SIRT1 transgenic mice show phenotypes resembling calorie restriction
Open accessAbstract
We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity.
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SIRT1 appears to be a positive regulator of insulin sensitivity.
“In contrast to these negative regulators of insulin action, SIRT1 appears to be a positive regulator of insulin sensitivity (43,44).”
From Insulin sensitivity: Modulation by nutrients and inflammation (2008) · cites this paper as [44]
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“Of note, it has been reported that Sirt1 transgenic mice have phenotypes that resemble DR [163] and show better physical activity in response”
Background
- Authors
- Bordone, L., Cohen, D., Robinson, A., Motta, M. C., Van Veen, E., Czopik, A., Steele, A. D., Crowe, H., Marmor, S., Luo, J., Gu, W., & Guarente, L.
- Affiliations
- Massachusetts Institute of Technology (US)
- University of California, San Francisco (US)
- Whitehead Institute for Biomedical Research (US)
- Columbia University (US)
- Corresponding author
- Bordone, Laura
- Venue
- Aging Cell
- Publisher
- Wiley
- Published
- 2007-08-13
- Volume
- 6
- Issue
- 6
- Pages
- 759-767
- ISSN
- 1474-9718 (ISSN-L)
- 1474-9726
- OpenAlex
- W2158124286
- Cited by
- 722
- References
- 29
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 22 · 2023: 21 · 2022: 16 · 2021: 25 · 2020: 34 · 2019: 32 · 2018: 38 · 2017: 28 · 2016: 38 · 2015: 36 · 2014: 50 · 2013: 85 · 2012: 51
- FWCI
- 25.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Aging Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Glenn Foundation for Medical Research
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- SIRT1, sirtuins, transgenic mice, beta-actin promoter, glucose tolerance, insulin, serum cholesterol, adipokines, body weight, rotorod performance, delayed reproduction, longevity, metabolic activity
- MeSH terms
- Animals, Blood Glucose, Cholesterol, Insulin, Longevity, Mice, Transgenic, Phenotype, Up-Regulation, Caloric Restriction, Sirtuins, Mice, Adipokines, Sirtuin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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