Lane, David P.

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 6,607

p53, guardian of the genome

Lane, D. P. (1992) · Nature

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 5,138

Awakening guardian angels: drugging the p53 pathway

Brown, C. J., Lain, S., Verma, C. S., Fersht, A. R., & Lane, D. P. (2009) · Nature Reviews Cancer

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 881

p53 isoforms can regulate p53 transcriptional activity

Bourdon, J.-C., Fernandes, K., Murray-Zmijewski, F., Liu, G., Diot, A., Xirodimas, D. P., Saville, M. K., & Lane, D. P. (2005) · Genes & Development

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 810

Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity

Xirodimas, D. P., Saville, M. K., Bourdon, J.-C., Hay, R. T., & Lane, D. P. (2004) · Cell

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 570

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

Sabapathy, K., & Lane, D. P. (2018) · Nature Reviews Clinical Oncology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 517

Translating p53 into the clinic

Cheok, C. F., Verma, C. S., Baselga, J., & Lane, D. P. (2011) · Nature Reviews Clinical Oncology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 381

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo

Böttger, A., Böttger, V., Sparks, A., Liu, W.-L., Howard, S. F., & Lane, D. P. (1997) · Current Biology

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 363

p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence

Fujita, K., Mondal, A. M., Horikawa, I., Nguyen, G. H., Kumamoto, K., Sohn, J. J., Bowman, E. D., Mathe, E. A., Schetter, A. J., Pine, S. R., et al. (2009) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 336

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

Stevenson, L. F., Sparks, A., Allende‐Vega, N., Xirodimas, D. P., Lane, D. P., & Saville, M. K. (2007) · The EMBO Journal

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 280

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

Stad, R., Little, N. A., Xirodimas, D. P., Frenk, R., van der Eb, A. J., Lane, D. P., Saville, M. K., & Jochemsen, A. G. (2001) · The EMBO Reports

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 234

Comparative study of the p53-mdm2 and p53-MDMX interfaces

Böttger, V., Böttger, A., Garcia-Echeverria, C., Ramos, Y. F., van der Eb, A. J., Jochemsen, A. G., & Lane, D. P. (1999) · Oncogene

Cancer-related Molecular PathwaysHeat shock proteins research

Cited by 189

Combining native and ‘omics’ mass spectrometry to identify endogenous ligands bound to membrane proteins

Gault, J., Liko, I., Landreh, M., Shutin, D., Bolla, J. R., Jefferies, D., Agasid, M., Yen, H.-Y., Ladds, M. J. G. W., Lane, D. P., et al. (2020) · Nature Methods

Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and Applications

Cited by 171

bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

Lim, S., Khoo, R., Peh, K. M., Teo, J., Chang, S. C., Ng, S., Beilhartz, G. L., Melnyk, R. A., Johannes, C. W., Brown, C. J., et al. (2020) · Proceedings of the National Academy of Sciences

Protein Degradation and InhibitorsUbiquitin and proteasome pathways

Cited by 170

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo

Xirodimas, D., Saville, M. K., Edling, C., Lane, D. P., & Laín, S. (2001) · Oncogene

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 169

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

Mondal, A. M., Horikawa, I., Pine, S. R., Fujita, K., Morgan, K. M., Vera, E., Mazur, S. J., Appella, E., Vojtesek, B., Blasco, M. A., et al. (2013) · Journal of Clinical Investigation

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 164

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo

Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J.-C., Woods, Y. L., & Lane, D. P. (2004) · Journal of Biological Chemistry

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 158

Hypophosphorylation of Mdm2 Augments p53 Stability

Blattner, C., Hay, T., Meek, D. W., & Lane, D. P. (2002) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 144

When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions

Bradbury, A. R. M., Trinklein, N. D., Thie, H., Wilkinson, I. C., Tandon, A. K., Anderson, S., Bladen, C. L., Jones, B., Aldred, S. F., Bestagno, M., et al. (2018) · mAbs

Monoclonal and Polyclonal Antibodies ResearchProtein purification and stability

Cited by 121

Radiation-induced astrocyte senescence is rescued by Δ133p53

Turnquist, C., Beck, J. A., Horikawa, I., Obiorah, I. E., Von Muhlinen, N., Vojtesek, B., Lane, D. P., Grunseich, C., Chahine, J. J., Ames, H. M., et al. (2019) · Neuro-Oncology

Telomeres, Telomerase, and SenescenceEffects of Radiation Exposure

Cited by 118

MdmX is a substrate for the deubiquitinating enzyme USP2a

Allende-Vega, N., Sparks, A., Lane, D. P., & Saville, M. K. (2010) · Oncogene

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

Cited by 100

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

Xirodimas, D. P., Chisholm, J., Desterro, J. M. S., Lane, D. P., & Hay, R. T. (2002) · FEBS Letters

Cancer-related Molecular PathwaysUbiquitin and proteasome pathways

Cited by 94

Nutlin-3 inhibits the NFκB Pathway in a p53 Dependent Manner: Implications in Lung Cancer Therapy

Dey, A., Wong, E. T., Bist, P., Tergaonkar, V., & Lane, D. (2007) · Cell Cycle

NF-κB Signaling PathwaysCancer-related Molecular Pathways

Cited by 70

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

Wong, J. H., Alfatah, M., Sin, M. F., Sim, H. M., Verma, C. S., Lane, D. P., & Arumugam, P. (2017) · BMC Biology

Cancer-related Molecular PathwaysFungal and yeast genetics research

Cited by 45