Honjo, Tasuku

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J., Malenkovich, N., Okazaki, T., Byrne, M. C., et al. (2000) · The Journal of Experimental Medicine

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 5,294

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai, Y., Long, A. J., Brown, J. A., Nunes, R., et al. (2001) · Nature Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 2,955

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Nishimura, H., Nose, M., Hiai, H., Minato, N., & Honjo, T. (1999) · Immunity

Systemic Lupus Erythematosus ResearchT-cell and B-cell Immunology

Cited by 2,749

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., et al. (2001) · Science

Viral Infections and Immunology ResearchCardiac Fibrosis and Remodeling

Cited by 1,868

Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

Agata, Y., Kawasaki, A., Nishimura, H., Ishida, Y., Tsubat, T., Yagita, H., & Honjo, T. (1996) · International Immunology

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 1,589

Programmed cell death 1 ligand 1 and tumor-infiltrating CD8 + T lymphocytes are prognostic factors of human ovarian cancer

Hamanishi, J., Mandai, M., Iwasaki, M., Okazaki, T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K., Minato, N., et al. (2007) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersOvarian cancer diagnosis and treatment

Cited by 1,378

PD-L1/B7H-1 Inhibits the Effector Phase of Tumor Rejection by T Cell Receptor (TCR) Transgenic CD8+ T Cells

Blank, C., Brown, I., Peterson, A. C., Spiotto, M., Iwai, Y., Honjo, T., & Gajewski, T. F. (2004) · Cancer Research

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 772

Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S. (2004) · Proceedings of the National Academy of Sciences

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 721

Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice

Okazaki, T., Tanaka, Y., Nishio, R., Mitsuiye, T., Mizoguchi, A., Wang, J., Ishida, M., Hiai, H., Matsumori, A., Minato, N., et al. (2003) · Nature Medicine

Viral Infections and Immunology ResearchCardiomyopathy and Myosin Studies

Cited by 689

Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells

Tanigaki, K., Han, H., Yamamoto, N., Tashiro, K., Ikegawa, M., Kuroda, K., Suzuki, A., Nakano, T., & Honjo, T. (2002) · Nature Immunology

T-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

Cited by 478

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

Paumen, M. B., Ishida, Y., Muramatsu, M., Yamamoto, M., & Honjo, T. (1997) · Journal of Biological Chemistry

Sphingolipid Metabolism and SignalingCell death mechanisms and regulation

Cited by 349

Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice

Al-Habsi, M., Chamoto, K., Matsumoto, K., Nomura, N., Zhang, B., Sugiura, Y., Sonomura, K., Maharani, A., Nakajima, Y., Wu, Y., et al. (2022) · Science

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 223

Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death

Shibahara, K., Asano, M., Ishida, Y., Aoki, T., Koike, T., & Honjo, T. (1995) · Gene

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 223

Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

Chamoto, K., Yaguchi, T., Tajima, M., & Honjo, T. (2023) · Nature Reviews Immunology

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 185

Fatal Autoimmune Hepatitis Induced by Concurrent Loss of Naturally Arising Regulatory T Cells and PD-1-Mediated Signaling

Kido, M., Watanabe, N., Okazaki, T., Akamatsu, T., Tanaka, J., Saga, K., Nishio, A., Honjo, T., & Chiba, T. (2008) · Gastroenterology

Liver Diseases and ImmunityT-cell and B-cell Immunology

Cited by 119

Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining

Stanlie, A., Yousif, A. S., Akiyama, H., Honjo, T., & Begum, N. A. (2014) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 101