Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
Abstract
Typical programmed cell death requires de novo macromolecular synthesis and shares common morphological changes referred to as apoptosis. To elucidate the molecular mechanism of apoptosis, we isolated cDNA clones that are induced in various types of apoptosis by the differential display method. Among such clones, the MA-3 mRNA was induced in all apoptosis-inducible cell lines tested so far, including thymocytes, T cells, B cells and pheochromocytoma. The nucleotide sequence of the MA-3 cDNA predicted an amino acid (aa) sequence of 469 aa, which did not reveal significant similarity to any known proteins and functional aa motifs in databases. The MA-3 mRNA was strongly expressed in the thymus although small amounts of the MA-3 mRNA were ubiquitously expressed in mouse adult tissues. The MA-3 gene was highly conserved during evolution and cross-hybridization bands were found not only in vertebrates but also in Drosophila melanogaster.
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PDCD4 is a tumor suppressor induced by apoptotic stimuli that regulates both translation and transcription.
“PDCD4 is a tumor suppressor induced by apoptotic stimuli that regulates both translation and transcription.”
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- Authors
- Shibahara, K., Asano, M., Ishida, Y., Aoki, T., Koike, T., & Honjo, T.
- Affiliations
- Kyoto University (JP)
- Hokkaido University (JP)
- Corresponding author
- Honjo, Tasuku
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 166
- Issue
- 2
- Pages
- 297-301
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W1965598882
- Cited by
- 223
- References
- 0
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 10 · 2020: 4 · 2019: 8 · 2018: 15 · 2017: 5 · 2016: 16 · 2015: 12 · 2014: 12 · 2013: 13 · 2012: 7
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
- Keywords
- apoptosis, programmed cell death, cDNA cloning, differential display, thymus, thymocytes, T cells, B cells, pheochromocytoma, gene expression, evolutionary conservation, Drosophila melanogaster, novel genes
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Biological Evolution, Molecular Sequence Data, Proteins, RNA, Messenger, Sequence Homology, Nucleic Acid, Thymus Gland, Tissue Distribution, Gene Expression, RNA-Binding Proteins, Apoptosis, DNA, Complementary, Apoptosis Regulatory Proteins, Mice, Rats
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