Betts, Michael R.

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 2,062

Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

Mathew, D., Giles, J. R., Baxter, A. E., Oldridge, D. A., Greenplate, A. R., Wu, J. E., Alanio, C., Kuri-Cervantes, L., Pampena, M. B., D’Andrea, K., et al. (2020) · Science

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 1,509

Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells

Brenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood

HIV Research and TreatmentT-cell and B-cell Immunology

Cited by 1,073

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Goel, R. R., Painter, M. M., Apostolidis, S. A., Mathew, D., Meng, W., Rosenfeld, A. M., Lundgreen, K. A., Reynaldi, A., Khoury, D. S., Pattekar, A., et al. (2021) · Science

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 873

Comprehensive mapping of immune perturbations associated with severe COVID-19

Kuri-Cervantes, L., Pampena, M. B., Meng, W., Rosenfeld, A. M., Ittner, C. A. G., Weisman, A. R., Agyekum, R. S., Mathew, D., Baxter, A. E., Vella, L. A., et al. (2020) · Science Immunology

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 723

Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination

Goel, R. R., Apostolidis, S. A., Painter, M. M., Mathew, D., Pattekar, A., Kuthuru, O., Gouma, S., Hicks, P., Meng, W., Rosenfeld, A. M., et al. (2021) · Science Immunology

SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinations

Cited by 655

Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination

Painter, M. M., Mathew, D., Goel, R. R., Apostolidis, S. A., Pattekar, A., Kuthuru, O., Baxter, A. E., Herati, R. S., Oldridge, D. A., Gouma, S., et al. (2021) · Immunity

SARS-CoV-2 and COVID-19 ResearchT-cell and B-cell Immunology

Cited by 499

Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry

Chattopadhyay, P. K., Price, D. A., Harper, T. F., Betts, M. R., Yu, J., Gostick, E., Perfetto, S. P., Goepfert, P., Koup, R. A., De Rosa, S. C., et al. (2006) · Nature Medicine

Quantum Dots Synthesis And PropertiesT-cell and B-cell Immunology

Cited by 372

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

Brantly, M. L., Chulay, J. D., Wang, L., Mueller, C., Humphries, M., Spencer, L. T., Rouhani, F., Conlon, T. J., Calcedo, R., Betts, M. R., et al. (2009) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 327

AAV-1–mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells

Mingozzi, F., Meulenberg, J. J., Hui, D. J., Basner-Tschakarjan, E., Hasbrouck, N. C., Edmonson, S. A., Hutnick, N. A., Betts, M. R., Kastelein, J. J., Stroes, E. S., et al. (2009) · Blood

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 295

Circulating CXCR5+PD-1+ Response Predicts Influenza Vaccine Antibody Responses in Young Adults but not Elderly Adults

Herati, R. S., Reuter, M. A., Dolfi, D. V., Mansfield, K. D., Aung, H., Badwan, O. Z., Kurupati, R. K., Kannan, S., Ertl, H., Schmader, K. E., et al. (2014) · The Journal of Immunology

Influenza Virus Research StudiesT-cell and B-cell Immunology

Cited by 177

T follicular helper cells in human efferent lymph retain lymphoid characteristics

Vella, L. A., Buggert, M., Manne, S., Herati, R. S., Sayin, I., Kuri-Cervantes, L., Bukh Brody, I., O’Boyle, K. C., Kaprielian, H., Giles, J. R., et al. (2019) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 155

Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6 blockade–refractory idiopathic multicentric Castleman disease

Fajgenbaum, D. C., Langan, R.-A., Japp, A. S., Partridge, H. L., Pierson, S. K., Singh, A., Arenas, D. J., Ruth, J. R., Nabel, C. S., Stone, K., et al. (2019) · Journal of Clinical Investigation

IgG4-Related and Inflammatory DiseasesViral-associated cancers and disorders

Cited by 147

CD40L expression permits CD8+ T cells to execute immunologic helper functions

Frentsch, M., Stark, R., Matzmohr, N., Meier, S., Durlanik, S., Schulz, A. R., Stervbo, U., Jürchott, K., Gebhardt, F., Heine, G., et al. (2013) · Blood

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 100

Class I-restricted T-cell responses to a polymorphic peptide in a gene therapy clinical trial for α-1-antitrypsin deficiency

Calcedo, R., Somanathan, S., Qin, Q., Betts, M. R., Rech, A. J., Vonderheide, R. H., Mueller, C., Flotte, T. R., & Wilson, J. M. (2017) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchImmunotherapy and Immune Responses

Cited by 79

Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease

Pai, R.-A. L., Japp, A. S., Gonzalez, M., Rasheed, R. F., Okumura, M., Arenas, D., Pierson, S. K., Powers, V., Layman, A. A. K., Kao, C., et al. (2020) · JCI Insight

IgG4-Related and Inflammatory DiseasesAutoimmune and Inflammatory Disorders Research

Cited by 68

Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders

Yadav, A., Betts, M. R., & Collman, R. G. (2016) · Journal of NeuroVirology

HIV Research and TreatmentHIV-related health complications and treatments

Cited by 31

Age-related differences in polyfunctional T cell responses

Van Epps, P., Banks, R., Aung, H., Betts, M. R., & Canaday, D. H. (2014) · Immunity & Ageing

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 22

Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes

Peterson, J. J., Chandel, S., James, K., Bennett, E. S., Wu, V., White, C. H., Allard, B., Clohosey, M., Whitaker, T., Baker, C., et al. (2026) · Journal of Clinical Investigation

HIV Research and TreatmentVirus-based gene therapy research

Cited by 7