Xu, Ming

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,287

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J. N., Xu, M., Weivoda, M. M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., et al. (2017) · Nature Medicine

Telomeres, Telomerase, and SenescenceBone Metabolism and Diseases

Cited by 1,182

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., et al. (2018) · EBioMedicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,032

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., et al. (2015) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 915

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M. M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang‐Verzosa, G., et al. (2019) · Aging Cell

Telomeres, Telomerase, and SenescenceAdipokines, Inflammation, and Metabolic Diseases

Cited by 658

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M. M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., et al. (2015) · eLife

Telomeres, Telomerase, and SenescenceAdipose Tissue and Metabolism

Cited by 604

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Ogrodnik, M., Zhu, Y., Langhi, L. G. P., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R. A., Giorgadze, N., Pirtskhalava, T., et al. (2019) · Cell Metabolism

Telomeres, Telomerase, and SenescenceNeurogenesis and neuroplasticity mechanisms

Cited by 536

Strategies for targeting senescent cells in human disease

Gasek, N. S., Kuchel, G. A., Kirkland, J. L., & Xu, M. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 501

Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015) · Diabetes

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 423

SenNet recommendations for detecting senescent cells in different tissues

Suryadevara, V., Hudgins, A. D., Rajesh, A., Pappalardo, A., Karpova, A., Dey, A. K., Hertzel, A., Agudelo, A., Rocha, A., Soygur, B., et al. (2024) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 408

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., Curran, G. L., Ogrodnik, M., Jurk, D., Johnson, K. O., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Osteoarthritis Treatment and MechanismsTelomeres, Telomerase, and Senescence

Cited by 352

The heterogeneity of cellular senescence: insights at the single-cell level

Cohn, R. L., Gasek, N. S., Kuchel, G. A., & Xu, M. (2023) · Trends in Cell Biology

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 294

Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes

Shen, X., Zheng, S., Thongboonkerd, V., Xu, M., Pierce, W. M., Klein, J. B., & Epstein, P. N. (2004) · American Journal of Physiology-Endocrinology and Metabolism

Mitochondrial Function and PathologyCardiovascular Function and Risk Factors

Cited by 258

Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

Wang, L., Wang, B., Gasek, N. S., Zhou, Y., Cohn, R. L., Martin, D. E., Zuo, W., Flynn, W. F., Guo, C., Jellison, E. R., et al. (2022) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 163

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo

Wang, B., Wang, L., Gasek, N. S., Zhou, Y., Kim, T., Guo, C., Jellison, E. R., Haynes, L., Yadav, S., Tchkonia, T., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 145

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J.-P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., et al. (2017) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Adipose Tissue and MetabolismHormonal and reproductive studies

Cited by 119

Endothelial NLRP3 Inflammasome Activation and Enhanced Neointima Formation in Mice by Adipokine Visfatin

Xia, M., Boini, K. M., Abais, J. M., Xu, M., Zhang, Y., & Li, P.-L. (2014) · The American Journal of Pathology

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 106

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

Xu, M., Tchkonia, T., & Kirkland, J. L. (2016) · Pharmacological Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 99

Transplanting cells from old but not young donors causes physical dysfunction in older recipients

Wang, B., Liu, Z., Chen, V. P., Wang, L., Inman, C. L., Zhou, Y., Guo, C., Tchkonia, T., Rowe, D. W., Kuchel, G. A., et al. (2020) · Aging Cell

Mesenchymal stem cell researchTelomeres, Telomerase, and Senescence

Cited by 76

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F. T., Milic, N. M., et al. (2019) · Biology of Sex Differences

Mesenchymal stem cell researchPregnancy and preeclampsia studies

Cited by 76

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

Wang, B., Wang, L., Gasek, N. S., Kuo, C.-L., Nie, J., Kim, T., Yan, P., Zhu, J., Torrance, B. L., Zhou, Y., et al. (2024) · Cell Metabolism

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 59

Clearance of p21 highly expressing senescent cells accelerates cutaneous wound healing

Gasek, N. S., Yan, P., Zhu, J., Purushothaman, K.-R., Kim, T., Wang, L., Wang, B., Flynn, W. F., Sun, M., Guo, C., et al. (2024) · Nature Aging

Telomeres, Telomerase, and SenescenceWound Healing and Treatments

Cited by 43

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40