Dow, Lukas E.

Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

Yun, J., Mullarky, E., Lu, C., Bosch, K. N., Kavalier, A., Rivera, K., Roper, J., Chio, I. I. C., Giannopoulou, E. G., Rago, C., et al. (2015) · Science

Vitamin C and Antioxidants ResearchCancer, Hypoxia, and Metabolism

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A rectal cancer organoid platform to study individual responses to chemoradiation

Ganesh, K., Wu, C., O’Rourke, K. P., Szeglin, B. C., Zheng, Y., Sauvé, C.-E. G., Adileh, M., Wasserman, I., Marco, M. R., Kim, A. S., et al. (2019) · Nature Medicine

Cancer Cells and MetastasisColorectal Cancer Surgical Treatments

Cited by 569

Optimized base editors enable efficient editing in cells, organoids and mice

Zafra, M. P., Schatoff, E. M., Katti, A., Foronda, M., Breinig, M., Schweitzer, A. Y., Simon, A., Han, T., Goswami, S., Montgomery, E., et al. (2018) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 347

A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference

Premsrirut, P. K., Dow, L. E., Kim, S. Y., Camiolo, M., Malone, C. D., Miething, C., Scuoppo, C., Zuber, J., Dickins, R. A., Kogan, S. C., et al. (2011) · Cell

RNA Interference and Gene DeliveryAnimal Genetics and Reproduction

Cited by 315

Dietary fructose improves intestinal cell survival and nutrient absorption

Taylor, S. R., Ramsamooj, S., Liang, R. J., Katti, A., Pozovskiy, R., Vasan, N., Hwang, S.-K., Nahiyaan, N., Francoeur, N. J., Schatoff, E. M., et al. (2021) · Nature

Diet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Cited by 288

Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis

Palikuqi, B., Nguyen, D.-H. T., Li, G., Schreiner, R., Pellegata, A. F., Liu, Y., Redmond, D., Geng, F., Lin, Y., Gómez-Salinero, J. M., et al. (2020) · Nature

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 259

WNT as a Driver and Dependency in Cancer

Parsons, M. J., Tammela, T., & Dow, L. E. (2021) · Cancer Discovery

Wnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies

Cited by 257

p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer

Tschaharganeh, D. F., Xue, W., Calvisi, D. F., Evert, M., Michurina, T. V., Dow, L. E., Banito, A., Katz, S. F., Kastenhuber, E. R., Weissmueller, S., et al. (2014) · Cell

Cancer-related Molecular PathwaysLiver physiology and pathology

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Adenine base editing in an adult mouse model of tyrosinaemia

Song, C.-Q., Jiang, T., Richter, M., Rhym, L. H., Koblan, L. W., Zafra, M. P., Schatoff, E. M., Doman, J. L., Cao, Y., Dow, L. E., et al. (2019) · Nature Biomedical Engineering

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 200

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

Dow, L. E., Kauffman, J. S., Caddy, J., Peterson, A. S., Jane, S. M., Russell, S. M., & Humbert, P. O. (2007) · Oncogene

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 187

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Pearson, H. B., Perez-Mancera, P. A., Dow, L. E., Ryan, A., Tennstedt, P., Bogani, D., Elsum, I., Greenfield, A., Tuveson, D. A., Simon, R., et al. (2011) · Journal of Clinical Investigation

Prostate Cancer Treatment and ResearchProtein Kinase Regulation and GTPase Signaling

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Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

Dow, L. E., Elsum, I. A., King, C. L., Kinross, K. M., Richardson, H. E., & Humbert, P. O. (2008) · Oncogene

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 171

A pipeline for the generation of shRNA transgenic mice

Dow, L. E., Premsrirut, P. K., Zuber, J., Fellmann, C., McJunkin, K., Miething, C., Park, Y., Dickins, R. A., Hannon, G. J., & Lowe, S. W. (2012) · Nature Protocols

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 159

An In Vivo Kras Allelic Series Reveals Distinct Phenotypes of Common Oncogenic Variants

Zafra, M. P., Parsons, M. J., Kim, J., Alonso-Curbelo, D., Goswami, S., Schatoff, E. M., Han, T., Katti, A., Fernandez, M. T. C., Wilkinson, J. E., et al. (2020) · Cancer Discovery

Protein Kinase Regulation and GTPase SignalingPancreatic and Hepatic Oncology Research

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Alveolar Differentiation Drives Resistance to KRAS Inhibition in Lung Adenocarcinoma

Li, Z., Zhuang, X., Pan, C.-H., Yan, Y., Thummalapalli, R., Hallin, J., Torborg, S., Singhal, A., Chang, J. C., Manchado, E., et al. (2024) · Cancer Discovery

Lung Cancer Treatments and MutationsCancer Cells and Metastasis

Cited by 74

The polarity protein Scribble regulates myelination and remyelination in the central nervous system

Jarjour, A. A., Boyd, A., Dow, L. E., Holloway, R. K., Goebbels, S., Humbert, P. O., Williams, A., & ffrench-Constant, C. (2015) · PLOS Biology

Neurogenesis and neuroplasticity mechanismsMultiple Sclerosis Research Studies

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