Nixon, Ralph A.

Olfactory Dysfunction Correlates with Amyloid-β Burden in an Alzheimer's Disease Mouse Model

Wesson, D. W., Levy, E., Nixon, R. A., & Wilson, D. A. (2010) · The Journal of Neuroscience

Olfactory and Sensory Function StudiesAlzheimer's disease research and treatments

Cited by 290

Down syndrome and Alzheimer's disease: common pathways, common goals

Hartley, D., Blumenthal, T., Carrillo, M., DiPaolo, G., Esralew, L., Gardiner, K., Granholm, A.-C., Iqbal, K., Krams, M., Lemere, C., et al. (2015) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 290

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for β-amyloid peptide over-production and localization in Alzheimer’s disease

Yu, W. H., Kumar, A., Peterhoff, C., Shapiro Kulnane, L., Uchiyama, Y., Lamb, B. T., Cuervo, A. M., & Nixon, R. A. (2004) · The International Journal of Biochemistry & Cell Biology

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 279

App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome

Cataldo, A. M., Petanceska, S., Peterhoff, C. M., Terio, N. B., Epstein, C. J., Villar, A., Carlson, E. J., Staufenbiel, M., & Nixon, R. A. (2003) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 241

Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy

Rothenberg, C., Srinivasan, D., Mah, L., Kaushik, S., Peterhoff, C. M., Ugolino, J., Fang, S., Cuervo, A. M., Nixon, R. A., & Monteiro, M. J. (2010) · Human Molecular Genetics

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 225

The Ubiquitin-Proteasome System and the Autophagic-Lysosomal System in Alzheimer Disease

Ihara, Y., Morishima-Kawashima, M., & Nixon, R. (2012) · Cold Spring Harbor Perspectives in Medicine

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 190

Cortical Plasticity in Alzheimer’s Disease in Humans and Rodents

Battaglia, F., Wang, H.-Y., Ghilardi, M. F., Gashi, E., Quartarone, A., Friedman, E., & Nixon, R. A. (2007) · Biological Psychiatry

Neuroscience and Neuropharmacology ResearchAlzheimer's disease research and treatments

Cited by 175

Dysfunction of autophagy and endosomal-lysosomal pathways: Roles in pathogenesis of Down syndrome and Alzheimer’s Disease

Colacurcio, D. J., Pensalfini, A., Jiang, Y., & Nixon, R. A. (2018) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 167

DNA strand breaks in Alzheimer’s disease

Adamec, E., Vonsattel, J. P., & Nixon, R. A. (1999) · Brain Research

Alzheimer's disease research and treatmentsDNA Repair Mechanisms

Cited by 167

Lysosomal Dysfunction in Down Syndrome Is APP-Dependent and Mediated by APP-βCTF (C99)

Jiang, Y., Sato, Y., Im, E., Berg, M., Bordi, M., Darji, S., Kumar, A., Mohan, P. S., Bandyopadhyay, U., Diaz, A., et al. (2019) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 166

The aging lysosome: An essential catalyst for late-onset neurodegenerative diseases

Nixon, R. A. (2020) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Autophagy in Disease and TherapyLysosomal Storage Disorders Research

Cited by 149

Lysosomal NEU1 deficiency affects amyloid precursor protein levels and amyloid-β secretion via deregulated lysosomal exocytosis

Annunziata, I., Patterson, A., Helton, D., Hu, H., Moshiach, S., Gomero, E., Nixon, R., & d’Azzo, A. (2013) · Nature Communications

Alzheimer's disease research and treatmentsGlycosylation and Glycoproteins Research

Cited by 146

A gene toolbox for monitoring autophagy transcription

Bordi, M., De Cegli, R., Testa, B., Nixon, R. A., Ballabio, A., & Cecconi, F. (2021) · Cell Death & Disease

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 131

Single-Walled Carbon Nanotubes Alleviate Autophagic/Lysosomal Defects in Primary Glia from a Mouse Model of Alzheimer’s Disease

Xue, X., Wang, L.-R., Sato, Y., Jiang, Y., Berg, M., Yang, D.-S., Nixon, R. A., & Liang, X.-J. (2014) · Nano Letters

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 125

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

Bordi, M., Darji, S., Sato, Y., Mellén, M., Berg, M. J., Kumar, A., Jiang, Y., & Nixon, R. A. (2019) · Cell Death & Disease

Autophagy in Disease and TherapyDown syndrome and intellectual disability research

Cited by 124

Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits

Yang, D.-S., Stavrides, P., Saito, M., Kumar, A., Rodriguez-Navarro, J. A., Pawlik, M., Huo, C., Walkley, S. U., Saito, M., Cuervo, A. M., et al. (2014) · Brain

Autophagy in Disease and TherapyAlzheimer's disease research and treatments

Cited by 114

Elevated Levels of the Endosomal‐Lysosomal Proteinase Cathepsin D in Cerebrospinal Fluid in Alzheimer Disease

Schwagerl, A. L., Mohan, P. S., Cataldo, A. M., Vonsattel, J. P., Kowall, N. W., & Nixon, R. A. (1995) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 107

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1‐mediated APP processing

Okada, H., Zhang, W., Peterhoff, C., Hwang, J. C., Nixon, R. A., Ryu, S. H., & Kim, T. (2010) · The FASEB Journal

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 102

Endocytic disturbances distinguish among subtypes of alzheimer's disease and related disorders

Cataldo, A., Rebeck, G. W., Ghetti, B., Hulette, C., Lippa, C., Van Broeckhoven, C., Van Duijn, C., Cras, P., Bogdanovic, N., Bird, T., et al. (2001) · Annals of Neurology

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 90

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn down syndrome mouse model

Choi, J. H. K., Berger, J. D., Mazzella, M. J., Morales‐Corraliza, J., Cataldo, A. M., Nixon, R. A., Ginsberg, S. D., Levy, E., & Mathews, P. M. (2009) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 83

Anesthesia-Induced Hyperphosphorylation Detaches 3-Repeat Tau from Microtubules without Affecting Their Stability In Vivo

Planel, E., Krishnamurthy, P., Miyasaka, T., Liu, L., Herman, M., Kumar, A., Bretteville, A., Figueroa, H. Y., Haung Yu, W., Whittington, R. A., et al. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsAnesthesia and Neurotoxicity Research

Cited by 79

The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease

Bendl, J., Hauberg, M. E., Girdhar, K., Im, E., Vicari, J. M., Rahman, S., Fernando, M. B., Townsley, K. G., Dong, P., Misir, R., et al. (2022) · Nature Neuroscience

Genomics and Chromatin DynamicsAlzheimer's disease research and treatments

Cited by 65