Lein, Pamela J.

A non-hallucinogenic psychedelic analogue with therapeutic potential

Cameron, L. P., Tombari, R. J., Lu, J., Pell, A. J., Hurley, Z. Q., Ehinger, Y., Vargas, M. V., McCarroll, M. N., Taylor, J. C., Myers-Turnbull, D., et al. (2021) · Nature

Psychedelics and Drug StudiesAlkaloids: synthesis and pharmacology

Cited by 473

Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity

Pessah, I. N., Cherednichenko, G., & Lein, P. J. (2010) · Pharmacology & Therapeutics

Toxic Organic Pollutants ImpactIon channel regulation and function

Cited by 231

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

Keil, K. P., & Lein, P. J. (2016) · Environmental Epigenetics

Autism Spectrum Disorder ResearchEpigenetics and DNA Methylation

Cited by 167

Developmental Exposure to Polychlorinated Biphenyls Interferes with Experience-Dependent Dendritic Plasticity and Ryanodine Receptor Expression in Weanling Rats

Yang, D., Kim, K. H., Phimister, A., Bachstetter, A. D., Ward, T. R., Stackman, R. W., Mervis, R. F., Wisniewski, A. B., Klein, S. L., Kodavanti, P. R. S., et al. (2009) · Environmental Health Perspectives

Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals

Cited by 166

PCB-95 Promotes Dendritic Growth via Ryanodine Receptor–Dependent Mechanisms

Wayman, G. A., Yang, D., Bose, D. D., Lesiak, A., Ledoux, V., Bruun, D., Pessah, I. N., & Lein, P. J. (2012) · Environmental Health Perspectives

Toxic Organic Pollutants ImpactNeuroscience and Neuropharmacology Research

Cited by 136

Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders

Stamou, M., Streifel, K. M., Goines, P. E., & Lein, P. J. (2013) · Neurotoxicology and Teratology

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 128

Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche, E., Grandjean, P., Crofton, K. M., Aschner, M., Goldberg, A., Heinonen, T., Hessel, E. V. S., Hogberg, H. T., Bennekou, S. H., Lein, P. J., et al. (2018) · Toxicology and Applied Pharmacology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 124

Transient stimulation with psychoplastogens is sufficient to initiate neuronal growth

Ly, C., Greb, A. C., Vargas, M. V., Duim, W. C., Grodzki, A. C. G., Lein, P. J., & Olson, D. E. (2021) · ACS Pharmacology & Translational Science

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 123

Putative adverse outcome pathways relevant to neurotoxicity

Bal-Price, A., Crofton, K. M., Sachana, M., Shafer, T. J., Behl, M., Forsby, A., Hargreaves, A., Landesmann, B., Lein, P. J., Louisse, J., et al. (2015) · Critical Reviews in Toxicology

Animal testing and alternativesImmunotoxicology and immune responses

Cited by 114

Identification of Psychoplastogenic N , N -Dimethylaminoisotryptamine (isoDMT) Analogues through Structure–Activity Relationship Studies

Dunlap, L. E., Azinfar, A., Ly, C., Cameron, L. P., Viswanathan, J., Tombari, R. J., Myers-Turnbull, D., Taylor, J. C., Grodzki, A. C., Lein, P. J., et al. (2020) · Journal of Medicinal Chemistry

Psychedelics and Drug StudiesSynthesis and bioactivity of alkaloids

Cited by 95

The Environmental Neurotoxicant PCB 95 Promotes Synaptogenesis via Ryanodine Receptor-Dependent miR132 Upregulation

Lesiak, A., Zhu, M., Chen, H., Appleyard, S. M., Impey, S., Lein, P. J., & Wayman, G. A. (2014) · The Journal of Neuroscience

Toxic Organic Pollutants ImpactNeuroscience and Neuropharmacology Research

Cited by 88

Immunologic and neurodevelopmental susceptibilities of autism

Pessah, I. N., Seegal, R. F., Lein, P. J., LaSalle, J., Yee, B. K., Van De Water, J., & Berman, R. F. (2008) · NeuroToxicology

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 51