressor network

He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692 · see citing works

Role of Mitochondria in Ferroptosis

Gao, M., Yi, J., Zhu, J., Minikes, A. M., Monian, P., Thompson, C. B., & Jiang, X. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.10.042 · Cited by 2,120 · see citing works

Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Dixon, S. J., Patel, D. N., Welsch, M., Skouta, R., Lee, E. D., Hayano, M., Thomas, A. G., Gleason, C. E., Tatonetti, N. P., Slusher, B. S., et al. (2014) · eLife · doi:10.7554/elife.02523 · Cited by 2,088 · see citing works

Glutaminolysis and transferrin regulate ferroptosis

Gao, M., Monian, P., Quadri, N., Ramasamy, R., & Jiang, X. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.06.011 · Cited by 2,069 · see citing works

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

Chang, T.-C., Wentzel, E. A., Kent, O. A., Ramachandran, K., Mullendore, M., Lee, K. H., Feldmann, G., Yamakuchi, M., Ferlito, M., Lowenstein, C. J., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.010 · Cited by 2,010 · see citing works

The first 30 years of p53: growing ever more complex.

Levine, A. J., & Oren, M. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2723 · Cited by 1,967 · see citing works

Putting p53 in context

Kastenhuber, E. R., & Lowe, S. W. (2017) · Cell · doi:10.1016/j.cell.2017.08.028 · Cited by 1,906 · see citing works

Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.

Yang, W. S., & Stockwell, B. R. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.02.010 · Cited by 1,876 · see citing works

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

Dolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446 · see citing works

Transcriptional Activation of miR-34a Contributes to p53-Mediated Apoptosis

Raver-Shapira, N., Marciano, E., Meiri, E., Spector, Y., Rosenfeld, N., Moskovits, N. B.-C., Bentwich, Z., & Oren, M. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.017 · Cited by 1,352 · see citing works

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

Kraft, V. A. N., Bezjian, C. T., Pfeiffer, S., Ringelstetter, L., Müller, C., Zandkarimi, F., Merl‐Pham, J., Bao, X., Anastasov, N., Kössl, J., et al. (2019) · ACS Central Science · doi:10.1021/acscentsci.9b01063 · Cited by 1,342 · see citing works

Emerging Mechanisms and Disease Relevance of Ferroptosis

Stockwell, B. R., Jiang, X., & Gu, W. J. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.02.009 · Cited by 1,108 · see citing works

Cytoplasmic functions of the tumour suppressor p53

Green, D. R., & Kroemer, G. (2009) · Nature · doi:10.1038/nature07986 · Cited by 1,106 · see citing works

P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080 · see citing works

The development of the concept of ferroptosis

Hirschhorn, T., & Stockwell, B. R. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.09.043 · Cited by 1,052 · see citing works

Antioxidant responses and cellular adjustments to oxidative stress

Espinosa-Diez, C., Miguel, V., Mennerich, D., Kietzmann, T., Sánchez-Pérez, P., Cadenas, S., & Lamas, S. (2015) · Redox Biology · doi:10.1016/j.redox.2015.07.008 · Cited by 1,046 · see citing works

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, J., & Gu, W. J. (2002) · Nature · doi:10.1038/nature737 · Cited by 1,027 · see citing works

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007 · see citing works

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Xie, Y., Zhu, S., Song, X., Sun, X., Fan, Y., Liu, J., Zhong, M., Yuan, H., Zhang, L., Billiar, T. R., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.055 · Cited by 952 · see citing works

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

Li, T., Kon, N., Jiang, L., Tan, M., Ludwig, T., Zhao, Y., Baer, R., & Gu, W. (2012) · Cell · doi:10.1016/j.cell.2012.04.026 · Cited by 912 · see citing works

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

Chu, B., Kon, N., Chen, D., Li, T., Liu, T., Jiang, L., Song, S., Tavana, O., & Gu, W. J. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0305-6 · Cited by 885 · see citing works

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001006107 · Cited by 862 · see citing works

p53: 800 million years of evolution and 40 years of discovery

Levine, A. J. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0262-1 · Cited by 850 · see citing works

Acetylation Is Indispensable for p53 Activation

Tang, Y., Zhao, W., Chen, Y., Zhao, Y., & Gu, W. (2008) · Cell · doi:10.1016/j.cell.2008.03.025 · Cited by 838 · see citing works

Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses

Ou, Y., Wang, S.-J., Li, D., Chu, B., & Gu, W. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607152113 · Cited by 775 · see citing works

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

Soula, M., Weber, R. A., Zilka, O., Alwaseem, H., La, K., Yen, F. S., Molina, H., García‐Bermúdez, J., Pratt, D. A., & Birsoy, K. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0613-y · Cited by 754 · see citing works

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

Kapralov, A. A., Yang, Q., Dar, H. H., Tyurina, Y. Y., Anthonymuthu, T. S., Kim, R., Croix, C. M. S., Mikulska‐Ruminska, K., Liu, B., Shrivastava, I. H., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-019-0462-8 · Cited by 657 · see citing works

Limiting the impact of light pollution on human health, environment and stellar visibility

Falchi, F., Cinzano, P., Elvidge, C. D., Keith, D. M., & Haim, A. (2011) · Journal of Environmental Management · doi:10.1016/j.jenvman.2011.06.029 · Cited by 602 · see citing works

The Hallmarks of Ferroptosis

Dixon, S. J., & Stockwell, B. R. (2018) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-030518-055844 · Cited by 589 · see citing works

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

Tarangelo, A., Magtanong, L., Bieging-Rolett, K. T., Li, Y., Ye, J., Attardi, L. D., & Dixon, S. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.077 · Cited by 564 · see citing works

Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart

Hoshino, A., Mita, Y., Okawa, Y., Ariyoshi, M., Iwai-Kanai, E., Ueyama, T., Ikeda, K., Ogata, T., & Matoba, S. (2013) · Nature Communications · doi:10.1038/ncomms3308 · Cited by 536 · see citing works

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Brady, C. A., Jiang, D., Mello, S. S., Johnson, T. M., Jarvis, L. A., Kozak, M. M., Broz, D. K., Basak, S., Park, E. J., McLaughlin, M. E., et al. (2011) · Cell · doi:10.1016/j.cell.2011.03.035 · Cited by 533 · see citing works

Long noncoding RNA LINC00336 inhibits ferroptosis in lung cancer by functioning as a competing endogenous RNA

Wang, M., Mao, C., Ouyang, L., Liu, Y., Lai, W., Liu, N., Shi, Y., Chen, L., Xiao, D., Yu, F., et al. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0304-y · Cited by 530 · see citing works

MEKK1/JNK signaling stabilizes and activates p53

Fuchs, S. Y., Adler, V., Pincus, M. R., & Ronai, Z. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10541 · Cited by 521 · see citing works

Characteristics and Biomarkers of Ferroptosis

Chen, X., Comish, P. B., Tang, D., & Kang, R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.637162 · Cited by 516 · see citing works

Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury

Li, Y., Cao, Y., Xiao, J., Shang, J., Tan, Q., Feng, P., Huang, W.-F., Wu, F., Zhang, H., & Zhang, X. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0528-x · Cited by 512 · see citing works

Hallmarks of Health

López-Otín, C., & Kroemer, G. (2021) · Cell · doi:10.1016/j.cell.2020.11.034 · Cited by 499 · see citing works

A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53

Mao, C., Wang, X., Liu, Y., Wang, M., Yan, B., Jiang, Y., Shi, Y., Shen, Y., Liu, X., Lai, W., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3454 · Cited by 493 · see citing works

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

Wang, S.-J., Li, D., Ou, Y., Jiang, L., Chen, Y., Zhao, Y., & Gu, W. J. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.09.022 · Cited by 463 · see citing works

Switching Apoptosis to Ferroptosis: Metal–Organic Network for High-Efficiency Anticancer Therapy

Zheng, D., Lei, Q., Zhu, J., Fan, J., Li, C., Li, C., Xu, Z., Cheng, S., & Zhang, X. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b04060 · Cited by 434 · see citing works

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

Zhang, C., Lin, M., Wu, R., Wang, X., Yang, B., Levine, A. J., Hu, W., & Feng, Z. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113884108 · Cited by 431 · see citing works

p53 modifications: exquisite decorations of the powerful guardian

Liu, Y., Tavana, O., & Gu, W. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz060 · Cited by 392 · see citing works

PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

Hong, T., Lei, G., Chen, X., Li, H., Zhang, X., Wu, N., Zhao, Y., Zhang, Y., & Wang, J. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101928 · Cited by 381 · see citing works

An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse modelPreprint

Jennis, M., Kung, C.-P., Basu, S., Budina-Kolomets, A., Leu, J. I.-J., Khaku, S., Scott, J. P., Cai, K. Q., Campbell, M. R., Porter, D. K., et al. (2016) · Genes & Development · doi:10.1101/gad.275891.115 · Cited by 355 · see citing works

Targeting p53 for the treatment of cancer

Duffy, M. J., Synnott, N. C., O’Grady, S., & Crown, J. P. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.07.005 · Cited by 351 · see citing works

iPLA2β-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

Chen, D., Chu, B., Yang, X., Liu, Z., Jin, Y., Kon, N., Rabadan, R., Jiang, X., Stockwell, B. R., & Gu, W. (2021) · Nature Communications · doi:10.1038/s41467-021-23902-6 · Cited by 348 · see citing works

p53 and Tumor Suppression: It Takes a Network

Boutelle, A. M., & Attardi, L. D. (2021) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.12.011 · Cited by 322 · see citing works

Inhibiting the system xC−/glutathione axis selectively targets cancers with mutant-p53 accumulation

Liu, D. S., Duong, C. P., Haupt, S., Montgomery, K. G., House, C. M., Azar, W. J., Pearson, H. B., Fisher, O. M., Read, M., Guerra, G. R., et al. (2017) · Nature Communications · doi:10.1038/ncomms14844 · Cited by 321 · see citing works

Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

Tang, L., Zhou, Y.-J., Xiong, X.-M., Li, N., Zhang, J.-J., Luo, X., & Peng, J. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.307 · Cited by 301 · see citing works

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Valente, L. J., Gray, D. H. D., Michalak, E. M., Hofbauer, J. P., Egle, A., Scott, C. L., Janic, A., & Strasser, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.012 · Cited by 292 · see citing works

ESCRT-III–dependent membrane repair blocks ferroptosis

Dai, E., Meng, L., Kang, R., Wang, X., & Tang, D. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.110 · Cited by 279 · see citing works

LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53

Lu, J., Xu, F., & Lu, H. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118305 · Cited by 279 · see citing works

Deletions linked to TP53 loss drive cancer through p53-independent mechanisms

Liu, Y., Chen, C., Xu, Z., Scuoppo, C., Rillahan, C. D., Gao, J., Spitzer, B. G., Bosbach, B., Kastenhuber, E. R., Baslan, T., et al. (2016) · Nature · doi:10.1038/nature17157 · Cited by 272 · see citing works

MDM2 and MDMX promote ferroptosis by PPARα-mediated lipid remodelingPreprint

Venkatesh, D., O'Brien, N. A., Zandkarimi, F., Tong, D. R., Stokes, M. E., Dunn, D., Kengmana, E. S., Aron, A. T., Klein, A. M., Csuka, J. M., et al. (2020) · Genes & Development · doi:10.1101/gad.334219.119 · Cited by 269 · see citing works

The complexity of p53-mediated metabolic regulation in tumor suppression

Liu, Y., & Gu, W. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.03.010 · Cited by 263 · see citing works

Quercetin induces p53‐independent cancer cell death through lysosome activation by the transcription factor EB and Reactive Oxygen Species‐dependent ferroptosis

Wang, Z., Ma, J., Li, X., Wu, Y., Shi, H., Chen, Y., Lu, G. X., Shen, H., Lu, G., & Zhou, J. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15350 · Cited by 238 · see citing works

Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation

Guan, Z., Chen, J., Li, X., & Dong, N. (2020) · Bioscience Reports · doi:10.1042/bsr20201807 · Cited by 235 · see citing works

Dynamic roles of p53-mediated metabolic activities in ROS-induced stress responses

Jiang, L., Hickman, J. H., Wang, S.-J., & Gu, W. J. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1068479 · Cited by 232 · see citing works

Deconstructing networks of p53-mediated tumor suppression in vivo

Kaiser, A. M., & Attardi, L. D. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.171 · Cited by 232 · see citing works

Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload

Wang, J., Deng, B., Liu, Q., Huang, Y., Chen, W., Li, J., Zhou, Z., Zhang, L., Liang, B., He, J., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02777-3 · Cited by 224 · see citing works

Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53

Wang, Y., Yang, L., Zhang, X., Cui, W., Liu, Y., Sun, Q., He, Q., Zhao, S., Zhang, G., Wang, Y., et al. (2019) · EMBO Reports · doi:10.15252/embr.201847563 · Cited by 215 · see citing works

A Dual PI3K/HDAC Inhibitor Induces Immunogenic Ferroptosis to Potentiate Cancer Immune Checkpoint Therapy

Fan, F., Liu, P., Bao, R., Chen, J., Zhou, M., Mo, Z., Ma, Y., Liu, H., Zhou, Y., Cai, X., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1547 · Cited by 215 · see citing works

p53‐mediated induction of Cox‐2 counteracts p53‐ or genotoxic stress‐induced apoptosis

Han, J. A., Kim, J., Ongusaha, P. P., Hwang, D. H., Ballou, L. R., Mahale, A., Aaronson, S. A., & Lee, S. W. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf591 · Cited by 213 · see citing works

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

Wang, Z., Ding, Y., Wang, X., Lu, S., Wang, C., He, C. H., Wang, L., Piao, M., Chi, G., Luo, Y., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.04.021 · Cited by 211 · see citing works

Genome-wide Characterization of miR-34a Induced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis

Kaller, M., Liffers, S., Oeljeklaus, S., Kuhlmann, K., Röh, S., Hoffmann, R. F. G., Warscheid, B., & Hermeking, H. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.010462 · Cited by 203 · see citing works

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

Lei, G., Zhang, Y., Hong, T., Zhang, X., Liu, X., Mao, C., Yan, Y., Koppula, P., Cheng, W., Sood, A. K., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01790-w · Cited by 201 · see citing works

Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways

Li, Y., Chen, F., Chen, J., Chan, S., He, Y., Liu, W., & Zhang, G. (2020) · Cancers · doi:10.3390/cancers12010138 · Cited by 191 · see citing works

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

Zhang, P., Chen, L., Zhao, Q., Du, X., Bi, M., Li, Y. H., Jiao, Q., & Jiang, H. F. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.015 · Cited by 190 · see citing works

The BRD7-P53-SLC25A28 axis regulates ferroptosis in hepatic stellate cells

Zhang, Z., Guo, M. L., Shen, M., Kong, D., Zhang, F., Shao, J., Tan, S., Wang, S., Chen, A., Cao, P., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101619 · Cited by 189 · see citing works

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats

Zhu, K., Zhu, X. Q., Sun, S., Yang, W., Liu, S., Tang, Z., Zhang, R., Li, J., Shen, T., & Hei, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113828 · Cited by 186 · see citing works

p53-dependent Induction of PVT1 and miR-1204

Barsotti, A. M., Beckerman, R., Laptenko, O., Huppi, K. E., Caplen, N. J., & Prives, C. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322875 · Cited by 185 · see citing works

APR-246 induces early cell death by ferroptosis in acute myeloid leukemia

Birsen, R., Larrue, C., Decroocq, J., Johnson, N., Guiraud, N., Gotanegre, M., Cantero-Aguilar, L., Grignano, E., Huynh, T., Fontenay, M., et al. (2021) · Haematologica · doi:10.3324/haematol.2020.259531 · Cited by 182 · see citing works

Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects

Ma, W., Sun, X., Zhu, Y., & Liu, N. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.033 · Cited by 164 · see citing works

Current developments of targeting the p53 signaling pathway for cancer treatment

Huang, J. L. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107720 · Cited by 155 · see citing works

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

Ou, Y., Wang, S.-J., Jiang, L., Zheng, B., & Gu, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616359 · Cited by 154 · see citing works

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2Preprint

Zhang, Y., Qian, Y., Zhang, J., Yan, W., Jung, Y.-S., Chen, M., Huang, E. C., Lloyd, K. C. K., Duan, Y., Wang, J., et al. (2017) · Genes & Development · doi:10.1101/gad.299388.117 · Cited by 151 · see citing works

P53‐dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride‐induced liver fibrosis and hepatic stellate cell activation

Wang, L., Zhang, Z., Li, M., Wang, F., Jia, Y., Zhang, F., Shao, J., Chen, A., & Zheng, S. (2018) · IUBMB Life · doi:10.1002/iub.1895 · Cited by 151 · see citing works

Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells

Luo, Y., Gao, X., Zou, L., Lei, M., Feng, J., & Hu, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1783485 · Cited by 151 · see citing works

Role of p53 in Neurodegenerative Diseases

Chang, J. R., Ghafouri, M., Mukerjee, R., Bagashev, A., Chabrashvili, T., & Sawaya, B. E. (2011) · Neurodegenerative Diseases · doi:10.1159/000329999 · Cited by 145 · see citing works

The most popular genes in the human genome

Dolgin, E. (2017) · Nature · doi:10.1038/d41586-017-07291-9 · Cited by 142 · see citing works

Role of ferroptosis in the process of diabetes-induced endothelial dysfunction

Luo, E., Li, H.-X., Qin, Y., Qiao, Y., Yan, G., Yao, Y., Li, L., Hou, J., Tang, C., & Wang, D. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i2.124 · Cited by 141 · see citing works

“Iron free” zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis

Zhang, C., Liu, Z., Zhang, Y., Ma, L., Song, E., & Song, Y. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2384-5 · Cited by 139 · see citing works

Artesunate Inhibits Growth of Sunitinib-Resistant Renal Cell Carcinoma Cells through Cell Cycle Arrest and Induction of Ferroptosis

Markowitsch, S. D., Schupp, P., Lauckner, J., Vakhrusheva, O., Slade, K. S., Mager, R., Efferth, T., Haferkamp, A., & Juengel, E. (2020) · Cancers · doi:10.3390/cancers12113150 · Cited by 129 · see citing works

Asah2 Represses the p53–Hmox1 Axis to Protect Myeloid-Derived Suppressor Cells from Ferroptosis

Zhu, H., Klement, J. D., Lu, C., Redd, P. S., Yang, D., Smith, A. D., Poschel, D. B., Zou, J., Liu, D., Wang, P. G., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000500 · Cited by 125 · see citing works

Ferroptosis in a sarcopenia model of senescence accelerated mouse prone 8 (SAMP8)

Huang, Y., Wu, B., Shen, D., Chen, J., Yu, Z., & Chen, C. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.53126 · Cited by 114 · see citing works

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Leu, J. I.-J., Murphy, M. E., & George, D. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821277116 · Cited by 112 · see citing works

PLA2G6-Associated Neurodegeneration (PLAN): Review of Clinical Phenotypes and Genotypes

Guo, Y.-P., Tang, B.-S., & Guo, J. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01100 · Cited by 111 · see citing works

Upregulation and activation of p53 by erastin‑induced reactive oxygen species contribute to cytotoxic and cytostatic effects in A549 lung cancer cells

Huang, C., Yang, M., Deng, J., Li, P., Su, W., & Jiang, R. (2018) · Oncology Reports · doi:10.3892/or.2018.6585 · Cited by 106 · see citing works

Suppression of Host p53 Is Critical for Plasmodium Liver-Stage Infection

Kaushansky, A., Ye, A. S., Austin, L. S., Mikolajczak, S. A., Vaughan, A. M., Camargo, N. M., Metzger, P. G., Douglass, A. N., MacBeath, G., & Kappe, S. H. I. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.02.010 · Cited by 105 · see citing works

Sorafenib inhibits proliferation and invasion of human hepatocellular carcinoma cells via up-regulation of p53 and suppressing FoxM1

Wei, J., Meng, F., Qu, K., Wang, Z., Wu, Q., Zhang, L.-Q., Pang, Q., & Liu, C. (2015) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.122 · Cited by 104 · see citing works

Insights of Crosstalk between p53 Protein and the MKK3/MKK6/p38 MAPK Signaling Pathway in Cancer

Stramucci, L., Pranteda, A., & Bossi, G. (2018) · Cancers · doi:10.3390/cancers10050131 · Cited by 104 · see citing works

SOCS1 regulates senescence and ferroptosis by modulating the expression of p53 target genes

Saint‐Germain, E., Mignacca, L., Vernier, M., Bobbala, D., Ilangumaran, S., & Ferbeyre, G. (2017) · Aging · doi:10.18632/aging.101306 · Cited by 101 · see citing works

Flubendazole, FDA-approved anthelmintic, elicits valid antitumor effects by targeting P53 and promoting ferroptosis in castration-resistant prostate cancer

Zhou, X., Zou, L., Chen, W., Yang, T., Luo, J., Wu, K., Shu, F., Tan, X., Yu, Y., Cen, S., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105305 · Cited by 99 · see citing works

Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells

Kan, X., Yin, Y., Song, C., Tan, L., Qiu, X., Liao, Y., Liu, W., Meng, S., Sun, Y., & Ding, C. (2021) · iScience · doi:10.1016/j.isci.2021.102837 · Cited by 99 · see citing works

Liver stage malaria infection is controlled by host regulators of lipid peroxidation

Kain, H. S., Glennon, E. K. K., Vijayan, K., Arang, N., Douglass, A. N., Fortin, C. L., Zuck, M., Lewis, A. J., Whiteside, S. L., Dudgeon, D. R., et al. (2020) · Cell Death & Differentiation · doi:10.1038/s41418-019-0338-1 · Cited by 91 · see citing works

Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition

Wang, M., Li, S., Wang, Y., Cheng, H., Su, J., & Li, Q. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115110 · Cited by 90 · see citing works

p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides

Zhang, Y., Xia, M., Zhou, Z., Hu, X., Wang, J., Zhang, M., Li, Y., Sun, L., Chen, F., & Yu, H. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s282489 · Cited by 90 · see citing works

Cytoglobin promotes sensitivity to ferroptosis by regulating p53‐YAP1 axis in colon cancer cells

Ye, S., Xu, M., Zhu, T., Chen, J., Shi, S., Jiang, H., Zheng, Q., Liao, Q., Ding, X., & Yang, X. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16400 · Cited by 88 · see citing works

Visible Blue Light Therapy: Molecular Mechanisms and Therapeutic Opportunities

Garza, Z. C. F., Born, M., Hilbers, P. A. J., van Riel, N. A. W., & Liebmann, J. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170727112206 · Cited by 87 · see citing works

miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities

Yang, X., Liu, J., Wang, C., Cheng, K. K. Y., Xu, H., Li, Q., Hua, T., Jiang, X., Sheng, L., Mao, J., et al. (2021) · Oncogenesis · doi:10.1038/s41389-021-00304-3 · Cited by 84 · see citing works

Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging

Li, T., Liu, X., Jiang, L., Manfredi, J. J., Zha, S., & Gu, W. (2016) · Oncotarget · doi:10.18632/oncotarget.7864 · Cited by 83 · see citing works

Chapter 5 Sirtuins and p53

van Leeuwen, I., & Laı́n, S. (2009) · Advances in cancer research · doi:10.1016/s0065-230x(09)02005-3 · Cited by 82 · see citing works

Ferritin reduction is essential for cerebral ischemia-induced hippocampal neuronal death through p53/SLC7A11-mediated ferroptosis

Chen, W., Jiang, L., Hu, Y., Tang, N., Liang, N., Li, X.-F., Chen, Y.-W., Qin, H., & Wu, L. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147216 · Cited by 82 · see citing works

Novel antitumor compound optimized from natural saponin Albiziabioside A induced caspase-dependent apoptosis and ferroptosis as a p53 activator through the mitochondrial pathway

Wei, G., Sun, J., Hou, Z., Luan, W., Wang, S., Cui, S., Cheng, M., & Liu, Y. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.036 · Cited by 81 · see citing works

The structure of iPLA2β reveals dimeric active sites and suggests mechanisms of regulation and localization

Malley, K. R., Koroleva, O., Miller, I. J., Sanishvili, R., Jenkins, C. M., Gross, R. W., & Korolev, S. (2018) · Nature Communications · doi:10.1038/s41467-018-03193-0 · Cited by 78 · see citing works

Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis

He, Z., Liao, W., Song, Q., Li, B., Liu, J., Xiong, Y., Song, C., & Yang, S. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4770 · Cited by 73 · see citing works

Isorhynchophylline Relieves Ferroptosis-Induced Nerve Damage after Intracerebral Hemorrhage Via miR-122-5p/TP53/SLC7A11 Pathway

Zhao, H., Li, X., Yang, L., Zhang, L., Jiang, X., Gao, W., Chen, P., Cheng, Y., Wang, F., & Liu, J. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03320-2 · Cited by 70 · see citing works

Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F

Kuganesan, N., Dlamini, S., Tillekeratne, L. M. V., & Taylor, W. R. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101365 · Cited by 70 · see citing works

Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis

Chen, C., Huang, Y., Xia, P., Zhang, F., Li, L., Wang, E., Guo, Q., & Ye, Z. (2021) · European Journal of Histochemistry · doi:10.4081/ejh.2021.3224 · Cited by 69 · see citing works

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

Nemade, H., Chaudhari, U., Acharya, A., Hescheler, J., Hengstler, J. G., Papadopoulos, S., & Sachinidis, A. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2170-7 · Cited by 65 · see citing works

CircKDM4C upregulates P53 by sponging hsa‐let‐7b‐5p to induce ferroptosis in acute myeloid leukemia

Dong, L., Huang, J., Zu, P., Liu, J., Gao, X. J., Du, J., & Li, Y. (2021) · Environmental Toxicology · doi:10.1002/tox.23126 · Cited by 65 · see citing works

Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway

Shi, L., Huang, C., Luo, Q., Xia, Y., Liu, W., Zeng, W., Cheng, A., Shi, R., & Zhengli, C. (2020) · Aging · doi:10.18632/aging.103225 · Cited by 64 · see citing works

Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis

Wang, X., Liu, K., Gong, H., Li, D., Chu, W., Zhao, D., Wang, X., & Xu, D. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115363 · Cited by 64 · see citing works

Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation

Liu, S., Zhao, Q., Peng, C. Y., Mao, Q., Wu, F., Zhang, F., Feng, Q., He, G., & Han, B. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113359 · Cited by 64 · see citing works

mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppressionPreprint

Kon, N., Ou, Y., Wang, S.-J., Li, H., Rustgi, A. K., & Gu, W. J. (2020) · Genes & Development · doi:10.1101/gad.340919.120 · Cited by 61 · see citing works

A-Lipoic Acid Alleviates Folic Acid-Induced Renal Damage Through Inhibition of Ferroptosis

Li, X., Zou, Y. S., Fu, Y., Xing, J., Wang, K., Wan, P., & Zhai, X. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.680544 · Cited by 61 · see citing works

A functionally significant SNP in TP53 and breast cancer risk in African-American women

Murphy, M. E., Liu, S., Yao, S., Huo, D., Liu, Q., Dolfi, S. C., Hirshfield, K. M., Hong, C. C., Hu, Q., Olshan, A. F., et al. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0007-9 · Cited by 57 · see citing works

p21 can be a barrier to ferroptosis independent of p53

Venkatesh, D., Stockwell, B. R., & Prives, C. L. (2020) · Aging · doi:10.18632/aging.103961 · Cited by 57 · see citing works

Regulation of ferroptosis by non‑coding RNAs in the development and treatment of cancer (Review)

Luo, Y., Huang, Q., He, B., Liu, Y., Huang, S., & Xiao, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7836 · Cited by 52 · see citing works

Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation

Chen, J., Zaal, E. A., Berkers, C. R., Ruijtenbeek, R., Garssen, J., & Redegeld, F. A. (2021) · Cells · doi:10.3390/cells10092287 · Cited by 49 · see citing works

Functional interplay among thiol-based redox signaling, metabolism, and ferroptosis unveiled by a genetic variant of <i>TP53</i>

Leu, J. I.-J., Murphy, M. E., & George, D. L. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2009943117 · Cited by 47 · see citing works

African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

Singh, K. S., Leu, J. I.-J., Barnoud, T., Vonteddu, P., Gnanapradeepan, K., Lin, C., Liu, Q., Barton, J. C., Kossenkov, A. V., George, D. L., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14151-9 · Cited by 45 · see citing works

Systems biology of ferroptosis: A modeling approach

Konstorum, A., Tesfay, L., Paul, B. T., Torti, F. M., Laubenbacher, R., & Torti, S. V. (2020) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2020.110222 · Cited by 45 · see citing works

Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress

Jin, Y., Gu, W. J., & Chen, W. (2020) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaa074 · Cited by 44 · see citing works

Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis

Kuang, H., Wang, T., Liu, L., Tang, C., Li, T., Ming, L., Wang, T., Zhong, W., & Wang, Y. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136134 · Cited by 40 · see citing works

Time Course of Changes in Sorafenib‐Treated Hepatocellular Carcinoma Cells Suggests Involvement of Phospho‐Regulated Signaling in Ferroptosis Induction

Werth, E. G., Rajbhandari, P., Stockwell, B. R., & Brown, L. M. (2020) · PROTEOMICS · doi:10.1002/pmic.202000006 · Cited by 36 · see citing works

SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury

Gao, J., Li, Y., & Song, R. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001679 · Cited by 33 · see citing works

p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells

Li, S., Wang, M., Wang, Y., Guo, Y., Tao, X., Wang, X., Cao, Y., Tian, S., & Li, Q. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105146 · Cited by 31 · see citing works

MicroRNA-34c acts as a bidirectional switch in the maturation of insulin-producing cells derived from mesenchymal stem cells

Bai, C., Gao, Y., Zhang, X., Yang, W., & Guan, W. (2017) · Oncotarget · doi:10.18632/oncotarget.21883 · Cited by 26 · see citing works

Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Meng, M., Huang, M., Liu, C., Wang, J.-M., Ren, W., Cui, S., Gu, J., Xie, J.-L., Ma, B., Yang, G.-Z., et al. (2021) · Aging · doi:10.18632/aging.203138 · Cited by 22 · see citing works

Biphasic Effects of Blue Light Irradiation on Human Umbilical Vein Endothelial Cells

Kan, K., Mu, Y., Bouschbacher, M., Sticht, C., Kuch, N., Sigl, M., Rahbari, N. N., Gretz, N., Pallavi, P., & Keese, M. A. (2021) · Biomedicines · doi:10.3390/biomedicines9070829 · Cited by 13 · see citing works

Targeting p53 pathways: mechanisms, structures, and advances in therapy

Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016 · see citing works

The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions

Lei, G., Zhuang, L., & Gan, B. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.03.011 · Cited by 615 · see citing works

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 545 · see citing works

Understanding the complexity of p53 in a new era of tumor suppression

Liu, Y., Su, Z., Tavana, O., & Gu, W. J. (2024) · Cancer Cell · doi:10.1016/j.ccell.2024.04.009 · Cited by 519 · see citing works

Mutant p53 in cancer: from molecular mechanism to therapeutic modulation

Chen, X., Zhang, T., Su, W., Dou, Z., Zhao, D., Jin, X., Lei, H., Wang, J., Xie, X., Cheng, B., et al. (2022) · Cell Death &amp; Disease · doi:10.1038/s41419-022-05408-1 · Cited by 494 · see citing works

GPX4, ferroptosis, and diseases

Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 450 · see citing works

The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks

Li, J., Jia, Y., Ding, Y.-X., Bai, J., Cao, F., & Li, F. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.83348 · Cited by 398 · see citing works

Overcoming cancer chemotherapy resistance by the induction of ferroptosis

Wang, Y., Wu, X., Zhao, R., Li, Y., Zou, W., Chen, J., & Wang, H. (2022) · Drug Resistance Updates · doi:10.1016/j.drup.2022.100916 · Cited by 368 · see citing works

Recent progress in ferroptosis: inducers and inhibitors

Du, Y., & Guo, Z. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01297-7 · Cited by 333 · see citing works

Cuproptosis: p53-regulated metabolic cell death?

Chen, X., Ling, H., Hao, Q., & Zhou, X. Y. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01125-0 · Cited by 280 · see citing works

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond

Mao, C., Wang, M., Zhuang, L., & Gan, B. (2024) · Protein & Cell · doi:10.1093/procel/pwae003 · Cited by 225 · see citing works

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer

Shen, L., Zhang, J., Zheng, Z., Yang, F., Liu, S., Wu, Y., Chen, Y., Xu, T., Mao, S., Yan, Y., et al. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.74546 · Cited by 176 · see citing works

Roles of reactive oxygen species in inflammation and cancer

Yu, Y., Liu, S., Yang, L., Song, P., Liu, Z., Liu, X., Yan, X., & Dong, Q. (2024) · MedComm · doi:10.1002/mco2.519 · Cited by 180 · see citing works

Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis

Zhou, S., Liu, J., Wan, A., Zhang, Y., & Qi, X. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01545-6 · Cited by 168 · see citing works

Ferroptosis and the bidirectional regulatory factor p53

Xu, R., Wang, W., & Zhang, W. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01517-8 · Cited by 158 · see citing works

Glutathione metabolism in ferroptosis and cancer therapy

Xue, X., Wang, M., Cui, J., Yang, M., Ma, L., Kang, R., Tang, D., & Wang, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217697 · Cited by 154 · see citing works

Insights on the crosstalk among different cell death mechanisms

Eskander, G., AbdelHamid, S. G., Wahdan, S. A., & Radwan, S. M. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02328-9 · Cited by 143 · see citing works

Ferroptosis: Mechanisms and role in diabetes mellitus and its complications

Liu, P., Zhang, Z., Cai, Y., Li, Z., Zhou, Q., & Chen, Q. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102201 · Cited by 136 · see citing works

Oxidative Stress and Cancer Therapy: Controlling Cancer Cells Using Reactive Oxygen Species

Ju, S., Singh, M. K., Han, S., Ranbhise, J. S., Ha, J., Choe, W., Yoon, K., Yeo, S. G., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252212387 · Cited by 129 · see citing works

The mechanisms of ferroptosis and its role in alzheimer’s disease

Ma, H., Dong, Y., Chu, Y., Guo, Y., & Li, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.965064 · Cited by 123 · see citing works

Ferroptosis in heart failure

Yang, X., Kawasaki, N. K., Min, J., Matsui, T., & Wang, F. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.10.004 · Cited by 114 · see citing works

Ferroptosis‐modulating small molecules for targeting drug‐resistant cancer: Challenges and opportunities in manipulating redox signaling

Koeberle, S. C., Kipp, A. P., Stuppner, H., & Koeberle, A. (2023) · Medicinal Research Reviews · doi:10.1002/med.21933 · Cited by 116 · see citing works

The Road from AKI to CKD: Molecular Mechanisms and Therapeutic Targets of Ferroptosis

Guo, R., Duan, J., Pan, S., Cheng, F., Qiao, Y., Feng, Q., Liu, D., & Liu, Z. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05969-9 · Cited by 106 · see citing works

Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling

Xiao, J., Luo, C., Li, A., Cai, F.-L., Wang, Y., Pan, X., Liu, X., Wang, Z., Xing, Z., Yu, L., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112010 · Cited by 108 · see citing works

Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation

Liu, D., Qin, H., Gao, Y., Sun, M., & Wang, M. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107258 · Cited by 94 · see citing works

Ferroptosis and Senescence: A Systematic Review

Coradduzza, D., Congiargiu, A., Chen, Z., Zinellu, A., Carru, C., & Medici, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043658 · Cited by 93 · see citing works

Ferroptosis: challenges and opportunities for nanomaterials in cancer therapy

Liu, Q., Zhao, Y., Zhou, H., & Chen, C. (2023) · Regenerative Biomaterials · doi:10.1093/rb/rbad004 · Cited by 89 · see citing works

Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases

Feng, Q., Yang, Y., Ren, K., Qiao, Y., Sun, Z., Pan, S., Liu, F., Liu, Y., Huo, J., Liu, D., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.85674 · Cited by 92 · see citing works

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

Xing, N., Du, Q., Guo, S., Xiang, G., Zhang, Y., Meng, X., Li, X., & Wang, S. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01407-z · Cited by 88 · see citing works

p53-regulated non-apoptotic cell death pathways and their relevance in cancer and other diseases

Liu, Y., Stockwell, B. R., Jiang, X., & Gu, W. J. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-025-00842-3 · Cited by 92 · see citing works

Ferroptosis in inflammatory arthritis: A promising future

Chang, S., Tang, M., Zhang, B., Xiang, D., & Li, F. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955069 · Cited by 87 · see citing works

Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment

Wang, W., Zhang, J., Wang, Y., Xu, Y., & Zhang, S. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.06.046 · Cited by 86 · see citing works

Ferroptosis: A double-edged sword

Wang, S., Guo, Q., Zhou, L., & Xia, X. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02037-9 · Cited by 88 · see citing works

Emerging significance and therapeutic targets of ferroptosis: a potential avenue for human kidney diseases

Li, J., Zheng, S., Fan, Y., & Tan, K. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06144-w · Cited by 82 · see citing works

Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases

Guo, D., Liu, Z., Zhou, J., Ke, C., & Li, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189947 · Cited by 81 · see citing works

SIRT3 Deficiency Enhances Ferroptosis and Promotes Cardiac Fibrosis via p53 Acetylation

Su, H., Cantrell, A. C., Chen, J., Gu, W. J., & Zeng, H. (2023) · Cells · doi:10.3390/cells12101428 · Cited by 78 · see citing works

Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis

Ming, T., Lei, J., Peng, Y., Wang, M., Liang, Y., Tang, S., Tao, Q., Wang, M., Tang, X., He, Z., et al. (2024) · Phytotherapy Research · doi:10.1002/ptr.8258 · Cited by 78 · see citing works

Ferroptosis: an important player in the inflammatory response in diabetic nephropathy

Li, J., Li, L., Zhang, Z., Chen, P., Shu, H., Yang, C., Chu, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294317 · Cited by 82 · see citing works

Ferroptosis and tumor immunotherapy: A promising combination therapy for tumors

Cai, H., Ren, Y., Chen, S., Wang, Y., & Chu, L. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1119369 · Cited by 76 · see citing works

p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis

Liao, Q., Deng, J., Tong, J., Gan, Y., Hong, W., Dong, H., Cao, M., Chen, X., Chen, Y., Xie, B., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.11.013 · Cited by 79 · see citing works

Ferroptotic stress facilitates smooth muscle cell dedifferentiation in arterial remodelling by disrupting mitochondrial homeostasis

Ji, Q., Zeng, F., Zhou, J., Wu, W., Wang, X.-J., Zhang, Z., Zhang, G., Tong, J., Sun, D.-Y., Zhang, J., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01099-5 · Cited by 74 · see citing works

Icariside II induces ferroptosis in renal cell carcinoma cells by regulating the miR-324-3p/GPX4 axis

Yu, R., Zhou, Y., Shi, S., Wang, X. B., Huang, S., & Yu, R. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154182 · Cited by 72 · see citing works

GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis

Kim, J.-W., Min, D. W., Kim, D., Kim, J., Kim, J. M., Lim, H., & Lee, J.-Y. (2023) · Scientific Reports · doi:10.1038/s41598-023-35978-9 · Cited by 72 · see citing works

Multifaceted Roles of Ferroptosis in Lung Diseases

Li, Y., Yang, Y., & Yang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.919187 · Cited by 72 · see citing works

Review: Mechanisms and perspective treatment of radioresistance in non-small cell lung cancer

Zhou, T., Zhang, L., He, J., Miao, Z., Li, Y., Zhang, Y., Liu, Z., Zhang, S.-Z., Chen, Y., Zhou, G.-C., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133899 · Cited by 70 · see citing works

Acetylation targeting chimera enables acetylation of the tumor suppressor p53

Kabir, M., Sun, N., Hu, X., Martin, T. C., Yi, J., Zhong, Y., Xiong, Y., Kaniskan, H. Ü., Gu, W., Parsons, R., et al. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c04640 · Cited by 65 · see citing works

Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke

Luan, Y., Huang, E., Huang, J., Huang, J.-J., Zhou, Z.-P., Zhou, Z.-P., Wang, C., Wu, M. T., Liu, Z.-F., & Wu, M. T. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0092 · Cited by 65 · see citing works

Antioxidant Systems as Modulators of Ferroptosis: Focus on Transcription Factors

Punziano, C., Trombetti, S., Cesaro, E., Grosso, M., & Faraonio, R. (2024) · Antioxidants · doi:10.3390/antiox13030298 · Cited by 70 · see citing works

A new ferroptosis-related signature model including messenger RNAs and long non-coding RNAs predicts the prognosis of gastric cancer patients

Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2023) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2023-0089 · Cited by 63 · see citing works

ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Liu, T., Xu, X., Li, J., Bai, M., Zhu, W., Liu, Y., Liu, S., Zhao, Z., Li, T., Jiang, N., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06333-7 · Cited by 62 · see citing works

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

Yang, X. P., Wang, Z., Самович, С. Н., Kapralov, A. A., Amoscato, A. A., Tyurin, V. A., Dar, H. H., Li, Z., Duan, S., Kon, N., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.006 · Cited by 62 · see citing works

The positive feedback loop of the NAT10/Mybbp1a/p53 axis promotes cardiomyocyte ferroptosis to exacerbate cardiac I/R injury

Qu, Z., Pang, X., Mei, Z., Li, Y., Zhang, Y., Huang, C., Liu, K., Yu, S., Wang, C., Sun, Z., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103145 · Cited by 62 · see citing works

p53 Promotes Ferroptosis in Macrophages Treated with Fe3O4 Nanoparticles

Wu, C., Shen, Z., Lu, Y., Sun, F., & Shi, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c00707 · Cited by 61 · see citing works

Targeting mutant p53: a key player in breast cancer pathogenesis and beyond

Qayoom, H., Haq, B. U., Sofi, S., Jan, N., Jan, A., & Mir, M. A. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01863-9 · Cited by 66 · see citing works

Deciphering the acetylation code of p53 in transcription regulation and tumor suppression

Xia, Z., Kon, N., Gu, A. P., Tavana, O., & Gu, W. (2022) · Oncogene · doi:10.1038/s41388-022-02331-9 · Cited by 60 · see citing works

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Lei, M., Zhang, Y.-L., Huang, F.-Y., Chen, H., Chen, M.-H., Wu, R.-H., Dai, S.-Z., He, G.-S., Tan, G.-H., & Zheng, W.-P. (2023) · Scientific Reports · doi:10.1038/s41598-023-49136-8 · Cited by 63 · see citing works

Interplay of Ferroptosis and Cuproptosis in Cancer: Dissecting Metal-Driven Mechanisms for Therapeutic Potentials

Wang, J., Li, J., Liu, J., Chan, K.-Y., Lee, J. H. S., Lin, K. N., Wang, C. C., & Lau, T. (2024) · Cancers · doi:10.3390/cancers16030512 · Cited by 61 · see citing works

ROS fine-tunes the function and fate of immune cells

Liu, S., Huang, B., Cao, J., Wang, Y., Xiao, H., Zhu, Y., & Zhang, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110069 · Cited by 61 · see citing works

Ferroptosis regulates hemolysis in stored murine and human red blood cells

D’Alessandro, A., Keele, G. R., Hay, A. M., Nemkov, T. G., Earley, E. J., Stephenson, D., Vincent, M. J., Deng, X., Stone, M., Dzieciątkowska, M., et al. (2024) · Blood · doi:10.1182/blood.2024026109 · Cited by 57 · see citing works

Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis

Chen, Y., Zhao, W., Hu, A., Lin, S., Chen, P., Yang, B., Fan, Z., Qi, J., Zhang, W., Gao, H., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05191-x · Cited by 56 · see citing works

Ferroptosis in cardiac hypertrophy and heart failure

Zhang, K., Tian, X.-M., Li, W., & Hao, L. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115765 · Cited by 54 · see citing works

Ginsenoside Rh4 Inhibits Colorectal Cancer Cell Proliferation by Inducing Ferroptosis via Autophagy Activation

Wu, Y., Pi, D., Chen, Y., Zuo, Q., Zhou, S., & Ouyang, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/6177553 · Cited by 53 · see citing works

Mesenchymal Stem Cell‐Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO‐1 Signaling Pathway

Liu, J., Huang, J., Zhang, Z., Zhang, R., Sun, Q., Zhang, Z., Liu, Y., & Ma, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3593294 · Cited by 54 · see citing works

p53 deacetylation alleviates calcium oxalate deposition-induced renal fibrosis by inhibiting ferroptosis

Ye, Z., Xia, Y., Li, L., Li, B., Chen, L., Yu, W., Ruan, Y., Rao, T., Zhou, X., & Fan, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114925 · Cited by 53 · see citing works

Critical Roles of the Cysteine–Glutathione Axis in the Production of γ-Glutamyl Peptides in the Nervous System

Fujii, J., Osaki, T., Soma, Y., & Matsuda, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098044 · Cited by 54 · see citing works

Cell Death Pathway Regulation by Functional Nanomedicines for Robust Antitumor Immunity

Li, Y., Guo, Y., Zhang, K., Zhu, R., Chen, X. S., Zhang, Z., & Yang, W. (2023) · Advanced Science · doi:10.1002/advs.202306580 · Cited by 50 · see citing works

The molecular mechanism of ferroptosis and its role in COPD

Meng, D., Zhu, C., Jia, R., Li, Z., Wang, W., & Song, S. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1052540 · Cited by 49 · see citing works

Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products

Stepanić, V., & Kučerová-Chlupáčová, M. (2023) · Molecules · doi:10.3390/molecules28020475 · Cited by 49 · see citing works

The mechanisms behind heatstroke-induced intestinal damage

Sun, M., Li, Q., Zou, Z., Liu, J., Gu, Z., & Li, L. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02210-0 · Cited by 49 · see citing works

Iron Metabolism and Ferroptosis in Peripheral Nerve Injury

Huang, L., Bian, M., Zhang, J., & Jiang, L.-B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5918218 · Cited by 44 · see citing works

Development and validation of cuproptosis-related gene signature in the prognostic prediction of liver cancer

Liu, Y., Liu, Y., Ye, S., Feng, H., & Ma, L. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.985484 · Cited by 47 · see citing works

Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis

Shi, H., Xiong, L., Yan, G., Du, S., Liu, J., & Shi, Y. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1156062 · Cited by 47 · see citing works

p53 and Zinc: A Malleable Relationship

Ha, J., Prela, O., Carpizo, D. R., & Loh, S. N. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.895887 · Cited by 48 · see citing works

Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression

Zhou, Y., Nakajima, R., Shirasawa, M., Fikriyanti, M., Zhao, L., Iwanaga, R., Bradford, A. P., Kurayoshi, K., Araki, K., & Ohtani, K. (2023) · Biology · doi:10.3390/biology12121511 · Cited by 49 · see citing works

Heavy metals, oxidative stress, and the role of AhR signaling

Kou, Z., Tran, F., & Dai, W. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116769 · Cited by 47 · see citing works

Mitochondrial defects caused by PARL deficiency lead to arrested spermatogenesis and ferroptosis

Radaelli, E., Assenmacher, C., Verrelle, J., Banerjee, E., Manero, F., Khiati, S., Girona, A., López‐Lluch, G., Navas, P., & Spinazzi, M. (2023) · eLife · doi:10.7554/elife.84710 · Cited by 43 · see citing works

Neuronal ferroptosis after intracerebral hemorrhage

Ren, S., Chen, Y., Wang, L., & Wu, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.966478 · Cited by 43 · see citing works

Mechanisms and inhibitors of ferroptosis in psoriasis

Zhou, Q., Yang, L., Li, T., Wang, K., Huang, X., Shi, J., & Wang, Y. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.1019447 · Cited by 42 · see citing works

Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model

Liu, P., Chen, W., Kang, Y., Wang, C., Wang, X., Liu, W., Hayashi, T., Qiu, Z., Mizuno, K., Hattori, S., et al. (2023) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2023.109691 · Cited by 44 · see citing works

A prospective strategy leveraging nanomedicine for cancer therapy: Pouring ferroptosis on apoptosis

Xia, Y., Zhang, J., & Liu, G. (2022) · Nano Today · doi:10.1016/j.nantod.2022.101740 · Cited by 41 · see citing works

Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway

Zou, W., Wang, X., Xia, X., Zhang, T., Nie, M., Xiong, J., & Fang, X. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149338 · Cited by 43 · see citing works

Ferroptosis meets inflammation: A new frontier in cancer therapy

Liu, H., Xue, H., Guo, Q., Xue, X., Yang, L., Zhao, K., & Liu, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217696 · Cited by 40 · see citing works

Lysionotin Induces Ferroptosis to Suppress Development of Colorectal Cancer via Promoting Nrf2 Degradation

Gao, Z., Jiang, J., Hou, L., & Ji, F. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1366957 · Cited by 40 · see citing works

Melatonin and ferroptosis: Mechanisms and therapeutic implications

Zhang, D., Jia, X., Lin, D., & Ma, J. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115909 · Cited by 39 · see citing works

Efficient evaluation of osteotoxicity and mechanisms of endocrine disrupting chemicals using network toxicology and molecular docking approaches: triclosan as a model compound

Wang, Z., Wang, J., Fu, Q., Zhao, H., Wang, Z., & Gao, Y. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118030 · Cited by 39 · see citing works

Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation

Yu, M., Li, H., Wang, B., Wu, Z., Wu, Z., Jiang, G., Wang, H., & Huang, Y. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110607 · Cited by 38 · see citing works

SBFI26 induces triple‐negative breast cancer cells ferroptosis via lipid peroxidation

He, G., Zhang, Y., Feng, Y., Chen, T., Liu, M., Zeng, Y., Yin, X., Qu, S., Huang, L., Ke, Y., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18212 · Cited by 37 · see citing works

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

Akiyama, H., Carter, B. Z., Andreeff, M., & Ishizawa, J. (2023) · Cells · doi:10.3390/cells12081128 · Cited by 38 · see citing works

Ferroptosis: Emerging Role in Diseases and Potential Implication of Bioactive Compounds

Patanè, G. T., Putaggio, S., Tellone, E., Barreca, D., Ficarra, S., Maffei, C., Calderaro, A., & Laganà, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417279 · Cited by 38 · see citing works

Inhibition of ferroptosis: A new direction in the treatment of ulcerative colitis by traditional Chinese medicine

Guo, M., Du, X., & Wang, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117787 · Cited by 37 · see citing works

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 46 · see citing works

p53 at the crossroad between mitochondrial reactive oxygen species and necroptosis

Rius‐Pérez, S. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.07.022 · Cited by 37 · see citing works

Berberine synergises with ferroptosis inducer sensitizing NSCLC to ferroptosis in p53-dependent SLC7A11-GPX4 pathway

Liao, W., Zhang, R., Chen, G., Zhu, X., Wu, W., Chen, Z., Jiang, C., Lin, Z., Ma, L., & Yu, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116832 · Cited by 37 · see citing works

Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53

Li, H., Wang, B., Wu, S., Dong, S., Jiang, G., Huang, Y., Tong, X., & Yu, M. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110479 · Cited by 35 · see citing works

The role of ferroptosis in metabolic diseases

Xie, L., Fang, B., & Zhang, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119480 · Cited by 35 · see citing works

Ferroptosis induction via targeting metabolic alterations in triple-negative breast cancer

Wang, Y., Sun, Y., Wang, F., Wang, H., & Hu, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115866 · Cited by 35 · see citing works

MAPK Signaling‐Mediated RFNG Phosphorylation and Nuclear Translocation Restrain Oxaliplatin‐Induced Apoptosis and Ferroptosis

Di, Y., Zhang, X., Wen, X., Qin, J., Ye, L., Wang, Y., Song, M. L., Wang, Z., & He, W. (2024) · Advanced Science · doi:10.1002/advs.202402795 · Cited by 35 · see citing works

DNA damage repair in megakaryopoiesis: molecular and clinical aspects

Eftekhar, Z., Aghaei, M., & Saki, N. (2024) · Expert Review of Hematology · doi:10.1080/17474086.2024.2391102 · Cited by 35 · see citing works

Multifunctional DNA Tetrahedron for Alzheimer’s Disease Mitochondria-Targeted Therapy by MicroRNA Regulation

Li, W., Peng, X., Mei, X., Dong, M., Li, Y., & Dong, H. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c03181 · Cited by 34 · see citing works

Ferroptosis and Pyroptosis in Epilepsy

Feng, F., Luo, R., Mu, D., & Cai, Q. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04018-6 · Cited by 34 · see citing works

Ferroptosis and the bidirectional regulatory factor p53

Xu, R., Wang, W., & Zhang, W. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01517-8 · Cited by 158 · see citing works

The Regulation of Ferroptosis by Tumor Suppressor p53 and its Pathway

Liu, J., Zhang, C., Wang, J., Hu, W., & Feng, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218387 · Cited by 250 · see citing works

p53 and Ferroptosis

Jiang, S., & Xie, Y. (2023) · Springer eBooks · doi:10.1007/978-3-031-39171-2_7

The tumor suppressor protein p53 and the ferroptosis network

Kang, R., Kroemer, G., & Tang, D. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.05.074 · Cited by 707 · see citing works

p53: A double-edged sword in tumor ferroptosis

Ji, H., Wang, W., Li, X., Han, X., Zhang, X., Wang, J., Liu, C., Huang, L., & Gao, W. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.106013 · Cited by 71 · see citing works