Dalkara, Deniz

In Vivo–Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

Dalkara, D., Byrne, L. C., Klimczak, R. R., Visel, M., Yin, L., Merigan, W. H., Flannery, J. G., & Schaffer, D. V. (2013) · Science Translational Medicine

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 734

Partial recovery of visual function in a blind patient after optogenetic therapy

Sahel, J.-A., Boulanger-Scemama, E., Pagot, C., Arleo, A., Galluppi, F., Martel, J. N., Esposti, S. D., Delaux, A., de Saint Aubert, J.-B., de Montleau, C., et al. (2021) · Nature Medicine

Photoreceptor and optogenetics researchRetinal Development and Disorders

Cited by 700

Inner limiting membrane barriers to aav-mediated retinal transduction from the vitreous

Dalkara, D., Kolstad, K. D., Caporale, N., Visel, M., Klimczak, R. R., Schaffer, D. V., & Flannery, J. G. (2009) · Molecular Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 357

Emerging therapies for inherited retinal degeneration

Scholl, H. P. N., Strauss, R. W., Singh, M. S., Dalkara, D., Roska, B., Picaud, S., & Sahel, J.-A. (2016) · Science Translational Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 219

Intravitreal injection of AAV2 transduces macaque inner retina

Yin, L., Greenberg, K., Hunter, J. J., Dalkara, D., Kolstad, K. D., Masella, B. D., Wolfe, R., Visel, M., Stone, D., Libby, R. T., et al. (2011) · Investigative Opthalmology & Visual Science

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 212

A Novel Adeno-Associated Viral Variant for Efficient and Selective Intravitreal Transduction of Rat Müller Cells

Klimczak, R. R., Koerber, J. T., Dalkara, D., Flannery, J. G., & Schaffer, D. V. (2009) · PLoS ONE

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 210

Early and late stage gene therapy interventions for inherited retinal degenerations

Botto, C., Rucli, M., Tekinsoy, M. D., Pulman, J., Sahel, J.-A., & Dalkara, D. (2022) · Progress in Retinal and Eye Research

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 190

LiGluR restores visual responses in rodent models of inherited blindness

Caporale, N., Kolstad, K. D., Lee, T., Tochitsky, I., Dalkara, D., Trauner, D., Kramer, R., Dan, Y., Isacoff, E. Y., & Flannery, J. G. (2011) · Molecular Therapy

Retinal Development and DisordersPhotoreceptor and optogenetics research

Cited by 182

Molecular evolution of adeno-associated virus for enhanced glial gene delivery

Koerber, J. T., Klimczak, R., Jang, J.-H., Dalkara, D., Flannery, J. G., & Schaffer, D. V. (2009) · Molecular Therapy

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 181

Nicotine inhibits the VTA-to-amygdala dopamine pathway to promote anxiety

Nguyen, C., Mondoloni, S., Le Borgne, T., Centeno, I., Come, M., Jehl, J., Solié, C., Reynolds, L. M., Durand-de Cuttoli, R., Tolu, S., et al. (2021) · Neuron

Neurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Cited by 136

Noninvasive gene delivery to foveal cones for vision restoration

Khabou, H., Garita-Hernandez, M., Chaffiol, A., Reichman, S., Jaillard, C., Brazhnikova, E., Bertin, S., Forster, V., Desrosiers, M., Winckler, C., et al. (2018) · JCI Insight

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 124

In vivo–directed evolution of adeno-associated virus in the primate retina

Byrne, L. C., Day, T. P., Visel, M., Strazzeri, J. A., Fortuny, C., Dalkara, D., Merigan, W. H., Schaffer, D. V., & Flannery, J. G. (2020) · JCI Insight

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 104

Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h−/− mouse

Byrne, L. C., Öztürk, B. E., Lee, T., Fortuny, C., Visel, M., Dalkara, D., Schaffer, D. V., & Flannery, J. G. (2014) · Gene Therapy

Retinal Development and DisordersVirus-based gene therapy research

Cited by 96

Dosage thresholds and influence of transgene cassette in adeno-associated virus–related toxicity

Khabou, H., Cordeau, C., Pacot, L., Fisson, S., & Dalkara, D. (2018) · Human Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 93

AAV-Mediated Gene Delivery to 3D Retinal Organoids Derived from Human Induced Pluripotent Stem Cells

Garita-Hernandez, M., Routet, F., Guibbal, L., Khabou, H., Toualbi, L., Riancho, L., Reichman, S., Duebel, J., Sahel, J.-A., Goureau, O., et al. (2020) · International Journal of Molecular Sciences

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 82

Insight into the mechanisms of enhanced retinal transduction by the engineered AAV2 capsid variant -7m8

Khabou, H., Desrosiers, M., Winckler, C., Fouquet, S., Auregan, G., Bemelmans, A., Sahel, J., & Dalkara, D. (2016) · Biotechnology and Bioengineering

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 71

Gene therapy for inherited retinal disease: Long-term durability of effect

Leroy, B. P., Fischer, M. D., Flannery, J. G., MacLaren, R. E., Dalkara, D., Scholl, H. P. N., Chung, D. C., Spera, C., Viriato, D., & Banhazi, J. (2023) · Ophthalmic Research

Retinal Development and DisordersVirus-based gene therapy research

Cited by 70

Vectors and Gene Delivery to the Retina

Planul, A., & Dalkara, D. (2017) · Annual Review of Vision Science

Retinal Development and DisordersVirus-based gene therapy research

Cited by 67

Optogenetic Light Sensors in Human Retinal Organoids

Garita-Hernandez, M., Guibbal, L., Toualbi, L., Routet, F., Chaffiol, A., Winckler, C., Harinquet, M., Robert, C., Fouquet, S., Bellow, S., et al. (2018) · Frontiers in Neuroscience

Photoreceptor and optogenetics researchRetinal Development and Disorders

Cited by 65

Changes in adeno-associated virus-mediated gene delivery in retinal degeneration

Kolstad, K. D., Dalkara, D., Guerin, K., Visel, M., Hoffmann, N., Schaffer, D. V., & Flannery, J. G. (2010) · Human Gene Therapy

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 63

Systemic and local immune responses to intraocular AAV vector administration in non-human primates

Ail, D., Ren, D., Brazhnikova, E., Nouvel-Jaillard, C., Bertin, S., Mirashrafi, S. B., Fisson, S., & Dalkara, D. (2022) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRetinal Development and Disorders

Cited by 61

Imaging light responses of foveal ganglion cells in the living macaque eye

Yin, L., Masella, B., Dalkara, D., Zhang, J., Flannery, J. G., Schaffer, D. V., Williams, D. R., & Merigan, W. H. (2014) · The Journal of Neuroscience

Retinal Development and DisordersVisual perception and processing mechanisms

Cited by 54

Immune responses to gene editing by viral and non-viral delivery vectors used in retinal gene therapy

Ren, D., Fisson, S., Dalkara, D., & Ail, D. (2022) · Pharmaceutics

Retinal Development and DisordersVirus-based gene therapy research

Cited by 52

AAV‐mediated gene delivery in Dp71‐null mouse model with compromised barriers

Vacca, O., Darche, M., Schaffer, D. V., Flannery, J. G., Sahel, J., Rendon, A., & Dalkara, D. (2014) · Glia

Retinal Development and DisordersVirus-based gene therapy research

Cited by 48