Mirny, Leonid A.

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

Lieberman-Aiden, E., van Berkum, N. L., Williams, L., Imakaev, M., Ragoczy, T., Telling, A., Amit, I., Lajoie, B. R., Sabo, P. J., Dorschner, M. O., et al. (2009) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 8,898

Formation of chromosomal domains by loop extrusion

Fudenberg, G., Imakaev, M., Lu, C., Goloborodko, A., Abdennur, N., & Mirny, L. A. (2016) · Cell Reports

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 2,003

Cooler: scalable storage for Hi-C data and other genomically labeled arrays

Abdennur, N., & Mirny, L. A. (2020) · Bioinformatics

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 1,759

Targeted Degradation of CTCF Decouples Local Insulation of Chromosome Domains from Genomic Compartmentalization

Nora, E. P., Goloborodko, A., Valton, A.-L., Gibcus, J. H., Uebersohn, A., Abdennur, N., Dekker, J., Mirny, L. A., & Bruneau, B. G. (2017) · Cell

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 1,709

Iterative correction of Hi-C data reveals hallmarks of chromosome organization

Imakaev, M., Fudenberg, G., McCord, R. P., Naumova, N., Goloborodko, A., Lajoie, B. R., Dekker, J., & Mirny, L. A. (2012) · Nature Methods

Genomics and Chromatin DynamicsGenomic variations and chromosomal abnormalities

Cited by 1,423

Two independent modes of chromatin organization revealed by cohesin removal

Schwarzer, W., Abdennur, N., Goloborodko, A., Pekowska, A., Fudenberg, G., Loe-Mie, Y., Fonseca, N. A., Huber, W., Haering, C. H., Mirny, L., et al. (2017) · Nature

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 1,196

Exploring the three-dimensional organization of genomes: Interpreting chromatin interaction data

Dekker, J., Marti-Renom, M. A., & Mirny, L. A. (2013) · Nature Reviews Genetics

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 1,068

Organization of the mitotic chromosome

Naumova, N., Imakaev, M., Fudenberg, G., Zhan, Y., Lajoie, B. R., Mirny, L. A., & Dekker, J. (2013) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 976

The 3D Genome as Moderator of Chromosomal Communication

Dekker, J., & Mirny, L. (2016) · Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 937

Single-nucleus Hi-C reveals unique chromatin reorganization at oocyte-to-zygote transition

Flyamer, I. M., Gassler, J., Imakaev, M., Brandão, H. B., Ulianov, S. V., Abdennur, N., Razin, S. V., Mirny, L. A., & Tachibana-Konwalski, K. (2017) · Nature

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 753

The 4D nucleome project

the 4D Nucleome Network, Dekker, J., Belmont, A. S., Guttman, M., Leshyk, V. O., Lis, J. T., Lomvardas, S., Mirny, L. A., O’Shea, C. C., Park, P. J., et al. (2017) · Nature

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 732

Heterochromatin drives compartmentalization of inverted and conventional nuclei

Falk, M., Feodorova, Y., Naumova, N., Imakaev, M., Lajoie, B. R., Leonhardt, H., Joffe, B., Dekker, J., Fudenberg, G., Solovei, I., et al. (2019) · Nature

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 646

Ultrastructural Details of Mammalian Chromosome Architecture

Krietenstein, N., Abraham, S., Venev, S. V., Abdennur, N., Gibcus, J., Hsieh, T.-H. S., Parsi, K. M., Yang, L., Maehr, R., Mirny, L. A., et al. (2020) · Molecular Cell

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 622

Dynamics of CTCF- and cohesin-mediated chromatin looping revealed by live-cell imaging

Gabriele, M., Brandão, H. B., Grosse-Holz, S., Jha, A., Dailey, G. M., Cattoglio, C., Hsieh, T.-H. S., Mirny, L., Zechner, C., & Hansen, A. S. (2022) · Science

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 506

Extensive Heterogeneity and Intrinsic Variation in Spatial Genome Organization

Finn, E. H., Pegoraro, G., Brandão, H. B., Valton, A.-L., Oomen, M. E., Dekker, J., Mirny, L., & Misteli, T. (2019) · Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 459

Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals

Sawai, C. M., Babovic, S., Upadhaya, S., Knapp, D. J. H. F., Lavin, Y., Lau, C. M., Goloborodko, A., Feng, J., Fujisaki, J., Ding, L., et al. (2016) · Immunity

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 381

Nucleosome-mediated cooperativity between transcription factors

Mirny, L. A. (2010) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 349

Protein Folding Theory: From Lattice to All-Atom Models

Mirny, L., & Shakhnovich, E. (2001) · Annual Review of Biophysics and Biomolecular Structure

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 341

Zfx Controls the Self-Renewal of Embryonic and Hematopoietic Stem Cells

Galan-Caridad, J. M., Harel, S., Arenzana, T. L., Hou, Z. E., Doetsch, F. K., Mirny, L. A., & Reizis, B. (2007) · Cell

Pluripotent Stem Cells ResearchHematopoietic Stem Cell Transplantation

Cited by 244

Chromosome organization by one-sided and two-sided loop extrusion

Banigan, E. J., van den Berg, A. A., Brandão, H. B., Marko, J. F., & Mirny, L. A. (2020) · eLife

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 146

RNA polymerases as moving barriers to condensin loop extrusion

Brandão, H. B., Paul, P., van den Berg, A. A., Rudner, D. Z., Wang, X., & Mirny, L. A. (2019) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 143

Chromatin loops as allosteric modulators of enhancer-promoter interactions

Doyle, B., Fudenberg, G., Imakaev, M., & Mirny, L. A. (2014) · PLoS Computational Biology

Genomics and Chromatin DynamicsDiffusion and Search Dynamics

Cited by 114

The chromosome folding problem and how cells solve it

Dekker, J., & Mirny, L. A. (2024) · Cell

Genomics and Chromatin DynamicsNuclear Structure and Function

Cited by 112

DNA-loop-extruding SMC complexes can traverse one another in vivo

Brandão, H. B., Ren, Z., Karaboja, X., Mirny, L. A., & Wang, X. (2021) · Nature Structural & Molecular Biology

Genomics and Chromatin DynamicsBacterial Genetics and Biotechnology

Cited by 90