Schwank, Gerald

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

Schwank, G., Koo, B.-K., Sasselli, V., Dekkers, J. F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C. K., et al. (2013) · Cell Stem Cell

CRISPR and Genetic EngineeringCystic Fibrosis Research Advances

Cited by 1,424

Sequential cancer mutations in cultured human intestinal stem cells

Drost, J., van Jaarsveld, R. H., Ponsioen, B., Zimberlin, C., van Boxtel, R., Buijs, A., Sachs, N., Overmeer, R. M., Offerhaus, G. J., Begthel, H., et al. (2015) · Nature

Cancer Cells and MetastasisGenetic factors in colorectal cancer

Cited by 1,067

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature

Cancer Genomics and DiagnosticsGenetic factors in colorectal cancer

Cited by 935

Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies

Nuciforo, S., Fofana, I., Matter, M. S., Blumer, T., Calabrese, D., Boldanova, T., Piscuoglio, S., Wieland, S., Ringnalda, F., Schwank, G., et al. (2018) · Cell Reports

Hepatocellular Carcinoma Treatment and PrognosisCancer Cells and Metastasis

Cited by 473

High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays

Brandenberg, N., Hoehnel, S., Kuttler, F., Homicsko, K., Ceroni, C., Ringel, T., Gjorevski, N., Schwank, G., Coukos, G., Turcatti, G., et al. (2020) · Nature Biomedical Engineering

3D Printing in Biomedical ResearchCancer Cells and Metastasis

Cited by 390

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Rothgangl, T., Dennis, M. K., Lin, P. J. C., Oka, R., Witzigmann, D., Villiger, L., Qi, W., Hruzova, M., Kissling, L., Lenggenhager, D., et al. (2021) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 378

Growth of Epithelial Organoids in a Defined Hydrogel

Broguiere, N., Isenmann, L., Hirt, C., Ringel, T., Placzek, S., Cavalli, E., Ringnalda, F., Villiger, L., Züllig, R., Lehmann, R., et al. (2018) · Advanced Materials

Hydrogels: synthesis, properties, applicationsCellular Mechanics and Interactions

Cited by 282

Advances in therapeutic CRISPR/Cas9 genome editing

Savić, N., & Schwank, G. (2016) · Translational Research

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 257

Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance

Ringel, T., Frey, N., Ringnalda, F., Janjuha, S., Cherkaoui, S., Butz, S., Srivatsa, S., Pirkl, M., Russo, G., Villiger, L., et al. (2020) · Cell Stem Cell

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 202

In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA

Villiger, L., Rothgangl, T., Witzigmann, D., Oka, R., Lin, P. J. C., Qi, W., Janjuha, S., Berk, C., Ringnalda, F., Beattie, M. B., et al. (2021) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 105

Predicting base editing outcomes with an attention-based deep learning algorithm trained on high-throughput target library screens

Marquart, K. F., Allam, A., Janjuha, S., Sintsova, A., Villiger, L., Frey, N., Krauthammer, M., & Schwank, G. (2021) · Nature Communications

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 102