Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

Boonstra, Jurjen J.; van Marion, Ronald; Beer, David G.; Lin, Lin; Chaves, Paula; Ribeiro, Catarina; Pereira, A. Dias; Roque, Lúcia; Darnton, S. Jane; Altorki, Nasser K.; Schrump, David S.; Klimstra, David S.; Tang, Laura H.; Eshleman, James R.; Alvarez, Hector; Shimada, Yutaka; van Dekken, Herman; Tilanus, Hugo W.; Dinjens, Winand N. M.

doi:10.1093/jnci/djp499

Cited by 127Esophageal Cancer Research and TreatmentCancer Cells and MetastasisIdentification and Quantification in Food

Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

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Boonstra, Jurjen J., van Marion, Ronald, Beer, David G., Lin, Lin, Chaves, Paula, Ribeiro, Catarina, Pereira, A. Dias, Roque, Lúcia +11 more·2010·JNCI: Journal of the National Cancer Institute

DOI 10.1093/jnci/djp499PMC PMC2902814

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Abstract

For decades, hundreds of different human tumor type-specific cell lines have been used in experimental cancer research as models for their respective tumors. The veracity of experimental results for a specific tumor type relies on the correct derivation of the cell line. In a worldwide effort, we verified the authenticity of all available esophageal adenocarcinoma (EAC) cell lines. We proved that the frequently used cell lines SEG-1 and BIC-1 and the SK-GT-5 cell line are in fact cell lines from other tumor types. Experimental results based on these contaminated cell lines have led to ongoing clinical trials recruiting EAC patients, to more than 100 scientific publications, and to at least three National Institutes of Health cancer research grants and 11 US patents, which emphasizes the importance of our findings. Widespread use of contaminated cell lines threatens the development of treatment strategies for EAC.

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STR profiling is the gold standard and authentication standard for cell line authentication.
“STR profiling remains the gold standard for cell line authentication.”
From The history, landscape, and outlook of human cell line authentication and security (2024) · cites this paper as [34]
The authentication methods passage (labeled Abstract in our copy; page unavailable) says the authors used STR profiling to compare cell lines with original tissues, alongside TP53 mutation analysis. It supports STR profiling as an authentication method but does not call it the gold standard or establish that it remains the standard. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Consequences of false findings from misidentified cell lines are potentially severe and costly, with grants, patents and even drug trials based on misidentified cells.
“Considering the biomedical nature of research conducted on these cell lines, consequences of false findings are potentially severe and costly [17], with grants, patents and even drug trials based on misidentified cells [18].”
From The ghosts of HeLa: How cell line misidentification contaminates the scientific literature (2017) · cites this paper as [18]
Contamination rates and the frequency of high-profile cases demonstrate universal vulnerability to CCCM.
“However, contamination rates and the frequency of high-profile cases demonstrate the universal vulnerability to CCCM [34][35][36][37].”
From The history, landscape, and outlook of human cell line authentication and security (2024) · cites this paper as [34]

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Authors: Boonstra, J. J., van Marion, R., Beer, D. G., Lin, L., Chaves, P., Ribeiro, C., Pereira, A. D., Roque, L., Darnton, S. J., Altorki, N. K., Schrump, D. S., Klimstra, D. S., Tang, L. H., Eshleman, J. R., Alvarez, H., Shimada, Y., van Dekken, H., Tilanus, H. W., & Dinjens, W. N. M.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
ORCID: Boonstra, Jurjen J.
Beer, David G.
Chaves, Paula
Ribeiro, Catarina
Pereira, A. Dias
Roque, Lúcia
Altorki, Nasser K.
Schrump, David S.
Klimstra, David S.
Tang, Laura H.
Eshleman, James R.
Shimada, Yutaka
Dinjens, Winand N. M.
Venue: JNCI: Journal of the National Cancer Institute
Publisher: Oxford University Press (OUP)
Published: 2010-02-24
Volume: 102
Issue: 4
Pages: 271-274
ISSN: 0027-8874 (ISSN-L)
1460-2105
DOI: 10.1093/jnci/djp499
PMC: PMC2902814
OpenAlex: W2120608850
Cited by: 127
References: 23
Citations by year: 2026: 1 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 12 · 2013: 17 · 2012: 11
FWCI: 18.58
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: JNCI Journal of the National Cancer Institute (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
HighWire Press Open Archive (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion)
Funders: National Cancer Institute (R01CA071606, R01CA154365)
Topics: Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Identification and Quantification in Food
Keywords: esophageal adenocarcinoma, cell line contamination, cell line authentication, cancer research models
MeSH terms: Sorafenib, Adenocarcinoma, Antineoplastic Agents, Benzenesulfonates, Carcinoma, Clinical Trials as Topic, Esophageal Neoplasms, Humans, Lung Neoplasms, National Institutes of Health (U.S.), Niacinamide, Oligonucleotides, Oligopeptides, Phenylurea Compounds, Pyridines, Stomach Neoplasms, United States, Colorectal Neoplasms, DNA Fingerprinting, Carcinoma, Large Cell, Telomerase, Tandem Repeat Sequences, Biomedical Research, Cell Line, Tumor, Protein Kinase Inhibitors

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Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

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