Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression

Tumors: Wounds That Do Not Heal

Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · see citing works

Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.

Garin‐Chesa, P., Old, L. J., & Rettig, W. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7235 · Cited by 749 · see citing works

The Sequential Analysis of Cancer Development

Farber, E., & Cameron, R. (1980) · Advances in cancer research · doi:10.1016/s0065-230x(08)60658-2 · Cited by 597 · see citing works

Antitumor effects of interferon

Gresser, I., & Tovey, M. G. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(78)90009-4 · Cited by 339 · see citing works

Stromal-epithelial interactions in adult organs

Cunha, G. R., Bigsby, R. M., Cooke, P. S., & Sugimura, Y. (1985) · Cell Differentiation · doi:10.1016/0045-6039(85)90481-6 · Cited by 309 · see citing works

Interleukins 1α and 6 and Tumor Necrosis Factor-α Are Paracrine Inhibitors of Human Melanocyte Proliferation and Melanogenesis

Swope, V. B., ABDEL‐MALEK, Z. A., Kassem, L. M., & Nordlund, J. J. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12460991 · Cited by 269 · see citing works

Specific growth response of ras-transformed embryo fibroblasts to tumour promoters

Dotto, G. P., Parada, L. F., & Weinberg, R. A. (1985) · Nature · doi:10.1038/318472a0 · Cited by 201 · see citing works

Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects

Kerbel, R. S. (1990) · Advances in cancer research · doi:10.1016/s0065-230x(08)60469-8 · Cited by 178 · see citing works

Cytokines in disease

Whicher, J. T., & Evans, S. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.7.1269 · Cited by 175 · see citing works

Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors

Rodeck, U., Herlyn, M., Menssen, H. D., Furlanetto, R. W., & Koprowski, H. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910400520 · Cited by 143 · see citing works

Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.

Dotto, G. P., Moellmann, G. E., Ghosh, S., Edwards, M., & Halaban, R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.3115 · Cited by 143 · see citing works

Malignant transformation of mouse primary keratinocytes by Harvey sarcoma virus and its modulation by surrounding normal cells.

Dotto, G. P., Weinberg, R. A., & Ariza, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.17.6389 · Cited by 136 · see citing works

Growth-Regulatory Factors for Normal, Premalignant, and Malignant Human Cells In Vitro

Herlyn, M., Kath, R., Williams, N. N., Valyi-Nagy, I. T., & Rodeck, U. (1990) · Advances in cancer research · doi:10.1016/s0065-230x(08)60812-x · Cited by 118 · see citing works

Loss of growth factor dependence and conversion of transforming growth factor-beta 1 inhibition to stimulation in metastatic H-ras-transformed murine fibroblasts.

SCHWARZ, L. C., Gingras, M., Goldberg, G., Greenberg, A. H., & Wright, J. (1988) · PubMed · Cited by 111 · see citing works

Leukocyte interleukins induce cultured endothelial cells to produce a highly organized, glycosaminoglycan-rich pericellular matrix.

Montesano, R., Mossaz, A., Ryser, J. E., Orci, L., & VASSALLI, P. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.5.1706 · Cited by 101 · see citing works

Clonal heterogeneity in fibroblast phenotype: Implications for the control of epithelial‐mesenchymal interactions

Schor, S. L., & Schor, A. M. (1987) · BioEssays · doi:10.1002/bies.950070503 · Cited by 101 · see citing works

Regulation of melanoma by the embryonic skin.

Gerschenson, M., Graves, K. H., Carson, S. D., Wells, R. S., & Pierce, G. B. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.19.7307 · Cited by 97 · see citing works

Preferential growth of mammary tumors in intact mammary fatpads.

Miller, F. R., Medina, D. J., & Heppner, G. H. (1981) · PubMed · Cited by 76 · see citing works

Skin fibroblasts obtained from cancer patients display foetal-like migratory behaviour on collagen gels

Schor, S. L., Schor, A. M., Durning, P. E., & Rushton, G. (1985) · Journal of Cell Science · doi:10.1242/jcs.73.1.235 · Cited by 75 · see citing works

Developmental regulation of mammary-derived growth inhibitor expression in bovine mammary tissue.

Kurtz, A., Vogel, F., Funa, K., Heldin, C. H., & Grosse, R. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.5.1779 · Cited by 70 · see citing works

Growth control in cultured 3T3 fibroblasts. V. Purification of an Mr 13,000 polypeptide responsible for growth inhibitory activity.

Hsu, Y., & Wang, J. L. (1986) · The Journal of Cell Biology · doi:10.1083/jcb.102.2.362 · Cited by 70 · see citing works

Enhanced Tumorigenicity, Melanogenesis, and Metastases of a Human Malignant Melanoma After Subdermal Implantation in Nude Mice

Cornil, I., Man, S., Fernandez, B., & Kerbel, R. S. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.12.938 · Cited by 69 · see citing works

Interaction with normal cells suppresses the transformed phenotype of v-myc-transformed quail muscle cells

Rocca, S. A. L., Grossi, M., Falcone, G., Alemà, S., & Tatò, F. (1989) · Cell · doi:10.1016/0092-8674(89)90409-1 · Cited by 55 · see citing works

Mesenchymal-epithelial interactions between normal and transformed human bladder cells.

Pritchett, T. R., Wang, J. K., & Jones, P. (1989) · PubMed · Cited by 41 · see citing works

Coincidental Acquisition of Growth Autonomy and Metastatic Potential During the Malignant Transformation of Factor-Dependent CCL39 Lung Fibroblasts

Chadwick, D. E., & Lagarde, A. (1988) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/80.5.318 · Cited by 38 · see citing works

Site of gene action in steel mice: Analysis of the pigment defect by mesoderm‐ectoderm recombinations

Mayer, T. C. (1973) · Journal of Experimental Zoology · doi:10.1002/jez.1401840308 · Cited by 28 · see citing works

Problems and Paradigms: Multistep emancipation of tumors from growth control: Can it be curbed in a single step?

Klein, G. (1990) · BioEssays · doi:10.1002/bies.950120708 · Cited by 12 · see citing works

Inhibitory diffusible factor IDF45, a G1 phase inhibitor

Blat, C., Chatelain, G., Desauty, G., & HAREL, L. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80737-2 · Cited by 12 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer.

Thalmann, G. N., Anezinis, P., Chang, S., Zhau, H. E., Kim, E. E., Hopwood, V. L., Pathak, S., von Eschenbach, A. C., & Chung, L. W. K. (1994) · PubMed · Cited by 727 · see citing works

Cancer associated fibroblasts (CAFs) in tumor microenvironment

Xing, F. (2010) · Frontiers in Bioscience · doi:10.2741/3613 · Cited by 682 · see citing works

Role of the stromal microenvironment in carcinogenesis of the prostate

Cunha, G. R., Hayward, S. W., Wang, Y. Z., & Ricke, W. A. (2003) · International Journal of Cancer · doi:10.1002/ijc.11335 · Cited by 373 · see citing works

‘Cancer associated fibroblasts’ – more than meets the eye

Madar, S., Goldstein, I., & Rotter, V. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.004 · Cited by 362 · see citing works

Inhibition of tumor growth by elimination of granulocytes.

Pekarek, L. A., Starr, B., Toledano, A. Y., & Schreiber, H. W. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.435 · Cited by 340 · see citing works

Tissue-resident stem cells promote breast cancer growth and metastasis

Muehlberg, F. L., Song, Y.-H., Krohn, A., Pinilla, S. P., Droll, L. H., Leng, X., Seidensticker, M., Ricke, J., Altman, A. M., Devarajan, E., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp036 · Cited by 330 · see citing works

Role of the tumor microenvironment in tumor progression and the clinical applications (Review)

YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320 · see citing works

In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy

Masson, R., Lefèbvre, O., Noël, A., Fahime, E. E., Chenard, M., Wendling, C., Kebers, F., LeMeur, M., Dierich, A., Foidart, J., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.6.1535 · Cited by 289 · see citing works

Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes

Fusenig, N. E., & Boukamp, P. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199811)23:3 · Cited by 282 · see citing works

Regulation of the anti-tumour immune response by cancer-associated fibroblasts

Harper, J. A., & Sainson, R. C. A. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2013.12.005 · Cited by 269 · see citing works

Optimal biologic dose of metronomic chemotherapy regimens is associated with maximum antiangiogenic activity

Shaked, Y., Emmenegger, U., Man, S., Cervi, D., Bertolini, F., Ben‐David, Y., & Kerbel, R. S. (2005) · Blood · doi:10.1182/blood-2005-04-1422 · Cited by 253 · see citing works

The human myoepithelial cell is a natural tumor suppressor.

Sternlicht, M. D., Kedeshian, P. A., Shao, Z. M., Safarians, S., & Barsky, S. H. (1997) · PubMed · Cited by 248 · see citing works

A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment

Panetta, J. C. (1996) · Bulletin of Mathematical Biology · doi:10.1007/bf02460591 · Cited by 233 · see citing works

Tumorigenic conversion of immortal human keratinocytes through stromal cell activation

Skobe, M., & Fusenig, N. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1050 · Cited by 231 · see citing works

Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12.

Nishioka, Y., Hirao, M., Robbins, P. D., Lotze, M. T., & Tahara, H. (1999) · PubMed · Cited by 228 · see citing works

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

Lü, C., & Kerbel, R. S. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.120.5.1281 · Cited by 224 · see citing works

Melanoma miRNA trafficking controls tumour primary niche formation

Dror, S., Sander, L., Doron, H., Sheinboim, D., Barzilai, A., Dishon, Y., Apcher, S., Golan, T., Greenberger, S., Barshack, I., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3399 · Cited by 214 · see citing works

Progression of human cutaneous melanoma is associated with loss of expression of c‐kit proto‐oncogene receptor

Natali, P. G., Nicotra, M., Winkler, A. B., Cavaliere, R., Bigotti, A., & Ullrich, A. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910520207 · Cited by 211 · see citing works

Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells

Mueller, M. M., & Fusenig, N. E. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700903.x · Cited by 177 · see citing works

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

Lü, C., Vickers, M. F., & Kerbel, R. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9215 · Cited by 170 · see citing works

Adipose tissue‐derived stem cells promote prostate tumor growth

Prantl, L., Muehlberg, F. L., Navone, N. M., Song, Y., Vykoukal, J. V., Logothetis, C. J., & Alt, E. (2010) · The Prostate · doi:10.1002/pros.21206 · Cited by 158 · see citing works

Pathophysiological Role of the Cytokine Network in the Anterior Pituitary Gland

ARZT, E. S., Páez-Pereda, M., Castro, C. P., Pagotto, U., Renner, U., & Stalla, G. K. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1998.0176 · Cited by 147 · see citing works

Tumor Microenvironment: Implications in Melanoma Resistance to Targeted Therapy and Immunotherapy

Falcone, I., Conciatori, F., Bazzichetto, C., Ferretti, G., Cognetti, F., Ciuffreda, L., & Milella, M. (2020) · Cancers · doi:10.3390/cancers12102870 · Cited by 147 · see citing works

Connexin43 suppresses proliferation of osteosarcoma U2OS cells through post-transcriptional regulation of p27

Zhang, Y.-W., Morita, I., Ikeda, M., Ma, K.-W., & Murota, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204563 · Cited by 140 · see citing works

The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice

Mrowietz, U., Schwenk, U., Maune, S., Bartels, J., Küpper, M., Fichtner, I., Schröder, J., & Schadendorf, D. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690164 · Cited by 137 · see citing works

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

Flach, E. H., Rebecca, V. W., Herlyn, M., Smalley, K. S. M., & Anderson, A. R. A. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200421k · Cited by 136 · see citing works

Directing the Self-assembly of Tumour Spheroids by Bioprinting Cellular Heterogeneous Models within Alginate/Gelatin Hydrogels

Jiang, T., Munguia-López, J. G., Flores-Torres, S., Grant, J., Vijayakumar, S., León‐Rodríguez, A. D., & Kinsella, J. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-04691-9 · Cited by 136 · see citing works

Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice

Fabra, À., Nakajima, M., BUCANA, C. D., & Fidler, I. J. (1992) · Differentiation · doi:10.1111/j.1432-0436.1992.tb00504.x · Cited by 133 · see citing works

Myoepithelial Cells: Autocrine and Paracrine Suppressors of Breast Cancer Progression

Barsky, S. H., & Karlin, N. J. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9585-5 · Cited by 132 · see citing works

Cell density mediated pericellular hypoxia leads to induction of HIF-1α via nitric oxide and Ras/MAP kinase mediated signaling pathways

Sheta, E. A., Trout, H., Gildea, J. J., Harding, M. A., & Theodorescu, D. (2001) · Oncogene · doi:10.1038/sj.onc.1204972 · Cited by 132 · see citing works

Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis

Nicolson, G. L. (1993) · Cancer and Metastasis Reviews · doi:10.1007/bf00665961 · Cited by 130 · see citing works

Growth retardation in glioma cells cocultured with cells overexpressing a gap junction protein.

Zhu, D., Kidder, G. M., Caveney, S., & Naus, C. C. G. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10218 · Cited by 129 · see citing works

High cancer cell death in syngeneic tumors developed in host mice deficient for the stromelysin-3 matrix metalloproteinase.

Boulay, A., Masson, R., Chenard, M., Fahime, E. E., Cassard, L., Bellocq, J., Sautès‐Fridman, C., Basset, P., & Rio, M. C. (2001) · PubMed · Cited by 127 · see citing works

Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitroevidence

Manov, I., Hirsh, M., Iancu, T. C., Malik, A., Sotnichenko, N., Band, M., Avivi, A., & Shams, I. (2013) · BMC Biology · doi:10.1186/1741-7007-11-91 · Cited by 126 · see citing works

Role of myoepithelial cells in breast tumor progression

Pandey, P. R. (2009) · Frontiers in bioscience · doi:10.2741/3617 · Cited by 126 · see citing works

Prognostic Impact of Cancer-Associated Stromal Cells in Patients With Stage I Lung Adenocarcinoma

Ito, M., Ishii, G., Nagai, K., Maeda, R., Nakano, Y., & Ochiai, A. (2012) · CHEST Journal · doi:10.1378/chest.11-2458 · Cited by 122 · see citing works

Tyrosinase Gene Expression is Regulated by p53

Khlgatian, M. K., Hadshiew, I., Asawanonda, P., Yaar, M., Eller, M. S., Gilchrest, B. A., Fujita, M., & Norris, D. A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01667.x · Cited by 121 · see citing works

Regulation of Mel-CAM/MUC18 expression on melanocytes of different stages of tumor progression by normal keratinocytes.

Shih, I., Elder, D. E., Hsu, M., & Herlyn, M. (1994) · PubMed Central · Cited by 122 · see citing works

The role of fibroblasts in tumor behavior

Gr�goire, M., & Lieubeau, B. (1995) · Cancer and Metastasis Reviews · doi:10.1007/bf00690602 · Cited by 119 · see citing works

Perspective of Targeting Cancer-Associated Fibroblasts in Melanoma

Zhou, L., YANG, K. Y., Andl, T., Wickett, R. R., & Zhang, Y. (2015) · Journal of Cancer · doi:10.7150/jca.10865 · Cited by 118 · see citing works

Photodynamic therapy of vulvar intraepithelial neoplasia using 5-aminolevulinic acid

Hillemanns, P., Untch, M., Dannecker, C., Baumgartner, R., Stepp, H. G., Diebold, J., Weingandt, H., Pr�ve, F., & Korell, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000301)85:5 · Cited by 110 · see citing works

Phosphorylation of p27 Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4

Larrea, M. D., Liang, J., Silva, T. D., Hong, F., Shao, S. H., Han, K. C.-Z., Dumont, D. J., & Slingerland, J. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.02300-07 · Cited by 107 · see citing works

Subungual melanoma of the hand

Quinn, M. J., Thompson, J. E., Crotty, K. A., McCarthy, W. H., & Coates, A. S. (1996) · The Journal Of Hand Surgery · doi:10.1016/s0363-5023(96)80371-6 · Cited by 100 · see citing works

Tumor Cell Interactions with the Extracellular Matrix During Invasion and Metastasis

Stetler‐Stevenson, W. G. (1993) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.9.1.541 · Cited by 97 · see citing works

The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype

Nguyen, M. T. N., Lee, M. C., Wang, J. L., Tomlinson, J. S., Shao, Z., Alpaugh, M. L., & Barsky, S. H. (2000) · Oncogene · doi:10.1038/sj.onc.1203677 · Cited by 89 · see citing works

Induction of Hepatocyte Growth Factor/Scatter Factor by Fibroblast Clustering Directly Promotes Tumor Cell Invasiveness

Kankuri, E. M., Cholujová, D., Comajova, M., Vaheri, A. I., & Bízik, J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1559 · Cited by 87 · see citing works

Nanovesicles engineered from ES cells for enhanced cell proliferation

Jeong, D., Jo, W., Yoon, J., Kim, J., Gianchandani, S., Gho, Y. S., & Park, J. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.07.047 · Cited by 88 · see citing works

Active Roles of Tumor Stroma in Breast Cancer Metastasis

Khamis, Z. I., Sahab, Z. J., & Sang, Q. A. (2012) · International Journal of Breast Cancer · doi:10.1155/2012/574025 · Cited by 86 · see citing works

Fibroblasts are critical determinants in prostatic cancer growth and dissemination

Chung, L. W. K. (1991) · Cancer and Metastasis Reviews · doi:10.1007/bf00050797 · Cited by 84 · see citing works

Fibroblasts Can Modulate the Phenotype of Malignant Epithelial Cellsin Vitro

Atula, S., Grenman, R. A., & Syrjänen, S. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3676 · Cited by 80 · see citing works

Interleukin-6 dependent induction of the cyclin dependent kinase inhibitor p21WAF1/CIP1 is lost during progression of human malignant melanoma

Flørenes, V. A., Lü, C., Bhattacharya, N., Rak, J. W., Sheehan, C., Slingerland, J. M., & Kerbel, R. S. (1999) · Oncogene · doi:10.1038/sj.onc.1202382 · Cited by 79 · see citing works

Podoplanin Expression Identified in Stromal Fibroblasts as a Favorable Prognostic Marker in Patients with Colorectal Carcinoma

Yamanashi, T., Nakanishi, Y., Fujii, G., Akishima‐Fukasawa, Y., Moriya, Y., Kanai, Y., Watanabe, M., & Hirohashi, S. (2009) · Oncology · doi:10.1159/000226112 · Cited by 78 · see citing works

Effect of cancer-associated fibroblasts on the migration of glioma cells in vitro

Trylčová, J., Bušek, P., Smetana, K., Balážiová, E., Dvořánková, B., Fíková, A., & Šedo, A. (2015) · Tumor Biology · doi:10.1007/s13277-015-3259-8 · Cited by 77 · see citing works

Characterization of an in vitro model of human melanoma invasion based on reconstructed human skin

Eves, P. C., Layton, C. J., Hedley, S. J., Dawson, R., Wagner, M., Morandini, R., Ghanem, G., & Neil, S. M. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03287.x · Cited by 75 · see citing works

TGF-β Signaling, Activated Stromal Fibroblasts, and Cysteine Cathepsins B and L Drive the Invasive Growth of Human Melanoma Cells

Yin, M., Soikkeli, J., Jahkola, T., Virolainen, S., Saksela, O., & Hölttä, E. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.08.027 · Cited by 74 · see citing works

Influence of Tumor Microenvironment and Fibroblast Population Plasticity on Melanoma Growth, Therapy Resistance and Immunoescape

Romano, V., Belviso, I., Venuta, A., Ruocco, M. R., Masone, S., Aliotta, F., Fiume, G., Montagnani, S., Avagliano, A., & Arcucci, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105283 · Cited by 73 · see citing works

Effects of genistein and daidzein on the cell growth, cell cycle, and differentiation of human and murine melanoma cells1 1The abbreviations used are: BSA, bovine serum albumin; FBS, fetal bovine serum; ECM, extracellular matrix; DMSO, dimethyl sulfoxide; PTK, protein tyrosine kinase.

Wang, H.-Z., Zhang, Y., Xie, L.-P., Yu, X.-Y., & Zhang, R.-Q. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00184-5 · Cited by 73 · see citing works

Hematopoietic origins of fibroblasts: I. In vivo studies of fibroblasts associated with solid tumors

LaRue, A. C., Masuya, M., Ebihara, Y., Fleming, P. A., Visconti, R. P., Minamiguchi, H., Ogawa, M., & Drake, C. J. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2005.10.009 · Cited by 73 · see citing works

Myoepithelial mRNA expression profiling reveals a common tumor-suppressor phenotype

Barsky, S. H. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00011-x · Cited by 72 · see citing works

Solamargine triggers cellular necrosis selectively in different types of human melanoma cancer cells through extrinsic lysosomal mitochondrial death pathway

Al-Sinani, S. S., Eltayeb, E. A., Coomber, B. L., & Adham, S. A. (2016) · Cancer Cell International · doi:10.1186/s12935-016-0287-4 · Cited by 71 · see citing works

Transforming growth factor-β1 enhances the invasiveness of human MDA-MB-231 breast cancer cells by up-regulating urokinase activity

Farina, A. R., Coppa, A., Tiberio, A., Tacconelli, A., Turco, A., Colletta, G., Gulino, A., & Mackay, A. R. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980302)75:5 · Cited by 121 · see citing works

The role of CAF derived exosomal microRNAs in the tumour microenvironment of melanoma

Shelton, M., Anene, C. A., Nsengimana, J., Roberts, W., Newton‐Bishop, J., & Boyne, J. R. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188456 · Cited by 69 · see citing works

Application of competition theory to tumour growth: Implications for tumour biology and treatment

Gatenby, R. A. (1996) · European Journal of Cancer · doi:10.1016/0959-8049(95)00658-3 · Cited by 65 · see citing works

Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis

Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works

A Complex and Evolutive Character: Two Face Aspects of ECM in Tumor Progression

Sala, M., Ros, M., & Saltel, F. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01620 · Cited by 55 · see citing works

Nanoparticle-Mediated Drug Delivery for Treating Melanoma

Mundra, V., Li, W., & Mahato, R. I. (2015) · Nanomedicine · doi:10.2217/nnm.15.111 · Cited by 63 · see citing works

Breast cancer cells attract the migration of adipose tissue-derived stem cells via the PDGF-BB/PDGFR-β signaling pathway

Gehmert, S., Gehmert, S., Prantl, L., Vykoukal, J. V., Alt, E., & Song, Y.-H. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.06.132 · Cited by 63 · see citing works

A host deficiency of discoidin domain receptor 2 ( DDR2 ) inhibits both tumour angiogenesis and metastasis

Zhang, S., Bu, X., Zhao, H., Yu, J., Wang, Y., Li, D., Zhu, C., Zhu, T., Ren, T., Liu, X., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4311 · Cited by 62 · see citing works

Mechanisms of Disease: breast tumor pathogenesis and the role of the myoepithelial cell

Barsky, S. H., & Karlin, N. J. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0450 · Cited by 60 · see citing works

Role of Stromal Fibroblasts in Cancer: Promoting or Impeding?

Angeli, F., Koumakis, G., Chen, M.-C., Kumar, S., & Delinassios, J. G. (2009) · Tumor Biology · doi:10.1159/000218708 · Cited by 58 · see citing works

Selective evolutionary pressure from the tissue microenvironment drives tumor progression

Smalley, K. S. M., Brafford, P. A., & Herlyn, M. (2005) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2005.06.002 · Cited by 54 · see citing works

Progressive loss of sensitivity to endothelium‐derived growth inhibitors expressed by human melanoma cells during disease progression

Rak, J. W., Hegmann, E. J., Lü, C., & Kerbel, R. S. (1994) · Journal of Cellular Physiology · doi:10.1002/jcp.1041590208 · Cited by 54 · see citing works

Conversion of Human Colonic Adenoma Cells to Adenocarcinoma Cells Through Inflammation in Nude Mice

Okada, F., Kawaguchi, T., Habelhah, H., Kobayashi, T., Tazawa, H., Takeichi, N., Kitagawa, T., & Hosokawa, M. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780172 · Cited by 54 · see citing works

Melanoma invasion in reconstructed human skin is influenced by skin cells – investigation of the role of proteolytic enzymes

Eves, P. C., Katerinaki, E., Simpson, C., Layton, C., Dawson, R., EVANS, G. S., & Neil, S. M. (2003) · Clinical & Experimental Metastasis · doi:10.1023/b:clin.0000006824.41376.b0 · Cited by 53 · see citing works

Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival

Flørenes, V. A., Skrede, M. L., Jørgensen, K., & Nesland, J. M. (2004) · Melanoma Research · doi:10.1097/01.cmr.0000129576.49313.26 · Cited by 52 · see citing works

Metastastic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction

Chen, Z., Smith, C. W., Kiel, D., & Waes, C. V. (1997) · Clinical & Experimental Metastasis · doi:10.1023/a:1018474910432 · Cited by 51 · see citing works

Endogenous interleukin 6 can function as an in vivo growth- stimulatory factor for advanced-stage human melanoma cells.

Lü, C., Sheehan, C., Rak, J. W., Chambers, C. A., Hozumi, N., & Kerbel, R. S. (1996) · PubMed · Cited by 51 · see citing works

Growth factor independence and growth regulatory pathways in human melanoma development

Rodeck, U. (1993) · Cancer and Metastasis Reviews · doi:10.1007/bf00665954 · Cited by 49 · see citing works

Human melanoma-derived ectosomes are enriched with specific glycan epitopes

Surman, M., Hoja-Łukowicz, D., Szwed, S., Drożdż, A., Stępień, E. Ł., & Przybyło, M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.06.026 · Cited by 48 · see citing works

A Cancer Invasion Model Combined with Cancer-Associated Fibroblasts Aggregates Incorporating Gelatin Hydrogel Microspheres Containing a p53 Inhibitor

Nii, T., Makino, K., & Tabata, Y. (2019) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2019.0189 · Cited by 47 · see citing works

The Role of Cytokines and Chemokines on Tumor Progression: A Review

Ardestani, S. K., Inserra, P. F., Solkoff, D., & WATSON, R. R. (1999) · Cancer Detection and Prevention · doi:10.1046/j.1525-1500.1999.99021.x · Cited by 47 · see citing works

Seed, soil and secreted hormones: Potential interactions of breast cancer cells with their endocrine/paracrine microenvironment and implications for treatment with bisphosphonates

Wilson, C., Holen, I., & Coleman, R. E. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.02.007 · Cited by 46 · see citing works

Quantifying rates of cell migration and cell proliferation in co-culture barrier assays reveals how skin and melanoma cells interact during melanoma spreading and invasion

Haridas, P., Penington, C. J., McGovern, J., McElwain, D. L. S., & Simpson, M. J. (2017) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2017.04.017 · Cited by 46 · see citing works

Epidermal growth factor receptor-mediated autocrine and paracrine stimulation of human transitional cell carcinoma.

Gleave, M. E., Hsieh, J., Wu, H., Hong, S. J., Zhau, H. E., Guthrie, P. D., & Chung, L. W. K. (1993) · PubMed · Cited by 46 · see citing works

Importance of orthotopic transplantation procedures in assessing the effects of transfected genes on human tumor growth and metastasis

Kerbel, R. S., Cornil, I., & Theodorescu, D. (1991) · Cancer and Metastasis Reviews · doi:10.1007/bf00050792 · Cited by 45 · see citing works

Targeting the Microenvironment in High Grade Serous Ovarian Cancer

Nwani, N. G., Sima, L. E., Nieves‐Neira, W., & Matei, D. E. (2018) · Cancers · doi:10.3390/cancers10080266 · Cited by 44 · see citing works

Interleukin-2 (IL-2) and IL-6 regulate c-fos protooncogene expression in human pituitary adenoma explants

Páez-Pereda, M., Goldberg, V., Chervín, A., Carrizo, G., Molina, A., Andrada, J. J., Sauer, J., Renner, U., Stalla, G. K., & ARZT, E. S. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(96)03924-x · Cited by 42 · see citing works

Role of Matrix, Fibroblasts and Type IV Collagenases in Tumor Progression and Invasion

Noël, A., Emonard, H., Polette, M., Birembaut, P., & Foidart, J. M. (1994) · Pathology - Research and Practice · doi:10.1016/s0344-0338(11)80999-4 · Cited by 42 · see citing works

Expression of multi-cytokine resistance and multi-growth factor independence in advanced stage metastatic cancer. Malignant melanoma as a paradigm.

Kerbel, R. S. (1992) · PubMed Central · Cited by 42 · see citing works

Transfer of malignant trait to BRCA1 deficient human fibroblasts following exposure to serum of cancer patients

Hamam, D., Abdouh, M., Gao, Z., Arena, V., Arena, M., & Arena, G. O. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0360-9 · Cited by 40 · see citing works

Tumor Metastasis to Brain: Role of Endothelial Cells, Neurotrophins, and Paracrine Growth Factors

Nicolson, G. L., Menter, D. G., Herrmann, J. L., Cavanaugh, P. G., Jia, L., Hamada, J., Yun, Z., Nakajima, M., & Marchetti, D. (1994) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.v5.i5.20 · Cited by 41 · see citing works

Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma

de Araújo, V. C., Altemani, A., Furuse, C., Martins, M. T., & de Araújo, N. S. (2006) · Oral Oncology · doi:10.1016/j.oraloncology.2005.12.021 · Cited by 40 · see citing works

Proteomic analysis of membrane rafts of melanoma cells identifies protein patterns characteristic of the tumor progression stage

Baruthio, F., Quadroni, M., Rüegg, C., & Mariotti, A. (2008) · PROTEOMICS · doi:10.1002/pmic.200800169 · Cited by 39 · see citing works

Differential responses of scirrhous and well-differentiated gastric cancer cells to orthotopic fibroblasts

Yashiro, M., Chung, Y.-S., Kubo, T., Hato, F., & Sowa, M. (1996) · British Journal of Cancer · doi:10.1038/bjc.1996.496 · Cited by 39 · see citing works

Fli-1 expression in malignant melanoma.

Torlakovic, E., Slipicevic, A., Flørenes, V. A., Chibbar, R., DeCoteau, J. F., & Bilalović, N. (2008) · PubMed · doi:10.14670/hh-23.1309 · Cited by 38 · see citing works

Tamoxifen enhances myoepithelial cell suppression of human breast carcinoma progression in vitro by two different effector mechanisms

Shao, Z., Radziszewski, W., & Barsky, S. H. (2000) · Cancer Letters · doi:10.1016/s0304-3835(00)00466-3 · Cited by 38 · see citing works

Expression of integrins α3β1 and α5β1 and GlcNAc β1,6 glycan branching influences metastatic melanoma cell migration on fibronectin

Pocheć, E., Janik, M., Hoja-Łukowicz, D., Link‐Lenczowski, P., Przybyło, M., & Lityń́ska, A. (2013) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2013.10.007 · Cited by 37 · see citing works

Advances in 3D bioprinting for the biofabrication of tumor models

Sánchez-Salazar, M. G., Álvarez, M. M., & Santiago, G. T. (2020) · Bioprinting · doi:10.1016/j.bprint.2020.e00120 · Cited by 36 · see citing works

STAT5 contributes to antiapoptosis in melanoma

Hassel, J. C., Winnemöller, D., Schartl, M., & Wellbrock, C. (2008) · Melanoma Research · doi:10.1097/cmr.0b013e32830ce7d7 · Cited by 37 · see citing works

Human fibroblasts are able to inhibit growth of human melanoma cells

Bantel‐Schaal, U. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00074-3 · Cited by 5 · see citing works

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

Lü, C., Vickers, M. F., & Kerbel, R. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.19.9215 · Cited by 170 · see citing works

Modulatory growth effects of 3T3 fibroblasts on cocultivated human melanoma cells.

Benathan, M., Pararas, C., & Frenk, E. (1991) · PubMed · Cited by 12 · see citing works

Fibroblasts Contribute to Melanoma Tumor Growth and Drug Resistance

Flach, E. H., Rebecca, V. W., Herlyn, M., Smalley, K. S. M., & Anderson, A. R. A. (2011) · Molecular Pharmaceutics · doi:10.1021/mp200421k · Cited by 136 · see citing works

Dual role of fibroblasts in tumor cell growth.

Koldovský, P., Haas, I., Bier, H., & Ganzer, U. (1995) · PubMed