Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
Open accessAbstract
The mechanism to maintain homeostasis of the gut microbiota remains largely unknown despite its critical role in the body defense. In the intestines of mice with deficiency of activation-induced cytidine deaminase (AID), the absence of hypermutated IgA is partially compensated for by the presence of large amounts of unmutated IgM and normal expression levels of defensins and angiogenins. We show here a predominant and persistent expansion of segmented filamentous bacteria throughout the small intestine of AID –/– mice. Reconstitution of lamina propria IgA production in AID –/– mice recovered the normal composition of gut flora and abolished the local and systemic activation of the immune system. The results indicate that secretions of IgAs rather than innate defense peptides are critical to regulation of commensal bacterial flora and that the segmented filamentous bacteria antigens are strong stimuli of the mucosal immune system.
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Defective IgA secretion or function induces microbial dysbiosis.
“In turn, defective IgA secretion or function induces microbial dysbiosis [46, 47].”
From Gut microbiota-mediated immunomodulation in tumor (2021) · cites this paper as [47]
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- Authors
- Suzuki, K., Meek, B., Doi, Y., Muramatsu, M., Chiba, T., Honjo, T., & Fagarasan, S.
- Affiliations
- Kyoto University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-02-06
- Volume
- 101
- Issue
- 7
- Pages
- 1981-1986
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC357038
- OpenAlex
- W2065174433
- Cited by
- 721
- References
- 25
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 31 · 2023: 29 · 2022: 26 · 2021: 37 · 2020: 35 · 2019: 46 · 2018: 37 · 2017: 37 · 2016: 41 · 2015: 49 · 2014: 63 · 2013: 41 · 2012: 36
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Kyoto University Research Information Repository (Kyoto University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- segmented filamentous bacteria, IgA deficiency, activation-induced cytidine deaminase, gut microbiota homeostasis, defensins, angiogenin, mucosal immunity, commensal bacteria, small intestine
- MeSH terms
- AICDA (Activation-Induced Cytidine Deaminase), Anaerobiosis, Anastomosis, Surgical, Animals, Bacteria, Cytidine Deaminase, DNA-Binding Proteins, Immunoglobulin A, Immunity, Innate, Intestine, Small, Mice, Inbred C57BL, Phenotype, Gene Deletion, Mice, Knockout, Immunity, Mucosal, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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