Duchen, Michael R.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

Chouchani, E. T., Pell, V. R., Gaude, E., Aksentijević, D., Sundier, S. Y., Robb, E. L., Logan, A., Nadtochiy, S. M., Ord, E. N. J., Smith, A. C., et al. (2014) · Nature

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

Gandhi, S., Wood-Kaczmar, A., Yao, Z., Plun-Favreau, H., Deas, E., Klupsch, K., Downward, J., Latchman, D. S., Tabrizi, S. J., Wood, N. W., et al. (2009) · Molecular Cell

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 682

Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death

Duchen, M. R. (1999) · The Journal of Physiology

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 610

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 587

Endothelial Mitochondria: Contributing to Vascular Function and Disease

Davidson, S. M., & Duchen, M. R. (2007) · Circulation Research

Mitochondrial Function and PathologyNitric Oxide and Endothelin Effects

Cited by 381

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection

Hausenloy, D., Wynne, A., Duchen, M., & Yellon, D. (2004) · Circulation

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 366

Changes in Intracellular Calcium and Glutathione in Astrocytes as the Primary Mechanism of Amyloid Neurotoxicity

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2003) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 337

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons

Wood-Kaczmar, A., Gandhi, S., Yao, Z., Abramov, A. S. Y., Miljan, E. A., Keen, G., Stanyer, L., Hargreaves, I., Klupsch, K., Deas, E., et al. (2008) · PLoS ONE

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 316

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation

BRENNAN, J., SOUTHWORTH, R., MEDINA, R., DAVIDSON, S., DUCHEN, M., & SHATTOCK, M. (2006) · Cardiovascular Research

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 242

Calcium signals induced by amyloid β peptide and their consequences in neurons and astrocytes in culture

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 223

Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders

Plotegher, N., & Duchen, M. R. (2017) · Trends in Molecular Medicine

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 161

Mitochondrial permeability transition pore: Sensitivity to opening and mechanistic dependence on substrate availability

Briston, T., Roberts, M., Lewis, S., Powney, B., M. Staddon, J., Szabadkai, G., & Duchen, M. R. (2017) · Scientific Reports

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 152

Deletion of the von Hippel–Lindau gene in pancreatic β cells impairs glucose homeostasis in mice

Cantley, J., Selman, C., Shukla, D., Abramov, A. Y., Forstreuter, F., Esteban, M. A., Claret, M., Lingard, S. J., Clements, M., Harten, S. K., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 127

Effects of metabolic inhibition on the membrane properties of isolated mouse primary sensory neurones

Duchen, M. R. (1990) · The Journal of Physiology

Ion channel regulation and functionMitochondrial Function and Pathology

Cited by 121

Crosstalk between Lysosomes and Mitochondria in Parkinson's Disease

Plotegher, N., & Duchen, M. R. (2017) · Frontiers in Cell and Developmental Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 106

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis

Warne, J., Pryce, G., Hill, J. M., Shi, X., Lennerås, F., Puentes, F., Kip, M., Hilditch, L., Walker, P., Simone, M. I., et al. (2016) · Journal of Biological Chemistry

Mitochondrial Function and PathologySignaling Pathways in Disease

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FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation

BRENNAN, J., BERRY, R., BAGHAI, M., DUCHEN, M., & SHATTOCK, M. (2006) · Cardiovascular Research

Cardiac Ischemia and ReperfusionMitochondrial Function and Pathology

Cited by 92

A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic ?-cells

Smith, P. A., Duchen, M. R., & Ashcroft, F. M. (1995) · Pfl�gers Archiv European Journal of Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 80

Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases

Osellame, L. D., & Duchen, M. R. (2013) · Autophagy

Lysosomal Storage Disorders ResearchAutophagy in Disease and Therapy

Cited by 79

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

De La Rossa, A., Laporte, M. H., Astori, S., Marissal, T., Montessuit, S., Sheshadri, P., Ramos-Fernández, E., Mendez, P., Khani, A., Quairiaux, C., et al. (2022) · eLife

Mitochondrial Function and PathologyEpilepsy research and treatment

Cited by 38

Mitochondrial Dysfunction in Neurodegenerative Disorders

Reeve, A. K., Turnbull, D. M., Duchen, M. R., & Krishnan, K. J. (2012) · Springer eBooks

Mitochondrial Function and PathologyParkinson's Disease Mechanisms and Treatments

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