Brash, Douglas E.

A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma

Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences

Nonmelanoma Skin Cancer StudiesSkin Protection and Aging

Cited by 1,959

Sunburn and p53 in the onset of skin cancer

Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature

Nonmelanoma Skin Cancer StudiesSkin Protection and Aging

Cited by 1,497

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., et al. (2012) · Nature Genetics

Melanoma and MAPK PathwaysCutaneous Melanoma Detection and Management

Cited by 1,191

Frequent clones of p53-mutated keratinocytes in normal human skin

Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E., & Brash, D. E. (1996) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysNonmelanoma Skin Cancer Studies

Cited by 685

Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure

Premi, S., Wallisch, S., Mano, C. M., Weiner, A. B., Bacchiocchi, A., Wakamatsu, K., Bechara, E. J. H., Halaban, R., Douki, T., & Brash, D. E. (2015) · Science

Photochemistry and Electron Transfer Studiesmelanin and skin pigmentation

Cited by 550

UV Signature Mutations

Brash, D. E. (2015) · Photochemistry and Photobiology

Cancer Genomics and DiagnosticsCarcinogens and Genotoxicity Assessment

Cited by 401

Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences.

Lippke, J. A., Gordon, L. K., Brash, D. E., & Haseltine, W. A. (1981) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 250

Photoproduct frequency is not the major determinant of UV base substitution hot spots or cold spots in human cells.

Brash, D. E., Seetharam, S., Kraemer, K. H., Seidman, M. M., & Bredberg, A. (1987) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 237

Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin

Takeuchi, S., Zhang, W., Wakamatsu, K., Ito, S., Hearing, V. J., Kraemer, K. H., & Brash, D. E. (2004) · Proceedings of the National Academy of Sciences

melanin and skin pigmentationSkin Protection and Aging

Cited by 196

Escaping the stem cell compartment: Sustained UVB exposure allows p53 -mutant keratinocytes to colonize adjacent epidermal proliferating units without incurring additional mutations

Zhang, W., Remenyik, E., Zelterman, D., Brash, D. E., & Wikonkal, N. M. (2001) · Proceedings of the National Academy of Sciences

Nonmelanoma Skin Cancer StudiesSkin Protection and Aging

Cited by 173

Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair

Rochette, P. J., & Brash, D. E. (2010) · PLoS Genetics

DNA Repair MechanismsTelomeres, Telomerase, and Senescence

Cited by 133

New careers for antioxidants

Brash, D. E., & Havre, P. A. (2002) · Proceedings of the National Academy of Sciences

Antioxidant Activity and Oxidative StressFree Radicals and Antioxidants

Cited by 108

Genomic sites hypersensitive to ultraviolet radiation

Premi, S., Han, L., Mehta, S., Knight, J., Zhao, D., Palmatier, M. A., Kornacker, K., & Brash, D. E. (2019) · Proceedings of the National Academy of Sciences

DNA Repair MechanismsCarcinogens and Genotoxicity Assessment

Cited by 95

Progressive apoptosis resistance prior to senescence and control by the anti-apoptotic protein BCL-xL

Rochette, P. J., & Brash, D. E. (2008) · Mechanisms of Ageing and Development

Cell death mechanisms and regulationTelomeres, Telomerase, and Senescence

Cited by 68

Next-generation sequencing methodologies to detect low-frequency mutations: “Catch me if you can”

Menon, V., & Brash, D. E. (2023) · Mutation Research - Reviews in Mutation Research

Cancer Genomics and DiagnosticsGenomics and Rare Diseases

Cited by 48

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes

Brash, D. E., Wikonkal, N. M., Remenyik, E., van der Horst, G. T. J., Friedberg, E. C., Cheo, D. L., van Steeg, H., Westerman, A., & van Kranen, H. J. (2001) · Journal of Investigative Dermatology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 47

Chemical excitation of electrons: A dark path to melanoma

Premi, S., & Brash, D. E. (2016) · DNA Repair

melanin and skin pigmentationDNA Repair Mechanisms

Cited by 47

Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling

Knezevic, D., Zhang, W., Rochette, P. J., & Brash, D. E. (2007) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 34

Colonization of adjacent stem cell compartments by mutant keratinocytes

BRASH, D., ZHANG, W., GROSSMAN, D., & TAKEUCHI, S. (2005) · Seminars in Cancer Biology

Nonmelanoma Skin Cancer StudiesSkin Protection and Aging

Cited by 32

Triplet-Energy Quenching Functions of Antioxidant Molecules

Angelé-Martínez, C., Goncalves, L. C. P., Premi, S., Augusto, F. A., Palmatier, M. A., Amar, S. K., & Brash, D. E. (2022) · Antioxidants

Free Radicals and AntioxidantsPhotochemistry and Electron Transfer Studies

Cited by 21

Chemiexcitation: Mammalian Photochemistry in the Dark†

Brash, D. E., & Goncalves, L. C. P. (2023) · Photochemistry and Photobiology

Photochemistry and Electron Transfer StudiesCircadian rhythm and melatonin

Cited by 16

Chemiexcited neurotransmitters and hormones create DNA photoproducts in the dark

Gonçalves, L. C. P., Angelé-Martínez, C., Premi, S., Palmatier, M. A., Prado, F. M., Di Mascio, P., Bastos, E. L., & Brash, D. E. (2023) · ACS Chemical Biology

Photochemistry and Electron Transfer StudiesCircadian rhythm and melatonin

Cited by 15