Fields, Stanley

A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae

Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature

Bioinformatics and Genomic NetworksFungal and yeast genetics research

Cited by 4,706

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 1,293

Deep mutational scanning: a new style of protein science

Fowler, D. M., & Fields, S. (2014) · Nature Methods

Genomics and Rare DiseasesCRISPR and Genetic Engineering

Cited by 1,287

Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling

Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 982

Substrate-specific activation of sirtuins by resveratrol

Kaeberlein, M., McDonagh, T., Heltweg, B., Hixon, J., Westman, E. A., Caldwell, S. D., Napper, A., Curtis, R., DiStefano, P. S., Fields, S., et al. (2005) · Journal of Biological Chemistry

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 745

Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

Hesselberth, J. R., Chen, X., Zhang, Z., Sabo, P. J., Sandstrom, R., Reynolds, A. P., Thurman, R. E., Neph, S., Kuehn, M. S., Noble, W. S., et al. (2009) · Nature Methods

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 559

High-resolution mapping of protein sequence-function relationships

Fowler, D. M., Araya, C. L., Fleishman, S. J., Kellogg, E. H., Stephany, J. J., Baker, D., & Fields, S. (2010) · Nature Methods

Chemical Synthesis and AnalysisProtein Structure and Dynamics

Cited by 516

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

Steffen, K. K., MacKay, V. L., Kerr, E. O., Tsuchiya, M., Hu, D., Fox, L. A., Dang, N., Johnston, E. D., Oakes, J. A., Tchao, B. N., et al. (2008) · Cell

Genetics, Aging, and Longevity in Model OrganismsFungal and yeast genetics research

Cited by 465

Sir2-Independent Life Span Extension by Calorie Restriction in Yeast

Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Cited by 441

A protein linkage map of Escherichia coli bacteriophage T7

Bartel, P. L., Roecklein, J. A., SenGupta, D., & Fields, S. (1996) · Nature Genetics

Bacterial Genetics and BiotechnologyBacteriophages and microbial interactions

Cited by 333

Engineering an allosteric transcription factor to respond to new ligands

Taylor, N. D., Garruss, A. S., Moretti, R., Chan, S., Arbing, M. A., Cascio, D., Rogers, J. K., Isaacs, F. J., Kosuri, S., Baker, D., et al. (2016) · Nature Methods

Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction

Cited by 328

Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator.

Hofer, F., Fields, S., Schneider, C., & Martin, G. S. (1994) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 287

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

Araya, C. L., Fowler, D. M., Chen, W., Muniez, I., Kelly, J. W., & Fields, S. (2012) · Proceedings of the National Academy of Sciences

Protein Structure and Dynamicsthermodynamics and calorimetric analyses

Cited by 230

Deep learning of the regulatory grammar of yeast 5′ untranslated regions from 500,000 random sequences

Cuperus, J. T., Groves, B., Kuchina, A., Rosenberg, A. B., Jojic, N., Fields, S., & Seelig, G. (2017) · Genome Research

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 205

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

Starita, L. M., Pruneda, J. N., Lo, R. S., Fowler, D. M., Kim, H. J., Hiatt, J. B., Shendure, J., Brzovic, P. S., Fields, S., & Klevit, R. E. (2013) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 183

Whole-genome sequencing of a laboratory-evolved yeast strain

Araya, C. L., Payen, C., Dunham, M. J., & Fields, S. (2010) · BMC Genomics

Genomics and Phylogenetic StudiesFungal and yeast genetics research

Cited by 113

Deep Mutational Scanning: A Highly Parallel Method to Measure the Effects of Mutation on Protein Function

Starita, L. M., & Fields, S. (2015) · Cold Spring Harbor Protocols

Fungal and yeast genetics researchCRISPR and Genetic Engineering

Cited by 32

Mapping functional regions of essential bacterial proteins with dominant-negative protein fragments

Savinov, A., Fernandez, A., & Fields, S. (2022) · Proceedings of the National Academy of Sciences

Chemical Synthesis and AnalysisBacterial Genetics and Biotechnology

Cited by 8