Saido, Takaomi C.

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease

Thal, D. R., Papassotiropoulos, A., Saido, T. C., Griffin, W. S. T., Mrak, R. E., Kölsch, H., Tredici, K. D., Attems, J., & Ghebremedhin, E. (2010) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 103

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Carpanini, S. M., Torvell, M., Bevan, R. J., Byrne, R. A. J., Daskoulidou, N., Saito, T., Saido, T. C., Taylor, P. R., Hughes, T. R., Zelek, W. M., et al. (2022) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsComplement system in diseases

Cited by 95

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice

Park, H., Cho, B., Kim, H., Saito, T., Saido, T. C., Won, K.-J., & Kim, J. (2023) · Nature Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 92

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL−G−F mice before prominent plaque deposition

Latif-Hernandez, A., Shah, D., Craessaerts, K., Saido, T., Saito, T., De Strooper, B., Van der Linden, A., & D’Hooge, R. (2019) · Behavioural Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 92

Preferential deposition of amyloid β protein (Aβ) in the form Aβ40 in Alzheimer's disease is associated with a gene dosage effect of the apolipoprotein E E4 allele

Mann, D. M. A., Iwatsubo, T., Pickering-Brown, S. M., Owen, F., Saido, T. C., & Perry, R. H. (1997) · Neuroscience Letters

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 91

Brain Trauma in Aged Transgenic Mice Induces Regression of Established Aβ Deposits

Nakagawa, Y., Reed, L., Nakamura, M., McIntosh, T. K., Smith, D. H., Saatman, K. E., Raghupathi, R., Clemens, J., Saido, T. C., Lee, V. M.-Y., et al. (2000) · Experimental Neurology

Alzheimer's disease research and treatmentsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 91

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2018) · BMC Neuroscience

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 90

Reduction in open field activity in the absence of memory deficits in the AppNL−G−F knock-in mouse model of Alzheimer’s disease

Whyte, L. S., Hemsley, K. M., Lau, A. A., Hassiotis, S., Saito, T., Saido, T. C., Hopwood, J. J., & Sargeant, T. J. (2018) · Behavioural Brain Research

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 88

Istradefylline reduces memory deficits in aging mice with amyloid pathology

Orr, A. G., Lo, I., Schumacher, H., Ho, K., Gill, M., Guo, W., Kim, D. H., Knox, A., Saito, T., Saido, T. C., et al. (2018) · Neurobiology of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

Sialylation enhances the secretion of neurotoxic amyloid‐β peptides

Nakagawa, K., Kitazume, S., Oka, R., Maruyama, K., Saido, T. C., Sato, Y., Endo, T., & Hashimoto, Y. (2006) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsGlycosylation and Glycoproteins Research

Cited by 83

Quantification of Modified Amyloid β Peptides in Alzheimer Disease and Down Syndrome Brains

Hosoda, R., Saido, T. C., Otvos, L., Arai, T., Mann, D. M. A., Lee, V. M.-Y., Trojanowski, J. Q., & Iwatsubo, T. (1998) · Journal of Neuropathology and Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 79

Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Sharoar, M. G., Palko, S., Ge, Y., Saido, T. C., & Yan, R. (2021) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 78

Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice

Kundu, P., Torres, E. R. S., Stagaman, K., Kasschau, K., Okhovat, M., Holden, S., Ward, S., Nevonen, K. A., Davis, B. A., Saito, T., et al. (2021) · Scientific Reports

Gut microbiota and healthAlzheimer's disease research and treatments

Cited by 75

Protease inhibitor coinfusion with amyloid β-protein results in enhanced deposition and toxicity in rat brain

Frautschy, S. A., Horn, D. L., Sigel, J. J., Harris-White, M. E., Mendoza, J. J., Yang, F., Saido, T. C., & Cole, G. M. (1998) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 65

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer’s disease

Sakakibara, Y., Sekiya, M., Saito, T., Saido, T. C., & Iijima, K. M. (2019) · BMC Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 65

Capillary CAA and perivascular Aβ-deposition: Two distinct features of Alzheimer's disease pathology

Attems, J., Yamaguchi, H., Saido, T. C., & Thal, D. R. (2010) · Journal of the Neurological Sciences

Alzheimer's disease research and treatmentsIntracerebral and Subarachnoid Hemorrhage Research

Cited by 63

PLD3 gene and processing of APP

Fazzari, P., Horre, K., Arranz, A. M., Frigerio, C. S., Saito, T., Saido, T. C., & De Strooper, B. (2017) · Nature

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 54

Apolipoprotein E co-localizes with newly formed amyloid β-protein (Aβ) deposits lacking immunoreactivity against N-terminal epitopes of Aβ in a genotype-dependent manner

Thal, D. R., Capetillo-Zarate, E., Schultz, C., Rüb, U., Saido, T. C., Yamaguchi, H., Haass, C., Griffin, W. S. T., Del Tredici, K., Braak, H., et al. (2005) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 50

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

Pohlkamp, T., Xian, X., Wong, C. H., Durakoglugil, M. S., Werthmann, G. C., Saido, T. C., Evers, B. M., White, C. L., Connor, J., Hammer, R. E., et al. (2021) · eLife

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 46

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and social and anxiety-related behaviours

Pervolaraki, E., Hall, S. P., Foresteire, D., Saito, T., Saido, T. C., Whittington, M. A., Lever, C., & Dachtler, J. (2018) · Disease Models & Mechanisms

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 43

Transgenic Expression of Intraneuronal Aβ 42 But Not Aβ 40 Leads to Cellular Aβ Lesions, Degeneration, and Functional Impairment without Typical Alzheimer's Disease Pathology

Abramowski, D., Rabe, S., Upadhaya, A. R., Reichwald, J., Danner, S., Staab, D., Capetillo-Zarate, E., Yamaguchi, H., Saido, T. C., Wiederhold, K.-H., et al. (2012) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 41

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

Iguchi, A., Takatori, S., Kimura, S., Muneto, H., Wang, K., Etani, H., Ito, G., Sato, H., Hori, Y., Sasaki, J., et al. (2023) · iScience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 37

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice

Sos, K. E., Mayer, M. I., Takács, V. T., Major, A., Bardóczi, Z., Beres, B. M., Szeles, T., Saito, T., Saido, T. C., Mody, I., et al. (2020) · PLOS ONE

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 37

A non-human primate model of familial Alzheimer’s disease

Sato, K., Sasaguri, H., Kumita, W., Inoue, T., Kurotaki, Y., Nagata, K., Mihira, N., Sato, K., Sakuma, T., Yamamoto, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory)

Alzheimer's disease research and treatmentsCRISPR and Genetic Engineering

Cited by 29