WNT as a Driver and Dependency in Cancer
Open accessAbstract
The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of WNT signaling is common, the type and frequency of genetic WNT pathway alterations can vary dramatically between different cancers, highlighting possible cancer-specific mechanisms for WNT-driven disease. In this review, we discuss how WNT pathway disruption contributes to tumorigenesis in different organs and how WNT affects the tumor cell and immune microenvironment. Finally, we describe recent and ongoing efforts to target oncogenic WNT signaling as a therapeutic strategy. Significance: WNT signaling is a fundamental regulator of tissue homeostasis and oncogenic driver in many cancer types. In this review, we highlight recent advances in our understanding of WNT signaling in cancer, particularly the complexities of WNT activation in distinct cancer types, its role in immune evasion, and the challenge of targeting the WNT pathway as a therapeutic strategy.
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The Wnt/β-catenin pathway plays a critical role in maintaining the cancer stem cell population in malignant tissues, making Wnt a potential target in CRC.
“The Wnt/β-catenin pathway also plays a critical role in maintaining the cancer stem cell (CSC) population in malignant tissues making Wnt a potential target in CRC [109]”
From Recent Advances in Therapeutic Strategies to Improve Colorectal Cancer Treatment (2024) · cites this paper as [109]
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- Authors
- Parsons, M. J., Tammela, T., & Dow, L. E.
- Affiliations
- Weill Cornell Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Dow, Lukas E.
- Venue
- Cancer Discovery
- Published
- 2021-09-13
- Volume
- 11
- Issue
- 10
- Pages
- 2413-2429
- ISSN
- 2159-8274 (ISSN-L)
- 2159-8290
- PMC
- PMC8487948
- OpenAlex
- W3199697997
- Cited by
- 257
- References
- 195
- Citations by year
- 2026: 36 · 2025: 50 · 2024: 70 · 2023: 56 · 2022: 41 · 2021: 4
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cancer Discovery (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Cancer Society (131461-RSG-17-202-01-TBG)
- NCI (1R01CA222517-01A1)
- Starr Cancer Consortium (SCC I14-0023)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Keywords
- Wnt signaling, carcinogenesis, tumor immune microenvironment, immune evasion, Wnt pathway inhibitors, cancer therapy, tissue homeostasis
- MeSH terms
- Humans, Neoplasms, Tumor Microenvironment, Wnt Signaling Pathway, Carcinogenesis
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