Klimstra, David S.

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Zehir, A., Benayed, R., Shah, R. H., Syed, A., Middha, S., Kim, H. R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S. M., et al. (2017) · Nature Medicine

Cancer Genomics and DiagnosticsBRCA gene mutations in cancer

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Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

Campanella, G., Hanna, M. G., Geneslaw, L., Miraflor, A., Werneck Krauss Silva, V., Busam, K. J., Brogi, E., Reuter, V. E., Klimstra, D. S., & Fuchs, T. J. (2019) · Nature Medicine

AI in cancer detectionRadiomics and Machine Learning in Medical Imaging

Cited by 2,799

Organoid models of human and mouse ductal pancreatic cancer

Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell

Pancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Cited by 2,150

Integrated genomic characterization of pancreatic ductal adenocarcinoma

Raphael, B. J., Hruban, R. H., Aguirre, A. J., Moffitt, R. A., Yeh, J. J., Stewart, C., Robertson, A. G., Cherniack, A. D., Gupta, M., Getz, G., et al. (2017) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 2,019

Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions

Hruban, R. H., Adsay, N. V., Albores–Saavedra, J., Compton, C., Garrett, E. S., Goodman, S. N., Kern, S. E., Klimstra, D. S., Klöppel, G., Longnecker, D. S., et al. (2001) · The American Journal of Surgical Pathology

Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research Advances

Cited by 1,126

An Illustrated Consensus on the Classification of Pancreatic Intraepithelial Neoplasia and Intraductal Papillary Mucinous Neoplasms

Hruban, R. H., Takaori, K., Klimstra, D. S., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Biankin, S. A., Compton, C., Fukushima, N., Furukawa, T., et al. (2004) · American Journal of Surgical Pathology

Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research Advances

Cited by 1,091

Cetuximab shows activity in colorectal cancer patients with tumors that do not express the epidermal growth factor receptor by immunohistochemistry.

Chung, K. Y., Shia, J., Kemeny, N. E., Shah, M., Schwartz, G. K., Tse, A., Hamilton, A., Pan, D., Schrag, D., Schwartz, L., et al. (2005) · Journal of Clinical Oncology

Colorectal Cancer Treatments and StudiesHER2/EGFR in Cancer Research

Cited by 1,081

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas

Basturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology

Pancreatic and Hepatic Oncology ResearchNeuroendocrine Tumor Research Advances

Cited by 864

Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients to Targeted and Immune Therapies

Harding, J. J., Nandakumar, S., Armenia, J., Khalil, D. N., Albano, M., Ly, M., Shia, J., Hechtman, J. F., Kundra, R., El Dika, I., et al. (2019) · Clinical Cancer Research

Hepatocellular Carcinoma Treatment and PrognosisCancer Genomics and Diagnostics

Cited by 602

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

Fisher, G. H., Wellen, S. L., Klimstra, D., Lenczowski, J. M., Tichelaar, J. W., Lizak, M. J., Whitsett, J. A., Koretsky, A., & Varmus, H. E. (2001) · Genes & Development

Protein Kinase Regulation and GTPase SignalingCancer-related Molecular Pathways

Cited by 582

A foundation model for clinical-grade computational pathology and rare cancers detection

Vorontsov, E., Bozkurt, A., Casson, A., Shaikovski, G., Zelechowski, M., Severson, K., Zimmermann, E., Hall, J., Tenenholtz, N., Fusi, N., et al. (2024) · Nature Medicine

AI in cancer detectionArtificial Intelligence in Healthcare and Education

Cited by 572

Multi-institutional Validation Study of the American Joint Commission on Cancer (8th Edition) Changes for T and N Staging in Patients With Pancreatic Adenocarcinoma

Allen, P. J., Kuk, D., Castillo, C. F.-D., Basturk, O., Wolfgang, C. L., Cameron, J. L., Lillemoe, K. D., Ferrone, C. R., Morales-Oyarvide, V., He, J., et al. (2017) · Annals of Surgery

Pancreatic and Hepatic Oncology ResearchCholangiocarcinoma and Gallbladder Cancer Studies

Cited by 485

Clinical implications of genomic alterations in the tumour and circulation of pancreatic cancer patients

Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Kay Li, Q., et al. (2015) · Nature Communications

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 484

A Combination of Molecular Markers and Clinical Features Improve the Classification of Pancreatic Cysts

Springer, S., Wang, Y., Dal Molin, M., Masica, D. L., Jiao, Y., Kinde, I., Blackford, A., Raman, S. P., Wolfgang, C. L., Tomita, T., et al. (2015) · Gastroenterology

Pancreatic and Hepatic Oncology ResearchCancer Genomics and Diagnostics

Cited by 477

Early Detection of Sporadic Pancreatic Cancer: Summative Review

Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., Batra, S. K., Brentnall, T. A., Canto, M., Cleeter, D. F., et al. (2015) · Pancreas

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 295

Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

Lowery, M. A., Wong, W., Jordan, E. J., Lee, J. W., Kemel, Y., Vijai, J., Mandelker, D., Zehir, A., Capanu, M., Salo-Mullen, E., et al. (2018) · JNCI: Journal of the National Cancer Institute

Pancreatic and Hepatic Oncology ResearchBRCA gene mutations in cancer

Cited by 224

A multimodality test to guide the management of patients with a pancreatic cyst

Springer, S., Masica, D. L., Dal Molin, M., Douville, C., Thoburn, C. J., Afsari, B., Li, L., Cohen, J. D., Thompson, E., Allen, P. J., et al. (2019) · Science Translational Medicine

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

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High Telomerase Activity in Primary Lung Cancers: Association With Increased Cell Proliferation Rates and Advanced Pathologic Stage

Albanell, J., Engelhardt, M., Han, W., Moore, M. A. S., Lonardo, F., Rusch, V., Langenfeld, J., Klimstra, D., Venkatraman, E., & Dmitrovsky, E. (1997) · JNCI Journal of the National Cancer Institute

Telomeres, Telomerase, and SenescenceLung Cancer Research Studies

Cited by 193

Novel artificial intelligence system increases the detection of prostate cancer in whole slide images of core needle biopsies

Raciti, P., Sue, J., Ceballos, R., Godrich, R., Kunz, J. D., Kapur, S., Reuter, V., Grady, L., Kanan, C., Klimstra, D. S., et al. (2020) · Modern Pathology

AI in cancer detectionArtificial Intelligence in Healthcare and Education

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Patterns and prognostic relevance of PD-1 and PD-L1 expression in colorectal carcinoma

Lee, L. H., Cavalcanti, M. S., Segal, N. H., Hechtman, J. F., Weiser, M. R., Smith, J. J., Garcia-Aguilar, J., Sadot, E., Ntiamoah, P., Markowitz, A. J., et al. (2016) · Modern Pathology

Cancer Immunotherapy and BiomarkersGenetic factors in colorectal cancer

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Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review

Kenner, B., Chari, S. T., Kelsen, D., Klimstra, D. S., Pandol, S. J., Rosenthal, M., Rustgi, A. K., Taylor, J. A., Yala, A., Abul-Husn, N., et al. (2021) · Pancreas

AI in cancer detectionPancreatic and Hepatic Oncology Research

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An independent assessment of an artificial intelligence system for prostate cancer detection shows strong diagnostic accuracy

Perincheri, S., Levi, A. W., Celli, R., Gershkovich, P., Rimm, D., Morrow, J. S., Rothrock, B., Raciti, P., Klimstra, D., & Sinard, J. (2021) · Modern Pathology

AI in cancer detectionArtificial Intelligence in Healthcare and Education

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Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

Boonstra, J. J., van Marion, R., Beer, D. G., Lin, L., Chaves, P., Ribeiro, C., Pereira, A. D., Roque, L., Darnton, S. J., Altorki, N. K., et al. (2010) · JNCI: Journal of the National Cancer Institute

Esophageal Cancer Research and TreatmentCancer Cells and Metastasis

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Precancerous neoplastic cells can move through the pancreatic ductal system

Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., et al. (2018) · Nature

Cancer Genomics and DiagnosticsPancreatic and Hepatic Oncology Research

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